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E9QAN8

- E9QAN8_MOUSE

UniProt

E9QAN8 - E9QAN8_MOUSE

Protein
Submitted name:

Protein Pik3c2b

Gene

Pik3c2b

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 3 out of 5- Protein predictedi
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    • History
      Entry version 34 (01 Oct 2014)
      Sequence version 1 (05 Apr 2011)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. 1-phosphatidylinositol-3-kinase activity Source: RefGenome
    2. 1-phosphatidylinositol-4-phosphate 3-kinase activity Source: RefGenome
    3. ATP binding Source: UniProtKB-KW
    4. lipid kinase activity Source: MGI
    5. phosphatidylinositol binding Source: InterPro
    6. protein binding Source: MGI

    GO - Biological processi

    1. phosphatidylinositol-3-phosphate biosynthetic process Source: GOC
    2. phosphatidylinositol-mediated signaling Source: InterPro
    3. protein kinase B signaling Source: MGI

    Keywords - Molecular functioni

    KinaseSAAS annotation, Transferase

    Keywords - Ligandi

    ATP-bindingSAAS annotation, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_198973. Synthesis of PIPs at the plasma membrane.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Protein Pik3c2bImported
    Gene namesi
    Name:Pik3c2bImported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 1

    Organism-specific databases

    MGIiMGI:2685045. Pik3c2b.

    Subcellular locationi

    GO - Cellular componenti

    1. endocytic vesicle Source: MGI
    2. phosphatidylinositol 3-kinase complex Source: RefGenome
    3. plasma membrane Source: RefGenome

    PTM / Processingi

    Proteomic databases

    PRIDEiE9QAN8.

    Expressioni

    Gene expression databases

    ArrayExpressiE9QAN8.
    BgeeiE9QAN8.

    Structurei

    3D structure databases

    ProteinModelPortaliE9QAN8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains 1 C2 domain.UniRule annotation
    Contains PI3K/PI4K domain.SAAS annotation
    Contains PIK helical domain.SAAS annotation

    Phylogenomic databases

    GeneTreeiENSGT00620000087805.
    KOiK00923.
    OMAiIHLQERP.
    OrthoDBiEOG71CFK4.
    TreeFamiTF102031.

