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E9Q9M5

- E9Q9M5_MOUSE

UniProt

E9Q9M5 - E9Q9M5_MOUSE

Protein

Ubiquitin carboxyl-terminal hydrolase

Gene

Usp19

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 31 (01 Oct 2014)
      Sequence version 1 (05 Apr 2011)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

    GO - Molecular functioni

    1. cysteine-type peptidase activity Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW
    3. ubiquitinyl hydrolase activity Source: InterPro

    GO - Biological processi

    1. ubiquitin-dependent protein catabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Protease, Thiol proteaseUniRule annotation

    Keywords - Biological processi

    Ubl conjugation pathwayUniRule annotation

    Keywords - Ligandi

    Metal-bindingSAAS annotation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolaseUniRule annotation (EC:3.4.19.12UniRule annotation)
    Gene namesi
    Name:Usp19Imported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 9

    Organism-specific databases

    MGIiMGI:1918722. Usp19.

    Expressioni

    Gene expression databases

    ArrayExpressiE9Q9M5.
    BgeeiE9Q9M5.

    Structurei

    3D structure databases

    ProteinModelPortaliE9Q9M5.
    SMRiE9Q9M5. Positions 306-420, 512-695, 1014-1233.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase C19 family.UniRule annotation
    Contains USP domain.SAAS annotation

    Phylogenomic databases

    GeneTreeiENSGT00670000097750.
    KOiK11847.

    Family and domain databases

    Gene3Di2.60.40.790. 2 hits.
    InterProiIPR007052. CS_dom.
    IPR008978. HSP20-like_chaperone.
    IPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR028889. UCH/PAN2.
    IPR002893. Znf_MYND.
    [Graphical view]
    PfamiPF04969. CS. 2 hits.
    PF00443. UCH. 1 hit.
    PF01753. zf-MYND. 1 hit.
    [Graphical view]
    SUPFAMiSSF49764. SSF49764. 2 hits.
    PROSITEiPS51203. CS. 1 hit.
    PS00972. UCH_2_1. 1 hit.
    PS00973. UCH_2_2. 1 hit.
    PS50235. UCH_2_3. 1 hit.
    PS01360. ZF_MYND_1. 1 hit.
    PS50865. ZF_MYND_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    E9Q9M5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSAGASATGP RRGPPGLEEA TSKKKQKDRA NLESKDGDAR RVSLPRKEPT     50
    KDELLLDWRQ SADEVIVKLR VGTGPVRLED VDAAFTDTDC VVRLPDGRQW 100
    GGVFFAEIQS SCTKVQARKG GLLQLVLPKK VPLLTWPSLL KPLGTQELVP 150
    GLQCQENGQE LSPIALEPGS EPRRAKQEAR NQKRAQGRGE VGSGAGPGTQ 200
    AGPSAKRAVH LRRGPEGEGS MDGPGPQGDA PSFLSDSATQ VEAEEKLCAP 250
    PMNTQTSLLS SEKSLALLTV EKTVSPRNDP VAPVMVQDRD PEPEQEDQVK 300
    EEMALGADPT ALVEEPESMV NLAFVKNDSY EKGPDSVVVH VYVKEIRRDS 350
    SRVLFREQDF TLIFQTRNLI EPEQCTFCFT ASRIDICLRK RQSQRWGGLE 400
    APATRGAVGG AKVAVPTGPT PLDSTPPGGG PHPLTGQEEA RAVEKEKPKA 450
    RSEDSGLDGV VARTPLEHVA PKPDPHLASP KPTCMVPPMP HSPVSGDSVE 500
    EDEEEEKKVC LPGFTGLVNL GNTCFMNSVI QSLSNTRELR DFFHDRSFEA 550
    EINYNNPLGT GGRLAIGFAV LLRALWKGTH QAFQPSKLKA IVASKASQFT 600
    GYAQHDAQEF MAFLLDGLHE DLNRIQNKPY TETVDSDGRP DEVVAEEAWQ 650
    RHKMRNDSFI VDLFQGQYKS KLVCPVCAKV SITFDPFLYL PVPLPQKQKV 700
    LPIFYFAREP HSKPIKFLVS VSKENSSASE VLDSLSQSVH VKPENLRLAE 750
    VIKNRFHRVF LPSHSLDAVS PTDVLLCFEL LSPELAKERV VVLEVQQRPQ 800
    VPSIPISKCA ACQRKQQSEE EKLKRCTRCY RVGYCNQFCQ KTHWPDHKGL 850
    CRPENIGYPF LVSVPASRLT YARLAQLLEG YARYSVSVFQ PPFQPGRMAL 900
    ESQSPGCTTL LSTSSLEAGD SEREPIQPSE LQLVTPVAEG DTGAHRVWPP 950
    ADRGPVPSTS GLSSEMLASG PIEGCPLLAG ERVSRPEAAV PGYQHSSESV 1000
    NTHTPQFFIY KIDASNREQR LEDKGETPLE LGDDCSLALV WRNNERLQEF 1050
    VLVASKELEC AEDPGSAGEA ARAGHFTLDQ CLNLFTRPEV LAPEEAWYCP 1100
    QCKQHREASK QLLLWRLPNV LIVQLKRFSF RSFIWRDKIN DLVEFPVRNL 1150
    DLSKFCIGQK EEQLPSYDLY AVINHYGGMI GGHYTACARL PNDRSSQRSD 1200
    VGWRLFDDST VTTVDESQVV TRYAYVLFYR RRNSPVERPP RASHSEHHPD 1250
    LGPAAEAAAS QGLGPGQAPE VAPTRTAPER FAPPVDRPAP TYSNMEEVD 1299
    Length:1,299
    Mass (Da):143,452
    Last modified:April 5, 2011 - v1
    Checksum:iC1AA0A6DBC1BE6CE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CT010508 Genomic DNA. No translation available.
    RefSeqiNP_663382.2. NM_145407.3.
    UniGeneiMm.289706.

