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E9Q876

- E9Q876_MOUSE

UniProt

E9Q876 - E9Q876_MOUSE

Protein
Submitted name:

Protein Abca12

Gene

Abca12

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 29 (01 Oct 2014)
      Sequence version 1 (05 Apr 2011)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. ATPase activity Source: InterPro
    2. ATP binding Source: UniProtKB-KW
    3. protein binding Source: MGI

    GO - Biological processi

    1. ceramide transport Source: MGI
    2. establishment of skin barrier Source: MGI
    3. keratinization Source: MGI
    4. keratinocyte differentiation Source: MGI
    5. lipid homeostasis Source: MGI
    6. lung alveolus development Source: MGI
    7. positive regulation of cholesterol efflux Source: MGI
    8. positive regulation of protein localization to cell surface Source: MGI
    9. surfactant homeostasis Source: MGI

    Keywords - Ligandi

    ATP-bindingUniRule annotation, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Protein Abca12Imported
    Gene namesi
    Name:Abca12Imported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 1

    Organism-specific databases

    MGIiMGI:2676312. Abca12.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: MGI
    2. mitochondrial inner membrane Source: MGI

    Expressioni

    Gene expression databases

    BgeeiE9Q876.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ABC transporter superfamily.UniRule annotation

    Phylogenomic databases

    GeneTreeiENSGT00750000117526.
    KOiK05646.
    OMAiGMAAPWY.
    OrthoDBiEOG78D7J6.
    PhylomeDBiE9Q876.
    TreeFamiTF105191.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    InterProiIPR003593. AAA+_ATPase.
    IPR026082. ABC_A.
    IPR003439. ABC_transporter-like.
    IPR017871. ABC_transporter_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PANTHERiPTHR19229. PTHR19229. 1 hit.
    PfamiPF00005. ABC_tran. 2 hits.
    [Graphical view]
    SMARTiSM00382. AAA. 2 hits.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 2 hits.
    PROSITEiPS00211. ABC_TRANSPORTER_1. 1 hit.
    PS50893. ABC_TRANSPORTER_2. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    E9Q876-1 [UniParc]FASTAAdd to Basket

    « Hide

    MASQFHQLRI LVWKNWLGVK RQPLWTLVLI LWPVIIFIIL AITRTKFPPT     50
    AKPTCYLAPR NLPSAGFFPF LQTLLCDTDS KCKDTPYGPR DLLRRKGIDG 100
    PLFKESEILK KPSNPKRDSN LSLRSTQVPE RSHTSLATVP PRPSYDLEGT 150
    GTENFNGSQL LTRILGLEKL LKQNSTPEDI RRELCESYPG YTADYAFSWV 200
    TLGKNVFNKF CLSNMTLLES SLQELKYQVS QMSSDPDNQK RVFRGLVQVL 250
    SFFSQVQQQR EVWQLLSSLP DVFQNGTSLS SLFGVLQKAN RVLLVVQKVY 300
    PRVQTDEGFS TLQKSVKHLL NTLDSPMQGD NSTHAWSDDD EQTLSPSSLA 350
    AQLLILENFE DAILNISSNS PYSPYLACVR NMTDNLAKGS PDNLKLLQST 400
    IHFRKSFLQN GSSEDSFPPF LEILKSKLSQ LRNLTELLCE SETFSSIKKS 450
    CQFSNMSFER LCEDHAFHVQ LIEAAELGTD LTTGLLYHDN IISAKLRGLL 500
    TGDPSKINLN VDWLLEQALQ MNYLENITRL IPTVEAMLHV NTSADASEKP 550
    GQLREMFKNI DLLKEDLRAI GMSNTSIDKL LAIPIPDNRA EIISRVFWLH 600
    SCDTNVTNPK LEDAMKEFCK LPLPERSHQS YLIGLTLLHY LDIYNFTYKV 650
    FFPRKDQKPM ERMMELFIKL REILNQLASG THPLLDKMRS LRQMHLPRSV 700
    PLTQAMYRNT RMNSPAGSFS TISQALCSQG ITTEYLTAML PSSQKPKGNH 750
    TKDFLTYKLT KEEIASKYGI PLNATPFCFS LYKDIINMPA GPVIWAFLKP 800
    MLLGKILYSP YNPTTKAIME KSNVTLRQLA ELREKSQEWM DKSPIFMNSF 850
    HLLNQTIPML QNTLRNPFVQ VFVKFSVGLD AVELLKQIDD LDVLRLKLVN 900
    NIDIIDQLNT LSSLTVNISS CVLYDRIQAS DTVEEMETVA EQLYKSNELF 950
    GSVIFKLPSN GSLHRGFDPE KVSLPPIVRY TIRMSLKTAQ TTRSIRTKIW 1000
    APGPHNSPSH NQIYGRAFIY LQDSIERAII ELQTGRNSQE VAVQVQAVPY 1050
    PCFMKDNFLT SVSYSLPIVL MVAWVVFIAA FVKKLVYEKD LRLHEYMKMM 1100
    GVNSCSHFFA WLIESIGFLL VTIAILIVIL KFGNILPKTN GFILFLYFSD 1150
    YSFSVIAMSY LISVFFNNTN IAALIGSLIY VIAFFPFIVL VTVEDELSYV 1200
    IKVFMSLLSP TAFSYASQYI ARYEEQGVGL QWENMYKSPV QDDTTSFGWL 1250
    CCLILADSFI YFFIAWYVRN VFPGTYGMAA PWYFPILPSY WKERFGCAEV 1300
    KHEKSNGLMF TNIMMQNTNP SASKTSPDCA FPSNIEPEPK DLQVGVALHG 1350
    VTKIYGSKTA VENLNLNFYE GHITSLLGPN GAGKTTTISM LTGLFGATAG 1400
    TIFVYGKDIK TDLNTVRKNM GVCMQHDVLF SYLTTKEHLL LYGSIKVPHW 1450
    TKTQLHEEVK RTLKDTGLYS HRHKRVGTLS GGMKRKLSIS IALIGGSRVV 1500
    ILDEPSTGVD PCSRRSIWDV ISKNKTARTI ILSTHHLDEA EVLSDRIAFL 1550
    EQGGLRCCGS PFYLKEAFGD GYHLTLTKKK SPNLDTNAIC DTVAVTAMIQ 1600
    SHLPEAYLKE DIGGELVYVL PPFSTKVSGA YLSLLRALDK GMGKLNIGCY 1650
    GISDTTVEEV FLNLTKDSQK SSNMSLEHLT QRKVGNPSAN GTSTPDDLSV 1700
    SSSNFTDRDD KVLTRSEKLE GFGLLLKKIM AILIKRFHHT RRNWKGLIAQ 1750
    VILPIVFVAT AMGLGTLRDS SNSYPEIMIS PSIYGTSEQT AFYANFDPST 1800
    SGLVSALWNF PGIDNVCLNT SDLQCLKKDD LGKWNTSGEA IDNFGVCSCS 1850
    DNVQECPKFN YHPPHRRTYS SQVIYNLTGK HMENYLITTA NHFVQKRYGG 1900
    WSFGMKLTND LRFDVTAVPD NRTLAKVWYD PEGYHSLPAY LNSLNNFLLR 1950
    VNMSEYDAAR HGIIMYSHPY PGVQDQEQAT ISSLIDILVA LSILMGYSVT 2000
    TASFVTYIVR EHQTKAKQLQ HISGIGVTCY WVTNFIYDMV FYLVPVAFSI 2050
    GVIAIFKLPA FYSGNNLGAV SLLLLLFGYA TFSWMYLLAG LFHETGMAFI 2100
    TYVCVNLFFG INSIVSLSVV YFLSKEKPND PTLELISETL KRIFLIFPQF 2150
    CFGYGLIELS QQQAVLDFLK AYGVEYPSET FEMDKLGAMF VALVSQGTMF 2200
    FLLRLLINEW LIKKLRLFFR KFTSSPIMET VDEDEDVRAE RFRVESGAAE 2250
    FDLVQLHRLT KTYQLIHKKI IAVNNISLGI PAGECFGLLG VNGAGKTTIF 2300
    KMLTGDIIPS SGNILIRNKS GSLGHVDSHS SLVGYCPQED ALDDLVTVEE 2350
    HLYFYARVHG IPEKDIKDTV HKLLRRLHLM AYKDRSTSMC SYGTKRKLST 2400
    ALALIGKPSI LLLDEPSSGM DPKSKRHLWR IISEEVQNKC SVILTSHSME 2450
    ECEALCTRLA IMVNGRFQCI GSLQHIKSRF GRGFTVKVHL KNNKVSMETL 2500
    TKFMQLHFPK TYLKDQHLSM LEYHVPVTAG GVANIFDLLE TNKTALNITN 2550
    FLVSQTTLEE VFINFAKDQK SYENVDTSSQ GSTISVDSQE DQLDS 2595
    Length:2,595
    Mass (Da):292,592
    Last modified:April 5, 2011 - v1
    Checksum:i17D651731EC35D05
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC107789 Genomic DNA. No translation available.
    AC138589 Genomic DNA. No translation available.
    RefSeqiNP_780419.2. NM_175210.3.
    UniGeneiMm.159251.

