Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20-specific

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E9QAE4 (E9QAE4_MOUSE) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 22. History...

Clusters with 100%, 90%, 50% identity |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry info Customize order

Names and origin

Protein names

Submitted name:
Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20-specific Ensembl ENSMUSP00000097089

Gene names

Name:

Nsd1 Ensembl ENSMUSP00000097089 MGI 1276545

Organism

Mus musculus (Mouse) [Reference proteome] Ensembl ENSMUSP00000097089

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	2691 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone]. SAAS SAAS001214

Sequence similarities

Contains 1 SET domain. RuleBase RU004538 SAAS SAAS001214

Contains 1 post-SET domain. RuleBase RU004541

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data. Ensembl ENSMUSP00000097089

Ontologies

Keywords
Cellular component	Nucleus SAAS SAAS003616
Domain	Zinc-finger SAAS SAAS001965 RuleBase RU000353
Ligand	Metal-binding Zinc
Molecular function	Methyltransferase SAAS SAAS001214 RuleBase RU004541 Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	gastrulation with mouth forming second Inferred from mutant phenotype PubMed 12805229. Source: MGI histone lysine methylation Inferred from electronic annotation. Source: GOC positive regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: Compara regulation of transcription, DNA-dependent Traceable author statement PubMed 9628876. Source: MGI
Cellular_component	nucleus Inferred from direct assay PubMed 18157086. Source: MGI
Molecular_function	chromatin binding Inferred from direct assay PubMed 15522233. Source: MGI histone methyltransferase activity Inferred from direct assay PubMed 12805229. Source: MGI histone-lysine N-methyltransferase activity Inferred from electronic annotation. Source: InterPro transcription cofactor activity Inferred from direct assay PubMed 9628876. Source: MGI zinc ion binding Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequences

Sequence

Length

Mass (Da)

Tools

E9QAE4 [UniParc].

Last modified April 5, 2011. Version 1.
Checksum: 9757638B75D6E773
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FASTA

2,691

296,364

        10         20         30         40         50         60 
MDRTCELSRR NCLLSFSNPV NLDASEDKDS PFGNGQSNFS EPLNGCTMQL PTAASGTSQN 

        70         80         90        100        110        120 
AYGQDSPSCY IPLRRLQDLA SMINVEYLSG SADGSESFQD PAKSDSRAQS PIVCTSLSPG 

       130        140        150        160        170        180 
GPTALAMKQE PTCNNSPELQ LRVTKTTKNG FLHFENFTGV DDADVDSEMD PEQPVTEDES 

       190        200        210        220        230        240 
IEEIFEETQT NATCNYEPKS ENGVEVAMGS EQDSMPESRH GAVERPFLPL APQTEKQKNK 

       250        260        270        280        290        300 
QRSEVDGSNE KTALLPAPTS LGDTNVTVEE QFNSINLSFQ DDPDSSPSPL GNMLEIPGTS 

       310        320        330        340        350        360 
SPSTSQELPF CQPKKKSTPL KYEVGDLIWA KFKRRPWWPC RICSDPLINT HSKMKVANRR 

       370        380        390        400        410        420 
PYREYYVEAF GDPSEKAWVA GKAIVMFEGR HQFEELPVLR KRGKQKEKGY RHKVPQKILS 

       430        440        450        460        470        480 
KWEASVGLAE QYDVPKGSKN QKCVSSSVKL DSEEDMPFED CTNDPDSEHL LLNGCLKSLA 

       490        500        510        520        530        540 
FDSEHSADEK EKPCAKSRVR KSSDNIKRTS VKKDLVPFES RKEERRGKIP DNLGLDFISG 

       550        560        570        580        590        600 
GVSDKQASNE LSRIANSLTG SSTAPGSFLF SSSVQNTAKT DFETPDCDSL SGLSESALIS 

       610        620        630        640        650        660 
KHSGEKKKLQ PGQVCSSKVQ LCYVGAGDEE KRSNSVSVST TSDDGCSDLD PTEHNSGFQN 

       670        680        690        700        710        720 
SVLGITDAFD KTENALSVHK NETQYSRYPV TNRIKEKQKS LITNSHADHL MGSTKTMEPE 

       730        740        750        760        770        780 
TAELSQVNLS DLKISSPIPK PQPEFRNDGL TTKFSAPPGI RNENPLTKGG LANQTLLPLK 

       790        800        810        820        830        840 
CRQPKFRSIK CKHKESPAVA ETSATSEDLS LKCCSSDTNG SPLANISKSG KGEGLKLLNN 

