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Protein
Submitted name:

Glycogen synthase kinase-3 beta

Gene

Gsk3b

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. beta-catenin binding Source: MGI
  3. kinase activity Source: MGI
  4. NF-kappaB binding Source: MGI
  5. p53 binding Source: MGI
  6. protein kinase A catalytic subunit binding Source: MGI
  7. protein kinase activity Source: MGI
  8. protein kinase binding Source: MGI
  9. protein serine/threonine kinase activity Source: MGI
  10. RNA polymerase II transcription factor binding Source: MGI
  11. tau-protein kinase activity Source: MGI
  12. ubiquitin protein ligase binding Source: MGI

GO - Biological processi

  1. axonogenesis Source: MGI
  2. canonical Wnt signaling pathway Source: MGI
  3. cell migration Source: MGI
  4. cell proliferation Source: MGI
  5. epithelial to mesenchymal transition Source: MGI
  6. ER overload response Source: MGI
  7. fat cell differentiation Source: MGI
  8. glycogen metabolic process Source: MGI
  9. hippocampus development Source: MGI
  10. intracellular signal transduction Source: MGI
  11. myoblast fusion Source: MGI
  12. myotube differentiation Source: MGI
  13. negative regulation of apoptotic process Source: MGI
  14. negative regulation of cardiac muscle hypertrophy Source: MGI
  15. negative regulation of neuron maturation Source: MGI
  16. negative regulation of neuron projection development Source: MGI
  17. negative regulation of NFAT protein import into nucleus Source: MGI
  18. negative regulation of protein binding Source: MGI
  19. negative regulation of protein complex assembly Source: MGI
  20. organ morphogenesis Source: MGI
  21. peptidyl-serine phosphorylation Source: MGI
  22. positive regulation of axon extension Source: MGI
  23. positive regulation of cell-matrix adhesion Source: MGI
  24. positive regulation of peptidyl-serine phosphorylation Source: MGI
  25. positive regulation of peptidyl-threonine phosphorylation Source: MGI
  26. positive regulation of proteasomal ubiquitin-dependent protein catabolic process Source: MGI
  27. positive regulation of protein binding Source: MGI
  28. positive regulation of protein complex assembly Source: MGI
  29. positive regulation of protein export from nucleus Source: MGI
  30. positive regulation of Rac GTPase activity Source: MGI
  31. positive regulation of stem cell differentiation Source: MGI
  32. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  33. protein export from nucleus Source: MGI
  34. protein localization to microtubule Source: MGI
  35. protein phosphorylation Source: MGI
  36. re-entry into mitotic cell cycle Source: MGI
  37. regulation of microtubule-based process Source: MGI
  38. regulation of neuron projection development Source: MGI
  39. superior temporal gyrus development Source: MGI
  40. Wnt signaling pathway Source: MGI
Complete GO annotation...

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Glycogen synthase kinase-3 betaImported
Gene namesi
Name:Gsk3bImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 16

Organism-specific databases

MGIiMGI:1861437. Gsk3b.

Subcellular locationi

GO - Cellular componenti

  1. beta-catenin destruction complex Source: MGI
  2. cell body Source: MGI
  3. centrosome Source: MGI
  4. cytoplasm Source: MGI
  5. cytosol Source: MGI
  6. dendritic shaft Source: MGI
  7. growth cone Source: MGI
  8. membrane-bounded organelle Source: MGI
  9. neuronal cell body Source: MGI
  10. neuronal postsynaptic density Source: MGI
  11. nucleus Source: MGI
  12. plasma membrane Source: MGI
  13. ribonucleoprotein complex Source: MGI
Complete GO annotation...

PTM / Processingi

Proteomic databases

MaxQBiE9QAQ5.
PRIDEiE9QAQ5.

Expressioni

Gene expression databases

BgeeiE9QAQ5.
ExpressionAtlasiE9QAQ5. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliE9QAQ5.
SMRiE9QAQ5. Positions 6-399.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00520000055635.
KOiK03083.
OMAiNAGERVQ.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E9QAQ5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSGRPRTTSF AESCKPVQQP SAFGSMKVSR DKDGSKVTTV VATPGQGPDR
60 70 80 90 100
PQEVSYTDTK VIGNGSFGVV YQAKLCDSGE LVAIKKVLQD KRFKNRELQI
110 120 130 140 150
MRKLDHCNIV RLRYFFYSSG EKKDEVYLNL VLDYVPETVY RVARHYSRAK
160 170 180 190 200
QTLPVIYVKL YMYQLFRSLA YIHSFGICHR DIKPQNLLLD PDTAVLKLCD
210 220 230 240 250
FGSAKQLVRG EPNVSYICSR YYRAPELIFG ATDYTSSIDV WSAGCVLAEL
260 270 280 290 300
LLGQPIFPGD SGVDQLVEII KVLGTPTREQ IREMNPNYTE FKFPQIKAHP
310 320 330 340 350
WTKDSPGAGH FTPGVRVFRP RTPPEAIALC SRLLEYTPTA RLTPLEACAH
360 370 380 390 400
SFFDELRDPN VKLPNGRDTP ALFNFTTQEL SSNPPLATIL IPPHARIQAA
410 420 430
ASPPANATAA SDTNAGDRGQ TNNAASASAS NST
Length:433
Mass (Da):47,990
Last modified:April 5, 2011 - v1
Checksum:i901D4D23D958F2D4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC120020 Genomic DNA. No translation available.
AC154284 Genomic DNA. No translation available.
RefSeqiXP_006522488.1. XM_006522425.1.
UniGeneiMm.394930.

Genome annotation databases

EnsembliENSMUST00000114750; ENSMUSP00000110398; ENSMUSG00000022812.
GeneIDi56637.
KEGGimmu:56637.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC120020 Genomic DNA. No translation available.
AC154284 Genomic DNA. No translation available.
RefSeqiXP_006522488.1. XM_006522425.1.
UniGeneiMm.394930.

3D structure databases

ProteinModelPortaliE9QAQ5.
SMRiE9QAQ5. Positions 6-399.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

MaxQBiE9QAQ5.
PRIDEiE9QAQ5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000114750; ENSMUSP00000110398; ENSMUSG00000022812.
GeneIDi56637.
KEGGimmu:56637.

Organism-specific databases

CTDi2932.
MGIiMGI:1861437. Gsk3b.

Phylogenomic databases

GeneTreeiENSGT00520000055635.
KOiK03083.
OMAiNAGERVQ.

Miscellaneous databases

ChiTaRSiGsk3b. mouse.
NextBioi35555931.
SOURCEiSearch...

Gene expression databases

BgeeiE9QAQ5.
ExpressionAtlasiE9QAQ5. baseline and differential.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  4. Ensembl
    Submitted (MAY-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiE9QAQ5_MOUSE
AccessioniPrimary (citable) accession number: E9QAQ5
Entry historyi
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: February 4, 2015
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.