E9Q8S8 (E9Q8S8_MOUSE) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Hexokinase-3 Ensembl ENSMUSP00000116717

Gene names

Name:

Hk3 Ensembl ENSMUSP00000116717 MGI 2670962

Organism

Mus musculus (Mouse) [Reference proteome] Ensembl ENSMUSP00000116717

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	877 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities	Belongs to the hexokinase family. RuleBase RU004510
Caution	The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data. Ensembl ENSMUSP00000116717

Ontologies

Keywords
Biological process	Glycolysis SAAS SAAS022672 RuleBase RU004049
Ligand	ATP-binding SAAS SAAS022672 RuleBase RU004049 Nucleotide-binding
Molecular function	Kinase SAAS SAAS022672 RuleBase RU004049 Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cellular glucose homeostasis Inferred from Biological aspect of Ancestor. Source: RefGenome glycolysis Inferred from Biological aspect of Ancestor. Source: RefGenome
Cellular_component	cytosol Inferred from Biological aspect of Ancestor. Source: RefGenome mitochondrion Inferred from direct assay PubMed 18614015. Source: MGI
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW fructokinase activity Inferred from Biological aspect of Ancestor. Source: RefGenome glucokinase activity Inferred from Biological aspect of Ancestor. Source: RefGenome mannokinase activity Inferred from Biological aspect of Ancestor. Source: RefGenome
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	E9Q8S8 [UniParc]. Last modified April 5, 2011. Version 1. Checksum: 85B718A47ACA24CE	FASTA	877	95,424
	10 20 30 40 50 60 MATIGPSGLH PGERASVCPH EGVPRPSGSL ELECLQQFKV TRTQLQQIQA SLLCSMEQAL 70 80 90 100 110 120 KGQDSPAPSV RMLPTYVRST PHGTEQGDFL VLELGATGAS LRVLWVTLTG TKECRVEPRS 130 140 150 160 170 180 REFVIPQEVI LGAGQQLFDF AARCLSEFLD AYPVENQGLK LGFNFSFPCH QTGLDRSTLI 190 200 210 220 230 240 SWTKGFRCSG VEGQDVVQLL RDAIQRQGTY RIDVVAMVND TVGTMMGCEL GTRPCEVGLI 250 260 270 280 290 300 VDTGTNACYM EEARHVAALD EDRGRTCVSI EWGSFYDEDA LGPVLTTFDS ALDRESLTPG 310 320 330 340 350 360 AQRFEKMIGG LYLGELVRLV LVHLTQHGVL FDGCASPALL SQGCILLDHV AEMEDTATGT 370 380 390 400 410 420 ARVHTILQDL GLSPRASDAE LVQYVCVAVC TRAAQLCAAA LAAVLSRLQH SREQQTLQVA 430 440 450 460 470 480 VATGGRVFER HPRRILEETL APFQLTLEQM TVVQAQMREA MIRGLQGEAS SLRMLPTYVR 490 500 510 520 530 540 ATPDGSERGD FLALDLGGTN FRVLLVRVAE GSVQIINQVY SIPECRAQGS GQKLFDHIVD 550 560 570 580 590 600 CIVDFQKRQG LSGQSLPLGF TFSFPCKQLG LDQGILLNWT KGFNASGCEG QDVVYLLREA 610 620 630 640 650 660 IRRRQAVELN VVAIVNDTVG TMMSCGYDDP RCEMGLIVGT GTNACYMEEL RNVASVPGDS 670 680 690 700 710 720 GLMCINMEWG AFGDDGSLGT LSTRFDTSVD QASINPGKQR FEKMISGMYL GEIVRHILLH 730 740 750 760 770 780 LTNLGVLFRG QKTQCLQARD IFKTKFLSEI ESDSLALRQV RAILEDLGLT LTSDDALMVL 790 800 810 820 830 840 EVCQAVSRRA AQLCGAGVAA VVEKIRENRG LQELTVSVGV DGTLYKLHPH FSKLVSATVR 850 860 870 KLAPQCTVTF LQSEDGSGKG AALVTAVACR LTQMAHV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J Ensembl ENSMUSP00000116717.
[2]	Ensembl Submitted (MAY-2011) to UniProtKB Cited for: IDENTIFICATION. Strain: C57BL/6J Ensembl ENSMUSP00000116717.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC154610 Genomic DNA. No translation available.
IPI	IPI00798510.
RefSeq	NP_001193320.1. NM_001206391.1.
UniGene	Mm.267479.
3D structure databases
ProteinModelPortal	E9Q8S8.
SMR	E9Q8S8. Positions 35-873.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000123097; ENSMUSP00000116717; ENSMUSG00000025877.
GeneID	212032.
KEGG	mmu:212032.
Organism-specific databases
CTD	3101.
MGI	MGI:2670962. Hk3.
Phylogenomic databases
GeneTree	ENSGT00390000017159.
KO	K00844.
Gene expression databases
ArrayExpress	E9Q8S8.
Bgee	E9Q8S8.
Family and domain databases
InterPro	IPR001312. Hexokinase. IPR022673. Hexokinase_C. IPR019807. Hexokinase_CS. IPR022672. Hexokinase_N. [Graphical view]
PANTHER	PTHR19443. PTHR19443. 1 hit.
Pfam	PF00349. Hexokinase_1. 2 hits. PF03727. Hexokinase_2. 1 hit. [Graphical view]
PRINTS	PR00475. HEXOKINASE.
PROSITE	PS00378. HEXOKINASES. 2 hits. [Graphical view]
ProtoNet	Search...
Other
NextBio	373427.
SOURCE	Search...

Entry information

Entry name

E9Q8S8_MOUSE

Accession

Primary (citable) accession number: E9Q8S8

Entry history

Integrated into UniProtKB/TrEMBL:	April 5, 2011
Last sequence update:	April 5, 2011
Last modified:	May 1, 2013
This is version 17 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)