       850        860        870        880        890        900 
MHEKTRDSSD IETAVVKHVL SELKELSYRS LSEDVSDSGT AKASKPLLFS SASSQNHIPI 

       910        920        930        940        950        960 
EPDYKFSTLL MMLKDMHDSK TKEQRLMTAQ NLASYRTPDR GDCSSGSPVG TSKVLVLGSS 

       970        980        990       1000       1010       1020 
TPNSEKPGDS TQDSVHQSPG GGDSALSGEL SSSLSSLASD KRELPACGKI RSNCIPRRNC 

      1030       1040       1050       1060       1070       1080 
GRAKPSSKLR ETISAQMVKP SVNPKALKTE RKRKFSRLPA VTLAANRLGN KESGSVNGPS 

      1090       1100       1110       1120       1130       1140 
RGGAEDPGKE EPLQQMDLLR NEDTHFSDVH FDSKAKQSDP DKNLEKEPSF ENRKGPELGS 

      1150       1160       1170       1180       1190       1200 
EMNTENDELH GVNQVVPKKR WQRLNQRRPK PGKRANRFRE KENSEGAFGV LLPADAVQKA 

      1210       1220       1230       1240       1250       1260 
REDYLEQRAP PTSKPEDSAA DPNHGSHSES VAPRLNVCEK SSVGMGDVEK ETGIPSLMPQ 

      1270       1280       1290       1300       1310       1320 
TKLPEPAIRS EKKRLRKPSK WLLEYTEEYD QIFAPKKKQK KVQEQVHKVS SRCEDESLLA 

      1330       1340       1350       1360       1370       1380 
RCQPSAQNKQ VDENSLISTK EEPPVLEREA PFLEGPLAQS DLGVTHAELP QLTLSVPVAP 

      1390       1400       1410       1420       1430       1440 
EASPRPALES EELLVKTPGN YESKRQRKPT KKLLESNDLD PGFMPKKGDL GLSRKCFEAS 

      1450       1460       1470       1480       1490       1500 
RSGNGIVESR ATSHLKEFSG GTTKIFDKPR KRKRQRLVTA RVHYKKVKKE DLTKDTPSSE 

      1510       1520       1530       1540       1550       1560 
GELLIHRTAA SPKEILEEGV EHDPGMSASK KLQVERGGGA ALKENVCQNC EKLGELLLCE 

      1570       1580       1590       1600       1610       1620 
AQCCGAFHLE CLGLPEMPRG KFICNECHTG IHTCFVCKQS GEDVKRCLLP LCGKFYHEEC 

      1630       1640       1650       1660       1670       1680 
VQKYPPTVTQ NKGFRCPLHI CITCHAANPA NVSASKGRLM RCVRCPVAYH ANDFCLAAGS 

      1690       1700       1710       1720       1730       1740 
KILASNSIIC PNHFTPRRGC RNHEHVNVSW CFVCSEGGSL LCCDSCPAAF HRECLNIDIP 

      1750       1760       1770       1780       1790       1800 
EGNWYCNDCK AGKKPHYREI VWVKVGRYRW WPAEICHPRA VPSNIDKMRH DVGEFPVLFF 

      1810       1820       1830       1840       1850       1860 
GSNDYLWTHQ ARVFPYMEGD VSSKDKMGKG VDGTYKKALQ EAAARFEELK AQKELRQLQE 

      1870       1880       1890       1900       1910       1920 
DRKNDKKPPP YKHIKVNRPI GRVQIFTADL SEIPRCNCKA TDENPCGIDS ECINRMLLYE 

      1930       1940       1950       1960       1970       1980 
CHPTVCPAGV RCQNQCFSKR QYPDVEIFRT LQRGWGLRTK TDIKKGEFVN EYVGELIDEE 

      1990       2000       2010       2020       2030       2040 
ECRARIRYAQ EHDITNFYML TLDKDRIIDA GPKGNYARFM NHCCQPNCET QKWSVNGDTR 

      2050       2060       2070       2080       2090       2100 
VGLFALSDIK AGTELTFNYN LECLGNGKTV CKCGAPNCSG FLGVRPKNQP IVTEEKSRKF 

      2110       2120       2130       2140       2150       2160 
KRKPHGKRRS QGEVTKERED ECFSCGDAGQ LVSCKKPGCP KVYHADCLNL TKRPAGKWEC 

