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E9Q8Y5

- E9Q8Y5_MOUSE

UniProt

E9Q8Y5 - E9Q8Y5_MOUSE

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Protein
Submitted name:

Clusterin

Gene

Clu

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 4 out of 5- Protein predictedi

Functioni

GO - Biological processi

  1. cell morphogenesis Source: Ensembl
  2. central nervous system myelin maintenance Source: Ensembl
  3. chaperone-mediated protein complex assembly Source: Ensembl
  4. chaperone-mediated protein folding Source: Ensembl
  5. intrinsic apoptotic signaling pathway Source: Ensembl
  6. microglial cell activation Source: Ensembl
  7. microglial cell proliferation Source: Ensembl
  8. negative regulation of beta-amyloid formation Source: Ensembl
  9. negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage Source: Ensembl
  10. negative regulation of protein homooligomerization Source: Ensembl
  11. positive regulation of apoptotic process Source: Ensembl
  12. positive regulation of intrinsic apoptotic signaling pathway Source: Ensembl
  13. positive regulation of neurofibrillary tangle assembly Source: Ensembl
  14. positive regulation of neuron death Source: Ensembl
  15. positive regulation of NF-kappaB transcription factor activity Source: Ensembl
  16. positive regulation of nitric oxide biosynthetic process Source: Ensembl
  17. positive regulation of proteasomal ubiquitin-dependent protein catabolic process Source: Ensembl
  18. positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process Source: Ensembl
  19. positive regulation of tau-protein kinase activity Source: Ensembl
  20. positive regulation of tumor necrosis factor production Source: Ensembl
  21. protein import Source: Ensembl
  22. protein stabilization Source: Ensembl
  23. regulation of beta-amyloid clearance Source: Ensembl
  24. regulation of neuronal signal transduction Source: Ensembl
  25. response to misfolded protein Source: Ensembl
  26. response to virus Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
ClusterinImported
Gene namesi
Name:CluImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 14

Organism-specific databases

MGIiMGI:88423. Clu.

Subcellular locationi

GO - Cellular componenti

  1. apical dendrite Source: Ensembl
  2. blood microparticle Source: Ensembl
  3. extracellular matrix Source: Ensembl
  4. extracellular vesicular exosome Source: Ensembl
  5. mitochondrion Source: Ensembl
  6. neurofibrillary tangle Source: Ensembl
  7. perinuclear region of cytoplasm Source: Ensembl
  8. spherical high-density lipoprotein particle Source: Ensembl
Complete GO annotation...

Expressioni

Gene expression databases

BgeeiE9Q8Y5.
ExpressionAtlasiE9Q8Y5. baseline and differential.

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00530000063668.

Family and domain databases

InterProiIPR016016. Clusterin.
IPR000753. Clusterin-like.
IPR016014. Clusterin_N.
[Graphical view]
PANTHERiPTHR10970:SF1. PTHR10970:SF1. 1 hit.
PfamiPF01093. Clusterin. 1 hit.
[Graphical view]
SMARTiSM00030. CLb. 1 hit.
[Graphical view]
PROSITEiPS00492. CLUSTERIN_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

E9Q8Y5 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKILLLCVAL LLIWDNGMVL GEQEVSDNEL QELSTQGSRY INKEIQNAVQ
60 70 80 90 100
GVKHIKTLIE KTNAERKSLL NSLEEAKKKK EDALEDTRDS EMKLKAFPEV
110 120 130 140 150
CNETMMALWE ECKPCLKHTC MKFYARVCRS GSGLVGQQLE EFLNQSSPFY
160 170 180 190 200
FWMNGDRIDS LLESDRQQSQ VLDAMQDSFA RASGIIDTLF QDRFFARELH
210 220 230 240 250
DPHYFSPIGF PHKRPHFLYP KSRLVRSLMS PSHYGPPSFH NMFQPFFEMI
260
HQAQQAMDVQ LHSPA
Length:265
Mass (Da):30,651
Last modified:April 5, 2011 - v1
Checksum:iFF78F9FF7B953D0E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei265 – 2651Imported

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC126444 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSMUST00000153460; ENSMUSP00000121633; ENSMUSG00000022037.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC126444 Genomic DNA. No translation available.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000153460 ; ENSMUSP00000121633 ; ENSMUSG00000022037 .

Organism-specific databases

MGIi MGI:88423. Clu.

Phylogenomic databases

GeneTreei ENSGT00530000063668.

Miscellaneous databases

ChiTaRSi CLU. mouse.
NextBioi 35555684.
SOURCEi Search...

Gene expression databases

Bgeei E9Q8Y5.
ExpressionAtlasi E9Q8Y5. baseline and differential.

Family and domain databases

InterProi IPR016016. Clusterin.
IPR000753. Clusterin-like.
IPR016014. Clusterin_N.
[Graphical view ]
PANTHERi PTHR10970:SF1. PTHR10970:SF1. 1 hit.
Pfami PF01093. Clusterin. 1 hit.
[Graphical view ]
SMARTi SM00030. CLb. 1 hit.
[Graphical view ]
PROSITEi PS00492. CLUSTERIN_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  2. Ensembl
    Submitted (MAY-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiE9Q8Y5_MOUSE
AccessioniPrimary (citable) accession number: E9Q8Y5
Entry historyi
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: October 29, 2014
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3