    Family and domain databases

    Gene3Di1.10.1070.11. 1 hit.
    1.25.40.70. 1 hit.
    2.60.40.150. 2 hits.
    3.30.1520.10. 1 hit.
    InterProiIPR016024. ARM-type_fold.
    IPR000008. C2_dom.
    IPR011009. Kinase-like_dom.
    IPR001683. Phox.
    IPR000403. PI3/4_kinase_cat_dom.
    IPR018936. PI3/4_kinase_CS.
    IPR002420. PI3K_C2_dom.
    IPR000341. PI3K_Ras-bd_dom.
    IPR015433. PI_Kinase.
    IPR001263. PInositide-3_kin_accessory_dom.
    IPR029071. Ubiquitin-rel_dom.
    [Graphical view]
    PANTHERiPTHR10048. PTHR10048. 1 hit.
    PfamiPF00168. C2. 1 hit.
    PF00454. PI3_PI4_kinase. 1 hit.
    PF00792. PI3K_C2. 1 hit.
    PF00794. PI3K_rbd. 1 hit.
    PF00613. PI3Ka. 1 hit.
    PF00787. PX. 1 hit.
    [Graphical view]
    SMARTiSM00239. C2. 1 hit.
    SM00142. PI3K_C2. 1 hit.
    SM00144. PI3K_rbd. 1 hit.
    SM00145. PI3Ka. 1 hit.
    SM00146. PI3Kc. 1 hit.
    SM00312. PX. 1 hit.
    [Graphical view]
    SUPFAMiSSF48371. SSF48371. 1 hit.
    SSF49562. SSF49562. 2 hits.
    SSF54236. SSF54236. 1 hit.
    SSF56112. SSF56112. 1 hit.
    SSF64268. SSF64268. 1 hit.
    PROSITEiPS50004. C2. 1 hit.
    PS00915. PI3_4_KINASE_1. 1 hit.
    PS00916. PI3_4_KINASE_2. 1 hit.
    PS50290. PI3_4_KINASE_3. 1 hit.
    PS51547. PI3K_C2. 1 hit.
    PS51546. PI3K_RBD. 1 hit.
    PS51545. PIK_HELICAL. 1 hit.
    PS50195. PX. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    E9QAN8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSSTQGNGEH WKSLESVGIS RKELAMAEAL QMEYDALSRL RHHKEESRAK     50
    QNTEPSLISW DEPALDFYSK PAGRRTDLKL LRGLSGSDPT LNYNSISPPE 100
    GLPNSTSQDP QPGPDPWPKG SLSGDYLYIF DGSEGRCSLS PGSGDTDGSC 150
    KKLSPPPLPP RVSIWDAPPL PPRKGSPSPS KISQPNDINS FSSAEQPPDK 200
    LLVAQDPEEG ELPDGRGQGH TLGSVDYDGI NDAITRLNLK STYDSEISSD 250
    ATRGWKEGRG PLDFNKDTSG KPVARSKTMP PQVPPRTYTS RYANRKNATP 300
    GNNRRISAAP VGSRPHTVAN GHELFEVSEE RDEEVAAFCH MLDILRTGSD 350
    IQDYSLTGCV WSTVTPSPEH LGDEVNLKVT VLCDSLREPL TFTCNCSSTV 400
    DLLIHQTLCY THDELREVDV GDFVLKPCGL EEFLQNKHAL GSHEYIQYCR 450
    KFDISIRLQL MEQKAIRSDL ARTVNDDQSP STLNYLIHLQ ERPVKQTISR 500
    QALSLLFDTY HNEVDAFLLA DGDFPLKADR VVQSVKAICN ALAAVETPEI 550
    TSALNQLPPC PSRMQPKIQK DPSVLSVREN REKVVEALTA AILDLVELYC 600
    STFNADFQTA VPGSRKHDLV QEACHFPGAL AFTVYGTHRI PIIWATSYED 650
    FYLSCSLSHG GKELCSPLQT RRAHFSKYLF HLIIWDQQIC FPVQVNRLPR 700
    ETLLCATLYA LPVPPPGGSS EANKQKRVPE ALGWVTTPLF NFRQVLTCGR 750
    KLLGLWPATQ ENSGARWSAP NFHQPDSVIL QIDFPSSAFD IKFTSPPGDK 800
    FSPRYEFGSL REEDQRKLKD ITQKESLYWL TDADKKQLWE KRYYCHTEVS 850
    SLPLVLASAP SWEWACLPDI YALLQQWTHM NHQDALGLLH ATFPDQEVRR 900
    MAVQWIGSLS DAELLDYLPQ LVQALKYECY LDSPLVRFLL KRAISDLRVT 950
    HYFFWLLKDS LKDSQFSIRY QYLLAALLCC CGKGLREEFN RQCWLVNTLA 1000
    KLAQQVREAT PSARQGILRV GLEEVKQFFA LNGSCRLPLS PSLLVKGIVP 1050
    RDCSYFNSNA VPLKLAFQNV DPLGENIRVI FKCGDDLRQD MLTLQMIRIM 1100
    SKIWVQEGLD MRMVIFRCFS TGRGKGMVEM IPNAETLRKI QVEHGVTGSF 1150
    KDRPLADWLQ KHNPGEDEYE KAVENFIYSC AGCCVATYIL GICDRHNDNI 1200
    MLKTTGHMFH IDFGRFLGHA QMFGNIKRDR APFVFTSDMA YVINGGDKPS 1250
    SRFHDFVDLC CQAYNLIRKH THLFLNLLGL MLSCGIPELS DLEDLKYVYD 1300
    ALRPQDTEAN ATTYFTRLIE SSLGSVATKL NFFIHNLAQM KFTGSDDRLT 1350
    LSFAPRTHTL KSSGRIRDVF LCRHEKIFHP SKGYVYVVKV MRENAHEATY 1400
    IQRTFEEFQE LHNKLRLLFP SSFLPSFPSR FVIGRSRGEA VAERRKEELN 1450
    GYIWHLIHAA PEVAECDLVY TFFHPLPRDE KASGPSPAPK SSDGTWARPV 1500
    GKVGGEVKLS ISYKNNKLFI MVMHIRGLQP LQDGNDPDPY VKIYLLPDPQ 1550
    KTTKRKTKVA RKTCNPTYNE MLVYDGIPKG DLQQRELQLS VLSEQGFWEN 1600
    LLLGEVHIRL RELDLAQEKT GWFGLGSRGH GT 1632
    Length:1,632
    Mass (Da):184,178
    Last modified:April 5, 2011 - v1
    Checksum:i9E775F4CFA3E7C66
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC107842 Genomic DNA. No translation available.
    AC137948 Genomic DNA. No translation available.
    RefSeqiNP_001092746.2. NM_001099276.2.
    XP_006529594.1. XM_006529531.1.
    XP_006529595.1. XM_006529532.1.
    UniGeneiMm.387308.

