Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Zinc finger protein 431

Gene

Znf431

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Sequence-specific DNA binding transcriptional repressor. Represses target gene transcription by recruiting HDAC1 and HDAC2 histone deacetylases. Acts as a specific transcriptional repressor for PTCH1 during embryonic development. Required for osteoblast differentiation and sonic hedgehog/SHH signaling response. Binds to the consensus site 5'-GCGCCC-3' in the promoter of PTCH1.2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri104 – 126C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri132 – 154C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri160 – 182C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri188 – 210C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri216 – 238C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri244 – 266C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri272 – 294C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri300 – 322C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri328 – 350C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri356 – 378C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri384 – 406C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri412 – 434C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri440 – 462C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri468 – 490C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri496 – 518C2H2-type 15PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

  • chromatin binding Source: UniProtKB
  • core promoter sequence-specific DNA binding Source: UniProtKB
  • histone deacetylase binding Source: UniProtKB
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

  • cell differentiation Source: UniProtKB-KW
  • negative regulation of DNA binding transcription factor activity Source: UniProtKB
  • negative regulation of osteoblast differentiation Source: UniProtKB
  • negative regulation of transcription by RNA polymerase II Source: UniProtKB
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionRepressor
Biological processDifferentiation, Transcription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 431
Alternative name(s):
Zinc finger protein 932
Gene namesi
Name:Znf431
Synonyms:Zfp431, Zfp932
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1916754 Zfp932

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004252651 – 526Zinc finger protein 431Add BLAST526

Proteomic databases

MaxQBiE9QAG8
PaxDbiE9QAG8
PRIDEiE9QAG8

PTM databases

iPTMnetiE9QAG8
PhosphoSitePlusiE9QAG8

Expressioni

Tissue specificityi

Expressed in brain, heart, lung, thymus, spleen, lymph node, liver, kidney, muscle, testis, ovary, skin and uterus.1 Publication

Developmental stagei

Expressed in limb mesenchyme at 10.5 dpc. Expressed in tooth, submandibular glands, thymus, thyroid, vibrissa follicles at 14.5 dpc.2 Publications

Gene expression databases

BgeeiENSMUSG00000066613
ExpressionAtlasiE9QAG8 baseline and differential
GenevisibleiE9QAG8 MM

Interactioni

Subunit structurei

Interacts (via KRAB domain) with HDAC2; the interaction is direct. Interacts (via KRAB domain) with HDAC1.2 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

  • histone deacetylase binding Source: UniProtKB

Protein-protein interaction databases

BioGridi213490, 2 interactors
IntActiE9QAG8, 2 interactors
STRINGi10090.ENSMUSP00000108159

Structurei

3D structure databases

ProteinModelPortaliE9QAG8
SMRiE9QAG8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 76KRABPROSITE-ProRule annotationAdd BLAST72

Domaini

The KRAB domain is necessary for its repressive activity.

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri104 – 126C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri132 – 154C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri160 – 182C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri188 – 210C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri216 – 238C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri244 – 266C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri272 – 294C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri300 – 322C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri328 – 350C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri356 – 378C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri384 – 406C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri412 – 434C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri440 – 462C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri468 – 490C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri496 – 518C2H2-type 15PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00760000119089
InParanoidiE9QAG8
OMAiFATSCEL
TreeFamiTF338854

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 15 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 9 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 15 hits
PS50157 ZINC_FINGER_C2H2_2, 15 hits

Sequencei

Sequence statusi: Complete.

E9QAG8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVDALTYDDV YVNFTQEEWA LLNPSQKSLY KDVMLETYRN LNAVGYNWED
60 70 80 90 100
SNIEEHCESS RRHGRHERNH TGEKPYEGIQ YGEAFVHHSS LQMRKIIHTG
110 120 130 140 150
EKRYKCNQCD KAYSRHSILQ IHKRTHSGEK PYECNQCGKA FTQHSHLKIH
160 170 180 190 200
MVTHTGEKPY KCDQCGKAFA FHSTLQVHKR THTGEKPYEC NQCSKAFAHH
210 220 230 240 250
CHLRVHKRIH TGEKPYKCDQ CGKAFVGQND LKRHERVHTG EKPYKCNECG
260 270 280 290 300
KAFVCNASLR THKTTHTGVK PYECKQCTKS FASHGQLQKH ERIHTGEKPY
310 320 330 340 350
KCDQCGKAFA SHDKFQKHER IHIGEKPYKC KQCTKSFASH DKLQKHERIH
360 370 380 390 400
TGEKPYECKQ CTKSFASHNK LQKHERIHTG EKPYKCDQCN KAFVYESYLQ
410 420 430 440 450
VHKKTHTGEK PYKCNECGKA FARHSHLKVH KITHTGEKPY KCNQCGKALA
460 470 480 490 500
YHSTLQVHQR THTGEKPYEC EQCGKAFANQ SYFQVHKRIH TGEKPYKCDQ
510 520
CGKAFVGSSD LKRHERVHTG RETLQM
Length:526
Mass (Da):61,280
Last modified:April 5, 2011 - v1
Checksum:i1F7F44631FEB1BA2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti323I → T in BC012405 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC123679 Genomic DNA No translation available.
BC012405 mRNA No translation available.
CCDSiCCDS59681.1
RefSeqiNP_663538.2, NM_145563.2
UniGeneiMm.441438

Genome annotation databases

EnsembliENSMUST00000112540; ENSMUSP00000108159; ENSMUSG00000066613
GeneIDi69504
KEGGimmu:69504
UCSCiuc008ypn.1 mouse

Similar proteinsi

Entry informationi

Entry nameiZN431_MOUSE
AccessioniPrimary (citable) accession number: E9QAG8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 19, 2014
Last sequence update: April 5, 2011
Last modified: March 28, 2018
This is version 56 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health