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E9QAN8

- E9QAN8_MOUSE

UniProt

E9QAN8 - E9QAN8_MOUSE

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Protein
Submitted name: Protein Pik3c2b
Gene
Pik3c2b
Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein predictedi

Functioni

GO - Molecular functioni

  1. 1-phosphatidylinositol-3-kinase activity Source: RefGenome
  2. 1-phosphatidylinositol-4-phosphate 3-kinase activity Source: RefGenome
  3. ATP binding Source: UniProtKB-KW
  4. lipid kinase activity Source: MGI
  5. phosphatidylinositol binding Source: InterPro
  6. protein binding Source: MGI
Complete GO annotation...

GO - Biological processi

  1. phosphatidylinositol-3-phosphate biosynthetic process Source: GOC
  2. phosphatidylinositol-mediated signaling Source: InterPro
  3. protein kinase B signaling Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

KinaseSAAS annotations, Transferase

Keywords - Ligandi

ATP-bindingSAAS annotations, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_198973. Synthesis of PIPs at the plasma membrane.

Names & Taxonomyi

Protein namesi
Submitted name:
Protein Pik3c2bImported
Gene namesi
Name:Pik3c2bImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 1

Organism-specific databases

MGIiMGI:2685045. Pik3c2b.

Subcellular locationi

GO - Cellular componenti

  1. endocytic vesicle Source: MGI
  2. phosphatidylinositol 3-kinase complex Source: RefGenome
  3. plasma membrane Source: RefGenome
Complete GO annotation...

PTM / Processingi

Proteomic databases

PRIDEiE9QAN8.

Expressioni

Gene expression databases

ArrayExpressiE9QAN8.
BgeeiE9QAN8.

Structurei

3D structure databases

ProteinModelPortaliE9QAN8.

Family & Domainsi

Sequence similaritiesi

Contains 1 C2 domain.UniRule annotation
Contains PI3K/PI4K domain.SAAS annotations
Contains PIK helical domain.SAAS annotations

Phylogenomic databases

GeneTreeiENSGT00620000087805.
KOiK00923.
OMAiIHLQERP.
OrthoDBiEOG71CFK4.
TreeFamiTF102031.

Family and domain databases

Gene3Di1.10.1070.11. 1 hit.
1.25.40.70. 1 hit.
2.60.40.150. 2 hits.
3.30.1520.10. 1 hit.
InterProiIPR016024. ARM-type_fold.
IPR000008. C2_dom.
IPR011009. Kinase-like_dom.
IPR001683. Phox.
IPR000403. PI3/4_kinase_cat_dom.
IPR018936. PI3/4_kinase_CS.
IPR002420. PI3K_C2_dom.
IPR000341. PI3K_Ras-bd_dom.
IPR015433. PI_Kinase.
IPR001263. PInositide-3_kin_accessory_dom.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PANTHERiPTHR10048. PTHR10048. 1 hit.
PfamiPF00168. C2. 1 hit.
PF00454. PI3_PI4_kinase. 1 hit.
PF00792. PI3K_C2. 1 hit.
PF00794. PI3K_rbd. 1 hit.
PF00613. PI3Ka. 1 hit.
PF00787. PX. 1 hit.
[Graphical view]
SMARTiSM00239. C2. 1 hit.
SM00142. PI3K_C2. 1 hit.
SM00144. PI3K_rbd. 1 hit.
SM00145. PI3Ka. 1 hit.
SM00146. PI3Kc. 1 hit.
SM00312. PX. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
SSF49562. SSF49562. 2 hits.
SSF54236. SSF54236. 1 hit.
SSF56112. SSF56112. 1 hit.
SSF64268. SSF64268. 1 hit.
PROSITEiPS50004. C2. 1 hit.
PS00915. PI3_4_KINASE_1. 1 hit.
PS00916. PI3_4_KINASE_2. 1 hit.
PS50290. PI3_4_KINASE_3. 1 hit.
PS51547. PI3K_C2. 1 hit.
PS51546. PI3K_RBD. 1 hit.
PS51545. PIK_HELICAL. 1 hit.
PS50195. PX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E9QAN8-1 [UniParc]FASTAAdd to Basket

