Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

E9Q9T4 (E9Q9T4_MOUSE) Unreviewed, UniProtKB/TrEMBL

Last modified July 9, 2014. Version 25. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry infoCustomize order

Protein attributes

Sequence length1609 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Soluble adenylyl cyclase that has a critical role in mammalian spermatogenesis. Produces the cAMP which mediates in part the cAMP-responsive nuclear factors indispensable for maturation of sperm in the epididymis. Induces capacitation, the maturational process that sperm undergo prior to fertilization. May be the bicarbonate sensor By similarity. PIRNR PIRNR011131

Catalytic activity

ATP = 3',5'-cyclic AMP + diphosphate. PIRNR PIRNR011131

Sequence similarities

Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. PIRNR PIRNR011131

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data. Ensembl ENSMUSP00000107067 Ensembl ENSMUSP00000107066

Sequences

Sequence LengthMass (Da)Tools
E9Q9T4 [UniParc].

Last modified April 5, 2011. Version 1.
Checksum: 50131B3B613F34FB

FASTA1,609185,903
        10         20         30         40         50         60 
MSARRQELQD RAIVKIAAHL PDLIVYGDFS PERPSVKCFD GVLMFVDISG FTAMTEKFST 

        70         80         90        100        110        120 
AMYMDRGAEQ LVEILNYYIS AIVEKVLIFG GDILKFAGDA LLALWKVERK QLKNIITVVI 

       130        140        150        160        170        180 
KCSLEIHGLF EAKEAEEGLD IRVKIGLAAG HITMLVFGDE TRNYFLVIGQ AVDDVRLAQN 

       190        200        210        220        230        240 
MAQMNDVILS PNCWQLCDRS MIEIERIPDQ RAVKVSFLKP PPTFNFDEFF TKCMGFMDYY 

       250        260        270        280        290        300 
PSGDHKNFLR LACMLESDPE LELSLQKYVM EIILKQIDDK QLRGYLSELR PVTIVFVNLM 

       310        320        330        340        350        360 
FKEQDKVEVI GSAIQAACVH ITSVLKVFRG QINKVFMFDK GCSFLCVFGF PGEKAPDEIT 

       370        380        390        400        410        420 
HALESAVDIF DFCSQVHKIR TVSIGVASGI VFCGIVGHTV RHEYTVIGQK VNIAARMMMY 

       430        440        450        460        470        480 
YPGIVSCDSV TYDGSNLPAY FFKELPKKVM KGVADPGPVY QCLGLNEKVM FGMAYLICNR 

       490        500        510        520        530        540 
YEGYPLLGRV REIDYFMSTM KDFLMTNCSR VLMYEGLPGY GKSQVLMEIE YLASQHENHR 

       550        560        570        580        590        600 
AVAIALTKIS FHQNFYTIQI LMANVLGLDT CKHYKERQTN LQNRVKTLLD EKFHCLLNDI 

       610        620        630        640        650        660 
FHVQFPVSRE MSRMSKIRKQ KQLEALFMKI LAQTVREERI IFIIDEAQFV DGTSWAFIEK 

       670        680        690        700        710        720 
LIRSMPIFIV MSLAPFSEVP CAAANAIMKN RNTTYITLGT MQPQEIRDKV CVDLSVSSIP 

       730        740        750        760        770        780 
RELDSYLVEG SCGIPYYCEE LLKNLDHHRV LLFQQAETEQ KTNVTWNNMF KHSVRPTDDM 

       790        800        810        820        830        840 
QLFTSISEGQ KEVCYLVSGV RLNNLSPPAS LKEISLVQLD SMSLSHQMLV RCAAIIGLTF 

       850        860        870        880        890        900 
TTELLFEILP CWNMKMMIKA LATLVESNVF NCFRSSKDLQ LALKQNVPTF EVHYRSLALK 

       910        920        930        940        950        960 
LKEGLTYGEE EELREMEGEV VECRILRFCR PIMQKTAYEL WLKDQKKVLH LKCARFLEES 

       970        980        990       1000       1010       1020 
AHRCNHCRNV DFIPYHHFIV DIRLNTLDMD TVKRMVTSQG FKIDEEEAIF SKSELPRKYK 

      1030       1040       1050       1060       1070       1080 
FPENLSITEI REKILHFFDN VILKMKSSPN DIIPLESCQC KELLQIVILP LAQHFVALEE 

      1090       1100       1110       1120       1130       1140 
NNKALYYFLE LASAYLILGD NYNAYMYLGE GERLLKSLTN EDSWSQTFEY ATFYSLKAEV 

      1150       1160       1170       1180       1190       1200 
CFNMGQMVLA KKMLRKALKL LNRMFPCNLL TLTFQMHVEK NRLSHFMNQH TQEGSVPGKK 

      1210       1220       1230       1240       1250       1260 
LAQLYLQASC FSLLWRIYSL NFFFHYKYYG HLAAMMEMNT SLETQNDFQI IKAYLDFSLY 

      1270       1280       1290       1300       1310       1320 
HHLAGYQGVW FKYEILVMEQ LLNLPLKGEA IEIMAYTADT LGHIKFLMGH LDLAIELGSR 

      1330       1340       1350       1360       1370       1380 
AHRMWSLLRN PNKYQMVLCR LSKPLFLKSR YKHLVQVLGW LWDLSVTEED IFSKAFFYFV 

      1390       1400       1410       1420       1430       1440 
CLDIMLYSGF IYRTFEECLE FIHHNEDNRI LKFQSGLLLG LYSCIAVWYA RLQEWDNFNK 

      1450       1460       1470       1480       1490       1500 
FSDRAKHLVT RRTPTVLYYE GISRYMEGQV LHLQKQIEEQ AENAQDSGVE ILKALETLVA 

      1510       1520       1530       1540       1550       1560 
QNTTGPVFYP RLYHLMAYVC ILMGDGHSCD FFLNTALELS ETHGNLLEKC WLSMSKEWWY 

      1570       1580       1590       1600 
SASELTGDQW LQTVLSLPSW DKIVSGKVTL QDVQKNKYLM RVNILDNPF 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC102776 Genomic DNA. No translation available.
AC162789 Genomic DNA. No translation available.
RefSeqXP_006496931.1. XM_006496868.1.
UniGeneMm.66952.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000111439; ENSMUSP00000107066; ENSMUSG00000026567.
ENSMUST00000111440; ENSMUSP00000107067; ENSMUSG00000026567.
GeneID271639.
KEGGmmu:271639.
UCSCuc007dje.1. mouse.

Organism-specific databases

CTD55811.
MGIMGI:2660854. Adcy10.

Phylogenomic databases

GeneTreeENSGT00390000001322.
KOK11265.

Family and domain databases

Gene3D3.30.70.1230. 2 hits.
InterProIPR001054. A/G_cyclase.
IPR016577. Adenylate_cylcase_typ10.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF00211. Guanylate_cyc. 2 hits.
[Graphical view]
PIRSFPIRSF011131. Soluble_adenylyl_cyclase. 1 hit.
SMARTSM00044. CYCc. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
SSF55073. SSF55073. 2 hits.
PROSITEPS50125. GUANYLATE_CYCLASE_2. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSADCY10. mouse.
NextBio35555797.
SOURCESearch...

Entry information

Entry nameE9Q9T4_MOUSE
AccessionPrimary (citable) accession number: E9Q9T4
Entry history
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: July 9, 2014
This is version 25 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)