ID   E9Q9V7_MOUSE            Unreviewed;       936 AA.
AC   E9Q9V7;
DT   05-APR-2011, integrated into UniProtKB/TrEMBL.
DT   05-APR-2011, sequence version 1.
DT   27-MAR-2024, entry version 80.
DE   SubName: Full=Snf2-related CREBBP activator protein {ECO:0000313|Ensembl:ENSMUSP00000063817.6};
GN   Name=Srcap {ECO:0000313|Ensembl:ENSMUSP00000063817.6,
GN   ECO:0000313|MGI:MGI:2444036};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000063817.6, ECO:0000313|Proteomes:UP000000589};
RN   [1] {ECO:0000313|Ensembl:ENSMUSP00000063817.6, ECO:0000313|Proteomes:UP000000589}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000063817.6,
RC   ECO:0000313|Proteomes:UP000000589};
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [2] {ECO:0007829|PubMed:21183079}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
RN   [3] {ECO:0000313|Ensembl:ENSMUSP00000063817.6}
RP   IDENTIFICATION.
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000063817.6};
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR   AlphaFoldDB; E9Q9V7; -.
DR   SMR; E9Q9V7; -.
DR   IntAct; E9Q9V7; 1.
DR   MINT; E9Q9V7; -.
DR   jPOST; E9Q9V7; -.
DR   MaxQB; E9Q9V7; -.
DR   PeptideAtlas; E9Q9V7; -.
DR   ProteomicsDB; 369471; -.
DR   Ensembl; ENSMUST00000066582.12; ENSMUSP00000063817.6; ENSMUSG00000053877.13.
DR   UCSC; uc009jvy.1; mouse.
DR   AGR; MGI:2444036; -.
DR   MGI; MGI:2444036; Srcap.
DR   VEuPathDB; HostDB:ENSMUSG00000053877; -.
DR   GeneTree; ENSGT00940000157457; -.
DR   HOGENOM; CLU_000315_12_1_1; -.
DR   TreeFam; TF106424; -.
DR   ChiTaRS; Srcap; mouse.
DR   Proteomes; UP000000589; Chromosome 7.
DR   Bgee; ENSMUSG00000053877; Expressed in undifferentiated genital tubercle and 181 other cell types or tissues.
DR   ExpressionAtlas; E9Q9V7; baseline and differential.
DR   GO; GO:0005794; C:Golgi apparatus; ISO:MGI.
DR   GO; GO:0016604; C:nuclear body; ISO:MGI.
DR   GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR   GO; GO:0005634; C:nucleus; ISO:MGI.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; ISO:MGI.
DR   GO; GO:0032991; C:protein-containing complex; ISO:MGI.
DR   GO; GO:0000812; C:Swr1 complex; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IBA:GO_Central.
DR   GO; GO:0140658; F:ATP-dependent chromatin remodeler activity; IEA:InterPro.
DR   GO; GO:0042393; F:histone binding; IBA:GO_Central.
DR   CDD; cd18003; DEXQc_SRCAP; 1.
DR   Gene3D; 1.20.120.850; SWI2/SNF2 ATPases, N-terminal domain; 1.
DR   Gene3D; 3.40.50.10810; Tandem AAA-ATPase domain; 1.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR014012; HSA_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR038718; SNF2-like_sf.
DR   InterPro; IPR000330; SNF2_N.
DR   PANTHER; PTHR45685:SF1; HELICASE SRCAP; 1.
DR   PANTHER; PTHR45685; HELICASE SRCAP-RELATED; 1.
DR   Pfam; PF07529; HSA; 1.
DR   Pfam; PF00176; SNF2-rel_dom; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00573; HSA; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51204; HSA; 1.
PE   1: Evidence at protein level;
KW   Reference proteome {ECO:0000313|Proteomes:UP000000589}.
FT   DOMAIN          105..177
FT                   /note="HSA"
FT                   /evidence="ECO:0000259|PROSITE:PS51204"
FT   DOMAIN          622..787
FT                   /note="Helicase ATP-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS51192"
FT   REGION          1..50
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          228..397
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          438..572
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..35
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        228..257
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        268..291
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        292..314
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        381..397
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        443..469
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        478..540
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        541..556
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   936 AA;  106320 MW;  7345C78F7D1DAFDF CRC64;
     MQSSPSTAHP QLPILQTQMV SDGMTGISPQ HIAQDSSLDG PPGPQDGTTV PLEGFSLSHA
     ADLVNRGQKW EKSHAEIAEQ AKHEAEIETR IAELRKEGFW SLKRLPKVPE PPRPKGHWDY
     LCEEMQWLSA DFAQERRWKR GVARKVVRMV IRHHEEQRQK EERARREEQA KLRRIASTMA
     KDVRQFWSNV EKVVQFKQQS RLEEKRKKAL DLHLDFIVGQ TEKYSDLLSQ SLNQPPASSK
     AGSSPCLGSS SAASSPPPPV SRLDDEDGDF QPQEEEEEDD EETIEVEEQQ EGNDAETQRR
     EIELLRHEGE LPLEELLRSL PPQLLGGPFS PSQTPSHDSD TQDGPEENIE EEPSQDLEVH
     PPSSAVTQCN KQRWHPDEDD EEFTANEDEE DEEDTIAAEE QLEGEVDHAM ELSELAREGE
     LSMEELLQQY AGAYACDASA PASGDSEDED EVEANSSDGE LEETVEEAAQ EDSSSQSDSA
     EECSEDEEDE HSEEEMSGSS QSEESESDES EDAQSQSQAD EEQDDEGEDD DVDDDDDDGF
     GVEYLLARDD ERSEVDGGSG PPTPGPTTTL GPKKEITDIA AAAESLQPKG YTLATTQVKT
     PIPLLLRGQL REYQHIGLDW LVTMYEKKLN GILADEMGLG KTIQTISLLA HLACEKGNWG
     PHLIIVPTSV MLNWEMELKR WCPSFKILTY YGAQKERKLK RQGWTKPNAF HVCITSYKLV
     LQDHQAFRRK NWRYLILDEA QNIKNFKSQR WQSLLNFNSQ RRLLLTGTPL QNSLMELWSL
     MHFLMPHVFQ SHREFKEWFS NPLTGMIEGS QEYNEGLVKR LHKVLRPFLL RRVKVDVEKQ
     MPKKYEHVIR CRLSKRQRCL YDDFMAQTTT KETLATGHFM SVINILMQLR KVCNHPNLFD
     PRPVTSPFIT PGICFSTASL VLRATEVHPL QVCSYP
//