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Protein
Submitted name:

ATP-binding cassette, sub-family A (ABC1), member 12

Gene

Abca12

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Protein predictedi

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi1378 – 1385ATPPROSITE-ProRule annotation8
Nucleotide bindingi2290 – 2297ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

  • ceramide transport Source: MGI
  • establishment of skin barrier Source: MGI
  • keratinization Source: MGI
  • keratinocyte differentiation Source: MGI
  • lipid homeostasis Source: MGI
  • lipid transport Source: MGI
  • lung alveolus development Source: MGI
  • phospholipid efflux Source: MGI
  • positive regulation of cholesterol efflux Source: MGI
  • positive regulation of protein localization to cell surface Source: MGI
  • protein localization to plasma membrane Source: MGI
  • regulated exocytosis Source: MGI
  • secretion by cell Source: MGI
  • surfactant homeostasis Source: MGI

Keywordsi

LigandATP-bindingPROSITE-ProRule annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-1369062 ABC transporters in lipid homeostasis

Names & Taxonomyi

Protein namesi
Submitted name:
ATP-binding cassette, sub-family A (ABC1), member 12Imported
Gene namesi
Name:Abca12Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:2676312 Abca12

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei24 – 43HelicalSequence analysisAdd BLAST20
Transmembranei1064 – 1087HelicalSequence analysisAdd BLAST24
Transmembranei1108 – 1130HelicalSequence analysisAdd BLAST23
Transmembranei1142 – 1166HelicalSequence analysisAdd BLAST25
Transmembranei1173 – 1193HelicalSequence analysisAdd BLAST21
Transmembranei1247 – 1268HelicalSequence analysisAdd BLAST22
Transmembranei1987 – 2009HelicalSequence analysisAdd BLAST23
Transmembranei2043 – 2062HelicalSequence analysisAdd BLAST20
Transmembranei2069 – 2087HelicalSequence analysisAdd BLAST19
Transmembranei2099 – 2123HelicalSequence analysisAdd BLAST25
Transmembranei2186 – 2207HelicalSequence analysisAdd BLAST22

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PaxDbiE9Q876
PRIDEiE9Q876

PTM databases

iPTMnetiE9Q876
PhosphoSitePlusiE9Q876

Expressioni

Gene expression databases

BgeeiENSMUSG00000050296
GenevisibleiE9Q876 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000084523

Structurei

3D structure databases

SMRiE9Q876
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1346 – 1577ABC transporterInterPro annotationAdd BLAST232
Domaini2254 – 2489ABC transporterInterPro annotationAdd BLAST236

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG0059 Eukaryota
COG1131 LUCA
GeneTreeiENSGT00760000118965
InParanoidiE9Q876
KOiK05646
OMAiNYSPPHR
OrthoDBiEOG091G007E
PhylomeDBiE9Q876
TreeFamiTF105191

Family and domain databases

InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR026082 ABCA
IPR030371 ABCA12
IPR027417 P-loop_NTPase
PANTHERiPTHR19229 PTHR19229, 1 hit
PTHR19229:SF29 PTHR19229:SF29, 1 hit
PfamiView protein in Pfam
PF00005 ABC_tran, 2 hits
SMARTiView protein in SMART
SM00382 AAA, 2 hits
SUPFAMiSSF52540 SSF52540, 2 hits
PROSITEiView protein in PROSITE
PS00211 ABC_TRANSPORTER_1, 1 hit
PS50893 ABC_TRANSPORTER_2, 2 hits

Sequencei

Sequence statusi: Complete.

