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Protein
Submitted name:

Neural cell adhesion molecule 1

Gene

Ncam1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-MMU-375165. NCAM signaling for neurite out-growth.
R-MMU-419037. NCAM1 interactions.
R-MMU-445144. Signal transduction by L1.
R-MMU-5673001. RAF/MAP kinase cascade.

Names & Taxonomyi

Protein namesi
Submitted name:
Neural cell adhesion molecule 1Imported
Gene namesi
Name:Ncam1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:97281. Ncam1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei714 – 73724HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence analysisAdd
BLAST
Chaini20 – 849830Sequence analysisPRO_5003245910Add
BLAST

Proteomic databases

MaxQBiE9QB01.
PaxDbiE9QB01.
PeptideAtlasiE9QB01.
PRIDEiE9QB01.

Expressioni

Gene expression databases

BgeeiENSMUSG00000039542.
ExpressionAtlasiE9QB01. baseline and differential.
GenevisibleiE9QB01. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000130668.

Structurei

3D structure databases

ProteinModelPortaliE9QB01.
SMRiE9QB01. Positions 20-697.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini20 – 11192Ig-like (immunoglobulin-like)InterPro annotationAdd
BLAST
Domaini116 – 18974Ig-like (immunoglobulin-like)InterPro annotationAdd
BLAST
Domaini212 – 30291Ig-like (immunoglobulin-like)InterPro annotationAdd
BLAST
Domaini309 – 40496Ig-like (immunoglobulin-like)InterPro annotationAdd
BLAST
Domaini407 – 49286Ig-like (immunoglobulin-like)InterPro annotationAdd
BLAST
Domaini500 – 599100Fibronectin type-IIIInterPro annotationAdd
BLAST
Domaini601 – 69797Fibronectin type-IIIInterPro annotationAdd
BLAST

Keywords - Domaini

RepeatSAAS annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG410IQJI. Eukaryota.
ENOG410XTGB. LUCA.
GeneTreeiENSGT00840000129722.
TreeFamiTF326195.

Family and domain databases

Gene3Di2.60.40.10. 7 hits.
InterProiIPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
IPR033019. Ncam1.
IPR009138. Neural_cell_adh.
[Graphical view]
PANTHERiPTHR10489:SF34. PTHR10489:SF34. 1 hit.
PfamiPF00041. fn3. 2 hits.
PF07679. I-set. 3 hits.
[Graphical view]
PRINTSiPR01838. NCAMFAMILY.
SMARTiSM00060. FN3. 2 hits.
SM00409. IG. 5 hits.
SM00408. IGc2. 5 hits.
SM00406. IGv. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 5 hits.
SSF49265. SSF49265. 1 hit.
PROSITEiPS50853. FN3. 2 hits.
PS50835. IG_LIKE. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E9QB01-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRTKDLIWT LFFLGTAVSL QVDIVPSQGE ISVGESKFFL CQVAGDAKDK
60 70 80 90 100
DISWFSPNGE KLSPNQQRIS VVWNDDDSST LTIYNANIDD AGIYKCVVTA
110 120 130 140 150
EDGTQSEATV NVKIFQKLMF KNAPTPQEFK EGEDAVIVCD VVSSLPPTII
160 170 180 190 200
WKHKGRDVIL KKDVRFIVLS NNYLQIRGIK KTDEGTYRCE GRILARGEIN
210 220 230 240 250
FKDIQVIVNV PPTVQARQSI VNATANLGQS VTLVCDADGF PEPTMSWTKD
260 270 280 290 300
GEPIENEEED DEKHIFSDDS SELTIRNVDK NDEAEYVCIA ENKAGEQDAS
310 320 330 340 350
IHLKVFAKPK ITYVENQTAM ELEEQVTLTC EASGDPIPSI TWRTSTRNIS
360 370 380 390 400
SEEKTLDGHM VVRSHARVSS LTLKSIQYTD AGEYICTASN TIGQDSQSMY
410 420 430 440 450
LEVQYAPKLQ GPVAVYTWEG NQVNITCEVF AYPSATISWF RDGQLLPSSN
460 470 480 490 500
YSNIKIYNTP SASYLEVTPD SENDFGNYNC TAVNRIGQES LEFILVQADT
510 520 530 540 550
PSSPSIDRVE PYSSTAQVQF DEPEATGGVP ILKYKAEWKS LGEESWHFKW
560 570 580 590 600
YDAKEANMEG IVTIMGLKPE TRYSVRLAAL NGKGLGEISA ATEFKTQPVR
610 620 630 640 650
EPSAPKLEGQ MGEDGNSIKV NLIKQDDGGS PIRHYLVKYR AKLASEWKPE
660 670 680 690 700
IRLPSGSDHV MLKSLDWNAE YEVYVVAENQ QGKSKAAHFV FRTSAQPTAI
710 720 730 740 750
PANGSPTAGL STGAIVGILI VIFVLLLVVM DITCYFLNKC GLLMCIAVNL
760 770 780 790 800
CGKAGPGAKG KDMEEGKAAF SKDESKEPIV EVRTEEERTP NHDGGKHTEP
810 820 830 840
NETTPLTEPE KGPVETKSEP PESEAKPAPT EVKTVPNDAT QTKENESKA
Length:849
Mass (Da):93,620
Last modified:February 4, 2015 - v2
Checksum:i440E244109D02AF1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC117630 Genomic DNA. No translation available.
AC140447 Genomic DNA. No translation available.
CT025676 Genomic DNA. No translation available.
RefSeqiNP_001297994.1. NM_001311065.1.
UniGeneiMm.439182.
Mm.4974.