      2170       2180       2190       2200       2210       2220 
PWHQCDVCGK EAASFCEMCP SSFCKQHREG MLFISKLDGR LSCTEHDPCG PNPLEPGEIR 

      2230       2240       2250       2260       2270       2280 
EYVPPTATSP PSPGTQPKEQ SSEMATQGPK KSDQPPTDAT QLLPLSKKAL TGSCQRPLLP 

      2290       2300       2310       2320       2330       2340 
ERPPERTDSS SHLLDRIRDL AGSGTKSQSL VSSQRPQDRP PAKEGPRPQP PDRASPMTRP 

      2350       2360       2370       2380       2390       2400 
SSSPSVSSLP LERPLRMTDS RLDKSIGAAS PKSQAVEKTP ASTGLRLSSP DRLLTTNSPK 

      2410       2420       2430       2440       2450       2460 
PQISDRPPEK SHASLTQRLP PPEKVLSAVV QSLVAKEKAL RPVDQNTQSK HRPAVVMDLI 

      2470       2480       2490       2500       2510       2520 
DLTPRQKERA ASPQEVTPQA DEKTAMLESS SWPSSKGLGH IPRATEKISV SESLQPSGKV 

      2530       2540       2550       2560       2570       2580 
AAPSEHPWQA VKSLTHARFL SPPSAKAFLY ESATQASGRT PVGAEQTPGP PSPAPGLVKQ 

      2590       2600       2610       2620       2630       2640 
VKQLSRGLTA KSGQSFRSLG KISASLPNEE KKLTTTEQSP WGLGKASPGA GLWPIVAGQT 

      2650       2660       2670       2680       2690 
LAQACWSAGG TQTLAQTCWS LGRGQDPKPE NAIQALNQAP SSRKCADSEK K

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J Ensembl ENSMUSP00000097089.
[2]	Ensembl Submitted (MAY-2011) to UniProtKB Cited for: IDENTIFICATION. Strain: C57BL/6J Ensembl ENSMUSP00000097089.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC160958 Genomic DNA. No translation available.
IPI	IPI00131111.
RefSeq	NP_032765.3. NM_008739.3.
UniGene	Mm.12964. Mm.168965.
3D structure databases
ProteinModelPortal	E9QAE4.
SMR	E9QAE4. Positions 1754-1851, 1853-2083, 2119-2211.
ModBase	Search...
Proteomic databases
PRIDE	E9QAE4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000099490; ENSMUSP00000097089; ENSMUSG00000021488.
GeneID	18193.
KEGG	mmu:18193.
Organism-specific databases
CTD	64324.
MGI	MGI:1276545. Nsd1.
Phylogenomic databases
GeneTree	ENSGT00700000104009.
KO	K15588.
OMA	NIDKMRH.
Gene expression databases
ArrayExpress	E9QAE4.
Bgee	E9QAE4.
Family and domain databases
Gene3D	3.30.40.10. 3 hits.
InterPro	IPR006560. AWS. IPR003616. Post-SET_dom. IPR000313. PWWP. IPR001214. SET_dom. IPR019786. Zinc_finger_PHD-type_CS. IPR011011. Znf_FYVE_PHD. IPR001965. Znf_PHD. IPR019787. Znf_PHD-finger. IPR001841. Znf_RING. IPR013083. Znf_RING/FYVE/PHD. [Graphical view]
Pfam	PF00628. PHD. 1 hit. PF00855. PWWP. 2 hits. PF00856. SET. 1 hit. [Graphical view]
SMART	SM00570. AWS. 1 hit. SM00249. PHD. 5 hits. SM00508. PostSET. 1 hit. SM00293. PWWP. 2 hits. SM00184. RING. 1 hit. SM00317. SET. 1 hit. [Graphical view]
SUPFAM	SSF57903. FYVE_PHD_ZnF. 3 hits.
PROSITE	PS51215. AWS. 1 hit. PS50868. POST_SET. 1 hit. PS50812. PWWP. 2 hits. PS50280. SET. 1 hit. PS01359. ZF_PHD_1. 2 hits. PS50016. ZF_PHD_2. 2 hits. PS50089. ZF_RING_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	NSD1. mouse.
NextBio	293540.
SOURCE	Search...

Entry information

Entry name

E9QAE4_MOUSE

Accession

Primary (citable) accession number: E9QAE4

Entry history

Integrated into UniProtKB/TrEMBL:	April 5, 2011
Last sequence update:	April 5, 2011
Last modified:	May 1, 2013
This is version 22 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Names·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry info

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequences

References

Cross-references

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information