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E9QAE4

- E9QAE4_MOUSE

UniProt

E9QAE4 - E9QAE4_MOUSE

Protein
Submitted name:

Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20-specific

Gene

Nsd1

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 3 out of 5- Protein predictedi
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    • History
      Entry version 33 (01 Oct 2014)
      Sequence version 1 (05 Apr 2011)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].SAAS annotation

    GO - Molecular functioni

    1. chromatin binding Source: MGI
    2. histone-lysine N-methyltransferase activity Source: InterPro
    3. histone methyltransferase activity Source: MGI
    4. transcription cofactor activity Source: MGI
    5. zinc ion binding Source: Ensembl

    GO - Biological processi

    1. gastrulation with mouth forming second Source: MGI
    2. histone methylation Source: GOC
    3. positive regulation of transcription, DNA-templated Source: Ensembl
    4. regulation of transcription, DNA-templated Source: MGI

    Keywords - Molecular functioni

    MethyltransferaseUniRule annotation, Transferase

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20-specificImported
    Gene namesi
    Name:Nsd1Imported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 13

    Organism-specific databases

    MGIiMGI:1276545. Nsd1.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: MGI

    Keywords - Cellular componenti

    NucleusSAAS annotation

    PTM / Processingi

    Proteomic databases

    PRIDEiE9QAE4.

    Expressioni

    Gene expression databases

    ArrayExpressiE9QAE4.
    BgeeiE9QAE4.

    Structurei

    3D structure databases

    ProteinModelPortaliE9QAE4.
    SMRiE9QAE4. Positions 1754-1851, 1853-2083, 2119-2211.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains 1 post-SET domain.UniRule annotation
    Contains SET domain.SAAS annotation
    Contains post-SET domain.SAAS annotation

    Keywords - Domaini

    Zinc-fingerUniRule annotationSAAS annotation

    Phylogenomic databases

    GeneTreeiENSGT00740000114921.
    KOiK15588.
    OMAiECRTGIH.
    OrthoDBiEOG7Z69BG.
    TreeFamiTF329088.

