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E9Q876

- E9Q876_MOUSE

UniProt

E9Q876 - E9Q876_MOUSE

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Protein
Submitted name: Protein Abca12
Gene
Abca12
Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. ATPase activity Source: InterPro
  3. protein binding Source: MGI

GO - Biological processi

  1. ceramide transport Source: MGI
  2. establishment of skin barrier Source: MGI
  3. keratinization Source: MGI
  4. keratinocyte differentiation Source: MGI
  5. lipid homeostasis Source: MGI
  6. lung alveolus development Source: MGI
  7. positive regulation of cholesterol efflux Source: MGI
  8. positive regulation of protein localization to cell surface Source: MGI
  9. surfactant homeostasis Source: MGI
Complete GO annotation...

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Protein Abca12Imported
Gene namesi
Name:Abca12Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 1

Organism-specific databases

MGIiMGI:2676312. Abca12.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: MGI
  2. mitochondrial inner membrane Source: MGI
Complete GO annotation...

Expressioni

Gene expression databases

BgeeiE9Q876.

Family & Domainsi

Sequence similaritiesi

Belongs to the ABC transporter superfamily.UniRule annotation

Phylogenomic databases

GeneTreeiENSGT00750000117526.
KOiK05646.
OMAiGMAAPWY.
OrthoDBiEOG78D7J6.
PhylomeDBiE9Q876.
TreeFamiTF105191.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR026082. ABC_A.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR19229. PTHR19229. 1 hit.
PfamiPF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E9Q876-1 [UniParc]FASTAAdd to Basket

« Hide

MASQFHQLRI LVWKNWLGVK RQPLWTLVLI LWPVIIFIIL AITRTKFPPT     50
AKPTCYLAPR NLPSAGFFPF LQTLLCDTDS KCKDTPYGPR DLLRRKGIDG 100
PLFKESEILK KPSNPKRDSN LSLRSTQVPE RSHTSLATVP PRPSYDLEGT 150
GTENFNGSQL LTRILGLEKL LKQNSTPEDI RRELCESYPG YTADYAFSWV 200
TLGKNVFNKF CLSNMTLLES SLQELKYQVS QMSSDPDNQK RVFRGLVQVL 250
SFFSQVQQQR EVWQLLSSLP DVFQNGTSLS SLFGVLQKAN RVLLVVQKVY 300
PRVQTDEGFS TLQKSVKHLL NTLDSPMQGD NSTHAWSDDD EQTLSPSSLA 350
AQLLILENFE DAILNISSNS PYSPYLACVR NMTDNLAKGS PDNLKLLQST 400
IHFRKSFLQN GSSEDSFPPF LEILKSKLSQ LRNLTELLCE SETFSSIKKS 450
CQFSNMSFER LCEDHAFHVQ LIEAAELGTD LTTGLLYHDN IISAKLRGLL 500
TGDPSKINLN VDWLLEQALQ MNYLENITRL IPTVEAMLHV NTSADASEKP 550
GQLREMFKNI DLLKEDLRAI GMSNTSIDKL LAIPIPDNRA EIISRVFWLH 600
SCDTNVTNPK LEDAMKEFCK LPLPERSHQS YLIGLTLLHY LDIYNFTYKV 650
FFPRKDQKPM ERMMELFIKL REILNQLASG THPLLDKMRS LRQMHLPRSV 700
PLTQAMYRNT RMNSPAGSFS TISQALCSQG ITTEYLTAML PSSQKPKGNH 750
TKDFLTYKLT KEEIASKYGI PLNATPFCFS LYKDIINMPA GPVIWAFLKP 800
MLLGKILYSP YNPTTKAIME KSNVTLRQLA ELREKSQEWM DKSPIFMNSF 850
HLLNQTIPML QNTLRNPFVQ VFVKFSVGLD AVELLKQIDD LDVLRLKLVN 900
NIDIIDQLNT LSSLTVNISS CVLYDRIQAS DTVEEMETVA EQLYKSNELF 950
GSVIFKLPSN GSLHRGFDPE KVSLPPIVRY TIRMSLKTAQ TTRSIRTKIW 1000
APGPHNSPSH NQIYGRAFIY LQDSIERAII ELQTGRNSQE VAVQVQAVPY 1050
PCFMKDNFLT SVSYSLPIVL MVAWVVFIAA FVKKLVYEKD LRLHEYMKMM 1100
GVNSCSHFFA WLIESIGFLL VTIAILIVIL KFGNILPKTN GFILFLYFSD 1150
YSFSVIAMSY LISVFFNNTN IAALIGSLIY VIAFFPFIVL VTVEDELSYV 1200
IKVFMSLLSP TAFSYASQYI ARYEEQGVGL QWENMYKSPV QDDTTSFGWL 1250
CCLILADSFI YFFIAWYVRN VFPGTYGMAA PWYFPILPSY WKERFGCAEV 1300
KHEKSNGLMF TNIMMQNTNP SASKTSPDCA FPSNIEPEPK DLQVGVALHG 1350
VTKIYGSKTA VENLNLNFYE GHITSLLGPN GAGKTTTISM LTGLFGATAG 1400
TIFVYGKDIK TDLNTVRKNM GVCMQHDVLF SYLTTKEHLL LYGSIKVPHW 1450
TKTQLHEEVK RTLKDTGLYS HRHKRVGTLS GGMKRKLSIS IALIGGSRVV 1500
ILDEPSTGVD PCSRRSIWDV ISKNKTARTI ILSTHHLDEA EVLSDRIAFL 1550
EQGGLRCCGS PFYLKEAFGD GYHLTLTKKK SPNLDTNAIC DTVAVTAMIQ 1600
SHLPEAYLKE DIGGELVYVL PPFSTKVSGA YLSLLRALDK GMGKLNIGCY 1650
GISDTTVEEV FLNLTKDSQK SSNMSLEHLT QRKVGNPSAN GTSTPDDLSV 1700
SSSNFTDRDD KVLTRSEKLE GFGLLLKKIM AILIKRFHHT RRNWKGLIAQ 1750
VILPIVFVAT AMGLGTLRDS SNSYPEIMIS PSIYGTSEQT AFYANFDPST 1800
SGLVSALWNF PGIDNVCLNT SDLQCLKKDD LGKWNTSGEA IDNFGVCSCS 1850
DNVQECPKFN YHPPHRRTYS SQVIYNLTGK HMENYLITTA NHFVQKRYGG 1900
WSFGMKLTND LRFDVTAVPD NRTLAKVWYD PEGYHSLPAY LNSLNNFLLR 1950
VNMSEYDAAR HGIIMYSHPY PGVQDQEQAT ISSLIDILVA LSILMGYSVT 2000
TASFVTYIVR EHQTKAKQLQ HISGIGVTCY WVTNFIYDMV FYLVPVAFSI 2050
GVIAIFKLPA FYSGNNLGAV SLLLLLFGYA TFSWMYLLAG LFHETGMAFI 2100
TYVCVNLFFG INSIVSLSVV YFLSKEKPND PTLELISETL KRIFLIFPQF 2150
CFGYGLIELS QQQAVLDFLK AYGVEYPSET FEMDKLGAMF VALVSQGTMF 2200
FLLRLLINEW LIKKLRLFFR KFTSSPIMET VDEDEDVRAE RFRVESGAAE 2250
FDLVQLHRLT KTYQLIHKKI IAVNNISLGI PAGECFGLLG VNGAGKTTIF 2300
KMLTGDIIPS SGNILIRNKS GSLGHVDSHS SLVGYCPQED ALDDLVTVEE 2350
HLYFYARVHG IPEKDIKDTV HKLLRRLHLM AYKDRSTSMC SYGTKRKLST 2400
ALALIGKPSI LLLDEPSSGM DPKSKRHLWR IISEEVQNKC SVILTSHSME 2450
ECEALCTRLA IMVNGRFQCI GSLQHIKSRF GRGFTVKVHL KNNKVSMETL 2500
TKFMQLHFPK TYLKDQHLSM LEYHVPVTAG GVANIFDLLE TNKTALNITN 2550
FLVSQTTLEE VFINFAKDQK SYENVDTSSQ GSTISVDSQE DQLDS 2595
Length:2,595
Mass (Da):292,592
Last modified:April 5, 2011 - v1
Checksum:i17D651731EC35D05
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC107789 Genomic DNA. No translation available.
AC138589 Genomic DNA. No translation available.
RefSeqiNP_780419.2. NM_175210.3.
UniGeneiMm.159251.

