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Protein

Superoxide dismutase [Cu-Zn]

Gene

sod3b

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Destroys radicals which are normally produced within the cells and which are toxic to biological systems.UniRule annotation

Catalytic activityi

2 superoxide + 2 H+ = O2 + H2O2.UniRule annotation

Cofactori

Protein has several cofactor binding sites:
  • Cu cationUniRule annotationNote: Binds 1 copper ion per subunit.UniRule annotation
  • Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
LigandCopperUniRule annotation, Metal-bindingUniRule annotation, ZincUniRule annotation

Enzyme and pathway databases

ReactomeiR-DRE-3299685. Detoxification of Reactive Oxygen Species.

Names & Taxonomyi

Protein namesi
Recommended name:
Superoxide dismutase [Cu-Zn]UniRule annotation (EC:1.15.1.1UniRule annotation)
Gene namesi
Name:sod3bImported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 1

Organism-specific databases

ZFINiZDB-GENE-030131-8743. sod3b.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 30Sequence analysisAdd BLAST30
ChainiPRO_500324330031 – 192Superoxide dismutase [Cu-Zn]Sequence analysisAdd BLAST162

Proteomic databases

PaxDbiE9QIM2.

Expressioni

Gene expression databases

ExpressionAtlasiE9QIM2. baseline.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000097881.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini53 – 185Sod_CuInterPro annotationAdd BLAST133

Sequence similaritiesi

Belongs to the Cu-Zn superoxide dismutase family.UniRule annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiKOG0441. Eukaryota.
COG2032. LUCA.
GeneTreeiENSGT00530000063226.
InParanoidiE9QIM2.
KOiK16627.
PhylomeDBiE9QIM2.
TreeFamiTF105133.

Family and domain databases

CDDicd00305. Cu-Zn_Superoxide_Dismutase. 1 hit.
Gene3Di2.60.40.200. 1 hit.
InterProiView protein in InterPro
IPR018152. SOD_Cu/Zn_BS.
IPR001424. SOD_Cu_Zn_dom.
PfamiView protein in Pfam
PF00080. Sod_Cu. 1 hit.
PRINTSiPR00068. CUZNDISMTASE.
SUPFAMiSSF49329. SSF49329. 1 hit.
PROSITEiView protein in PROSITE
PS00087. SOD_CU_ZN_1. 1 hit.
PS00332. SOD_CU_ZN_2. 1 hit.

Sequencei

Sequence statusi: Complete.

E9QIM2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIRFNILPLL AFLLSCHVLF CGSGSGLAYA SNSDSLQAVC RMQPNTRLEP
60 70 80 90 100
GMPRVYGHIL FRQSGPKEKL SVTFRLYGLP ADSQQPRAMH IHEYGDLSRG
110 120 130 140 150
CDSTGGHYNP LNVNHPQHPG DFGNFVPVNK KIRQSLESPA TLFGKLSIVG
160 170 180 190
RSVVIHEGKD DLGRGGNVGS LLNGNAGGRL ACCVIGLRNP QN
Length:192
Mass (Da):20,778
Last modified:April 5, 2011 - v1
Checksum:i03B77EA2974EBECC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR847546 Genomic DNA. No translation available.
RefSeqiXP_001332758.1. XM_001332722.7.
UniGeneiDr.155460.
Dr.36400.

Genome annotation databases

EnsembliENSDART00000112150; ENSDARP00000097881; ENSDARG00000079183.
GeneIDi794006.
KEGGidre:794006.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR847546 Genomic DNA. No translation available.
RefSeqiXP_001332758.1. XM_001332722.7.
UniGeneiDr.155460.
Dr.36400.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000097881.

Proteomic databases

PaxDbiE9QIM2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000112150; ENSDARP00000097881; ENSDARG00000079183.
GeneIDi794006.
KEGGidre:794006.

Organism-specific databases

CTDi794006.
ZFINiZDB-GENE-030131-8743. sod3b.

Phylogenomic databases

eggNOGiKOG0441. Eukaryota.
COG2032. LUCA.
GeneTreeiENSGT00530000063226.
InParanoidiE9QIM2.
KOiK16627.
PhylomeDBiE9QIM2.
TreeFamiTF105133.

Enzyme and pathway databases

ReactomeiR-DRE-3299685. Detoxification of Reactive Oxygen Species.

Gene expression databases

ExpressionAtlasiE9QIM2. baseline.

Family and domain databases

CDDicd00305. Cu-Zn_Superoxide_Dismutase. 1 hit.
Gene3Di2.60.40.200. 1 hit.
InterProiView protein in InterPro
IPR018152. SOD_Cu/Zn_BS.
IPR001424. SOD_Cu_Zn_dom.
PfamiView protein in Pfam
PF00080. Sod_Cu. 1 hit.
PRINTSiPR00068. CUZNDISMTASE.
SUPFAMiSSF49329. SSF49329. 1 hit.
PROSITEiView protein in PROSITE
PS00087. SOD_CU_ZN_1. 1 hit.
PS00332. SOD_CU_ZN_2. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiE9QIM2_DANRE
AccessioniPrimary (citable) accession number: E9QIM2
Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: February 15, 2017
This is version 48 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.