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E9QAQ5

- E9QAQ5_MOUSE

UniProt

E9QAQ5 - E9QAQ5_MOUSE

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Protein
Submitted name: Glycogen synthase kinase-3 beta
Gene
Gsk3b
Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. beta-catenin binding Source: MGI
  3. protein binding Source: MGI
  4. protein kinase activity Source: MGI
  5. protein serine/threonine kinase activity Source: MGI
  6. tau-protein kinase activity Source: MGI

GO - Biological processi

  1. ER overload response Source: MGI
  2. Wnt signaling pathway Source: MGI
  3. axonogenesis Source: MGI
  4. canonical Wnt signaling pathway Source: MGI
  5. cell migration Source: MGI
  6. cell proliferation Source: MGI
  7. fat cell differentiation Source: MGI
  8. intracellular signal transduction Source: MGI
  9. myoblast fusion Source: MGI
  10. myotube differentiation Source: MGI
  11. negative regulation of apoptotic process Source: MGI
  12. negative regulation of cardiac muscle hypertrophy Source: MGI
  13. negative regulation of neuron maturation Source: MGI
  14. negative regulation of neuron projection development Source: MGI
  15. organ morphogenesis Source: MGI
  16. peptidyl-serine phosphorylation Source: MGI
  17. positive regulation of peptidyl-serine phosphorylation Source: MGI
  18. positive regulation of peptidyl-threonine phosphorylation Source: MGI
  19. positive regulation of proteasomal ubiquitin-dependent protein catabolic process Source: MGI
  20. positive regulation of protein binding Source: MGI
  21. positive regulation of stem cell differentiation Source: MGI
  22. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  23. protein export from nucleus Source: MGI
  24. protein localization to microtubule Source: MGI
  25. protein phosphorylation Source: MGI
  26. re-entry into mitotic cell cycle Source: MGI
Complete GO annotation...

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Glycogen synthase kinase-3 betaImported
Gene namesi
Name:Gsk3bImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 16

Organism-specific databases

MGIiMGI:1861437. Gsk3b.

Subcellular locationi

GO - Cellular componenti

  1. beta-catenin destruction complex Source: MGI
  2. cell body Source: MGI
  3. cytosol Source: MGI
  4. dendritic shaft Source: MGI
  5. growth cone Source: MGI
  6. membrane-bounded organelle Source: MGI
  7. neuronal cell body Source: MGI
  8. nucleus Source: MGI
  9. ribonucleoprotein complex Source: MGI
Complete GO annotation...

PTM / Processingi

Proteomic databases

PRIDEiE9QAQ5.

Expressioni

Gene expression databases

ArrayExpressiE9QAQ5.
BgeeiE9QAQ5.

Structurei

3D structure databases

ProteinModelPortaliE9QAQ5.
SMRiE9QAQ5. Positions 6-399.

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00520000055635.
KOiK03083.
OMAiNAGERVQ.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E9QAQ5-1 [UniParc]FASTAAdd to Basket

« Hide

MSGRPRTTSF AESCKPVQQP SAFGSMKVSR DKDGSKVTTV VATPGQGPDR    50
PQEVSYTDTK VIGNGSFGVV YQAKLCDSGE LVAIKKVLQD KRFKNRELQI 100
MRKLDHCNIV RLRYFFYSSG EKKDEVYLNL VLDYVPETVY RVARHYSRAK 150
QTLPVIYVKL YMYQLFRSLA YIHSFGICHR DIKPQNLLLD PDTAVLKLCD 200
FGSAKQLVRG EPNVSYICSR YYRAPELIFG ATDYTSSIDV WSAGCVLAEL 250
LLGQPIFPGD SGVDQLVEII KVLGTPTREQ IREMNPNYTE FKFPQIKAHP 300
WTKDSPGAGH FTPGVRVFRP RTPPEAIALC SRLLEYTPTA RLTPLEACAH 350
SFFDELRDPN VKLPNGRDTP ALFNFTTQEL SSNPPLATIL IPPHARIQAA 400
ASPPANATAA SDTNAGDRGQ TNNAASASAS NST 433
Length:433
Mass (Da):47,990
Last modified:April 5, 2011 - v1
Checksum:i901D4D23D958F2D4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC120020 Genomic DNA. No translation available.
AC154284 Genomic DNA. No translation available.
RefSeqiXP_006522488.1. XM_006522425.1.
UniGeneiMm.394930.

Genome annotation databases

EnsembliENSMUST00000114750; ENSMUSP00000110398; ENSMUSG00000022812.
GeneIDi56637.
KEGGimmu:56637.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC120020 Genomic DNA. No translation available.
AC154284 Genomic DNA. No translation available.
RefSeqi XP_006522488.1. XM_006522425.1.
UniGenei Mm.394930.

3D structure databases

ProteinModelPortali E9QAQ5.
SMRi E9QAQ5. Positions 6-399.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi E9QAQ5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000114750 ; ENSMUSP00000110398 ; ENSMUSG00000022812 .
GeneIDi 56637.
KEGGi mmu:56637.

Organism-specific databases

CTDi 2932.
MGIi MGI:1861437. Gsk3b.

Phylogenomic databases

GeneTreei ENSGT00520000055635.
KOi K03083.
OMAi NAGERVQ.

Miscellaneous databases

ChiTaRSi GSK3B. mouse.
NextBioi 35555931.
SOURCEi Search...

Gene expression databases

ArrayExpressi E9QAQ5.
Bgeei E9QAQ5.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SMARTi SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  4. Ensembl
    Submitted (MAY-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiE9QAQ5_MOUSE
AccessioniPrimary (citable) accession number: E9QAQ5
Entry historyi
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: September 3, 2014
This is version 28 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

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