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Protein
Submitted name:

Protein Pik3c2b

Gene

Pik3c2b

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

KinaseSAAS annotation, Transferase

Keywords - Ligandi

ATP-bindingSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_272541. Synthesis of PIPs at the plasma membrane.

Names & Taxonomyi

Protein namesi
Submitted name:
Protein Pik3c2bImported
Gene namesi
Name:Pik3c2bImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:2685045. Pik3c2b.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: GO_Central
  • endocytic vesicle Source: MGI
  • phosphatidylinositol 3-kinase complex Source: GO_Central
  • plasma membrane Source: GO_Central
Complete GO annotation...

PTM / Processingi

Proteomic databases

MaxQBiE9QAN8.
PRIDEiE9QAN8.

Expressioni

Gene expression databases

BgeeiE9QAN8.
ExpressionAtlasiE9QAN8. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000076911.

Structurei

3D structure databases

ProteinModelPortaliE9QAN8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 C2 domain.UniRule annotation
Contains PI3K/PI4K domain.SAAS annotation
Contains PIK helical domain.SAAS annotation

Phylogenomic databases

GeneTreeiENSGT00760000119110.
InParanoidiE9QAN8.
KOiK00923.
OMAiIHLQERP.
OrthoDBiEOG71CFK4.
TreeFamiTF102031.

