Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Uncharacterized protein

Gene

pcsk1

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine proteaseUniRule annotationSAAS annotation

Enzyme and pathway databases

ReactomeiR-DRE-209952. Peptide hormone biosynthesis.
R-DRE-264876. Insulin processing.

Protein family/group databases

MEROPSiS08.072.

Names & Taxonomyi

Protein namesi
Submitted name:
Uncharacterized proteinImported
Gene namesi
Name:pcsk1Imported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 21

Organism-specific databases

ZFINiZDB-GENE-071009-1. pcsk1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_500324473224 – 754Sequence analysisAdd BLAST731

Proteomic databases

PaxDbiE9QIE6.

Expressioni

Gene expression databases

BgeeiENSDARG00000002600.
ExpressionAtlasiE9QIE6. differential.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000004083.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini32 – 108S8_pro-domainInterPro annotationAdd BLAST77
Domaini161 – 445Peptidase S8InterPro annotationAdd BLAST285
Domaini507 – 594P_proproteinInterPro annotationAdd BLAST88
Domaini713 – 751Proho_convertInterPro annotationAdd BLAST39

Sequence similaritiesi

Belongs to the peptidase S8 family.UniRule annotationSAAS annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiKOG3525. Eukaryota.
COG1404. LUCA.
COG4935. LUCA.
GeneTreeiENSGT00750000117358.

Family and domain databases

Gene3Di2.60.120.260. 1 hit.
3.30.70.850. 1 hit.
3.40.50.200. 1 hit.
InterProiIPR008979. Galactose-bd-like.
IPR000209. Peptidase_S8/S53_dom.
IPR023827. Peptidase_S8_Asp-AS.
IPR022398. Peptidase_S8_His-AS.
IPR023828. Peptidase_S8_Ser-AS.
IPR015500. Peptidase_S8_subtilisin-rel.
IPR022005. Proho_convert.
IPR009020. Propept_inh.
IPR002884. PrprotnconvertsP.
IPR032815. S8_pro-domain.
[Graphical view]
PANTHERiPTHR10795. PTHR10795. 1 hit.
PfamiPF01483. P_proprotein. 1 hit.
PF00082. Peptidase_S8. 1 hit.
PF12177. Proho_convert. 1 hit.
PF16470. S8_pro-domain. 1 hit.
[Graphical view]
PRINTSiPR00723. SUBTILISIN.
SUPFAMiSSF49785. SSF49785. 1 hit.
SSF52743. SSF52743. 1 hit.
SSF54897. SSF54897. 1 hit.
PROSITEiPS00136. SUBTILASE_ASP. 1 hit.
PS00137. SUBTILASE_HIS. 1 hit.
PS00138. SUBTILASE_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E9QIE6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEERCRPMLL CSVLALVCAL VSSAVDRQYL NEWAVEIPGG VQNARSIADE
60 70 80 90 100
FGYQLVRQIG ALENHYLFKR HSHPSRTKRS ADHITKRLSE DDRVSWAEQQ
110 120 130 140 150
YEKRRAKRAP LGVECKDCSV DKLFDDPMWN QQWYLQDTRT SSSLPKLDLH
160 170 180 190 200
VIPVWKKGIT GKGVVITVLD DGLEWNHTDI YPNYDPAASY DFNDNDPDPF
210 220 230 240 250
PRYDSTNENK HGTRCAGEIA MQADNNKCGV GVAYNSKVGG IRMLDGIVTD
260 270 280 290 300
AIEASSIGYN PDHVDIYSAS WGPNDDGKTV EGPGRLAQKA FEYGIQKGRG
310 320 330 340 350
GKGSIFVWAS GNGGRQGDNC DCDGYTDSLY TISISSASQQ GLSPWYAEKC
360 370 380 390 400
SSTLATAYSS GDYTDQRITS ADLHNECTET HTGTSASAPL AAGIFALALE
410 420 430 440 450
QNPDLTWRDL QHLVVWTSEF DPLANNPGWK RNGAGLMVNS RFGFGLLNAK
460 470 480 490 500
ALVDLADPKV WKHVPEKKQC IVRDETFQPR PLKAAGEISI EIPTKACAGQ
510 520 530 540 550
ANSVMSLEHV QVEVSIEYTR RGDLHITLTS PSGTTTVLLA ERERDTSSNG
560 570 580 590 600
FRNWAFMSVH TWGENPTGTW ILKITDTSGR MENEGQIISW KLILHGTSEK
610 620 630 640 650
PEHMKKARVY TPYNAVQNDR RGVEPMEDMM KEAPTPALKP EIPNQAIPDS
660 670 680 690 700
PPSTASMSIP EVNSGPSTAN LALLRLLQSA FNRQMPAAPP KSFQQERIPP
710 720 730 740 750
QKLYQALDLL NRYRASQNGL FNDYSDNFYR AQPYRHRDDR LLQALFDMLR

DDQQ
Length:754
Mass (Da):84,075
Last modified:April 5, 2011 - v1
Checksum:i737C2E5B7CDA5F64
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX511081 Genomic DNA. No translation available.
RefSeqiXP_017208229.1. XM_017352740.1.
UniGeneiDr.89425.

Genome annotation databases

EnsembliENSDART00000147473; ENSDARP00000118568; ENSDARG00000002600.
GeneIDi100005716.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX511081 Genomic DNA. No translation available.
RefSeqiXP_017208229.1. XM_017352740.1.
UniGeneiDr.89425.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000004083.

Protein family/group databases

MEROPSiS08.072.

Proteomic databases

PaxDbiE9QIE6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000147473; ENSDARP00000118568; ENSDARG00000002600.
GeneIDi100005716.

Organism-specific databases

ZFINiZDB-GENE-071009-1. pcsk1.

Phylogenomic databases

eggNOGiKOG3525. Eukaryota.
COG1404. LUCA.
COG4935. LUCA.
GeneTreeiENSGT00750000117358.

Enzyme and pathway databases

ReactomeiR-DRE-209952. Peptide hormone biosynthesis.
R-DRE-264876. Insulin processing.

Gene expression databases

BgeeiENSDARG00000002600.
ExpressionAtlasiE9QIE6. differential.

Family and domain databases

Gene3Di2.60.120.260. 1 hit.
3.30.70.850. 1 hit.
3.40.50.200. 1 hit.
InterProiIPR008979. Galactose-bd-like.
IPR000209. Peptidase_S8/S53_dom.
IPR023827. Peptidase_S8_Asp-AS.
IPR022398. Peptidase_S8_His-AS.
IPR023828. Peptidase_S8_Ser-AS.
IPR015500. Peptidase_S8_subtilisin-rel.
IPR022005. Proho_convert.
IPR009020. Propept_inh.
IPR002884. PrprotnconvertsP.
IPR032815. S8_pro-domain.
[Graphical view]
PANTHERiPTHR10795. PTHR10795. 1 hit.
PfamiPF01483. P_proprotein. 1 hit.
PF00082. Peptidase_S8. 1 hit.
PF12177. Proho_convert. 1 hit.
PF16470. S8_pro-domain. 1 hit.
[Graphical view]
PRINTSiPR00723. SUBTILISIN.
SUPFAMiSSF49785. SSF49785. 1 hit.
SSF52743. SSF52743. 1 hit.
SSF54897. SSF54897. 1 hit.
PROSITEiPS00136. SUBTILASE_ASP. 1 hit.
PS00137. SUBTILASE_HIS. 1 hit.
PS00138. SUBTILASE_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiE9QIE6_DANRE
AccessioniPrimary (citable) accession number: E9QIE6
Entry historyi
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: November 30, 2016
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.