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E9Q9T4

- E9Q9T4_MOUSE

UniProt

E9Q9T4 - E9Q9T4_MOUSE

Protein

Adenylate cyclase type 10

Gene

Adcy10

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 26 (01 Oct 2014)
      Sequence version 1 (05 Apr 2011)
      Previous versions | rss
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    Functioni

    Soluble adenylyl cyclase that has a critical role in mammalian spermatogenesis. Produces the cAMP which mediates in part the cAMP-responsive nuclear factors indispensable for maturation of sperm in the epididymis. Induces capacitation, the maturational process that sperm undergo prior to fertilization. May be the bicarbonate sensor.UniRule annotation

    Catalytic activityi

    ATP = 3',5'-cyclic AMP + diphosphate.UniRule annotation

    GO - Molecular functioni

    1. adenylate cyclase activity Source: MGI
    2. ATP binding Source: UniProtKB-KW
    3. magnesium ion binding Source: InterPro

    GO - Biological processi

    1. intracellular signal transduction Source: InterPro
    2. spermatogenesis Source: InterPro

    Keywords - Molecular functioni

    LyaseUniRule annotation

    Keywords - Biological processi

    cAMP biosynthesisUniRule annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotation, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Adenylate cyclase type 10UniRule annotation (EC:4.6.1.1UniRule annotation)
    Gene namesi
    Name:Adcy10Imported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 1

    Organism-specific databases

    MGIiMGI:2660854. Adcy10.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: MGI
    2. membrane Source: MGI

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.UniRule annotation

    Phylogenomic databases

    GeneTreeiENSGT00390000001322.
    KOiK11265.

    Family and domain databases

    Gene3Di3.30.70.1230. 2 hits.
    InterProiIPR001054. A/G_cyclase.
    IPR016577. Adenylate_cylcase_typ10.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF00211. Guanylate_cyc. 2 hits.
    [Graphical view]
    PIRSFiPIRSF011131. Soluble_adenylyl_cyclase. 1 hit.
    SMARTiSM00044. CYCc. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    SSF55073. SSF55073. 2 hits.
    PROSITEiPS50125. GUANYLATE_CYCLASE_2. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    E9Q9T4-1 [UniParc]FASTAAdd to Basket

