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E9Q9M5

- E9Q9M5_MOUSE

UniProt

E9Q9M5 - E9Q9M5_MOUSE

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Protein

Ubiquitin carboxyl-terminal hydrolase

Gene
Usp19
Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

GO - Molecular functioni

  1. cysteine-type peptidase activity Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. ubiquitinyl hydrolase activity Source: InterPro

GO - Biological processi

  1. ubiquitin-dependent protein catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol proteaseUniRule annotation

Keywords - Biological processi

Ubl conjugation pathwayUniRule annotation

Keywords - Ligandi

Metal-bindingSAAS annotations

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolaseUniRule annotation (EC:3.4.19.12UniRule annotation)
Gene namesi
Name:Usp19Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 9

Organism-specific databases

MGIiMGI:1918722. Usp19.

Expressioni

Gene expression databases

ArrayExpressiE9Q9M5.
BgeeiE9Q9M5.

Structurei

3D structure databases

ProteinModelPortaliE9Q9M5.
SMRiE9Q9M5. Positions 306-420, 512-695, 1014-1233.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase C19 family.UniRule annotation
Contains USP domain.SAAS annotations

Phylogenomic databases

GeneTreeiENSGT00670000097750.
KOiK11847.

Family and domain databases

Gene3Di2.60.40.790. 2 hits.
InterProiIPR007052. CS_dom.
IPR008978. HSP20-like_chaperone.
IPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
IPR002893. Znf_MYND.
[Graphical view]
PfamiPF04969. CS. 2 hits.
PF00443. UCH. 1 hit.
PF01753. zf-MYND. 1 hit.
[Graphical view]
SUPFAMiSSF49764. SSF49764. 2 hits.
PROSITEiPS51203. CS. 1 hit.
PS00972. UCH_2_1. 1 hit.
PS00973. UCH_2_2. 1 hit.
PS50235. UCH_2_3. 1 hit.
PS01360. ZF_MYND_1. 1 hit.
PS50865. ZF_MYND_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E9Q9M5-1 [UniParc]FASTAAdd to Basket