    Genome annotation databases

    EnsembliENSMUST00000087268; ENSMUSP00000084523; ENSMUSG00000050296.
    GeneIDi74591.
    KEGGimmu:74591.
    UCSCiuc011wmq.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC107789 Genomic DNA. No translation available.
    AC138589 Genomic DNA. No translation available.
    RefSeqi NP_780419.2. NM_175210.3.
    UniGenei Mm.159251.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000087268 ; ENSMUSP00000084523 ; ENSMUSG00000050296 .
    GeneIDi 74591.
    KEGGi mmu:74591.
    UCSCi uc011wmq.1. mouse.

    Organism-specific databases

    CTDi 26154.
    MGIi MGI:2676312. Abca12.

    Phylogenomic databases

    GeneTreei ENSGT00750000117526.
    KOi K05646.
    OMAi GMAAPWY.
    OrthoDBi EOG78D7J6.
    PhylomeDBi E9Q876.
    TreeFami TF105191.

    Miscellaneous databases

    ChiTaRSi ABCA12. mouse.
    NextBioi 341173.
    PROi E9Q876.
    SOURCEi Search...

    Gene expression databases

    Bgeei E9Q876.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    InterProi IPR003593. AAA+_ATPase.
    IPR026082. ABC_A.
    IPR003439. ABC_transporter-like.
    IPR017871. ABC_transporter_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    PANTHERi PTHR19229. PTHR19229. 1 hit.
    Pfami PF00005. ABC_tran. 2 hits.
    [Graphical view ]
    SMARTi SM00382. AAA. 2 hits.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 2 hits.
    PROSITEi PS00211. ABC_TRANSPORTER_1. 1 hit.
    PS50893. ABC_TRANSPORTER_2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6JImported.
    2. Ensembl
      Submitted (MAY-2011) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: C57BL/6JImported.

    Entry informationi

    Entry nameiE9Q876_MOUSE
    AccessioniPrimary (citable) accession number: E9Q876
    Entry historyi
    Integrated into UniProtKB/TrEMBL: April 5, 2011
    Last sequence update: April 5, 2011
    Last modified: October 1, 2014
    This is version 29 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Caution

    The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3