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E9Q8S8

- E9Q8S8_MOUSE

UniProt

E9Q8S8 - E9Q8S8_MOUSE

Protein
Submitted name:

Hexokinase-3

Gene

Hk3

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 27 (01 Oct 2014)
      Sequence version 1 (05 Apr 2011)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. fructokinase activity Source: RefGenome
    3. glucokinase activity Source: RefGenome
    4. mannokinase activity Source: RefGenome

    GO - Biological processi

    1. carbohydrate phosphorylation Source: GOC
    2. cellular glucose homeostasis Source: RefGenome
    3. glucose 6-phosphate metabolic process Source: GOC
    4. glycolytic process Source: RefGenome

    Keywords - Molecular functioni

    KinaseUniRule annotationSAAS annotation, Transferase

    Keywords - Biological processi

    GlycolysisUniRule annotationSAAS annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Hexokinase-3Imported
    Gene namesi
    Name:Hk3Imported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 13

    Organism-specific databases

    MGIiMGI:2670962. Hk3.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: RefGenome
    2. mitochondrion Source: MGI

    Expressioni

    Gene expression databases

    ArrayExpressiE9Q8S8.
    BgeeiE9Q8S8.

    Structurei

    3D structure databases

    ProteinModelPortaliE9Q8S8.
    SMRiE9Q8S8. Positions 35-873.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the hexokinase family.UniRule annotation

    Phylogenomic databases

    GeneTreeiENSGT00390000017159.
    KOiK00844.

    Family and domain databases

    InterProiIPR001312. Hexokinase.
    IPR022673. Hexokinase_C.
    IPR019807. Hexokinase_CS.
    IPR022672. Hexokinase_N.
    [Graphical view]
    PANTHERiPTHR19443. PTHR19443. 1 hit.
    PfamiPF00349. Hexokinase_1. 2 hits.
    PF03727. Hexokinase_2. 1 hit.
    [Graphical view]
    PRINTSiPR00475. HEXOKINASE.
    PROSITEiPS00378. HEXOKINASES. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    E9Q8S8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MATIGPSGLH PGERASVCPH EGVPRPSGSL ELECLQQFKV TRTQLQQIQA    50
    SLLCSMEQAL KGQDSPAPSV RMLPTYVRST PHGTEQGDFL VLELGATGAS 100
    LRVLWVTLTG TKECRVEPRS REFVIPQEVI LGAGQQLFDF AARCLSEFLD 150
    AYPVENQGLK LGFNFSFPCH QTGLDRSTLI SWTKGFRCSG VEGQDVVQLL 200
    RDAIQRQGTY RIDVVAMVND TVGTMMGCEL GTRPCEVGLI VDTGTNACYM 250
    EEARHVAALD EDRGRTCVSI EWGSFYDEDA LGPVLTTFDS ALDRESLTPG 300
    AQRFEKMIGG LYLGELVRLV LVHLTQHGVL FDGCASPALL SQGCILLDHV 350
    AEMEDTATGT ARVHTILQDL GLSPRASDAE LVQYVCVAVC TRAAQLCAAA 400
    LAAVLSRLQH SREQQTLQVA VATGGRVFER HPRRILEETL APFQLTLEQM 450
    TVVQAQMREA MIRGLQGEAS SLRMLPTYVR ATPDGSERGD FLALDLGGTN 500
    FRVLLVRVAE GSVQIINQVY SIPECRAQGS GQKLFDHIVD CIVDFQKRQG 550
    LSGQSLPLGF TFSFPCKQLG LDQGILLNWT KGFNASGCEG QDVVYLLREA 600
    IRRRQAVELN VVAIVNDTVG TMMSCGYDDP RCEMGLIVGT GTNACYMEEL 650
    RNVASVPGDS GLMCINMEWG AFGDDGSLGT LSTRFDTSVD QASINPGKQR 700
    FEKMISGMYL GEIVRHILLH LTNLGVLFRG QKTQCLQARD IFKTKFLSEI 750
    ESDSLALRQV RAILEDLGLT LTSDDALMVL EVCQAVSRRA AQLCGAGVAA 800
    VVEKIRENRG LQELTVSVGV DGTLYKLHPH FSKLVSATVR KLAPQCTVTF 850
    LQSEDGSGKG AALVTAVACR LTQMAHV 877
    Length:877
    Mass (Da):95,424
    Last modified:April 5, 2011 - v1
    Checksum:i85B718A47ACA24CE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC154610 Genomic DNA. No translation available.
    RefSeqiNP_001193320.1. NM_001206391.1.
    UniGeneiMm.267479.

    Genome annotation databases

    EnsembliENSMUST00000123097; ENSMUSP00000116717; ENSMUSG00000025877.
    GeneIDi212032.
    KEGGimmu:212032.
    UCSCiuc007qps.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC154610 Genomic DNA. No translation available.
    RefSeqi NP_001193320.1. NM_001206391.1.
    UniGenei Mm.267479.

    3D structure databases

    ProteinModelPortali E9Q8S8.
    SMRi E9Q8S8. Positions 35-873.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000123097 ; ENSMUSP00000116717 ; ENSMUSG00000025877 .
    GeneIDi 212032.
    KEGGi mmu:212032.
    UCSCi uc007qps.2. mouse.

    Organism-specific databases

    CTDi 3101.
    MGIi MGI:2670962. Hk3.

    Phylogenomic databases

    GeneTreei ENSGT00390000017159.
    KOi K00844.

    Miscellaneous databases

    NextBioi 373427.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi E9Q8S8.
    Bgeei E9Q8S8.

    Family and domain databases

    InterProi IPR001312. Hexokinase.
    IPR022673. Hexokinase_C.
    IPR019807. Hexokinase_CS.
    IPR022672. Hexokinase_N.
    [Graphical view ]
    PANTHERi PTHR19443. PTHR19443. 1 hit.
    Pfami PF00349. Hexokinase_1. 2 hits.
    PF03727. Hexokinase_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00475. HEXOKINASE.
    PROSITEi PS00378. HEXOKINASES. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6JImported.
    2. Ensembl
      Submitted (MAY-2011) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: C57BL/6JImported.

    Entry informationi

    Entry nameiE9Q8S8_MOUSE
    AccessioniPrimary (citable) accession number: E9Q8S8
    Entry historyi
    Integrated into UniProtKB/TrEMBL: April 5, 2011
    Last sequence update: April 5, 2011
    Last modified: October 1, 2014
    This is version 27 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Caution

    The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3