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Protein
Submitted name:

Glucocorticoid receptor

Gene

Nr3c1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • adrenal gland development Source: MGI
  • cellular response to steroid hormone stimulus Source: MGI
  • glucocorticoid metabolic process Source: MGI
  • glucocorticoid receptor signaling pathway Source: MGI
  • mammary gland duct morphogenesis Source: MGI
  • maternal behavior Source: MGI
  • negative regulation of glucocorticoid mediated signaling pathway Source: MGI
  • positive regulation of neuron apoptotic process Source: MGI
  • positive regulation of transcription from RNA polymerase II promoter Source: MGI
  • regulation of glucocorticoid biosynthetic process Source: MGI
  • regulation of gluconeogenesis Source: MGI
  • regulation of transcription, DNA-templated Source: MGI
  • transcription from RNA polymerase II promoter Source: GOC
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_276696. Nuclear Receptor transcription pathway.

Names & Taxonomyi

Protein namesi
Submitted name:
Glucocorticoid receptorImported
Gene namesi
Name:Nr3c1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:95824. Nr3c1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: MGI
  • cytosol Source: MGI
  • intracellular Source: MGI
  • membrane Source: MGI
  • nucleoplasm Source: MGI
  • nucleus Source: MGI
Complete GO annotation...

Expressioni

Gene expression databases

BgeeiE9Q8A6.
ExpressionAtlasiE9Q8A6. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000025300.

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00760000118887.

Family and domain databases

InterProiIPR001409. Glcrtcd_rcpt.
[Graphical view]
PfamiPF02155. GCR. 1 hit.
[Graphical view]
PRINTSiPR00528. GLCORTICOIDR.

Sequencei

Sequence statusi: Fragment.

E9Q8A6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSKESLAPP GRDEVPSSLL GRGRGSVMDL YKTLRGGATV KVSASSPSVA
60 70 80 90 100
AASQADSKQQ RILLDFSKGS ASNAQQQQQQ QQQQQQQQQQ QPQPDLSKAV
110 120 130
SLSMGLYMGE TETKVMGNDL GYPQQGQLGL
Length:130
Mass (Da):13,909
Last modified:May 27, 2015 - v5
Checksum:iD15327A9A19DA3C9
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei130 – 1301Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC007995 Genomic DNA. No translation available.
AC124417 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSMUST00000124115; ENSMUSP00000119630; ENSMUSG00000024431.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC007995 Genomic DNA. No translation available.
AC124417 Genomic DNA. No translation available.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000025300.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000124115; ENSMUSP00000119630; ENSMUSG00000024431.

Organism-specific databases

MGIiMGI:95824. Nr3c1.

Phylogenomic databases

GeneTreeiENSGT00760000118887.

Enzyme and pathway databases

ReactomeiREACT_276696. Nuclear Receptor transcription pathway.

Miscellaneous databases

ChiTaRSiNr3c1. mouse.
NextBioi35555599.
SOURCEiSearch...

Gene expression databases

BgeeiE9Q8A6.
ExpressionAtlasiE9Q8A6. baseline and differential.

Family and domain databases

InterProiIPR001409. Glcrtcd_rcpt.
[Graphical view]
PfamiPF02155. GCR. 1 hit.
[Graphical view]
PRINTSiPR00528. GLCORTICOIDR.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  3. Ensembl
    Submitted (MAY-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiE9Q8A6_MOUSE
AccessioniPrimary (citable) accession number: E9Q8A6
Entry historyi
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: May 27, 2015
Last modified: July 22, 2015
This is version 39 of the entry and version 5 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.