Genome annotation databases

EnsembliENSMUST00000087268; ENSMUSP00000084523; ENSMUSG00000050296.
GeneIDi74591.
KEGGimmu:74591.
UCSCiuc011wmq.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC107789 Genomic DNA. No translation available.
AC138589 Genomic DNA. No translation available.
RefSeqi NP_780419.2. NM_175210.3.
UniGenei Mm.159251.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000087268 ; ENSMUSP00000084523 ; ENSMUSG00000050296 .
GeneIDi 74591.
KEGGi mmu:74591.
UCSCi uc011wmq.1. mouse.

Organism-specific databases

CTDi 26154.
MGIi MGI:2676312. Abca12.

Phylogenomic databases

GeneTreei ENSGT00750000117526.
KOi K05646.
OMAi GMAAPWY.
OrthoDBi EOG78D7J6.
PhylomeDBi E9Q876.
TreeFami TF105191.

Miscellaneous databases

ChiTaRSi ABCA12. mouse.
NextBioi 341173.
PROi E9Q876.
SOURCEi Search...

Gene expression databases

Bgeei E9Q876.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
InterProi IPR003593. AAA+_ATPase.
IPR026082. ABC_A.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
PANTHERi PTHR19229. PTHR19229. 1 hit.
Pfami PF00005. ABC_tran. 2 hits.
[Graphical view ]
SMARTi SM00382. AAA. 2 hits.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 2 hits.
PROSITEi PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  2. Ensembl
    Submitted (MAY-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiE9Q876_MOUSE
AccessioniPrimary (citable) accession number: E9Q876
Entry historyi
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: July 9, 2014
This is version 28 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3