Family and domain databases

Gene3Di1.10.1070.11. 1 hit.
1.25.40.70. 1 hit.
2.60.40.150. 2 hits.
3.30.1520.10. 1 hit.
InterProiIPR016024. ARM-type_fold.
IPR000008. C2_dom.
IPR011009. Kinase-like_dom.
IPR001683. Phox.
IPR000403. PI3/4_kinase_cat_dom.
IPR018936. PI3/4_kinase_CS.
IPR002420. PI3K_C2_dom.
IPR000341. PI3K_Ras-bd_dom.
IPR015433. PI_Kinase.
IPR001263. PInositide-3_kin_accessory_dom.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PANTHERiPTHR10048. PTHR10048. 1 hit.
PfamiPF00168. C2. 1 hit.
PF00454. PI3_PI4_kinase. 1 hit.
PF00792. PI3K_C2. 1 hit.
PF00794. PI3K_rbd. 1 hit.
PF00613. PI3Ka. 1 hit.
PF00787. PX. 1 hit.
[Graphical view]
SMARTiSM00239. C2. 1 hit.
SM00142. PI3K_C2. 1 hit.
SM00144. PI3K_rbd. 1 hit.
SM00145. PI3Ka. 1 hit.
SM00146. PI3Kc. 1 hit.
SM00312. PX. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
SSF49562. SSF49562. 2 hits.
SSF54236. SSF54236. 1 hit.
SSF56112. SSF56112. 1 hit.
SSF64268. SSF64268. 1 hit.
PROSITEiPS50004. C2. 1 hit.
PS00915. PI3_4_KINASE_1. 1 hit.
PS00916. PI3_4_KINASE_2. 1 hit.
PS50290. PI3_4_KINASE_3. 1 hit.
PS51547. PI3K_C2. 1 hit.
PS51546. PI3K_RBD. 1 hit.
PS51545. PIK_HELICAL. 1 hit.
PS50195. PX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E9QAN8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSTQGNGEH WKSLESVGIS RKELAMAEAL QMEYDALSRL RHHKEESRAK
60 70 80 90 100
QNTEPSLISW DEPALDFYSK PAGRRTDLKL LRGLSGSDPT LNYNSISPPE
110 120 130 140 150
GLPNSTSQDP QPGPDPWPKG SLSGDYLYIF DGSEGRCSLS PGSGDTDGSC
160 170 180 190 200
KKLSPPPLPP RVSIWDAPPL PPRKGSPSPS KISQPNDINS FSSAEQPPDK
210 220 230 240 250
LLVAQDPEEG ELPDGRGQGH TLGSVDYDGI NDAITRLNLK STYDSEISSD
260 270 280 290 300
ATRGWKEGRG PLDFNKDTSG KPVARSKTMP PQVPPRTYTS RYANRKNATP
310 320 330 340 350
GNNRRISAAP VGSRPHTVAN GHELFEVSEE RDEEVAAFCH MLDILRTGSD
360 370 380 390 400
IQDYSLTGCV WSTVTPSPEH LGDEVNLKVT VLCDSLREPL TFTCNCSSTV
410 420 430 440 450
DLLIHQTLCY THDELREVDV GDFVLKPCGL EEFLQNKHAL GSHEYIQYCR
460 470 480 490 500
KFDISIRLQL MEQKAIRSDL ARTVNDDQSP STLNYLIHLQ ERPVKQTISR
510 520 530 540 550
QALSLLFDTY HNEVDAFLLA DGDFPLKADR VVQSVKAICN ALAAVETPEI
560 570 580 590 600
TSALNQLPPC PSRMQPKIQK DPSVLSVREN REKVVEALTA AILDLVELYC
610 620 630 640 650
STFNADFQTA VPGSRKHDLV QEACHFPGAL AFTVYGTHRI PIIWATSYED
660 670 680 690 700
FYLSCSLSHG GKELCSPLQT RRAHFSKYLF HLIIWDQQIC FPVQVNRLPR
710 720 730 740 750
ETLLCATLYA LPVPPPGGSS EANKQKRVPE ALGWVTTPLF NFRQVLTCGR
760 770 780 790 800
KLLGLWPATQ ENSGARWSAP NFHQPDSVIL QIDFPSSAFD IKFTSPPGDK
810 820 830 840 850
FSPRYEFGSL REEDQRKLKD ITQKESLYWL TDADKKQLWE KRYYCHTEVS
860 870 880 890 900
SLPLVLASAP SWEWACLPDI YALLQQWTHM NHQDALGLLH ATFPDQEVRR
910 920 930 940 950
MAVQWIGSLS DAELLDYLPQ LVQALKYECY LDSPLVRFLL KRAISDLRVT
960 970 980 990 1000
HYFFWLLKDS LKDSQFSIRY QYLLAALLCC CGKGLREEFN RQCWLVNTLA
1010 1020 1030 1040 1050
KLAQQVREAT PSARQGILRV GLEEVKQFFA LNGSCRLPLS PSLLVKGIVP
1060 1070 1080 1090 1100
RDCSYFNSNA VPLKLAFQNV DPLGENIRVI FKCGDDLRQD MLTLQMIRIM
1110 1120 1130 1140 1150
SKIWVQEGLD MRMVIFRCFS TGRGKGMVEM IPNAETLRKI QVEHGVTGSF
1160 1170 1180 1190 1200
KDRPLADWLQ KHNPGEDEYE KAVENFIYSC AGCCVATYIL GICDRHNDNI
1210 1220 1230 1240 1250
MLKTTGHMFH IDFGRFLGHA QMFGNIKRDR APFVFTSDMA YVINGGDKPS
1260 1270 1280 1290 1300
SRFHDFVDLC CQAYNLIRKH THLFLNLLGL MLSCGIPELS DLEDLKYVYD
1310 1320 1330 1340 1350
ALRPQDTEAN ATTYFTRLIE SSLGSVATKL NFFIHNLAQM KFTGSDDRLT
1360 1370 1380 1390 1400
LSFAPRTHTL KSSGRIRDVF LCRHEKIFHP SKGYVYVVKV MRENAHEATY
1410 1420 1430 1440 1450
IQRTFEEFQE LHNKLRLLFP SSFLPSFPSR FVIGRSRGEA VAERRKEELN
1460 1470 1480 1490 1500
GYIWHLIHAA PEVAECDLVY TFFHPLPRDE KASGPSPAPK SSDGTWARPV
1510 1520 1530 1540 1550
GKVGGEVKLS ISYKNNKLFI MVMHIRGLQP LQDGNDPDPY VKIYLLPDPQ
1560 1570 1580 1590 1600
KTTKRKTKVA RKTCNPTYNE MLVYDGIPKG DLQQRELQLS VLSEQGFWEN
1610 1620 1630
LLLGEVHIRL RELDLAQEKT GWFGLGSRGH GT
Length:1,632
Mass (Da):184,178
Last modified:April 5, 2011 - v1
Checksum:i9E775F4CFA3E7C66
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC107842 Genomic DNA. No translation available.
AC137948 Genomic DNA. No translation available.
RefSeqiNP_001092746.2. NM_001099276.2.
XP_006529594.1. XM_006529531.2.
XP_006529595.1. XM_006529532.1.
UniGeneiMm.387308.

