Ubiquitin carboxyl-terminal hydrolase

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E9Q9M5 (E9Q9M5_MOUSE) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 20. History...

Clusters with 100%, 90%, 50% identity |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry info Customize order

Names and origin

Protein names

Recommended name:
Ubiquitin carboxyl-terminal hydrolase RuleBase RU004435
EC=3.4.19.12 RuleBase RU004435

Gene names

Name:

Usp19 Ensembl ENSMUSP00000128573 MGI 1918722

Organism

Mus musculus (Mouse) [Reference proteome] Ensembl ENSMUSP00000128573

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	1299 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal). RuleBase RU004435
Sequence similarities	Belongs to the peptidase C19 family. RuleBase RU004434
Caution	The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data. Ensembl ENSMUSP00000128573

Ontologies

Keywords
Biological process	Ubl conjugation pathway RuleBase RU004434
Ligand	Metal-binding SAAS SAAS002893
Molecular function	Hydrolase Protease Thiol protease RuleBase RU004434
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	ubiquitin-dependent protein catabolic process Inferred from electronic annotation. Source: InterPro
Molecular_function	cysteine-type peptidase activity Inferred from electronic annotation. Source: UniProtKB-KW ubiquitin thiolesterase activity Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

Sequence

Length

Mass (Da)

Tools

E9Q9M5 [UniParc].

Last modified April 5, 2011. Version 1.
Checksum: C1AA0A6DBC1BE6CE
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FASTA

1,299

143,452

        10         20         30         40         50         60 
MSAGASATGP RRGPPGLEEA TSKKKQKDRA NLESKDGDAR RVSLPRKEPT KDELLLDWRQ 

        70         80         90        100        110        120 
SADEVIVKLR VGTGPVRLED VDAAFTDTDC VVRLPDGRQW GGVFFAEIQS SCTKVQARKG 

       130        140        150        160        170        180 
GLLQLVLPKK VPLLTWPSLL KPLGTQELVP GLQCQENGQE LSPIALEPGS EPRRAKQEAR 

       190        200        210        220        230        240 
NQKRAQGRGE VGSGAGPGTQ AGPSAKRAVH LRRGPEGEGS MDGPGPQGDA PSFLSDSATQ 

       250        260        270        280        290        300 
VEAEEKLCAP PMNTQTSLLS SEKSLALLTV EKTVSPRNDP VAPVMVQDRD PEPEQEDQVK 

       310        320        330        340        350        360 
EEMALGADPT ALVEEPESMV NLAFVKNDSY EKGPDSVVVH VYVKEIRRDS SRVLFREQDF 

       370        380        390        400        410        420 
TLIFQTRNLI EPEQCTFCFT ASRIDICLRK RQSQRWGGLE APATRGAVGG AKVAVPTGPT 

       430        440        450        460        470        480 
PLDSTPPGGG PHPLTGQEEA RAVEKEKPKA RSEDSGLDGV VARTPLEHVA PKPDPHLASP 

       490        500        510        520        530        540 
KPTCMVPPMP HSPVSGDSVE EDEEEEKKVC LPGFTGLVNL GNTCFMNSVI QSLSNTRELR 

       550        560        570        580        590        600 
DFFHDRSFEA EINYNNPLGT GGRLAIGFAV LLRALWKGTH QAFQPSKLKA IVASKASQFT 

       610        620        630        640        650        660 
GYAQHDAQEF MAFLLDGLHE DLNRIQNKPY TETVDSDGRP DEVVAEEAWQ RHKMRNDSFI 

       670        680        690        700        710        720 
VDLFQGQYKS KLVCPVCAKV SITFDPFLYL PVPLPQKQKV LPIFYFAREP HSKPIKFLVS 

       730        740        750        760        770        780 
VSKENSSASE VLDSLSQSVH VKPENLRLAE VIKNRFHRVF LPSHSLDAVS PTDVLLCFEL 

