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Protein
Submitted name:

GTPase KRas

Gene

Kras

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

  1. GTPase activity Source: MGI
  2. GTP binding Source: UniProtKB-KW
  3. protein complex binding Source: MGI

GO - Biological processi

  1. actin cytoskeleton organization Source: MGI
  2. epithelial tube branching involved in lung morphogenesis Source: MGI
  3. homeostasis of number of cells within a tissue Source: MGI
  4. metabolic process Source: GOC
  5. negative regulation of cell differentiation Source: MGI
  6. negative regulation of neuron apoptotic process Source: MGI
  7. positive regulation of cell proliferation Source: MGI
  8. positive regulation of gene expression Source: MGI
  9. positive regulation of protein phosphorylation Source: MGI
  10. positive regulation of Rac protein signal transduction Source: MGI
  11. Ras protein signal transduction Source: MGI
  12. regulation of long-term neuronal synaptic plasticity Source: MGI
  13. regulation of synaptic transmission, GABAergic Source: MGI
  14. striated muscle cell differentiation Source: MGI
  15. visual learning Source: MGI
Complete GO annotation...

Keywords - Ligandi

GTP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
GTPase KRasImported
Gene namesi
Name:KrasImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:96680. Kras.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: MGI
  2. extrinsic component of cytoplasmic side of plasma membrane Source: MGI
  3. focal adhesion Source: MGI
  4. membrane Source: MGI
Complete GO annotation...

PTM / Processingi

Proteomic databases

PRIDEiE9Q8V2.

Expressioni

Gene expression databases

BgeeiE9Q8V2.
ExpressionAtlasiE9Q8V2. baseline and differential.

Structurei

3D structure databases

SMRiE9Q8V2. Positions 1-37.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00780000121849.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR001806. Small_GTPase.
IPR020849. Small_GTPase_Ras.
[Graphical view]
PANTHERiPTHR24070. PTHR24070. 1 hit.
PfamiPF00071. Ras. 1 hit.
[Graphical view]
PRINTSiPR00449. RASTRNSFRMNG.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51421. RAS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E9Q8V2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40
MTEYKLVVVG AGGVGKSALT IQLIQNHFVD EYDPTIERTN
Length:40
Mass (Da):4,408
Last modified:April 4, 2011 - v1
Checksum:i43F6602AA5B411D7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC157091 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSMUST00000156486; ENSMUSP00000119414; ENSMUSG00000030265.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC157091 Genomic DNA. No translation available.

3D structure databases

SMRiE9Q8V2. Positions 1-37.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiE9Q8V2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000156486; ENSMUSP00000119414; ENSMUSG00000030265.

Organism-specific databases

MGIiMGI:96680. Kras.

Phylogenomic databases

GeneTreeiENSGT00780000121849.

Miscellaneous databases

ChiTaRSiKras. mouse.
NextBioi35555670.
SOURCEiSearch...

Gene expression databases

BgeeiE9Q8V2.
ExpressionAtlasiE9Q8V2. baseline and differential.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR001806. Small_GTPase.
IPR020849. Small_GTPase_Ras.
[Graphical view]
PANTHERiPTHR24070. PTHR24070. 1 hit.
PfamiPF00071. Ras. 1 hit.
[Graphical view]
PRINTSiPR00449. RASTRNSFRMNG.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51421. RAS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  2. Ensembl
    Submitted (APR-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiE9Q8V2_MOUSE
AccessioniPrimary (citable) accession number: E9Q8V2
Entry historyi
Integrated into UniProtKB/TrEMBL: April 4, 2011
Last sequence update: April 4, 2011
Last modified: March 31, 2015
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.