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Protein
Submitted name:

Unconventional myosin-XVIIIa

Gene

Myo18a

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Motor protein, MyosinSAAS annotation

Keywords - Ligandi

ATP-bindingSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Unconventional myosin-XVIIIaImported
Gene namesi
Name:Myo18aImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:2667185. Myo18a.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Proteomic databases

EPDiE9QAX2.
PaxDbiE9QAX2.

Expressioni

Gene expression databases

BgeeiE9QAX2.
ExpressionAtlasiE9QAX2. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000090563.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini220 – 31192PDZ (DHR)InterPro annotationAdd
BLAST
Domaini453 – 1229777Myosin motorInterPro annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili1293 – 134856Sequence analysisAdd
BLAST
Coiled coili1356 – 139742Sequence analysisAdd
BLAST
Coiled coili1419 – 1545127Sequence analysisAdd
BLAST
Coiled coili1553 – 163280Sequence analysisAdd
BLAST
Coiled coili1638 – 168649Sequence analysisAdd
BLAST
Coiled coili1757 – 185498Sequence analysisAdd
BLAST
Coiled coili1861 – 1972112Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.SAAS annotation
Contains 1 PDZ (DHR) domain.UniRule annotation
Contains IQ domain.SAAS annotation
Contains myosin motor domain.SAAS annotation

Keywords - Domaini

Coiled coilSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG0161. Eukaryota.
COG5022. LUCA.
GeneTreeiENSGT00840000129849.
OMAiIPRPGHR.
TreeFamiTF339614.

