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Protein
Submitted name:

Glucocorticoid receptor

Gene

Nr3c1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

  1. DNA binding Source: MGI
  2. glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity Source: MGI
  3. glucocorticoid receptor activity Source: MGI
  4. protein dimerization activity Source: MGI
  5. RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: MGI
  6. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: MGI
  7. sequence-specific DNA binding Source: MGI
  8. sequence-specific DNA binding transcription factor activity Source: MGI
  9. steroid binding Source: MGI
  10. steroid hormone binding Source: MGI

GO - Biological processi

  1. adrenal gland development Source: MGI
  2. cellular response to steroid hormone stimulus Source: MGI
  3. glucocorticoid metabolic process Source: MGI
  4. glucocorticoid receptor signaling pathway Source: MGI
  5. mammary gland duct morphogenesis Source: MGI
  6. maternal behavior Source: MGI
  7. negative regulation of glucocorticoid mediated signaling pathway Source: MGI
  8. positive regulation of neuron apoptotic process Source: MGI
  9. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  10. regulation of glucocorticoid biosynthetic process Source: MGI
  11. regulation of gluconeogenesis Source: MGI
  12. regulation of transcription, DNA-templated Source: MGI
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_276696. Nuclear Receptor transcription pathway.

Names & Taxonomyi

Protein namesi
Submitted name:
Glucocorticoid receptorImported
Gene namesi
Name:Nr3c1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:95824. Nr3c1.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: MGI
  2. cytosol Source: MGI
  3. intracellular Source: MGI
  4. membrane Source: MGI
  5. nucleoplasm Source: MGI
  6. nucleus Source: MGI
Complete GO annotation...

Expressioni

Gene expression databases

BgeeiE9Q8A6.
ExpressionAtlasiE9Q8A6. baseline and differential.

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00760000118887.

Family and domain databases

InterProiIPR001409. Glcrtcd_rcpt.
[Graphical view]
PfamiPF02155. GCR. 2 hits.
[Graphical view]
PRINTSiPR00528. GLCORTICOIDR.

Sequencei

Sequence statusi: Fragment.

E9Q8A6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSKESLAPP GRDEVPSSLL GRGRGSVMDL YKTLRGGATV KVSASSPSVA
60 70 80 90 100
AASQADSKQQ RILLDFSKGS ASNAQQQQQQ QQQQQQQQQQ QPQPDLSKAV
110 120
SLSMGLYMGE TETKVMGNDL GYPQQGQLG
Length:129
Mass (Da):13,796
Last modified:February 4, 2015 - v4
Checksum:iC327A9A19DA3C9C3
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei129 – 1291Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC007995 Genomic DNA. No translation available.
AC124417 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSMUST00000124115; ENSMUSP00000119630; ENSMUSG00000024431.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC007995 Genomic DNA. No translation available.
AC124417 Genomic DNA. No translation available.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000124115; ENSMUSP00000119630; ENSMUSG00000024431.

Organism-specific databases

MGIiMGI:95824. Nr3c1.

Phylogenomic databases

GeneTreeiENSGT00760000118887.

Enzyme and pathway databases

ReactomeiREACT_276696. Nuclear Receptor transcription pathway.

Miscellaneous databases

ChiTaRSiNr3c1. mouse.
NextBioi35555599.
SOURCEiSearch...

Gene expression databases

BgeeiE9Q8A6.
ExpressionAtlasiE9Q8A6. baseline and differential.

Family and domain databases

InterProiIPR001409. Glcrtcd_rcpt.
[Graphical view]
PfamiPF02155. GCR. 2 hits.
[Graphical view]
PRINTSiPR00528. GLCORTICOIDR.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  2. Ensembl
    Submitted (MAY-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiE9Q8A6_MOUSE
AccessioniPrimary (citable) accession number: E9Q8A6
Entry historyi
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: February 4, 2015
Last modified: April 1, 2015
This is version 36 of the entry and version 4 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.