« Hide

MSAGASATGP RRGPPGLEEA TSKKKQKDRA NLESKDGDAR RVSLPRKEPT     50
KDELLLDWRQ SADEVIVKLR VGTGPVRLED VDAAFTDTDC VVRLPDGRQW 100
GGVFFAEIQS SCTKVQARKG GLLQLVLPKK VPLLTWPSLL KPLGTQELVP 150
GLQCQENGQE LSPIALEPGS EPRRAKQEAR NQKRAQGRGE VGSGAGPGTQ 200
AGPSAKRAVH LRRGPEGEGS MDGPGPQGDA PSFLSDSATQ VEAEEKLCAP 250
PMNTQTSLLS SEKSLALLTV EKTVSPRNDP VAPVMVQDRD PEPEQEDQVK 300
EEMALGADPT ALVEEPESMV NLAFVKNDSY EKGPDSVVVH VYVKEIRRDS 350
SRVLFREQDF TLIFQTRNLI EPEQCTFCFT ASRIDICLRK RQSQRWGGLE 400
APATRGAVGG AKVAVPTGPT PLDSTPPGGG PHPLTGQEEA RAVEKEKPKA 450
RSEDSGLDGV VARTPLEHVA PKPDPHLASP KPTCMVPPMP HSPVSGDSVE 500
EDEEEEKKVC LPGFTGLVNL GNTCFMNSVI QSLSNTRELR DFFHDRSFEA 550
EINYNNPLGT GGRLAIGFAV LLRALWKGTH QAFQPSKLKA IVASKASQFT 600
GYAQHDAQEF MAFLLDGLHE DLNRIQNKPY TETVDSDGRP DEVVAEEAWQ 650
RHKMRNDSFI VDLFQGQYKS KLVCPVCAKV SITFDPFLYL PVPLPQKQKV 700
LPIFYFAREP HSKPIKFLVS VSKENSSASE VLDSLSQSVH VKPENLRLAE 750
VIKNRFHRVF LPSHSLDAVS PTDVLLCFEL LSPELAKERV VVLEVQQRPQ 800
VPSIPISKCA ACQRKQQSEE EKLKRCTRCY RVGYCNQFCQ KTHWPDHKGL 850
CRPENIGYPF LVSVPASRLT YARLAQLLEG YARYSVSVFQ PPFQPGRMAL 900
ESQSPGCTTL LSTSSLEAGD SEREPIQPSE LQLVTPVAEG DTGAHRVWPP 950
ADRGPVPSTS GLSSEMLASG PIEGCPLLAG ERVSRPEAAV PGYQHSSESV 1000
NTHTPQFFIY KIDASNREQR LEDKGETPLE LGDDCSLALV WRNNERLQEF 1050
VLVASKELEC AEDPGSAGEA ARAGHFTLDQ CLNLFTRPEV LAPEEAWYCP 1100
QCKQHREASK QLLLWRLPNV LIVQLKRFSF RSFIWRDKIN DLVEFPVRNL 1150
DLSKFCIGQK EEQLPSYDLY AVINHYGGMI GGHYTACARL PNDRSSQRSD 1200
VGWRLFDDST VTTVDESQVV TRYAYVLFYR RRNSPVERPP RASHSEHHPD 1250
LGPAAEAAAS QGLGPGQAPE VAPTRTAPER FAPPVDRPAP TYSNMEEVD 1299
Length:1,299
Mass (Da):143,452
Last modified:April 5, 2011 - v1
Checksum:iC1AA0A6DBC1BE6CE
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CT010508 Genomic DNA. No translation available.
RefSeqiNP_663382.2. NM_145407.3.
UniGeneiMm.289706.

Genome annotation databases

EnsembliENSMUST00000166103; ENSMUSP00000128573; ENSMUSG00000006676.
GeneIDi71472.
KEGGimmu:71472.
UCSCiuc012har.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CT010508 Genomic DNA. No translation available.
RefSeqi NP_663382.2. NM_145407.3.
UniGenei Mm.289706.

3D structure databases

ProteinModelPortali E9Q9M5.
SMRi E9Q9M5. Positions 306-420, 512-695, 1014-1233.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000166103 ; ENSMUSP00000128573 ; ENSMUSG00000006676 .
GeneIDi 71472.
KEGGi mmu:71472.
UCSCi uc012har.1. mouse.

Organism-specific databases

CTDi 10869.
MGIi MGI:1918722. Usp19.

Phylogenomic databases

GeneTreei ENSGT00670000097750.
KOi K11847.

Miscellaneous databases

ChiTaRSi USP19. mouse.
NextBioi 333851.
SOURCEi Search...

Gene expression databases

ArrayExpressi E9Q9M5.
Bgeei E9Q9M5.

Family and domain databases

Gene3Di 2.60.40.790. 2 hits.
InterProi IPR007052. CS_dom.
IPR008978. HSP20-like_chaperone.
IPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
IPR002893. Znf_MYND.
[Graphical view ]
Pfami PF04969. CS. 2 hits.
PF00443. UCH. 1 hit.
PF01753. zf-MYND. 1 hit.
[Graphical view ]
SUPFAMi SSF49764. SSF49764. 2 hits.
PROSITEi PS51203. CS. 1 hit.
PS00972. UCH_2_1. 1 hit.
PS00973. UCH_2_2. 1 hit.
PS50235. UCH_2_3. 1 hit.
PS01360. ZF_MYND_1. 1 hit.
PS50865. ZF_MYND_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  2. Ensembl
    Submitted (MAY-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiE9Q9M5_MOUSE
AccessioniPrimary (citable) accession number: E9Q9M5
Entry historyi
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: September 3, 2014
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

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