Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

E9QAQ5

- E9QAQ5_MOUSE

UniProt

E9QAQ5 - E9QAQ5_MOUSE

Protein
Submitted name:

Glycogen synthase kinase-3 beta

Gene

Gsk3b

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 29 (01 Oct 2014)
      Sequence version 1 (05 Apr 2011)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. beta-catenin binding Source: MGI
    3. protein binding Source: MGI
    4. protein kinase activity Source: MGI
    5. protein serine/threonine kinase activity Source: MGI
    6. tau-protein kinase activity Source: MGI

    GO - Biological processi

    1. axonogenesis Source: MGI
    2. canonical Wnt signaling pathway Source: MGI
    3. cell migration Source: MGI
    4. cell proliferation Source: MGI
    5. ER overload response Source: MGI
    6. fat cell differentiation Source: MGI
    7. intracellular signal transduction Source: MGI
    8. myoblast fusion Source: MGI
    9. myotube differentiation Source: MGI
    10. negative regulation of apoptotic process Source: MGI
    11. negative regulation of cardiac muscle hypertrophy Source: MGI
    12. negative regulation of neuron maturation Source: MGI
    13. negative regulation of neuron projection development Source: MGI
    14. organ morphogenesis Source: MGI
    15. peptidyl-serine phosphorylation Source: MGI
    16. positive regulation of peptidyl-serine phosphorylation Source: MGI
    17. positive regulation of peptidyl-threonine phosphorylation Source: MGI
    18. positive regulation of proteasomal ubiquitin-dependent protein catabolic process Source: MGI
    19. positive regulation of protein binding Source: MGI
    20. positive regulation of stem cell differentiation Source: MGI
    21. positive regulation of transcription from RNA polymerase II promoter Source: MGI
    22. protein export from nucleus Source: MGI
    23. protein localization to microtubule Source: MGI
    24. protein phosphorylation Source: MGI
    25. re-entry into mitotic cell cycle Source: MGI
    26. Wnt signaling pathway Source: MGI

    Keywords - Ligandi

    ATP-bindingUniRule annotation, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Glycogen synthase kinase-3 betaImported
    Gene namesi
    Name:Gsk3bImported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 16

    Organism-specific databases

    MGIiMGI:1861437. Gsk3b.

    Subcellular locationi

    GO - Cellular componenti

    1. beta-catenin destruction complex Source: MGI
    2. cell body Source: MGI
    3. cytosol Source: MGI
    4. dendritic shaft Source: MGI
    5. growth cone Source: MGI
    6. membrane-bounded organelle Source: MGI
    7. neuronal cell body Source: MGI
    8. nucleus Source: MGI
    9. ribonucleoprotein complex Source: MGI

    PTM / Processingi

    Proteomic databases

    PRIDEiE9QAQ5.

    Expressioni

    Gene expression databases

    ArrayExpressiE9QAQ5.
    BgeeiE9QAQ5.

    Structurei

    3D structure databases

    ProteinModelPortaliE9QAQ5.
    SMRiE9QAQ5. Positions 6-399.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    GeneTreeiENSGT00520000055635.
    KOiK03083.
    OMAiNAGERVQ.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    SMARTiSM00220. S_TKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    E9QAQ5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSGRPRTTSF AESCKPVQQP SAFGSMKVSR DKDGSKVTTV VATPGQGPDR    50
    PQEVSYTDTK VIGNGSFGVV YQAKLCDSGE LVAIKKVLQD KRFKNRELQI 100
    MRKLDHCNIV RLRYFFYSSG EKKDEVYLNL VLDYVPETVY RVARHYSRAK 150
    QTLPVIYVKL YMYQLFRSLA YIHSFGICHR DIKPQNLLLD PDTAVLKLCD 200
    FGSAKQLVRG EPNVSYICSR YYRAPELIFG ATDYTSSIDV WSAGCVLAEL 250
    LLGQPIFPGD SGVDQLVEII KVLGTPTREQ IREMNPNYTE FKFPQIKAHP 300
    WTKDSPGAGH FTPGVRVFRP RTPPEAIALC SRLLEYTPTA RLTPLEACAH 350
    SFFDELRDPN VKLPNGRDTP ALFNFTTQEL SSNPPLATIL IPPHARIQAA 400
    ASPPANATAA SDTNAGDRGQ TNNAASASAS NST 433
    Length:433
    Mass (Da):47,990
    Last modified:April 5, 2011 - v1
    Checksum:i901D4D23D958F2D4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC120020 Genomic DNA. No translation available.
    AC154284 Genomic DNA. No translation available.
    RefSeqiXP_006522488.1. XM_006522425.1.
    UniGeneiMm.394930.

    Genome annotation databases

    EnsembliENSMUST00000114750; ENSMUSP00000110398; ENSMUSG00000022812.
    GeneIDi56637.
    KEGGimmu:56637.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC120020 Genomic DNA. No translation available.
    AC154284 Genomic DNA. No translation available.
    RefSeqi XP_006522488.1. XM_006522425.1.
    UniGenei Mm.394930.

    3D structure databases

    ProteinModelPortali E9QAQ5.
    SMRi E9QAQ5. Positions 6-399.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi E9QAQ5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000114750 ; ENSMUSP00000110398 ; ENSMUSG00000022812 .
    GeneIDi 56637.
    KEGGi mmu:56637.

    Organism-specific databases

    CTDi 2932.
    MGIi MGI:1861437. Gsk3b.

    Phylogenomic databases

    GeneTreei ENSGT00520000055635.
    KOi K03083.
    OMAi NAGERVQ.

    Miscellaneous databases

    ChiTaRSi GSK3B. mouse.
    NextBioi 35555931.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi E9QAQ5.
    Bgeei E9QAQ5.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SMARTi SM00220. S_TKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6JImported.
    4. Ensembl
      Submitted (MAY-2011) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: C57BL/6JImported.

    Entry informationi

    Entry nameiE9QAQ5_MOUSE
    AccessioniPrimary (citable) accession number: E9QAQ5
    Entry historyi
    Integrated into UniProtKB/TrEMBL: April 5, 2011
    Last sequence update: April 5, 2011
    Last modified: October 1, 2014
    This is version 29 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Caution

    The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3