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    MSARRQELQD RAIVKIAAHL PDLIVYGDFS PERPSVKCFD GVLMFVDISG     50
    FTAMTEKFST AMYMDRGAEQ LVEILNYYIS AIVEKVLIFG GDILKFAGDA 100
    LLALWKVERK QLKNIITVVI KCSLEIHGLF EAKEAEEGLD IRVKIGLAAG 150
    HITMLVFGDE TRNYFLVIGQ AVDDVRLAQN MAQMNDVILS PNCWQLCDRS 200
    MIEIERIPDQ RAVKVSFLKP PPTFNFDEFF TKCMGFMDYY PSGDHKNFLR 250
    LACMLESDPE LELSLQKYVM EIILKQIDDK QLRGYLSELR PVTIVFVNLM 300
    FKEQDKVEVI GSAIQAACVH ITSVLKVFRG QINKVFMFDK GCSFLCVFGF 350
    PGEKAPDEIT HALESAVDIF DFCSQVHKIR TVSIGVASGI VFCGIVGHTV 400
    RHEYTVIGQK VNIAARMMMY YPGIVSCDSV TYDGSNLPAY FFKELPKKVM 450
    KGVADPGPVY QCLGLNEKVM FGMAYLICNR YEGYPLLGRV REIDYFMSTM 500
    KDFLMTNCSR VLMYEGLPGY GKSQVLMEIE YLASQHENHR AVAIALTKIS 550
    FHQNFYTIQI LMANVLGLDT CKHYKERQTN LQNRVKTLLD EKFHCLLNDI 600
    FHVQFPVSRE MSRMSKIRKQ KQLEALFMKI LAQTVREERI IFIIDEAQFV 650
    DGTSWAFIEK LIRSMPIFIV MSLAPFSEVP CAAANAIMKN RNTTYITLGT 700
    MQPQEIRDKV CVDLSVSSIP RELDSYLVEG SCGIPYYCEE LLKNLDHHRV 750
    LLFQQAETEQ KTNVTWNNMF KHSVRPTDDM QLFTSISEGQ KEVCYLVSGV 800
    RLNNLSPPAS LKEISLVQLD SMSLSHQMLV RCAAIIGLTF TTELLFEILP 850
    CWNMKMMIKA LATLVESNVF NCFRSSKDLQ LALKQNVPTF EVHYRSLALK 900
    LKEGLTYGEE EELREMEGEV VECRILRFCR PIMQKTAYEL WLKDQKKVLH 950
    LKCARFLEES AHRCNHCRNV DFIPYHHFIV DIRLNTLDMD TVKRMVTSQG 1000
    FKIDEEEAIF SKSELPRKYK FPENLSITEI REKILHFFDN VILKMKSSPN 1050
    DIIPLESCQC KELLQIVILP LAQHFVALEE NNKALYYFLE LASAYLILGD 1100
    NYNAYMYLGE GERLLKSLTN EDSWSQTFEY ATFYSLKAEV CFNMGQMVLA 1150
    KKMLRKALKL LNRMFPCNLL TLTFQMHVEK NRLSHFMNQH TQEGSVPGKK 1200
    LAQLYLQASC FSLLWRIYSL NFFFHYKYYG HLAAMMEMNT SLETQNDFQI 1250
    IKAYLDFSLY HHLAGYQGVW FKYEILVMEQ LLNLPLKGEA IEIMAYTADT 1300
    LGHIKFLMGH LDLAIELGSR AHRMWSLLRN PNKYQMVLCR LSKPLFLKSR 1350
    YKHLVQVLGW LWDLSVTEED IFSKAFFYFV CLDIMLYSGF IYRTFEECLE 1400
    FIHHNEDNRI LKFQSGLLLG LYSCIAVWYA RLQEWDNFNK FSDRAKHLVT 1450
    RRTPTVLYYE GISRYMEGQV LHLQKQIEEQ AENAQDSGVE ILKALETLVA 1500
    QNTTGPVFYP RLYHLMAYVC ILMGDGHSCD FFLNTALELS ETHGNLLEKC 1550
    WLSMSKEWWY SASELTGDQW LQTVLSLPSW DKIVSGKVTL QDVQKNKYLM 1600
    RVNILDNPF 1609
    Length:1,609
    Mass (Da):185,903
    Last modified:April 5, 2011 - v1
    Checksum:i50131B3B613F34FB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC102776 Genomic DNA. No translation available.
    AC162789 Genomic DNA. No translation available.
    RefSeqiXP_006496931.1. XM_006496868.1.
    UniGeneiMm.66952.

    Genome annotation databases

    EnsembliENSMUST00000111439; ENSMUSP00000107066; ENSMUSG00000026567.
    ENSMUST00000111440; ENSMUSP00000107067; ENSMUSG00000026567.
    GeneIDi271639.
    KEGGimmu:271639.
    UCSCiuc007dje.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC102776 Genomic DNA. No translation available.
    AC162789 Genomic DNA. No translation available.
    RefSeqi XP_006496931.1. XM_006496868.1.
    UniGenei Mm.66952.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000111439 ; ENSMUSP00000107066 ; ENSMUSG00000026567 .
    ENSMUST00000111440 ; ENSMUSP00000107067 ; ENSMUSG00000026567 .
    GeneIDi 271639.
    KEGGi mmu:271639.
    UCSCi uc007dje.1. mouse.

    Organism-specific databases

    CTDi 55811.
    MGIi MGI:2660854. Adcy10.

    Phylogenomic databases

    GeneTreei ENSGT00390000001322.
    KOi K11265.

    Miscellaneous databases

    ChiTaRSi ADCY10. mouse.
    NextBioi 35555797.
    SOURCEi Search...

    Family and domain databases

    Gene3Di 3.30.70.1230. 2 hits.
    InterProi IPR001054. A/G_cyclase.
    IPR016577. Adenylate_cylcase_typ10.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF00211. Guanylate_cyc. 2 hits.
    [Graphical view ]
    PIRSFi PIRSF011131. Soluble_adenylyl_cyclase. 1 hit.
    SMARTi SM00044. CYCc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    SSF55073. SSF55073. 2 hits.
    PROSITEi PS50125. GUANYLATE_CYCLASE_2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6JImported.
    2. Ensembl
      Submitted (MAY-2011) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: C57BL/6JImported.
    3. Ensembl
      Submitted (FEB-2012) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: C57BL/6JImported.

    Entry informationi

    Entry nameiE9Q9T4_MOUSE
    AccessioniPrimary (citable) accession number: E9Q9T4
    Entry historyi
    Integrated into UniProtKB/TrEMBL: April 5, 2011
    Last sequence update: April 5, 2011
    Last modified: October 1, 2014
    This is version 26 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Caution

    The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3