Nr3c1

Functionⁱ

GO - Molecular functionⁱ

DNA binding Source: InterPro
glucocorticoid receptor activity Source: InterPro
steroid binding Source: InterPro

GO - Biological processⁱ

regulation of transcription, DNA-templated Source: InterPro

Complete GO annotation...

Enzyme and pathway databases

Reactomeⁱ	R-MMU-383280. Nuclear Receptor transcription pathway.

Reactomeⁱ

R-MMU-383280. Nuclear Receptor transcription pathway.

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: Glucocorticoid receptorImported Automatic assertion inferred from database entriesⁱ Ensembl:ENSMUSP00000119630
Gene namesⁱ	Name:Nr3c1Imported Automatic assertion inferred from database entriesⁱ Ensembl:ENSMUSP00000119630 MGI:95824
Organismⁱ	Mus musculus (Mouse)Imported Automatic assertion inferred from database entriesⁱ Ensembl:ENSMUSP00000119630 Proteomes:UP000000589
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 18

Organism-specific databases

MGIⁱ	MGI:95824. Nr3c1.

Subcellular locationⁱ

GO - Cellular componentⁱ

nucleus Source: InterPro

Complete GO annotation...

PTM / Processingⁱ

Proteomic databases

PaxDbⁱ	E9Q8A6.
PeptideAtlasⁱ	E9Q8A6.

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000024431.
ExpressionAtlasⁱ	E9Q8A6. baseline and differential.

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000025300.

STRINGⁱ

10090.ENSMUSP00000025300.

Family & Domainsⁱ

Phylogenomic databases

eggNOGⁱ	KOG3575. Eukaryota. ENOG410XRZC. LUCA.
GeneTreeⁱ	ENSGT00760000118887.

Family and domain databases

InterProⁱ	IPR001409. Glcrtcd_rcpt. [Graphical view]
Pfamⁱ	PF02155. GCR. 2 hits. [Graphical view]
PRINTSⁱ	PR00528. GLCORTICOIDR.

Sequenceⁱ

Sequence statusⁱ: Fragment.

E9Q8A6-1 [UniParc]FASTA Add to basket

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        10         20         30         40         50
MDSKESLAPP GRDEVPSSLL GRGRGSVMDL YKTLRGGATV KVSASSPSVA 
        60         70         80         90        100
AASQADSKQQ RILLDFSKGS ASNAQQQQQQ QQQQQQQQQQ QPQPDLSKAV 
       110        120        130
SLSMGLYMGE TETKVMGNDL GYPQQGQLGL

Length:130

Mass (Da):13,909

Last modified:February 17, 2016 - v7

Checksum:ⁱD15327A9A19DA3C9

GO

Experimental Info

Feature key	Position(s)	Length	Description	Graphical view	Feature identifier	Actions
Non-terminal residueⁱ	130 – 130	1	Imported Automatic assertion inferred from database entriesⁱ Ensembl:ENSMUSP00000119630

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC007995 Genomic DNA. No translation available. AC124417 Genomic DNA. No translation available.

Select the link destinations:
EMBLⁱ
GenBankⁱ
DDBJⁱ

Links Updated

AC007995 Genomic DNA. No translation available.
AC124417 Genomic DNA. No translation available.

Genome annotation databases

Ensemblⁱ	ENSMUST00000124115; ENSMUSP00000119630; ENSMUSG00000024431.

Ensemblⁱ

ENSMUST00000124115; ENSMUSP00000119630; ENSMUSG00000024431.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC007995 Genomic DNA. No translation available. AC124417 Genomic DNA. No translation available.

Select the link destinations:
EMBLⁱ
GenBankⁱ
DDBJⁱ

Links Updated

AC007995 Genomic DNA. No translation available.
AC124417 Genomic DNA. No translation available.

3D structure databases

ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000025300.

STRINGⁱ

10090.ENSMUSP00000025300.

Proteomic databases

PaxDbⁱ	E9Q8A6.
PeptideAtlasⁱ	E9Q8A6.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000124115; ENSMUSP00000119630; ENSMUSG00000024431.

Ensemblⁱ

ENSMUST00000124115; ENSMUSP00000119630; ENSMUSG00000024431.

Organism-specific databases

MGIⁱ	MGI:95824. Nr3c1.

Phylogenomic databases

eggNOGⁱ	KOG3575. Eukaryota. ENOG410XRZC. LUCA.
GeneTreeⁱ	ENSGT00760000118887.

Enzyme and pathway databases

Reactomeⁱ	R-MMU-383280. Nuclear Receptor transcription pathway.

Reactomeⁱ

R-MMU-383280. Nuclear Receptor transcription pathway.

Miscellaneous databases

ChiTaRSⁱ	Nr3c1. mouse.
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000024431.
ExpressionAtlasⁱ	E9Q8A6. baseline and differential.

Family and domain databases

InterProⁱ	IPR001409. Glcrtcd_rcpt. [Graphical view]
Pfamⁱ	PF02155. GCR. 2 hits. [Graphical view]
PRINTSⁱ	PR00528. GLCORTICOIDR.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ

E9Q8A6_MOUSE

Accessionⁱ

Primary (citable) accession number: E9Q8A6

Entry historyⁱ

Integrated into UniProtKB/TrEMBL:	April 5, 2011
Last sequence update:	February 17, 2016
Last modified:	September 7, 2016
This is version 48 of the entry and version 7 of the sequence. [Complete history]

Entry statusⁱ

Unreviewed (UniProtKB/TrEMBL)

Miscellaneousⁱ

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termⁱ

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - E9Q8A6 (E9Q8A6_MOUSE)

UniProt

E9Q8A6 - E9Q8A6_MOUSE

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Glucocorticoid receptor

Select a section on the left to see content.

<p>Provides any useful information about the protein, mostly biological knowledge.</p><p><a href='../manual/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:</p><p><a href='../manual/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:</p><p><a href='../manual/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>Provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.</p><p><a href='../manual/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>Provides information on the location and the topology of the mature protein in the cell.</p><p><a href='../manual/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:</p><p><a href='../manual/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>Describes post-translational modifications (PTMs) and/or processing events.</p><p><a href='../manual/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

<p>Provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.</p><p><a href='../manual/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>Provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.</p><p><a href='../manual/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>Provides information on sequence similarities with other proteins and the domain(s) present in a protein.</p><p><a href='../manual/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Phylogenomic databases

Family and domain databases

<p>Displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.</p><p><a href='../manual/sequences_section' target='_top'>More...</a></p>Sequencei

Experimental Info

Sequence databases

Genome annotation databases

<p>Is used to point to information related to entries and found in data collections other than UniProtKB.</p><p><a href='../manual/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>Provides general information on the entry.</p><p><a href='../manual/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>Contains any relevant information that doesn’t fit in any other defined sections</p><p><a href='../manual/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Caution

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Family & Domainsⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