Genome annotation databases

EnsembliENSMUST00000166811; ENSMUSP00000130668; ENSMUSG00000039542.
GeneIDi17967.
UCSCiuc009pjf.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC117630 Genomic DNA. No translation available.
AC140447 Genomic DNA. No translation available.
CT025676 Genomic DNA. No translation available.
RefSeqiNP_001297994.1. NM_001311065.1.
UniGeneiMm.439182.
Mm.4974.

3D structure databases

ProteinModelPortaliE9QB01.
SMRiE9QB01. Positions 20-697.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000130668.

Proteomic databases

MaxQBiE9QB01.
PaxDbiE9QB01.
PeptideAtlasiE9QB01.
PRIDEiE9QB01.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000166811; ENSMUSP00000130668; ENSMUSG00000039542.
GeneIDi17967.
UCSCiuc009pjf.1. mouse.

Organism-specific databases

CTDi4684.
MGIiMGI:97281. Ncam1.

Phylogenomic databases

eggNOGiENOG410IQJI. Eukaryota.
ENOG410XTGB. LUCA.
GeneTreeiENSGT00840000129722.
TreeFamiTF326195.

Enzyme and pathway databases

ReactomeiR-MMU-375165. NCAM signaling for neurite out-growth.
R-MMU-419037. NCAM1 interactions.
R-MMU-445144. Signal transduction by L1.
R-MMU-5673001. RAF/MAP kinase cascade.

Miscellaneous databases

ChiTaRSiNcam1. mouse.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000039542.
ExpressionAtlasiE9QB01. baseline and differential.
GenevisibleiE9QB01. MM.

Family and domain databases

Gene3Di2.60.40.10. 7 hits.
InterProiIPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
IPR033019. Ncam1.
IPR009138. Neural_cell_adh.
[Graphical view]
PANTHERiPTHR10489:SF34. PTHR10489:SF34. 1 hit.
PfamiPF00041. fn3. 2 hits.
PF07679. I-set. 3 hits.
[Graphical view]
PRINTSiPR01838. NCAMFAMILY.
SMARTiSM00060. FN3. 2 hits.
SM00409. IG. 5 hits.
SM00408. IGc2. 5 hits.
SM00406. IGv. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 5 hits.
SSF49265. SSF49265. 1 hit.
PROSITEiPS50853. FN3. 2 hits.
PS50835. IG_LIKE. 5 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiE9QB01_MOUSE
AccessioniPrimary (citable) accession number: E9QB01
Entry historyi
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: February 4, 2015
Last modified: September 7, 2016
This is version 54 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.