« Hide

MSSTQGNGEH WKSLESVGIS RKELAMAEAL QMEYDALSRL RHHKEESRAK     50
QNTEPSLISW DEPALDFYSK PAGRRTDLKL LRGLSGSDPT LNYNSISPPE 100
GLPNSTSQDP QPGPDPWPKG SLSGDYLYIF DGSEGRCSLS PGSGDTDGSC 150
KKLSPPPLPP RVSIWDAPPL PPRKGSPSPS KISQPNDINS FSSAEQPPDK 200
LLVAQDPEEG ELPDGRGQGH TLGSVDYDGI NDAITRLNLK STYDSEISSD 250
ATRGWKEGRG PLDFNKDTSG KPVARSKTMP PQVPPRTYTS RYANRKNATP 300
GNNRRISAAP VGSRPHTVAN GHELFEVSEE RDEEVAAFCH MLDILRTGSD 350
IQDYSLTGCV WSTVTPSPEH LGDEVNLKVT VLCDSLREPL TFTCNCSSTV 400
DLLIHQTLCY THDELREVDV GDFVLKPCGL EEFLQNKHAL GSHEYIQYCR 450
KFDISIRLQL MEQKAIRSDL ARTVNDDQSP STLNYLIHLQ ERPVKQTISR 500
QALSLLFDTY HNEVDAFLLA DGDFPLKADR VVQSVKAICN ALAAVETPEI 550
TSALNQLPPC PSRMQPKIQK DPSVLSVREN REKVVEALTA AILDLVELYC 600
STFNADFQTA VPGSRKHDLV QEACHFPGAL AFTVYGTHRI PIIWATSYED 650
FYLSCSLSHG GKELCSPLQT RRAHFSKYLF HLIIWDQQIC FPVQVNRLPR 700
ETLLCATLYA LPVPPPGGSS EANKQKRVPE ALGWVTTPLF NFRQVLTCGR 750
KLLGLWPATQ ENSGARWSAP NFHQPDSVIL QIDFPSSAFD IKFTSPPGDK 800
FSPRYEFGSL REEDQRKLKD ITQKESLYWL TDADKKQLWE KRYYCHTEVS 850
SLPLVLASAP SWEWACLPDI YALLQQWTHM NHQDALGLLH ATFPDQEVRR 900
MAVQWIGSLS DAELLDYLPQ LVQALKYECY LDSPLVRFLL KRAISDLRVT 950
HYFFWLLKDS LKDSQFSIRY QYLLAALLCC CGKGLREEFN RQCWLVNTLA 1000
KLAQQVREAT PSARQGILRV GLEEVKQFFA LNGSCRLPLS PSLLVKGIVP 1050
RDCSYFNSNA VPLKLAFQNV DPLGENIRVI FKCGDDLRQD MLTLQMIRIM 1100
SKIWVQEGLD MRMVIFRCFS TGRGKGMVEM IPNAETLRKI QVEHGVTGSF 1150
KDRPLADWLQ KHNPGEDEYE KAVENFIYSC AGCCVATYIL GICDRHNDNI 1200
MLKTTGHMFH IDFGRFLGHA QMFGNIKRDR APFVFTSDMA YVINGGDKPS 1250
SRFHDFVDLC CQAYNLIRKH THLFLNLLGL MLSCGIPELS DLEDLKYVYD 1300
ALRPQDTEAN ATTYFTRLIE SSLGSVATKL NFFIHNLAQM KFTGSDDRLT 1350
LSFAPRTHTL KSSGRIRDVF LCRHEKIFHP SKGYVYVVKV MRENAHEATY 1400
IQRTFEEFQE LHNKLRLLFP SSFLPSFPSR FVIGRSRGEA VAERRKEELN 1450
GYIWHLIHAA PEVAECDLVY TFFHPLPRDE KASGPSPAPK SSDGTWARPV 1500
GKVGGEVKLS ISYKNNKLFI MVMHIRGLQP LQDGNDPDPY VKIYLLPDPQ 1550
KTTKRKTKVA RKTCNPTYNE MLVYDGIPKG DLQQRELQLS VLSEQGFWEN 1600
LLLGEVHIRL RELDLAQEKT GWFGLGSRGH GT 1632
Length:1,632
Mass (Da):184,178
Last modified:April 5, 2011 - v1
Checksum:i9E775F4CFA3E7C66
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC107842 Genomic DNA. No translation available.
AC137948 Genomic DNA. No translation available.
RefSeqiNP_001092746.2. NM_001099276.2.
XP_006529594.1. XM_006529531.1.
XP_006529595.1. XM_006529532.1.
UniGeneiMm.387308.