    Family and domain databases

    Gene3Di3.30.40.10. 3 hits.
    InterProiIPR006560. AWS.
    IPR003616. Post-SET_dom.
    IPR000313. PWWP_dom.
    IPR001214. SET_dom.
    IPR019786. Zinc_finger_PHD-type_CS.
    IPR011011. Znf_FYVE_PHD.
    IPR001965. Znf_PHD.
    IPR019787. Znf_PHD-finger.
    IPR001841. Znf_RING.
    IPR013083. Znf_RING/FYVE/PHD.
    [Graphical view]
    PfamiPF00628. PHD. 1 hit.
    PF00855. PWWP. 2 hits.
    PF00856. SET. 1 hit.
    [Graphical view]
    SMARTiSM00570. AWS. 1 hit.
    SM00249. PHD. 5 hits.
    SM00508. PostSET. 1 hit.
    SM00293. PWWP. 2 hits.
    SM00184. RING. 1 hit.
    SM00317. SET. 1 hit.
    [Graphical view]
    SUPFAMiSSF57903. SSF57903. 3 hits.
    PROSITEiPS51215. AWS. 1 hit.
    PS50868. POST_SET. 1 hit.
    PS50812. PWWP. 2 hits.
    PS50280. SET. 1 hit.
    PS01359. ZF_PHD_1. 2 hits.
    PS50016. ZF_PHD_2. 2 hits.
    PS50089. ZF_RING_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    E9QAE4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDRTCELSRR NCLLSFSNPV NLDASEDKDS PFGNGQSNFS EPLNGCTMQL     50
    PTAASGTSQN AYGQDSPSCY IPLRRLQDLA SMINVEYLSG SADGSESFQD 100
    PAKSDSRAQS PIVCTSLSPG GPTALAMKQE PTCNNSPELQ LRVTKTTKNG 150
    FLHFENFTGV DDADVDSEMD PEQPVTEDES IEEIFEETQT NATCNYEPKS 200
    ENGVEVAMGS EQDSMPESRH GAVERPFLPL APQTEKQKNK QRSEVDGSNE 250
    KTALLPAPTS LGDTNVTVEE QFNSINLSFQ DDPDSSPSPL GNMLEIPGTS 300
    SPSTSQELPF CQPKKKSTPL KYEVGDLIWA KFKRRPWWPC RICSDPLINT 350
    HSKMKVANRR PYREYYVEAF GDPSEKAWVA GKAIVMFEGR HQFEELPVLR 400
    KRGKQKEKGY RHKVPQKILS KWEASVGLAE QYDVPKGSKN QKCVSSSVKL 450
    DSEEDMPFED CTNDPDSEHL LLNGCLKSLA FDSEHSADEK EKPCAKSRVR 500
    KSSDNIKRTS VKKDLVPFES RKEERRGKIP DNLGLDFISG GVSDKQASNE 550
    LSRIANSLTG SSTAPGSFLF SSSVQNTAKT DFETPDCDSL SGLSESALIS 600
    KHSGEKKKLQ PGQVCSSKVQ LCYVGAGDEE KRSNSVSVST TSDDGCSDLD 650
    PTEHNSGFQN SVLGITDAFD KTENALSVHK NETQYSRYPV TNRIKEKQKS 700
    LITNSHADHL MGSTKTMEPE TAELSQVNLS DLKISSPIPK PQPEFRNDGL 750
    TTKFSAPPGI RNENPLTKGG LANQTLLPLK CRQPKFRSIK CKHKESPAVA 800
    ETSATSEDLS LKCCSSDTNG SPLANISKSG KGEGLKLLNN MHEKTRDSSD 850
    IETAVVKHVL SELKELSYRS LSEDVSDSGT AKASKPLLFS SASSQNHIPI 900
    EPDYKFSTLL MMLKDMHDSK TKEQRLMTAQ NLASYRTPDR GDCSSGSPVG 950
    TSKVLVLGSS TPNSEKPGDS TQDSVHQSPG GGDSALSGEL SSSLSSLASD 1000
    KRELPACGKI RSNCIPRRNC GRAKPSSKLR ETISAQMVKP SVNPKALKTE 1050
    RKRKFSRLPA VTLAANRLGN KESGSVNGPS RGGAEDPGKE EPLQQMDLLR 1100
    NEDTHFSDVH FDSKAKQSDP DKNLEKEPSF ENRKGPELGS EMNTENDELH 1150
    GVNQVVPKKR WQRLNQRRPK PGKRANRFRE KENSEGAFGV LLPADAVQKA 1200
    REDYLEQRAP PTSKPEDSAA DPNHGSHSES VAPRLNVCEK SSVGMGDVEK 1250
    ETGIPSLMPQ TKLPEPAIRS EKKRLRKPSK WLLEYTEEYD QIFAPKKKQK 1300
    KVQEQVHKVS SRCEDESLLA RCQPSAQNKQ VDENSLISTK EEPPVLEREA 1350
    PFLEGPLAQS DLGVTHAELP QLTLSVPVAP EASPRPALES EELLVKTPGN 1400
    YESKRQRKPT KKLLESNDLD PGFMPKKGDL GLSRKCFEAS RSGNGIVESR 1450
    ATSHLKEFSG GTTKIFDKPR KRKRQRLVTA RVHYKKVKKE DLTKDTPSSE 1500
    GELLIHRTAA SPKEILEEGV EHDPGMSASK KLQVERGGGA ALKENVCQNC 1550
    EKLGELLLCE AQCCGAFHLE CLGLPEMPRG KFICNECHTG IHTCFVCKQS 1600
    GEDVKRCLLP LCGKFYHEEC VQKYPPTVTQ NKGFRCPLHI CITCHAANPA 1650
    NVSASKGRLM RCVRCPVAYH ANDFCLAAGS KILASNSIIC PNHFTPRRGC 1700
    RNHEHVNVSW CFVCSEGGSL LCCDSCPAAF HRECLNIDIP EGNWYCNDCK 1750
    AGKKPHYREI VWVKVGRYRW WPAEICHPRA VPSNIDKMRH DVGEFPVLFF 1800
    GSNDYLWTHQ ARVFPYMEGD VSSKDKMGKG VDGTYKKALQ EAAARFEELK 1850
    AQKELRQLQE DRKNDKKPPP YKHIKVNRPI GRVQIFTADL SEIPRCNCKA 1900
    TDENPCGIDS ECINRMLLYE CHPTVCPAGV RCQNQCFSKR QYPDVEIFRT 1950
    LQRGWGLRTK TDIKKGEFVN EYVGELIDEE ECRARIRYAQ EHDITNFYML 2000
    TLDKDRIIDA GPKGNYARFM NHCCQPNCET QKWSVNGDTR VGLFALSDIK 2050
    AGTELTFNYN LECLGNGKTV CKCGAPNCSG FLGVRPKNQP IVTEEKSRKF 2100
    KRKPHGKRRS QGEVTKERED ECFSCGDAGQ LVSCKKPGCP KVYHADCLNL 2150
    TKRPAGKWEC PWHQCDVCGK EAASFCEMCP SSFCKQHREG MLFISKLDGR 2200
    LSCTEHDPCG PNPLEPGEIR EYVPPTATSP PSPGTQPKEQ SSEMATQGPK 2250
    KSDQPPTDAT QLLPLSKKAL TGSCQRPLLP ERPPERTDSS SHLLDRIRDL 2300
    AGSGTKSQSL VSSQRPQDRP PAKEGPRPQP PDRASPMTRP SSSPSVSSLP 2350
    LERPLRMTDS RLDKSIGAAS PKSQAVEKTP ASTGLRLSSP DRLLTTNSPK 2400
    PQISDRPPEK SHASLTQRLP PPEKVLSAVV QSLVAKEKAL RPVDQNTQSK 2450
    HRPAVVMDLI DLTPRQKERA ASPQEVTPQA DEKTAMLESS SWPSSKGLGH 2500
    IPRATEKISV SESLQPSGKV AAPSEHPWQA VKSLTHARFL SPPSAKAFLY 2550
    ESATQASGRT PVGAEQTPGP PSPAPGLVKQ VKQLSRGLTA KSGQSFRSLG 2600
    KISASLPNEE KKLTTTEQSP WGLGKASPGA GLWPIVAGQT LAQACWSAGG 2650
    TQTLAQTCWS LGRGQDPKPE NAIQALNQAP SSRKCADSEK K 2691
    Length:2,691
    Mass (Da):296,364
    Last modified:April 5, 2011 - v1
    Checksum:i9757638B75D6E773
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC160958 Genomic DNA. No translation available.
    RefSeqiNP_032765.3. NM_008739.3.
    XP_006517197.1. XM_006517134.1.
    XP_006517198.1. XM_006517135.1.
    XP_006517199.1. XM_006517136.1.
    XP_006517200.1. XM_006517137.1.
    XP_006517201.1. XM_006517138.1.
    XP_006517202.1. XM_006517139.1.
    XP_006517203.1. XM_006517140.1.
    XP_006517204.1. XM_006517141.1.
    XP_006517205.1. XM_006517142.1.
    UniGeneiMm.12964.
    Mm.168965.