    Genome annotation databases

    EnsembliENSMUST00000166103; ENSMUSP00000128573; ENSMUSG00000006676.
    GeneIDi71472.
    KEGGimmu:71472.
    UCSCiuc012har.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CT010508 Genomic DNA. No translation available.
    RefSeqi NP_663382.2. NM_145407.3.
    UniGenei Mm.289706.

    3D structure databases

    ProteinModelPortali E9Q9M5.
    SMRi E9Q9M5. Positions 306-420, 512-695, 1014-1233.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000166103 ; ENSMUSP00000128573 ; ENSMUSG00000006676 .
    GeneIDi 71472.
    KEGGi mmu:71472.
    UCSCi uc012har.1. mouse.

    Organism-specific databases

    CTDi 10869.
    MGIi MGI:1918722. Usp19.

    Phylogenomic databases

    GeneTreei ENSGT00670000097750.
    KOi K11847.

    Miscellaneous databases

    ChiTaRSi USP19. mouse.
    NextBioi 333851.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi E9Q9M5.
    Bgeei E9Q9M5.

    Family and domain databases

    Gene3Di 2.60.40.790. 2 hits.
    InterProi IPR007052. CS_dom.
    IPR008978. HSP20-like_chaperone.
    IPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR028889. UCH/PAN2.
    IPR002893. Znf_MYND.
    [Graphical view ]
    Pfami PF04969. CS. 2 hits.
    PF00443. UCH. 1 hit.
    PF01753. zf-MYND. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49764. SSF49764. 2 hits.
    PROSITEi PS51203. CS. 1 hit.
    PS00972. UCH_2_1. 1 hit.
    PS00973. UCH_2_2. 1 hit.
    PS50235. UCH_2_3. 1 hit.
    PS01360. ZF_MYND_1. 1 hit.
    PS50865. ZF_MYND_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6JImported.
    2. Ensembl
      Submitted (MAY-2011) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: C57BL/6JImported.

    Entry informationi

    Entry nameiE9Q9M5_MOUSE
    AccessioniPrimary (citable) accession number: E9Q9M5
    Entry historyi
    Integrated into UniProtKB/TrEMBL: April 5, 2011
    Last sequence update: April 5, 2011
    Last modified: October 1, 2014
    This is version 31 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Caution

    The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3