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Protein

Ubiquitin carboxyl-terminal hydrolase

Gene

Usp19

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol proteaseUniRule annotation

Keywords - Biological processi

Ubl conjugation pathwayUniRule annotation

Keywords - Ligandi

Metal-bindingSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolaseUniRule annotation (EC:3.4.19.12UniRule annotation)
Gene namesi
Name:Usp19Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1918722. Usp19.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Expressioni

Gene expression databases

BgeeiE9Q9M5.
ExpressionAtlasiE9Q9M5. baseline and differential.
GenevisibleiE9Q9M5. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000006854.

Structurei

3D structure databases

ProteinModelPortaliE9Q9M5.
SMRiE9Q9M5. Positions 306-420, 512-695, 1014-1233.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase C19 family.UniRule annotation
Contains USP domain.SAAS annotation

Phylogenomic databases

GeneTreeiENSGT00670000097750.

Family and domain databases

Gene3Di2.60.40.790. 2 hits.
InterProiIPR007052. CS_dom.
IPR008978. HSP20-like_chaperone.
IPR001394. Peptidase_C19_UCH.
IPR018200. USP_CS.
IPR028889. USP_dom.
IPR002893. Znf_MYND.
[Graphical view]
PfamiPF04969. CS. 2 hits.
PF00443. UCH. 1 hit.
PF01753. zf-MYND. 1 hit.
[Graphical view]
SUPFAMiSSF49764. SSF49764. 2 hits.
PROSITEiPS51203. CS. 1 hit.
PS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
PS01360. ZF_MYND_1. 1 hit.
PS50865. ZF_MYND_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E9Q9M5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAGASATGP RRGPPGLEEA TSKKKQKDRA NLESKDGDAR RVSLPRKEPT
60 70 80 90 100
KDELLLDWRQ SADEVIVKLR VGTGPVRLED VDAAFTDTDC VVRLPDGRQW
110 120 130 140 150
GGVFFAEIQS SCTKVQARKG GLLQLVLPKK VPLLTWPSLL KPLGTQELVP
160 170 180 190 200
GLQCQENGQE LSPIALEPGS EPRRAKQEAR NQKRAQGRGE VGSGAGPGTQ
210 220 230 240 250
AGPSAKRAVH LRRGPEGEGS MDGPGPQGDA PSFLSDSATQ VEAEEKLCAP
260 270 280 290 300
PMNTQTSLLS SEKSLALLTV EKTVSPRNDP VAPVMVQDRD PEPEQEDQVK
310 320 330 340 350
EEMALGADPT ALVEEPESMV NLAFVKNDSY EKGPDSVVVH VYVKEIRRDS
360 370 380 390 400
SRVLFREQDF TLIFQTRNLI EPEQCTFCFT ASRIDICLRK RQSQRWGGLE
410 420 430 440 450
APATRGAVGG AKVAVPTGPT PLDSTPPGGG PHPLTGQEEA RAVEKEKPKA
460 470 480 490 500
RSEDSGLDGV VARTPLEHVA PKPDPHLASP KPTCMVPPMP HSPVSGDSVE
510 520 530 540 550
EDEEEEKKVC LPGFTGLVNL GNTCFMNSVI QSLSNTRELR DFFHDRSFEA
560 570 580 590 600
EINYNNPLGT GGRLAIGFAV LLRALWKGTH QAFQPSKLKA IVASKASQFT
610 620 630 640 650
GYAQHDAQEF MAFLLDGLHE DLNRIQNKPY TETVDSDGRP DEVVAEEAWQ
660 670 680 690 700
RHKMRNDSFI VDLFQGQYKS KLVCPVCAKV SITFDPFLYL PVPLPQKQKV
710 720 730 740 750
LPIFYFAREP HSKPIKFLVS VSKENSSASE VLDSLSQSVH VKPENLRLAE
760 770 780 790 800
VIKNRFHRVF LPSHSLDAVS PTDVLLCFEL LSPELAKERV VVLEVQQRPQ
810 820 830 840 850
VPSIPISKCA ACQRKQQSEE EKLKRCTRCY RVGYCNQFCQ KTHWPDHKGL
860 870 880 890 900
CRPENIGYPF LVSVPASRLT YARLAQLLEG YARYSVSVFQ PPFQPGRMAL
910 920 930 940 950
ESQSPGCTTL LSTSSLEAGD SEREPIQPSE LQLVTPVAEG DTGAHRVWPP
960 970 980 990 1000
ADRGPVPSTS GLSSEMLASG PIEGCPLLAG ERVSRPEAAV PGYQHSSESV
1010 1020 1030 1040 1050
NTHTPQFFIY KIDASNREQR LEDKGETPLE LGDDCSLALV WRNNERLQEF
1060 1070 1080 1090 1100
VLVASKELEC AEDPGSAGEA ARAGHFTLDQ CLNLFTRPEV LAPEEAWYCP
1110 1120 1130 1140 1150
QCKQHREASK QLLLWRLPNV LIVQLKRFSF RSFIWRDKIN DLVEFPVRNL
1160 1170 1180 1190 1200
DLSKFCIGQK EEQLPSYDLY AVINHYGGMI GGHYTACARL PNDRSSQRSD
1210 1220 1230 1240 1250
VGWRLFDDST VTTVDESQVV TRYAYVLFYR RRNSPVERPP RASHSEHHPD
1260 1270 1280 1290
LGPAAEAAAS QGLGPGQAPE VAPTRTAPER FAPPVDRPAP TYSNMEEVD
Length:1,299
Mass (Da):143,452
Last modified:April 5, 2011 - v1
Checksum:iC1AA0A6DBC1BE6CE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CT010508 Genomic DNA. No translation available.
RefSeqiNP_663382.2. NM_145407.3.
UniGeneiMm.289706.

