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Protein

Carcinoembryonic antigen-related cell adhesion molecule 16

Gene

Ceacam16

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Required for proper hearing, it may play a role in maintaining the integrity of the tectorial membrane.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Protein family/group databases

MEROPSiI43.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Carcinoembryonic antigen-related cell adhesion molecule 16
Gene namesi
Name:Ceacam16
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:2685615. Ceacam16.

Subcellular locationi

GO - Cellular componenti

  • extracellular space Source: UniProtKB
  • stereocilium tip Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi142 – 1421T → P: Does not affect the interaction with TECTA nor subcellular localization. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence analysisAdd
BLAST
Chaini23 – 426404Carcinoembryonic antigen-related cell adhesion molecule 16PRO_0000417874Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi38 – 381N-linked (GlcNAc...)Sequence analysis
Disulfide bondi155 ↔ 202PROSITE-ProRule annotation
Glycosylationi217 – 2171N-linked (GlcNAc...)Sequence analysis
Disulfide bondi253 ↔ 294PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiE9QA28.
PRIDEiE9QA28.

Expressioni

Tissue specificityi

Expressed in cochlear outer hair cells (OHC).1 Publication

Developmental stagei

Abundantly expressed in cochleae from embryonic day 17 to postnatal day 42.1 Publication

Gene expression databases

BgeeiE9QA28.

Interactioni

Subunit structurei

Homooligomer; can for homodimers and homotetramers. Interacts with TECTA.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000014830.

Structurei

3D structure databases

ProteinModelPortaliE9QA28.
SMRiE9QA28. Positions 23-407.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini134 – 21986Ig-like C2-type 1Add
BLAST
Domaini224 – 31087Ig-like C2-type 2Add
BLAST

Sequence similaritiesi

Belongs to the immunoglobulin superfamily. CEA family.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IFE1. Eukaryota.
ENOG410YR1P. LUCA.
GeneTreeiENSGT00760000119187.
HOGENOMiHOG000004760.
InParanoidiE9QA28.
KOiK06499.
OMAiRWFFNGD.
OrthoDBiEOG74BJS7.
PhylomeDBiE9QA28.
TreeFamiTF336859.

Family and domain databases

Gene3Di2.60.40.10. 4 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PfamiPF13895. Ig_2. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 4 hits.
SM00408. IGc2. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 4 hits.
PROSITEiPS50835. IG_LIKE. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

E9QA28-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKMPLTWYSW FLLSAWILNT GAEISITPEP AQPAEGDNVT LVVHGLSGEL
60 70 80 90 100
LAYNWYAGPT LSLTFLVASY IVSTGDETPG PAHTGREAVR PDGSLDIHGA
110 120 130 140 150
LPGHTGTYIL QTLNRQFQTE VGYGHMQVYE ILAPPTVMAN DTALVERRDT
160 170 180 190 200
LRLVCSSPSP AEVRWFFNGD ALPVAVRLGM SPDGRMLTRH GVRREEAGAY
210 220 230 240 250
QCEVWNPVSV SRSEPLNLTV YFGPERVAIL QDSTTRTGCT IKVDFNMSLT
260 270 280 290 300
LWCVARSCPE PEYVWAFNGK ALKNGQDHLN ISSMTAAHEG TYTCIAKNSK
310 320 330 340 350
TLLSGSASVV VKLSAAAVAM MIVPVPTKPT EGQDVTLTVQ GYPKDLLVYA
360 370 380 390 400
WYRGPASEPN RLLSQLPSGN WIAGPAHTGR EVGFANCSLL VQKLNLTDAG
410 420
RYTLKTVTLQ GKTDTLEVEL QVAPLE
Length:426
Mass (Da):46,352
Last modified:April 5, 2011 - v1
Checksum:iB2A348370AB0AB46
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti133 – 1331A → T in AAI41088 (PubMed:15489334).Curated
Sequence conflicti247 – 2471M → T in AAI41088 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC149085 Genomic DNA. No translation available.
BC141087 mRNA. Translation: AAI41088.1.
CCDSiCCDS39805.1.
RefSeqiNP_001028591.2. NM_001033419.2.
XP_006540172.1. XM_006540109.1.
XP_006540173.1. XM_006540110.1.
XP_011248907.1. XM_011250605.1.
XP_011248908.1. XM_011250606.1.
UniGeneiMm.260192.

Genome annotation databases

EnsembliENSMUST00000014830; ENSMUSP00000014830; ENSMUSG00000014686.
GeneIDi330483.
KEGGimmu:330483.
UCSCiuc009fnm.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC149085 Genomic DNA. No translation available.
BC141087 mRNA. Translation: AAI41088.1.
CCDSiCCDS39805.1.
RefSeqiNP_001028591.2. NM_001033419.2.
XP_006540172.1. XM_006540109.1.
XP_006540173.1. XM_006540110.1.
XP_011248907.1. XM_011250605.1.
XP_011248908.1. XM_011250606.1.
UniGeneiMm.260192.

3D structure databases

ProteinModelPortaliE9QA28.
SMRiE9QA28. Positions 23-407.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000014830.

Protein family/group databases

MEROPSiI43.001.

Proteomic databases

PaxDbiE9QA28.
PRIDEiE9QA28.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000014830; ENSMUSP00000014830; ENSMUSG00000014686.
GeneIDi330483.
KEGGimmu:330483.
UCSCiuc009fnm.1. mouse.

Organism-specific databases

CTDi388551.
MGIiMGI:2685615. Ceacam16.

Phylogenomic databases

eggNOGiENOG410IFE1. Eukaryota.
ENOG410YR1P. LUCA.
GeneTreeiENSGT00760000119187.
HOGENOMiHOG000004760.
InParanoidiE9QA28.
KOiK06499.
OMAiRWFFNGD.
OrthoDBiEOG74BJS7.
PhylomeDBiE9QA28.
TreeFamiTF336859.

Miscellaneous databases

NextBioi399403.
PROiE9QA28.
SOURCEiSearch...

Gene expression databases

BgeeiE9QA28.

Family and domain databases

Gene3Di2.60.40.10. 4 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PfamiPF13895. Ig_2. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 4 hits.
SM00408. IGc2. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 4 hits.
PROSITEiPS50835. IG_LIKE. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  3. "Carcinoembryonic antigen-related cell adhesion molecule 16 interacts with alpha-tectorin and is mutated in autosomal dominant hearing loss (DFNA4)."
    Zheng J., Miller K.K., Yang T., Hildebrand M.S., Shearer A.E., DeLuca A.P., Scheetz T.E., Drummond J., Scherer S.E., Legan P.K., Goodyear R.J., Richardson G.P., Cheatham M.A., Smith R.J., Dallos P.
    Proc. Natl. Acad. Sci. U.S.A. 108:4218-4223(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: DEVELOPMENTAL STAGE, TISSUE SPECIFICITY, MUTAGENESIS OF THR-142, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiCEA16_MOUSE
AccessioniPrimary (citable) accession number: E9QA28
Secondary accession number(s): B2RUD6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 13, 2012
Last sequence update: April 5, 2011
Last modified: May 11, 2016
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.