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Protein
Submitted name:

Glycogen synthase kinase-3 beta

Gene

Gsk3b

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • axonogenesis Source: MGI
  • canonical Wnt signaling pathway Source: MGI
  • cell migration Source: MGI
  • cell proliferation Source: MGI
  • epithelial to mesenchymal transition Source: MGI
  • ER overload response Source: MGI
  • fat cell differentiation Source: MGI
  • glycogen metabolic process Source: MGI
  • hippocampus development Source: MGI
  • intracellular signal transduction Source: MGI
  • myoblast fusion Source: MGI
  • myotube differentiation Source: MGI
  • negative regulation of apoptotic process Source: MGI
  • negative regulation of cardiac muscle hypertrophy Source: MGI
  • negative regulation of neuron maturation Source: MGI
  • negative regulation of neuron projection development Source: MGI
  • negative regulation of NFAT protein import into nucleus Source: MGI
  • negative regulation of protein binding Source: MGI
  • negative regulation of protein complex assembly Source: MGI
  • organ morphogenesis Source: MGI
  • peptidyl-serine phosphorylation Source: MGI
  • positive regulation of axon extension Source: MGI
  • positive regulation of cell-matrix adhesion Source: MGI
  • positive regulation of GTPase activity Source: MGI
  • positive regulation of peptidyl-serine phosphorylation Source: MGI
  • positive regulation of peptidyl-threonine phosphorylation Source: MGI
  • positive regulation of proteasomal ubiquitin-dependent protein catabolic process Source: MGI
  • positive regulation of protein binding Source: MGI
  • positive regulation of protein complex assembly Source: MGI
  • positive regulation of protein export from nucleus Source: MGI
  • positive regulation of stem cell differentiation Source: MGI
  • positive regulation of transcription from RNA polymerase II promoter Source: MGI
  • protein autophosphorylation Source: MGI
  • protein export from nucleus Source: MGI
  • protein localization to microtubule Source: MGI
  • protein phosphorylation Source: MGI
  • re-entry into mitotic cell cycle Source: MGI
  • regulation of microtubule-based process Source: MGI
  • regulation of neuron projection development Source: MGI
  • superior temporal gyrus development Source: MGI
  • Wnt signaling pathway Source: MGI
Complete GO annotation...

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Glycogen synthase kinase-3 betaImported
Gene namesi
Name:Gsk3bImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:1861437. Gsk3b.

Subcellular locationi

GO - Cellular componenti

  • beta-catenin destruction complex Source: MGI
  • cell body Source: MGI
  • centrosome Source: MGI
  • cytoplasm Source: MGI
  • cytosol Source: MGI
  • dendritic shaft Source: MGI
  • growth cone Source: MGI
  • membrane-bounded organelle Source: MGI
  • neuronal cell body Source: MGI
  • neuronal postsynaptic density Source: MGI
  • nucleoplasm Source: MGI
  • nucleus Source: MGI
  • plasma membrane Source: MGI
  • ribonucleoprotein complex Source: MGI
Complete GO annotation...

PTM / Processingi

Proteomic databases

MaxQBiE9QAQ5.
PRIDEiE9QAQ5.

Expressioni

Gene expression databases

BgeeiE9QAQ5.
ExpressionAtlasiE9QAQ5. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000023507.

Structurei

3D structure databases

ProteinModelPortaliE9QAQ5.
SMRiE9QAQ5. Positions 6-399.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00520000055635.
KOiK03083.
OMAiNAGERVQ.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E9QAQ5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGRPRTTSF AESCKPVQQP SAFGSMKVSR DKDGSKVTTV VATPGQGPDR
60 70 80 90 100
PQEVSYTDTK VIGNGSFGVV YQAKLCDSGE LVAIKKVLQD KRFKNRELQI
110 120 130 140 150
MRKLDHCNIV RLRYFFYSSG EKKDEVYLNL VLDYVPETVY RVARHYSRAK
160 170 180 190 200
QTLPVIYVKL YMYQLFRSLA YIHSFGICHR DIKPQNLLLD PDTAVLKLCD
210 220 230 240 250
FGSAKQLVRG EPNVSYICSR YYRAPELIFG ATDYTSSIDV WSAGCVLAEL
260 270 280 290 300
LLGQPIFPGD SGVDQLVEII KVLGTPTREQ IREMNPNYTE FKFPQIKAHP
310 320 330 340 350
WTKDSPGAGH FTPGVRVFRP RTPPEAIALC SRLLEYTPTA RLTPLEACAH
360 370 380 390 400
SFFDELRDPN VKLPNGRDTP ALFNFTTQEL SSNPPLATIL IPPHARIQAA
410 420 430
ASPPANATAA SDTNAGDRGQ TNNAASASAS NST
Length:433
Mass (Da):47,990
Last modified:April 5, 2011 - v1
Checksum:i901D4D23D958F2D4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC120020 Genomic DNA. No translation available.
AC154284 Genomic DNA. No translation available.
RefSeqiXP_006522488.1. XM_006522425.1.
UniGeneiMm.394930.

Genome annotation databases

EnsembliENSMUST00000114750; ENSMUSP00000110398; ENSMUSG00000022812.
GeneIDi56637.
KEGGimmu:56637.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC120020 Genomic DNA. No translation available.
AC154284 Genomic DNA. No translation available.
RefSeqiXP_006522488.1. XM_006522425.1.
UniGeneiMm.394930.

3D structure databases

ProteinModelPortaliE9QAQ5.
SMRiE9QAQ5. Positions 6-399.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000023507.

Proteomic databases

MaxQBiE9QAQ5.
PRIDEiE9QAQ5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000114750; ENSMUSP00000110398; ENSMUSG00000022812.
GeneIDi56637.
KEGGimmu:56637.

Organism-specific databases

CTDi2932.
MGIiMGI:1861437. Gsk3b.

Phylogenomic databases

GeneTreeiENSGT00520000055635.
KOiK03083.
OMAiNAGERVQ.

Miscellaneous databases

ChiTaRSiGsk3b. mouse.
NextBioi35555931.
SOURCEiSearch...

Gene expression databases

BgeeiE9QAQ5.
ExpressionAtlasiE9QAQ5. baseline and differential.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  5. Ensembl
    Submitted (MAY-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiE9QAQ5_MOUSE
AccessioniPrimary (citable) accession number: E9QAQ5
Entry historyi
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: June 24, 2015
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.