Genome annotation databases

EnsembliENSMUST00000166103; ENSMUSP00000128573; ENSMUSG00000006676.
GeneIDi71472.
UCSCiuc012har.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CT010508 Genomic DNA. No translation available.
RefSeqiNP_663382.2. NM_145407.3.
UniGeneiMm.289706.

3D structure databases

ProteinModelPortaliE9Q9M5.
SMRiE9Q9M5. Positions 306-420, 512-695, 1014-1233.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000006854.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000166103; ENSMUSP00000128573; ENSMUSG00000006676.
GeneIDi71472.
UCSCiuc012har.1. mouse.

Organism-specific databases

CTDi10869.
MGIiMGI:1918722. Usp19.

Phylogenomic databases

GeneTreeiENSGT00670000097750.

Miscellaneous databases

ChiTaRSiUsp19. mouse.
NextBioi333851.
SOURCEiSearch...

Gene expression databases

BgeeiE9Q9M5.
ExpressionAtlasiE9Q9M5. baseline and differential.
GenevisibleiE9Q9M5. MM.

Family and domain databases

Gene3Di2.60.40.790. 2 hits.
InterProiIPR007052. CS_dom.
IPR008978. HSP20-like_chaperone.
IPR001394. Peptidase_C19_UCH.
IPR018200. USP_CS.
IPR028889. USP_dom.
IPR002893. Znf_MYND.
[Graphical view]
PfamiPF04969. CS. 2 hits.
PF00443. UCH. 1 hit.
PF01753. zf-MYND. 1 hit.
[Graphical view]
SUPFAMiSSF49764. SSF49764. 2 hits.
PROSITEiPS51203. CS. 1 hit.
PS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
PS01360. ZF_MYND_1. 1 hit.
PS50865. ZF_MYND_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  3. Ensembl
    Submitted (MAY-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiE9Q9M5_MOUSE
AccessioniPrimary (citable) accession number: E9Q9M5
Entry historyi
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: July 22, 2015
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.