Family and domain databases

Gene3Di2.30.42.10. 1 hit.
3.40.50.300. 1 hit.
4.10.270.10. 1 hit.
InterProiIPR000048. IQ_motif_EF-hand-BS.
IPR031244. MYO18A.
IPR027401. Myosin-like_IQ_dom.
IPR001609. Myosin_head_motor_dom.
IPR002928. Myosin_tail.
IPR027417. P-loop_NTPase.
IPR001478. PDZ.
[Graphical view]
PANTHERiPTHR13140:SF421. PTHR13140:SF421. 4 hits.
PfamiPF00063. Myosin_head. 2 hits.
PF01576. Myosin_tail_1. 1 hit.
PF00595. PDZ. 1 hit.
[Graphical view]
PRINTSiPR00193. MYOSINHEAVY.
SMARTiSM00015. IQ. 1 hit.
SM00242. MYSc. 1 hit.
SM00228. PDZ. 1 hit.
[Graphical view]
SUPFAMiSSF50156. SSF50156. 1 hit.
SSF52540. SSF52540. 3 hits.
PROSITEiPS50096. IQ. 1 hit.
PS51456. MYOSIN_MOTOR. 1 hit.
PS50106. PDZ. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E9QAX2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFNLMKKDKD KDGGRKEKKE KKEKKERMSA AELRSLEEMS MRRGFFNLNR
60 70 80 90 100
SSKRESKTRL EISNPIPIKV ASGSDLHLTD IDSDSNRGSI ILDSGHLSTA
110 120 130 140 150
SSSDDLKGEE GSFRGSVLQR AAKFGSLAKQ NSQMIVKRFS FSQRSRDESA
160 170 180 190 200
SETSTPSEHS AAPSPQVEVR TLEGQLMQHP GLGIPRPGPR SRVPELVTKR
210 220 230 240 250
FPADLRLPAL VPPPPPALRE LELQRRPTGD FGFSLRRTTM LDRAPEGQAY
260 270 280 290 300
RRVVHFAEPG AGTKDLALGL VPGDRLVEIN GQNVENKSRD EIVEMIRQSG
310 320 330 340 350
DSVRLKVQPI PELSELSRSW LRTGEGHRRE PADLDPEAAS PAYSQVGCSC
360 370 380 390 400
PTQEPSAFSS DNPPPPPCTW AGVCARASCW SAKTEEQIAA EEAWYETEKV
410 420 430 440 450
WLVHRDGFSL ASQLKSEELS LPEGKARVKL DHDGAILDVD EDDIEKANAP
460 470 480 490 500
SCDRLEDLAS LVYLNESSVL HTLRQRYGAS LLHTYAGPSL LVLSTRGAPA
510 520 530 540 550
VYSEKVMHMF KGCRREDMAP HIYAVAQTAY RAMLMSRQDQ SIVLLGSSGS
560 570 580 590 600
GKTTSFQHLV QYLATIAGTS GTKVFSVEKW QALSTLLEAF GNSPTIMNGS
610 620 630 640 650
ATRFSQILSL DFDQAGQVAS ASIQTMLLEK LRVARRPASE ATFNVFYYLL
660 670 680 690 700
ACGDATLRTE LHLNHLAENN VFGIVPLSKP EEKQKAAQQF SKLQAAMKVL
710 720 730 740 750
AISPEEQKTC WLILASIYHL GAAGATKEAA EAGRKQFARH EWAQKAAYLL
760 770 780 790 800
GCSLEELSSA IFKHQLKGGT LQRSTSFRQG PEESGLGEGT KLSALECLEG
810 820 830 840 850
MASGLYSELF TLLISLVNRA LKSSQHSLCS MMIVDTPGFQ NPEWGGSARG
860 870 880 890 900
ASFEELCHNY AQDRLQRLFH ERTFLQELER YKEDNIELAF DDLEPVADDS
910 920 930 940 950
VAAVDQASHL VRSLAHADEA RGLLWLLEEE ALVPGATEDA LLDRLFSYYG
960 970 980 990 1000
PQEGDKKGQS PLLRSSKPRH FLLGHSHGTN WVEYNVAGWL NYTKQNPATQ
1010 1020 1030 1040 1050
NAPRLLQDSQ KKIISNLFLG RAGSATVLSG SIAGLEGGSQ LALRRATSMR
1060 1070 1080 1090 1100
KTFTTGMAAV KKKSLCIQIK LQVDALIDTI KRSKMHFVHC FLPVAEGWPG
1110 1120 1130 1140 1150
EPRSASSRRV SSSSELDLPP GDPCEAGLLQ LDVSLLRAQL RGSRLLDAMR
1160 1170 1180 1190 1200
MYRQGYPDHM VFSEFRRRFD VLAPHLTKKH GRNYIVVDEK RAVEELLESL
1210 1220 1230 1240 1250
DLEKSSCCLG LSRVFFRAGT LARLEEQRDE QTSRHLTLFQ AACRGYLARQ
1260 1270 1280 1290 1300
HFKKRKIQDL AIRCVQKNIK KNKGVKDWPW WKLFTTVRPL IQVQLSEEQI
1310 1320 1330 1340 1350
RNKDEEIQQL RSKLEKVEKE RNELRLSSDR LETRISELTS ELTDERNTGE
1360 1370 1380 1390 1400
SASQLLDAET AERLRTEKEM KELQTQYDAL KKQMEVMEME VMEARLIRAA
1410 1420 1430 1440 1450
EINGEVDDDD AGGEWRLKYE RAVREVDFTK KRLQQELEDK MEVEQQSRRQ
1460 1470 1480 1490 1500
LERRLGDLQA DSDESQRALQ QLKKKCQRLT AELQDTKLHL EGQQVRNHEL
1510 1520 1530 1540 1550
EKKQRRFDSE LSQAHEETQR EKLQREKLQR EKDMLLAEAF SLKQQMEEKD
1560 1570 1580 1590 1600
LDIAGFTQKV VSLEAELQDI SSQESKDEAS LAKVKKQLRD LEAKVKDQEE
1610 1620 1630 1640 1650
ELDEQAGSIQ MLEQAKLRLE MEMERMRQTH SKEMESRDEE VEEARQSCQK
1660 1670 1680 1690 1700
KLKQMEVQLE EEYEDKQKAL REKRELESKL STLSDQVNQR DFESEKRLRK
1710 1720 1730 1740 1750
DLKRTKALLA DAQIMLDHLK NNAPSKREIA QLKNQLEESE FTCAAAVKAR
1760 1770 1780 1790 1800
KAMEVEMEDL HLQIDDIAKA KTALEEQLSR LQREKNEIQN RLEEDQEDMN
1810 1820 1830 1840 1850
ELMKKHKAAV AQASRDMAQM NDLQAQIEES NKEKQELQEK LQALQSQVEF
1860 1870 1880 1890 1900
LEQSMVDKSL VSRQEAKIRE LETRLEFEKT QVKRLENLAS RLKETMEKLT
1910 1920 1930 1940 1950
EERDQRAAAE NREKEQNKRL QRQLRDTKEE MSELARKEAE ASRKKHELEM
1960 1970 1980 1990 2000
DLESLEAANQ SLQADLKLAF KRIGDLQAAI EDEMESDENE DLINSEGDSD
2010 2020 2030 2040 2050
VDSELEDRVD GVKSWLSKNK GPSKAPSDDG SLKSSSPTSH WKPLAPDPSD
2060 2070 2080
DEHDPVDSIS RPRFSHSYLS DSDTEAKLTE TSA
Length:2,083
Mass (Da):235,817
Last modified:April 5, 2011 - v1
Checksum:i7DBD39B7765E55C8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL591065 Genomic DNA. No translation available.
RefSeqiNP_001278142.1. NM_001291213.1.
XP_011247392.1. XM_011249090.1.
UniGeneiMm.341248.
Mm.476162.