    Genome annotation databases

    EnsembliENSMUST00000077730; ENSMUSP00000076911; ENSMUSG00000026447.
    GeneIDi240752.
    KEGGimmu:240752.
    UCSCiuc011wry.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC107842 Genomic DNA. No translation available.
    AC137948 Genomic DNA. No translation available.
    RefSeqi NP_001092746.2. NM_001099276.2.
    XP_006529594.1. XM_006529531.1.
    XP_006529595.1. XM_006529532.1.
    UniGenei Mm.387308.

    3D structure databases

    ProteinModelPortali E9QAN8.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi E9QAN8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000077730 ; ENSMUSP00000076911 ; ENSMUSG00000026447 .
    GeneIDi 240752.
    KEGGi mmu:240752.
    UCSCi uc011wry.1. mouse.

    Organism-specific databases

    CTDi 5287.
    MGIi MGI:2685045. Pik3c2b.

    Phylogenomic databases

    GeneTreei ENSGT00620000087805.
    KOi K00923.
    OMAi IHLQERP.
    OrthoDBi EOG71CFK4.
    TreeFami TF102031.

    Enzyme and pathway databases

    Reactomei REACT_198973. Synthesis of PIPs at the plasma membrane.

    Miscellaneous databases

    NextBioi 384709.
    PROi E9QAN8.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi E9QAN8.
    Bgeei E9QAN8.

    Family and domain databases

    Gene3Di 1.10.1070.11. 1 hit.
    1.25.40.70. 1 hit.
    2.60.40.150. 2 hits.
    3.30.1520.10. 1 hit.
    InterProi IPR016024. ARM-type_fold.
    IPR000008. C2_dom.
    IPR011009. Kinase-like_dom.
    IPR001683. Phox.
    IPR000403. PI3/4_kinase_cat_dom.
    IPR018936. PI3/4_kinase_CS.
    IPR002420. PI3K_C2_dom.
    IPR000341. PI3K_Ras-bd_dom.
    IPR015433. PI_Kinase.
    IPR001263. PInositide-3_kin_accessory_dom.
    IPR029071. Ubiquitin-rel_dom.
    [Graphical view ]
    PANTHERi PTHR10048. PTHR10048. 1 hit.
    Pfami PF00168. C2. 1 hit.
    PF00454. PI3_PI4_kinase. 1 hit.
    PF00792. PI3K_C2. 1 hit.
    PF00794. PI3K_rbd. 1 hit.
    PF00613. PI3Ka. 1 hit.
    PF00787. PX. 1 hit.
    [Graphical view ]
    SMARTi SM00239. C2. 1 hit.
    SM00142. PI3K_C2. 1 hit.
    SM00144. PI3K_rbd. 1 hit.
    SM00145. PI3Ka. 1 hit.
    SM00146. PI3Kc. 1 hit.
    SM00312. PX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48371. SSF48371. 1 hit.
    SSF49562. SSF49562. 2 hits.
    SSF54236. SSF54236. 1 hit.
    SSF56112. SSF56112. 1 hit.
    SSF64268. SSF64268. 1 hit.
    PROSITEi PS50004. C2. 1 hit.
    PS00915. PI3_4_KINASE_1. 1 hit.
    PS00916. PI3_4_KINASE_2. 1 hit.
    PS50290. PI3_4_KINASE_3. 1 hit.
    PS51547. PI3K_C2. 1 hit.
    PS51546. PI3K_RBD. 1 hit.
    PS51545. PIK_HELICAL. 1 hit.
    PS50195. PX. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6JImported.
    2. Ensembl
      Submitted (MAY-2011) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: C57BL/6JImported.

    Entry informationi

    Entry nameiE9QAN8_MOUSE
    AccessioniPrimary (citable) accession number: E9QAN8
    Entry historyi
    Integrated into UniProtKB/TrEMBL: April 5, 2011
    Last sequence update: April 5, 2011
    Last modified: October 1, 2014
    This is version 34 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Caution

    The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3