Transcription factor 7-like 2 - Mus musculus (Mouse)

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E9Q990 (E9Q990_MOUSE) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 19. History...

Clusters with 100%, 90%, 50% identity |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry info Customize order

Names and origin

Protein names

Submitted name:
Transcription factor 7-like 2 Ensembl ENSMUSP00000107286

Gene names

Name:

Tcf7l2 Ensembl ENSMUSP00000107286 MGI 1202879

Organism

Mus musculus (Mouse) [Reference proteome] Ensembl ENSMUSP00000107286

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	435 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data. Ensembl ENSMUSP00000107286

Ontologies

Keywords
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	bone mineralization Inferred from genetic interaction PubMed 19213727. Source: MGI canonical Wnt receptor signaling pathway Inferred from mutant phenotype PubMed 10937998. Source: MGI catenin import into nucleus Inferred from direct assay PubMed 9792805. Source: MGI embryonic digestive tract morphogenesis Inferred from genetic interaction PubMed 15057272. Source: MGI embryonic genitalia morphogenesis Inferred from genetic interaction PubMed 15057272. Source: MGI embryonic hindgut morphogenesis Inferred from genetic interaction PubMed 15057272. Source: MGI face morphogenesis Inferred from genetic interaction PubMed 17699607. Source: MGI myoblast cell fate commitment Inferred from mutant phenotype PubMed 10937998. Source: MGI negative regulation of BMP signaling pathway Inferred from mutant phenotype PubMed 17919533. Source: MGI negative regulation of fat cell differentiation Inferred from mutant phenotype PubMed 10937998. Source: MGI negative regulation of fibroblast growth factor receptor signaling pathway Inferred from mutant phenotype PubMed 17919533. Source: MGI negative regulation of organ growth Inferred from mutant phenotype PubMed 17919533. Source: MGI neural tube development Inferred from genetic interaction PubMed 15057272. Source: MGI odontogenesis of dentin-containing tooth Inferred from genetic interaction PubMed 17699607. Source: MGI oligodendrocyte development Inferred from mutant phenotype PubMed 19741146. Source: MGI pituitary gland development Inferred from mutant phenotype PubMed 17919533. Source: MGI positive regulation of apoptotic process Inferred from mutant phenotype PubMed 17919533. Source: MGI positive regulation of epithelial cell proliferation Inferred from mutant phenotype PubMed 19251639. Source: MGI positive regulation of transcription from RNA polymerase II promoter Inferred from direct assay PubMed 20044351. Source: MGI regulation of insulin secretion involved in cellular response to glucose stimulus Inferred from mutant phenotype PubMed 19168596. Source: MGI regulation of myelination Inferred from mutant phenotype PubMed 19503085. Source: MGI regulation of oligodendrocyte differentiation Inferred from mutant phenotype PubMed 19503085. Source: MGI regulation of skeletal muscle tissue development Inferred from mutant phenotype PubMed 21177349. Source: MGI secretory granule localization Inferred from mutant phenotype PubMed 19168596. Source: MGI skin development Inferred from genetic interaction PubMed 19718027. Source: MGI somatic stem cell maintenance Inferred from mutant phenotype PubMed 10027409 PubMed 19251639 PubMed 9697701. Source: MGI
Cellular_component	transcription factor complex Inferred from direct assay PubMed 12861022. Source: MGI
Molecular_function	beta-catenin binding Inferred from direct assay PubMed 19503085 PubMed 9784592. Source: MGI chromatin binding Inferred from direct assay PubMed 17727834. Source: MGI sequence-specific DNA binding Inferred from Biological aspect of Ancestor. Source: RefGenome sequence-specific DNA binding transcription factor activity Inferred from Biological aspect of Ancestor. Source: RefGenome transcription regulatory region DNA binding Inferred from direct assay PubMed 20044351. Source: MGI
Complete GO annotation...

Sequences

Sequence

Length

Mass (Da)

Tools

E9Q990 [UniParc].

Last modified April 5, 2011. Version 1.
Checksum: CF627CCABA4A1E88
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FASTA

435

48,653

        10         20         30         40         50         60 
MPQLNGGGGD DLGANDELIS FKDEGEQEEK NSENSSAERD LADVKSSLVN ESETNQNSSS 

        70         80         90        100        110        120 
DSEAERRPPP RSESFRDKSR ESLEEAAKRQ DGGLFKGPPY PGYPFIMIPD LTSPYLPNGS 

       130        140        150        160        170        180 
LSPTARTLHF QSGSTHYSAY KTIEHQIAIQ YLQMKWPLLD VQAGSLQSRQ TLKDARSPSP 

       190        200        210        220        230        240 
AHIVSNKVPV VQHPHHVHPL TPLITYSNEH FTPGNPPPHL PADVDPKTGI PRPPHPPDIS 

       250        260        270        280        290        300 
PYYPLSPGTV GQIPHPLGWQ GQPVYPITTG GFRHPYPTAL TVNASMSSFL SSRFPPHMVP 

       310        320        330        340        350        360 
PHHTLHTTGI PHPAIVTPTV KQESSQSDVG SLHSSKHQDS KKEEEKKKPH IKKPLNAFML 

       370        380        390        400        410        420 
YMKEMRAKVV AECTLKESAA INQILGRRWH ALSREEQAKY YELARKERQL HMQLYPGWSA 

       430 
RDNYEKKKVR SLHTR

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J Ensembl ENSMUSP00000107286.
[2]	Ensembl Submitted (MAY-2011) to UniProtKB Cited for: IDENTIFICATION. Strain: C57BL/6J Ensembl ENSMUSP00000107286.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC118695 Genomic DNA. No translation available. AC137148 Genomic DNA. No translation available. AC157916 Genomic DNA. No translation available.
IPI	IPI00831494.
RefSeq	NP_001136392.1. NM_001142920.1.
UniGene	Mm.139815.
3D structure databases
ProteinModelPortal	E9Q990.
SMR	E9Q990. Positions 12-49, 350-424.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000111658; ENSMUSP00000107286; ENSMUSG00000024985.
GeneID	21416.
KEGG	mmu:21416.
Organism-specific databases
CTD	6934.
MGI	MGI:1202879. Tcf7l2.
Phylogenomic databases
GeneTree	ENSGT00390000009964.
KO	K04491.
Gene expression databases
ArrayExpress	E9Q990.
Bgee	E9Q990.
Family and domain databases
Gene3D	1.10.30.10. 1 hit.
InterPro	IPR013558. CTNNB1-bd_N. IPR009071. HMG_box_dom. IPR024940. TCF/LEF. [Graphical view]
PANTHER	PTHR10373. PTHR10373. 1 hit.
Pfam	PF08347. CTNNB1_binding. 1 hit. PF00505. HMG_box. 1 hit. [Graphical view]
SMART	SM00398. HMG. 1 hit. [Graphical view]
SUPFAM	SSF47095. HMG-box. 1 hit.
PROSITE	PS50118. HMG_BOX_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	TCF7L2. mouse.
NextBio	300716.
SOURCE	Search...

Entry information

Entry name

E9Q990_MOUSE

Accession

Primary (citable) accession number: E9Q990

Entry history

Integrated into UniProtKB/TrEMBL:	April 5, 2011
Last sequence update:	April 5, 2011
Last modified:	May 1, 2013
This is version 19 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Names·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry info

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information