Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Anion exchange protein

Gene

Slc4a4

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Ion transportUniRule annotation, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Anion exchange proteinUniRule annotation
Gene namesi
Name:Slc4a4Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1927555. Slc4a4.

Subcellular locationi

  • Membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei469 – 49224HelicalUniRule annotationAdd
BLAST
Transmembranei504 – 53330HelicalUniRule annotationAdd
BLAST
Transmembranei553 – 57119HelicalUniRule annotationAdd
BLAST
Transmembranei726 – 74823HelicalUniRule annotationAdd
BLAST
Transmembranei777 – 79721HelicalUniRule annotationAdd
BLAST
Transmembranei818 – 84225HelicalUniRule annotationAdd
BLAST
Transmembranei878 – 89720HelicalUniRule annotationAdd
BLAST
Transmembranei904 – 92320HelicalUniRule annotationAdd
BLAST
Transmembranei955 – 98632HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

MaxQBiE9Q8N8.
PaxDbiE9Q8N8.
PeptideAtlasiE9Q8N8.
PRIDEiE9Q8N8.

PTM databases

iPTMnetiE9Q8N8.

Expressioni

Gene expression databases

BgeeiENSMUSG00000060961.
ExpressionAtlasiE9Q8N8. baseline and differential.
GenevisibleiE9Q8N8. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000121744.

Structurei

3D structure databases

ProteinModelPortaliE9Q8N8.
SMRiE9Q8N8. Positions 107-382, 453-493.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini138 – 387250Band_3_cytoInterPro annotationAdd
BLAST
Domaini436 – 955520HCO3_cotranspInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the anion exchanger (TC 2.A.31) family. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

eggNOGiKOG1172. Eukaryota.
ENOG410XPHD. LUCA.
GeneTreeiENSGT00760000119021.
OMAiVCSFMAL.
OrthoDBiEOG091G01FT.
TreeFamiTF313630.

Family and domain databases

Gene3Di3.40.1100.10. 1 hit.
InterProiIPR013769. Band3_cytoplasmic_dom.
IPR011531. HCO3_transpt_C.
IPR003020. HCO3_transpt_euk.
IPR003024. Na/HCO3_transpt.
IPR016152. PTrfase/Anion_transptr.
[Graphical view]
PANTHERiPTHR11453. PTHR11453. 2 hits.
PfamiPF07565. Band_3_cyto. 1 hit.
PF00955. HCO3_cotransp. 1 hit.
[Graphical view]
PRINTSiPR01231. HCO3TRNSPORT.
PR01232. NAHCO3TRSPRT.
SUPFAMiSSF55804. SSF55804. 1 hit.
TIGRFAMsiTIGR00834. ae. 1 hit.

Sequencei

Sequence statusi: Complete.