    Genome annotation databases

    EnsembliENSMUST00000099490; ENSMUSP00000097089; ENSMUSG00000021488.
    GeneIDi18193.
    KEGGimmu:18193.
    UCSCiuc007qqd.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC160958 Genomic DNA. No translation available.
    RefSeqi NP_032765.3. NM_008739.3.
    XP_006517197.1. XM_006517134.1.
    XP_006517198.1. XM_006517135.1.
    XP_006517199.1. XM_006517136.1.
    XP_006517200.1. XM_006517137.1.
    XP_006517201.1. XM_006517138.1.
    XP_006517202.1. XM_006517139.1.
    XP_006517203.1. XM_006517140.1.
    XP_006517204.1. XM_006517141.1.
    XP_006517205.1. XM_006517142.1.
    UniGenei Mm.12964.
    Mm.168965.

    3D structure databases

    ProteinModelPortali E9QAE4.
    SMRi E9QAE4. Positions 1754-1851, 1853-2083, 2119-2211.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi E9QAE4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000099490 ; ENSMUSP00000097089 ; ENSMUSG00000021488 .
    GeneIDi 18193.
    KEGGi mmu:18193.
    UCSCi uc007qqd.1. mouse.

    Organism-specific databases

    CTDi 64324.
    MGIi MGI:1276545. Nsd1.

    Phylogenomic databases

    GeneTreei ENSGT00740000114921.
    KOi K15588.
    OMAi ECRTGIH.
    OrthoDBi EOG7Z69BG.
    TreeFami TF329088.

    Miscellaneous databases

    ChiTaRSi NSD1. mouse.
    NextBioi 293540.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi E9QAE4.
    Bgeei E9QAE4.

    Family and domain databases

    Gene3Di 3.30.40.10. 3 hits.
    InterProi IPR006560. AWS.
    IPR003616. Post-SET_dom.
    IPR000313. PWWP_dom.
    IPR001214. SET_dom.
    IPR019786. Zinc_finger_PHD-type_CS.
    IPR011011. Znf_FYVE_PHD.
    IPR001965. Znf_PHD.
    IPR019787. Znf_PHD-finger.
    IPR001841. Znf_RING.
    IPR013083. Znf_RING/FYVE/PHD.
    [Graphical view ]
    Pfami PF00628. PHD. 1 hit.
    PF00855. PWWP. 2 hits.
    PF00856. SET. 1 hit.
    [Graphical view ]
    SMARTi SM00570. AWS. 1 hit.
    SM00249. PHD. 5 hits.
    SM00508. PostSET. 1 hit.
    SM00293. PWWP. 2 hits.
    SM00184. RING. 1 hit.
    SM00317. SET. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57903. SSF57903. 3 hits.
    PROSITEi PS51215. AWS. 1 hit.
    PS50868. POST_SET. 1 hit.
    PS50812. PWWP. 2 hits.
    PS50280. SET. 1 hit.
    PS01359. ZF_PHD_1. 2 hits.
    PS50016. ZF_PHD_2. 2 hits.
    PS50089. ZF_RING_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6JImported.
    2. Ensembl
      Submitted (MAY-2011) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: C57BL/6JImported.

    Entry informationi

    Entry nameiE9QAE4_MOUSE
    AccessioniPrimary (citable) accession number: E9QAE4
    Entry historyi
    Integrated into UniProtKB/TrEMBL: April 5, 2011
    Last sequence update: April 5, 2011
    Last modified: October 1, 2014
    This is version 33 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Caution

    The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3