Genome annotation databases

EnsembliENSMUST00000077730; ENSMUSP00000076911; ENSMUSG00000026447.
GeneIDi240752.
KEGGimmu:240752.
UCSCiuc011wry.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC107842 Genomic DNA. No translation available.
AC137948 Genomic DNA. No translation available.
RefSeqiNP_001092746.2. NM_001099276.2.
XP_006529594.1. XM_006529531.2.
XP_006529595.1. XM_006529532.1.
UniGeneiMm.387308.

3D structure databases

ProteinModelPortaliE9QAN8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000076911.

Proteomic databases

MaxQBiE9QAN8.
PRIDEiE9QAN8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000077730; ENSMUSP00000076911; ENSMUSG00000026447.
GeneIDi240752.
KEGGimmu:240752.
UCSCiuc011wry.1. mouse.

Organism-specific databases

CTDi5287.
MGIiMGI:2685045. Pik3c2b.

Phylogenomic databases

GeneTreeiENSGT00760000119110.
InParanoidiE9QAN8.
KOiK00923.
OMAiIHLQERP.
OrthoDBiEOG71CFK4.
TreeFamiTF102031.

Enzyme and pathway databases

ReactomeiREACT_272541. Synthesis of PIPs at the plasma membrane.

Miscellaneous databases

NextBioi384709.
PROiE9QAN8.
SOURCEiSearch...

Gene expression databases

BgeeiE9QAN8.
ExpressionAtlasiE9QAN8. baseline and differential.

Family and domain databases

Gene3Di1.10.1070.11. 1 hit.
1.25.40.70. 1 hit.
2.60.40.150. 2 hits.
3.30.1520.10. 1 hit.
InterProiIPR016024. ARM-type_fold.
IPR000008. C2_dom.
IPR011009. Kinase-like_dom.
IPR001683. Phox.
IPR000403. PI3/4_kinase_cat_dom.
IPR018936. PI3/4_kinase_CS.
IPR002420. PI3K_C2_dom.
IPR000341. PI3K_Ras-bd_dom.
IPR015433. PI_Kinase.
IPR001263. PInositide-3_kin_accessory_dom.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PANTHERiPTHR10048. PTHR10048. 1 hit.
PfamiPF00168. C2. 1 hit.
PF00454. PI3_PI4_kinase. 1 hit.
PF00792. PI3K_C2. 1 hit.
PF00794. PI3K_rbd. 1 hit.
PF00613. PI3Ka. 1 hit.
PF00787. PX. 1 hit.
[Graphical view]
SMARTiSM00239. C2. 1 hit.
SM00142. PI3K_C2. 1 hit.
SM00144. PI3K_rbd. 1 hit.
SM00145. PI3Ka. 1 hit.
SM00146. PI3Kc. 1 hit.
SM00312. PX. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
SSF49562. SSF49562. 2 hits.
SSF54236. SSF54236. 1 hit.
SSF56112. SSF56112. 1 hit.
SSF64268. SSF64268. 1 hit.
PROSITEiPS50004. C2. 1 hit.
PS00915. PI3_4_KINASE_1. 1 hit.
PS00916. PI3_4_KINASE_2. 1 hit.
PS50290. PI3_4_KINASE_3. 1 hit.
PS51547. PI3K_C2. 1 hit.
PS51546. PI3K_RBD. 1 hit.
PS51545. PIK_HELICAL. 1 hit.
PS50195. PX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  3. Ensembl
    Submitted (MAY-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiE9QAN8_MOUSE
AccessioniPrimary (citable) accession number: E9QAN8
Entry historyi
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: June 24, 2015
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.