E9Q8N8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEDEAVLDRG ASFLKHVCDE EEVEGHHTIY IGVHVPKSYR RRRRHKRKAG
60 70 80 90 100
HKEKKEKERI SENYSDKSDV ENADESSSSI LKPLISPAAE RIRFILGEED
110 120 130 140 150
DSPAPPQLFT ELDELLAVDG QEMEWKETAR WIKFEEKVEQ GGERWSKPHV
160 170 180 190 200
ATLSLHSLFE LRTCMEKGSI MLDREASSLP QLVEMIADHQ IETGLLKPDL
210 220 230 240 250
KDKVTYTLLR KHRHQTKKSN LRSLADIGKT VSSASRMFSN PDNGSPAMTH
260 270 280 290 300
RNLTSSSLND ISDKPEKDQL KNKFMKKLPR DAEASNVLVG EVDFLDTPFI
310 320 330 340 350
AFVRLQQAVM LGALTEVPVP TRFLFILLGP KGKAKSYHEI GRAIATLMSD
360 370 380 390 400
EVFHDIAYKA KDRHDLIAGI DEFLDEVIVL PPGEWDPTIR IEPPKSLPSS
410 420 430 440 450
DKRKNMYSGG ENVQMNGDTP HDGGHGGGGH GDCEELQRTG RFCGGLIKDI
460 470 480 490 500
KRKAPFFASD FYDALNIQAL SAILFIYLAT VTNAITFGGL LGDATDNMQG
510 520 530 540 550
VLESFLGTAV SGAIFCLFAG QPLTILSSTG PVLVFERLLF NFSKDHNFDY
560 570 580 590 600
LEFRLWIGLW SAFMCLVLVA TDASFLVQYF TRFTEEGFSS LISFIFIYDA
610 620 630 640 650
FKKMIKLADY YPINSDFKVG YNTHFSCACL PPDPVNLSVS NDTTLAPEDL
660 670 680 690 700
PTISSTDMYH NVTFDWAYLS KKECVKYGGK LVGNNCDFVP DITLMSFILF
710 720 730 740 750
LGTYTSSMAM KKFKTSRYFP TTARKLISDF AIILSILIFC VIDALVGVDT
760 770 780 790 800
PKLIVPSEFK PTSPNRGWFV PPFGGNPWWV CLAAAIPALL VTILIFMDQQ
810 820 830 840 850
ITAVIVNRKE HKLKKGAGYH LDLFWVAILM VVCSFMALPW YVAATVISIA
860 870 880 890 900
HIDSLKMETE TSAPGEQPKF LGVREQRVTG TLVFILTGLS VFMAPILKFI
910 920 930 940 950
PMPVLYGVFL YMGVASLNGV QFMDRLKLLL MPLKHQPDFI YLRHVPLRRV
960 970 980 990 1000
HLFTFLQVLC LALLWILKST VAAIIFPVMI LALVAVRKGM DYLFSQHDLS
1010 1020 1030 1040 1050
FLDDVIPEKD KKKKEDEKKK KKKKGSLDSD NDDEKDPQHS SNATHHADKI
1060 1070 1080 1090
PFLESLGLPS PPRTPVKVVP QIRIEREPED NDYLWRSKGT ETTL
Length:1,094
Mass (Da):123,086
Last modified:April 5, 2011 - v1
Checksum:i649CCCA17865934C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC140492 Genomic DNA. No translation available.
AC162690 Genomic DNA. No translation available.
AC165240 Genomic DNA. No translation available.
RefSeqiNP_001129732.1. NM_001136260.1.
UniGeneiMm.41044.

Genome annotation databases

EnsembliENSMUST00000156238; ENSMUSP00000121744; ENSMUSG00000060961.
GeneIDi54403.
UCSCiuc008yaj.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC140492 Genomic DNA. No translation available.
AC162690 Genomic DNA. No translation available.
AC165240 Genomic DNA. No translation available.
RefSeqiNP_001129732.1. NM_001136260.1.
UniGeneiMm.41044.

3D structure databases

ProteinModelPortaliE9Q8N8.
SMRiE9Q8N8. Positions 107-382, 453-493.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000121744.

PTM databases

iPTMnetiE9Q8N8.

Proteomic databases

MaxQBiE9Q8N8.
PaxDbiE9Q8N8.
PeptideAtlasiE9Q8N8.
PRIDEiE9Q8N8.

Protocols and materials databases

DNASUi54403.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000156238; ENSMUSP00000121744; ENSMUSG00000060961.
GeneIDi54403.
UCSCiuc008yaj.2. mouse.

Organism-specific databases

CTDi8671.
MGIiMGI:1927555. Slc4a4.

Phylogenomic databases

eggNOGiKOG1172. Eukaryota.
ENOG410XPHD. LUCA.
GeneTreeiENSGT00760000119021.
OMAiVCSFMAL.
OrthoDBiEOG091G01FT.
TreeFamiTF313630.

Miscellaneous databases

ChiTaRSiSlc4a4. mouse.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000060961.
ExpressionAtlasiE9Q8N8. baseline and differential.
GenevisibleiE9Q8N8. MM.

Family and domain databases

Gene3Di3.40.1100.10. 1 hit.
InterProiIPR013769. Band3_cytoplasmic_dom.
IPR011531. HCO3_transpt_C.
IPR003020. HCO3_transpt_euk.
IPR003024. Na/HCO3_transpt.
IPR016152. PTrfase/Anion_transptr.
[Graphical view]
PANTHERiPTHR11453. PTHR11453. 2 hits.
PfamiPF07565. Band_3_cyto. 1 hit.
PF00955. HCO3_cotransp. 1 hit.
[Graphical view]
PRINTSiPR01231. HCO3TRNSPORT.
PR01232. NAHCO3TRSPRT.
SUPFAMiSSF55804. SSF55804. 1 hit.
TIGRFAMsiTIGR00834. ae. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiE9Q8N8_MOUSE
AccessioniPrimary (citable) accession number: E9Q8N8
Entry historyi
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: September 7, 2016
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation
The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.