Genome annotation databases

EnsembliENSMUST00000168348; ENSMUSP00000130696; ENSMUSG00000000631.
GeneIDi360013.
UCSCiuc011xzy.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL591065 Genomic DNA. No translation available.
RefSeqiNP_001278142.1. NM_001291213.1.
XP_011247392.1. XM_011249090.1.
UniGeneiMm.341248.
Mm.476162.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000090563.

Proteomic databases

EPDiE9QAX2.
PaxDbiE9QAX2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000168348; ENSMUSP00000130696; ENSMUSG00000000631.
GeneIDi360013.
UCSCiuc011xzy.2. mouse.

Organism-specific databases

CTDi399687.
MGIiMGI:2667185. Myo18a.

Phylogenomic databases

eggNOGiKOG0161. Eukaryota.
COG5022. LUCA.
GeneTreeiENSGT00840000129849.
OMAiIPRPGHR.
TreeFamiTF339614.

Miscellaneous databases

ChiTaRSiMyo18a. mouse.
SOURCEiSearch...

Gene expression databases

BgeeiE9QAX2.
ExpressionAtlasiE9QAX2. baseline and differential.

Family and domain databases

Gene3Di2.30.42.10. 1 hit.
3.40.50.300. 1 hit.
4.10.270.10. 1 hit.
InterProiIPR000048. IQ_motif_EF-hand-BS.
IPR031244. MYO18A.
IPR027401. Myosin-like_IQ_dom.
IPR001609. Myosin_head_motor_dom.
IPR002928. Myosin_tail.
IPR027417. P-loop_NTPase.
IPR001478. PDZ.
[Graphical view]
PANTHERiPTHR13140:SF421. PTHR13140:SF421. 4 hits.
PfamiPF00063. Myosin_head. 2 hits.
PF01576. Myosin_tail_1. 1 hit.
PF00595. PDZ. 1 hit.
[Graphical view]
PRINTSiPR00193. MYOSINHEAVY.
SMARTiSM00015. IQ. 1 hit.
SM00242. MYSc. 1 hit.
SM00228. PDZ. 1 hit.
[Graphical view]
SUPFAMiSSF50156. SSF50156. 1 hit.
SSF52540. SSF52540. 3 hits.
PROSITEiPS50096. IQ. 1 hit.
PS51456. MYOSIN_MOTOR. 1 hit.
PS50106. PDZ. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Comprehensive identification of phosphorylation sites in postsynaptic density preparations."
    Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L.
    Mol. Cell. Proteomics 5:914-922(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  3. "Specific phosphopeptide enrichment with immobilized titanium ion affinity chromatography adsorbent for phosphoproteome analysis."
    Zhou H., Ye M., Dong J., Han G., Jiang X., Wu R., Zou H.
    J. Proteome Res. 7:3957-3967(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. Ensembl
    Submitted (MAY-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiE9QAX2_MOUSE
AccessioniPrimary (citable) accession number: E9QAX2
Entry historyi
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: June 8, 2016
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.