       790        800        810        820        830        840 
LSPELAKERV VVLEVQQRPQ VPSIPISKCA ACQRKQQSEE EKLKRCTRCY RVGYCNQFCQ 

       850        860        870        880        890        900 
KTHWPDHKGL CRPENIGYPF LVSVPASRLT YARLAQLLEG YARYSVSVFQ PPFQPGRMAL 

       910        920        930        940        950        960 
ESQSPGCTTL LSTSSLEAGD SEREPIQPSE LQLVTPVAEG DTGAHRVWPP ADRGPVPSTS 

       970        980        990       1000       1010       1020 
GLSSEMLASG PIEGCPLLAG ERVSRPEAAV PGYQHSSESV NTHTPQFFIY KIDASNREQR 

      1030       1040       1050       1060       1070       1080 
LEDKGETPLE LGDDCSLALV WRNNERLQEF VLVASKELEC AEDPGSAGEA ARAGHFTLDQ 

      1090       1100       1110       1120       1130       1140 
CLNLFTRPEV LAPEEAWYCP QCKQHREASK QLLLWRLPNV LIVQLKRFSF RSFIWRDKIN 

      1150       1160       1170       1180       1190       1200 
DLVEFPVRNL DLSKFCIGQK EEQLPSYDLY AVINHYGGMI GGHYTACARL PNDRSSQRSD 

      1210       1220       1230       1240       1250       1260 
VGWRLFDDST VTTVDESQVV TRYAYVLFYR RRNSPVERPP RASHSEHHPD LGPAAEAAAS 

      1270       1280       1290 
QGLGPGQAPE VAPTRTAPER FAPPVDRPAP TYSNMEEVD

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J Ensembl ENSMUSP00000128573.
[2]	Ensembl Submitted (MAY-2011) to UniProtKB Cited for: IDENTIFICATION. Strain: C57BL/6J Ensembl ENSMUSP00000128573.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CT010508 Genomic DNA. No translation available.
IPI	IPI00955120.
RefSeq	NP_663382.2. NM_145407.3.
UniGene	Mm.289706.
3D structure databases
ProteinModelPortal	E9Q9M5.
SMR	E9Q9M5. Positions 306-420, 512-695, 1014-1233.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000166103; ENSMUSP00000128573; ENSMUSG00000006676.
GeneID	71472.
KEGG	mmu:71472.
Organism-specific databases
CTD	10869.
MGI	MGI:1918722. Usp19.
Phylogenomic databases
GeneTree	ENSGT00670000097750.
KO	K11847.
Gene expression databases
ArrayExpress	E9Q9M5.
Bgee	E9Q9M5.
Family and domain databases
InterPro	IPR007052. CS-like_domain. IPR017447. CS_domain. IPR015054. DUF1872. IPR008978. HSP20-like_chaperone. IPR018200. Pept_C19ubi-hydrolase_C_CS. IPR001394. Peptidase_C19. IPR002893. Znf_MYND. [Graphical view]
Pfam	PF04969. CS. 1 hit. PF08959. DUF1872. 1 hit. PF00443. UCH. 1 hit. PF01753. zf-MYND. 1 hit. [Graphical view]
SUPFAM	SSF49764. HSP20_chap. 2 hits.
PROSITE	PS51203. CS. 1 hit. PS00972. UCH_2_1. 1 hit. PS00973. UCH_2_2. 1 hit. PS50235. UCH_2_3. 1 hit. PS01360. ZF_MYND_1. 1 hit. PS50865. ZF_MYND_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	USP19. mouse.
NextBio	333851.
SOURCE	Search...

Entry information

Entry name

E9Q9M5_MOUSE

Accession

Primary (citable) accession number: E9Q9M5

Entry history

Integrated into UniProtKB/TrEMBL:	April 5, 2011
Last sequence update:	April 5, 2011
Last modified:	May 1, 2013
This is version 20 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Names·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry info

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information