Nr3c1

Functionⁱ

GO - Molecular functionⁱ

DNA binding Source: InterPro
glucocorticoid receptor activity Source: InterPro
steroid binding Source: InterPro

Complete GO annotation...

GO - Biological processⁱ

regulation of transcription, DNA-templated Source: InterPro

Complete GO annotation...

Enzyme and pathway databases

Reactomeⁱ	R-MMU-3371497. HSP90 chaperone cycle for steroid hormone receptors (SHR). R-MMU-383280. Nuclear Receptor transcription pathway.

Reactomeⁱ

R-MMU-3371497. HSP90 chaperone cycle for steroid hormone receptors (SHR).
R-MMU-383280. Nuclear Receptor transcription pathway.

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: Glucocorticoid receptorImported
Gene namesⁱ	Name:Nr3c1Imported
Organismⁱ	Mus musculus (Mouse)Imported
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 18

Organism-specific databases

MGIⁱ	MGI:95824. Nr3c1.

Subcellular locationⁱ

GO - Cellular componentⁱ

nucleus Source: InterPro

Complete GO annotation...

PTM / Processingⁱ

Proteomic databases

PaxDbⁱ	E9Q8A6.
PeptideAtlas More...PeptideAtlasⁱ	E9Q8A6.

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000024431.
ExpressionAtlasⁱ	E9Q8A6. baseline and differential.

Structureⁱ

3D structure databases

SMRⁱ	E9Q8A6.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Phylogenomic databases

eggNOGⁱ	KOG3575. Eukaryota. ENOG410XRZC. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118887.

Family and domain databases

InterProⁱ	View protein in InterPro IPR001409. Glcrtcd_rcpt.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF02155. GCR. 2 hits.
PRINTSⁱ	PR00528. GLCORTICOIDR.

Sequenceⁱ

Sequence statusⁱ: Fragment.

E9Q8A6-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MDSKESLAPP GRDEVPSSLL GRGRGSVMDL YKTLRGGATV KVSASSPSVA 
        60         70         80         90        100
AASQADSKQQ RILLDFSKGS ASNAQQQQQQ QQQQQQQQQQ QPQPDLSKAV 
       110        120 
SLSMGLYMGE TETKVMGNDL GYPQQGQLG

Length:129

Mass (Da):13,796

Last modified:October 5, 2016 - v8

Checksum:ⁱC327A9A19DA3C9C3

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Non-terminal residueⁱ	129	Imported		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC007995 Genomic DNA. No translation available. AC124417 Genomic DNA. No translation available.

Select the link destinations:
EMBLⁱ
GenBankⁱ
DDBJⁱ

Links Updated

AC007995 Genomic DNA. No translation available.
AC124417 Genomic DNA. No translation available.

Genome annotation databases

Ensemblⁱ	ENSMUST00000124115; ENSMUSP00000119630; ENSMUSG00000024431.

Ensemblⁱ

ENSMUST00000124115; ENSMUSP00000119630; ENSMUSG00000024431.

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC007995 Genomic DNA. No translation available. AC124417 Genomic DNA. No translation available.

Select the link destinations:
EMBLⁱ
GenBankⁱ
DDBJⁱ

Links Updated

AC007995 Genomic DNA. No translation available.
AC124417 Genomic DNA. No translation available.

3D structure databases

SMRⁱ	E9Q8A6.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Proteomic databases

PaxDbⁱ	E9Q8A6.
PeptideAtlas More...PeptideAtlasⁱ	E9Q8A6.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000124115; ENSMUSP00000119630; ENSMUSG00000024431.

Ensemblⁱ

ENSMUST00000124115; ENSMUSP00000119630; ENSMUSG00000024431.

Organism-specific databases

MGIⁱ	MGI:95824. Nr3c1.

Phylogenomic databases

eggNOGⁱ	KOG3575. Eukaryota. ENOG410XRZC. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118887.

Enzyme and pathway databases

Reactomeⁱ	R-MMU-3371497. HSP90 chaperone cycle for steroid hormone receptors (SHR). R-MMU-383280. Nuclear Receptor transcription pathway.

Reactomeⁱ

R-MMU-3371497. HSP90 chaperone cycle for steroid hormone receptors (SHR).
R-MMU-383280. Nuclear Receptor transcription pathway.

Miscellaneous databases

ChiTaRSⁱ	Nr3c1. mouse.
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000024431.
ExpressionAtlasⁱ	E9Q8A6. baseline and differential.

Family and domain databases

InterProⁱ	View protein in InterPro IPR001409. Glcrtcd_rcpt.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF02155. GCR. 2 hits.
PRINTSⁱ	PR00528. GLCORTICOIDR.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	E9Q8A6_MOUSE
Accessionⁱ	E9Q8A6Primary (citable) accession number: E9Q8A6
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	April 5, 2011
	Last sequence update:	October 5, 2016
	Last modified:	July 5, 2017
	This is version 56 of the entry and version 8 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

Miscellaneousⁱ

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termⁱ

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - E9Q8A6 (E9Q8A6_MOUSE)

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Glucocorticoid receptor

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Caution

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Expressionⁱ

Structureⁱ

Family & Domainsⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