Genome annotation databases

EnsembliENSMUST00000077730; ENSMUSP00000076911; ENSMUSG00000026447.
GeneIDi240752.
KEGGimmu:240752.
UCSCiuc011wry.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC107842 Genomic DNA. No translation available.
AC137948 Genomic DNA. No translation available.
RefSeqi NP_001092746.2. NM_001099276.2.
XP_006529594.1. XM_006529531.1.
XP_006529595.1. XM_006529532.1.
UniGenei Mm.387308.

3D structure databases

ProteinModelPortali E9QAN8.
ModBasei Search...

Proteomic databases

PRIDEi E9QAN8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000077730 ; ENSMUSP00000076911 ; ENSMUSG00000026447 .
GeneIDi 240752.
KEGGi mmu:240752.
UCSCi uc011wry.1. mouse.

Organism-specific databases

CTDi 5287.
MGIi MGI:2685045. Pik3c2b.

Phylogenomic databases

GeneTreei ENSGT00620000087805.
KOi K00923.
OMAi IHLQERP.
OrthoDBi EOG71CFK4.
TreeFami TF102031.

Enzyme and pathway databases

Reactomei REACT_198973. Synthesis of PIPs at the plasma membrane.

Miscellaneous databases

NextBioi 384709.
PROi E9QAN8.
SOURCEi Search...

Gene expression databases

ArrayExpressi E9QAN8.
Bgeei E9QAN8.

Family and domain databases

Gene3Di 1.10.1070.11. 1 hit.
1.25.40.70. 1 hit.
2.60.40.150. 2 hits.
3.30.1520.10. 1 hit.
InterProi IPR016024. ARM-type_fold.
IPR000008. C2_dom.
IPR011009. Kinase-like_dom.
IPR001683. Phox.
IPR000403. PI3/4_kinase_cat_dom.
IPR018936. PI3/4_kinase_CS.
IPR002420. PI3K_C2_dom.
IPR000341. PI3K_Ras-bd_dom.
IPR015433. PI_Kinase.
IPR001263. PInositide-3_kin_accessory_dom.
IPR029071. Ubiquitin-rel_dom.
[Graphical view ]
PANTHERi PTHR10048. PTHR10048. 1 hit.
Pfami PF00168. C2. 1 hit.
PF00454. PI3_PI4_kinase. 1 hit.
PF00792. PI3K_C2. 1 hit.
PF00794. PI3K_rbd. 1 hit.
PF00613. PI3Ka. 1 hit.
PF00787. PX. 1 hit.
[Graphical view ]
SMARTi SM00239. C2. 1 hit.
SM00142. PI3K_C2. 1 hit.
SM00144. PI3K_rbd. 1 hit.
SM00145. PI3Ka. 1 hit.
SM00146. PI3Kc. 1 hit.
SM00312. PX. 1 hit.
[Graphical view ]
SUPFAMi SSF48371. SSF48371. 1 hit.
SSF49562. SSF49562. 2 hits.
SSF54236. SSF54236. 1 hit.
SSF56112. SSF56112. 1 hit.
SSF64268. SSF64268. 1 hit.
PROSITEi PS50004. C2. 1 hit.
PS00915. PI3_4_KINASE_1. 1 hit.
PS00916. PI3_4_KINASE_2. 1 hit.
PS50290. PI3_4_KINASE_3. 1 hit.
PS51547. PI3K_C2. 1 hit.
PS51546. PI3K_RBD. 1 hit.
PS51545. PIK_HELICAL. 1 hit.
PS50195. PX. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  2. Ensembl
    Submitted (MAY-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiE9QAN8_MOUSE
AccessioniPrimary (citable) accession number: E9QAN8
Entry historyi
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: September 3, 2014
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

Similar proteinsi