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Protein

Hexokinase

Gene

Hk3

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + D-hexose = ADP + D-hexose 6-phosphate.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotationSAAS annotation, Transferase

Keywords - Biological processi

GlycolysisUniRule annotationSAAS annotation

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
HexokinaseUniRule annotation (EC:2.7.1.1UniRule annotation)
Gene namesi
Name:Hk3Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:2670962. Hk3.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: GO_Central
  • mitochondrion Source: MGI
Complete GO annotation...

Expressioni

Gene expression databases

BgeeiE9Q8S8.
ExpressionAtlasiE9Q8S8. baseline and differential.
GenevisibleiE9Q8S8. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000051215.

Structurei

3D structure databases

ProteinModelPortaliE9Q8S8.
SMRiE9Q8S8. Positions 35-873.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the hexokinase family.UniRule annotation

Phylogenomic databases

GeneTreeiENSGT00390000017159.
KOiK00844.

Family and domain databases

InterProiIPR001312. Hexokinase.
IPR019807. Hexokinase_BS.
IPR022673. Hexokinase_C.
IPR022672. Hexokinase_N.
[Graphical view]
PANTHERiPTHR19443. PTHR19443. 1 hit.
PfamiPF00349. Hexokinase_1. 2 hits.
PF03727. Hexokinase_2. 1 hit.
[Graphical view]
PROSITEiPS00378. HEXOKINASE_1. 2 hits.
PS51748. HEXOKINASE_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E9Q8S8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATIGPSGLH PGERASVCPH EGVPRPSGSL ELECLQQFKV TRTQLQQIQA
60 70 80 90 100
SLLCSMEQAL KGQDSPAPSV RMLPTYVRST PHGTEQGDFL VLELGATGAS
110 120 130 140 150
LRVLWVTLTG TKECRVEPRS REFVIPQEVI LGAGQQLFDF AARCLSEFLD
160 170 180 190 200
AYPVENQGLK LGFNFSFPCH QTGLDRSTLI SWTKGFRCSG VEGQDVVQLL
210 220 230 240 250
RDAIQRQGTY RIDVVAMVND TVGTMMGCEL GTRPCEVGLI VDTGTNACYM
260 270 280 290 300
EEARHVAALD EDRGRTCVSI EWGSFYDEDA LGPVLTTFDS ALDRESLTPG
310 320 330 340 350
AQRFEKMIGG LYLGELVRLV LVHLTQHGVL FDGCASPALL SQGCILLDHV
360 370 380 390 400
AEMEDTATGT ARVHTILQDL GLSPRASDAE LVQYVCVAVC TRAAQLCAAA
410 420 430 440 450
LAAVLSRLQH SREQQTLQVA VATGGRVFER HPRRILEETL APFQLTLEQM
460 470 480 490 500
TVVQAQMREA MIRGLQGEAS SLRMLPTYVR ATPDGSERGD FLALDLGGTN
510 520 530 540 550
FRVLLVRVAE GSVQIINQVY SIPECRAQGS GQKLFDHIVD CIVDFQKRQG
560 570 580 590 600
LSGQSLPLGF TFSFPCKQLG LDQGILLNWT KGFNASGCEG QDVVYLLREA
610 620 630 640 650
IRRRQAVELN VVAIVNDTVG TMMSCGYDDP RCEMGLIVGT GTNACYMEEL
660 670 680 690 700
RNVASVPGDS GLMCINMEWG AFGDDGSLGT LSTRFDTSVD QASINPGKQR
710 720 730 740 750
FEKMISGMYL GEIVRHILLH LTNLGVLFRG QKTQCLQARD IFKTKFLSEI
760 770 780 790 800
ESDSLALRQV RAILEDLGLT LTSDDALMVL EVCQAVSRRA AQLCGAGVAA
810 820 830 840 850
VVEKIRENRG LQELTVSVGV DGTLYKLHPH FSKLVSATVR KLAPQCTVTF
860 870
LQSEDGSGKG AALVTAVACR LTQMAHV
Length:877
Mass (Da):95,424
Last modified:April 5, 2011 - v1
Checksum:i85B718A47ACA24CE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC154610 Genomic DNA. No translation available.
RefSeqiNP_001193320.1. NM_001206391.1.
UniGeneiMm.267479.

Genome annotation databases

EnsembliENSMUST00000123097; ENSMUSP00000116717; ENSMUSG00000025877.
GeneIDi212032.
KEGGimmu:212032.
UCSCiuc007qps.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC154610 Genomic DNA. No translation available.
RefSeqiNP_001193320.1. NM_001206391.1.
UniGeneiMm.267479.

3D structure databases

ProteinModelPortaliE9Q8S8.
SMRiE9Q8S8. Positions 35-873.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000051215.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000123097; ENSMUSP00000116717; ENSMUSG00000025877.
GeneIDi212032.
KEGGimmu:212032.
UCSCiuc007qps.2. mouse.

Organism-specific databases

CTDi3101.
MGIiMGI:2670962. Hk3.

Phylogenomic databases

GeneTreeiENSGT00390000017159.
KOiK00844.

Miscellaneous databases

NextBioi373427.
SOURCEiSearch...

Gene expression databases

BgeeiE9Q8S8.
ExpressionAtlasiE9Q8S8. baseline and differential.
GenevisibleiE9Q8S8. MM.

Family and domain databases

InterProiIPR001312. Hexokinase.
IPR019807. Hexokinase_BS.
IPR022673. Hexokinase_C.
IPR022672. Hexokinase_N.
[Graphical view]
PANTHERiPTHR19443. PTHR19443. 1 hit.
PfamiPF00349. Hexokinase_1. 2 hits.
PF03727. Hexokinase_2. 1 hit.
[Graphical view]
PROSITEiPS00378. HEXOKINASE_1. 2 hits.
PS51748. HEXOKINASE_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  3. Ensembl
    Submitted (MAY-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiE9Q8S8_MOUSE
AccessioniPrimary (citable) accession number: E9Q8S8
Entry historyi
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: June 24, 2015
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.