E9Q876-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASQFHQLRI LVWKNWLGVK RQPLWTLVLI LWPVIIFIIL AITRTKFPPT
60 70 80 90 100
AKPTCYLAPR NLPSAGFFPF LQTLLCDTDS KCKDTPYGPR DLLRRKGIDG
110 120 130 140 150
PLFKESEILK KPSNPKRDSN LSLRSTQVPE RSHTSLATVP PRPSYDLEGT
160 170 180 190 200
GTENFNGSQL LTRILGLEKL LKQNSTPEDI RRELCESYPG YTADYAFSWV
210 220 230 240 250
TLGKNVFNKF CLSNMTLLES SLQELKYQVS QMSSDPDNQK RVFRGLVQVL
260 270 280 290 300
SFFSQVQQQR EVWQLLSSLP DVFQNGTSLS SLFGVLQKAN RVLLVVQKVY
310 320 330 340 350
PRVQTDEGFS TLQKSVKHLL NTLDSPMQGD NSTHAWSDDD EQTLSPSSLA
360 370 380 390 400
AQLLILENFE DAILNISSNS PYSPYLACVR NMTDNLAKGS PDNLKLLQST
410 420 430 440 450
IHFRKSFLQN GSSEDSFPPF LEILKSKLSQ LRNLTELLCE SETFSSIKKS
460 470 480 490 500
CQFSNMSFER LCEDHAFHVQ LIEAAELGTD LTTGLLYHDN IISAKLRGLL
510 520 530 540 550
TGDPSKINLN VDWLLEQALQ MNYLENITRL IPTVEAMLHV NTSADASEKP
560 570 580 590 600
GQLREMFKNI DLLKEDLRAI GMSNTSIDKL LAIPIPDNRA EIISRVFWLH
610 620 630 640 650
SCDTNVTNPK LEDAMKEFCK LPLPERSHQS YLIGLTLLHY LDIYNFTYKV
660 670 680 690 700
FFPRKDQKPM ERMMELFIKL REILNQLASG THPLLDKMRS LRQMHLPRSV
710 720 730 740 750
PLTQAMYRNT RMNSPAGSFS TISQALCSQG ITTEYLTAML PSSQKPKGNH
760 770 780 790 800
TKDFLTYKLT KEEIASKYGI PLNATPFCFS LYKDIINMPA GPVIWAFLKP
810 820 830 840 850
MLLGKILYSP YNPTTKAIME KSNVTLRQLA ELREKSQEWM DKSPIFMNSF
860 870 880 890 900
HLLNQTIPML QNTLRNPFVQ VFVKFSVGLD AVELLKQIDD LDVLRLKLVN
910 920 930 940 950
NIDIIDQLNT LSSLTVNISS CVLYDRIQAS DTVEEMETVA EQLYKSNELF
960 970 980 990 1000
GSVIFKLPSN GSLHRGFDPE KVSLPPIVRY TIRMSLKTAQ TTRSIRTKIW
1010 1020 1030 1040 1050
APGPHNSPSH NQIYGRAFIY LQDSIERAII ELQTGRNSQE VAVQVQAVPY
1060 1070 1080 1090 1100
PCFMKDNFLT SVSYSLPIVL MVAWVVFIAA FVKKLVYEKD LRLHEYMKMM
1110 1120 1130 1140 1150
GVNSCSHFFA WLIESIGFLL VTIAILIVIL KFGNILPKTN GFILFLYFSD
1160 1170 1180 1190 1200
YSFSVIAMSY LISVFFNNTN IAALIGSLIY VIAFFPFIVL VTVEDELSYV
1210 1220 1230 1240 1250
IKVFMSLLSP TAFSYASQYI ARYEEQGVGL QWENMYKSPV QDDTTSFGWL
1260 1270 1280 1290 1300
CCLILADSFI YFFIAWYVRN VFPGTYGMAA PWYFPILPSY WKERFGCAEV
1310 1320 1330 1340 1350
KHEKSNGLMF TNIMMQNTNP SASKTSPDCA FPSNIEPEPK DLQVGVALHG
1360 1370 1380 1390 1400
VTKIYGSKTA VENLNLNFYE GHITSLLGPN GAGKTTTISM LTGLFGATAG
1410 1420 1430 1440 1450
TIFVYGKDIK TDLNTVRKNM GVCMQHDVLF SYLTTKEHLL LYGSIKVPHW
1460 1470 1480 1490 1500
TKTQLHEEVK RTLKDTGLYS HRHKRVGTLS GGMKRKLSIS IALIGGSRVV
1510 1520 1530 1540 1550
ILDEPSTGVD PCSRRSIWDV ISKNKTARTI ILSTHHLDEA EVLSDRIAFL
1560 1570 1580 1590 1600
EQGGLRCCGS PFYLKEAFGD GYHLTLTKKK SPNLDTNAIC DTVAVTAMIQ
1610 1620 1630 1640 1650
SHLPEAYLKE DIGGELVYVL PPFSTKVSGA YLSLLRALDK GMGKLNIGCY
1660 1670 1680 1690 1700
GISDTTVEEV FLNLTKDSQK SSNMSLEHLT QRKVGNPSAN GTSTPDDLSV
1710 1720 1730 1740 1750
SSSNFTDRDD KVLTRSEKLE GFGLLLKKIM AILIKRFHHT RRNWKGLIAQ
1760 1770 1780 1790 1800
VILPIVFVAT AMGLGTLRDS SNSYPEIMIS PSIYGTSEQT AFYANFDPST
1810 1820 1830 1840 1850
SGLVSALWNF PGIDNVCLNT SDLQCLKKDD LGKWNTSGEA IDNFGVCSCS
1860 1870 1880 1890 1900
DNVQECPKFN YHPPHRRTYS SQVIYNLTGK HMENYLITTA NHFVQKRYGG
1910 1920 1930 1940 1950
WSFGMKLTND LRFDVTAVPD NRTLAKVWYD PEGYHSLPAY LNSLNNFLLR
1960 1970 1980 1990 2000
VNMSEYDAAR HGIIMYSHPY PGVQDQEQAT ISSLIDILVA LSILMGYSVT
2010 2020 2030 2040 2050
TASFVTYIVR EHQTKAKQLQ HISGIGVTCY WVTNFIYDMV FYLVPVAFSI
2060 2070 2080 2090 2100
GVIAIFKLPA FYSGNNLGAV SLLLLLFGYA TFSWMYLLAG LFHETGMAFI
2110 2120 2130 2140 2150
TYVCVNLFFG INSIVSLSVV YFLSKEKPND PTLELISETL KRIFLIFPQF
2160 2170 2180 2190 2200
CFGYGLIELS QQQAVLDFLK AYGVEYPSET FEMDKLGAMF VALVSQGTMF
2210 2220 2230 2240 2250
FLLRLLINEW LIKKLRLFFR KFTSSPIMET VDEDEDVRAE RFRVESGAAE
2260 2270 2280 2290 2300
FDLVQLHRLT KTYQLIHKKI IAVNNISLGI PAGECFGLLG VNGAGKTTIF
2310 2320 2330 2340 2350
KMLTGDIIPS SGNILIRNKS GSLGHVDSHS SLVGYCPQED ALDDLVTVEE
2360 2370 2380 2390 2400
HLYFYARVHG IPEKDIKDTV HKLLRRLHLM AYKDRSTSMC SYGTKRKLST
2410 2420 2430 2440 2450
ALALIGKPSI LLLDEPSSGM DPKSKRHLWR IISEEVQNKC SVILTSHSME
2460 2470 2480 2490 2500
ECEALCTRLA IMVNGRFQCI GSLQHIKSRF GRGFTVKVHL KNNKVSMETL
2510 2520 2530 2540 2550
TKFMQLHFPK TYLKDQHLSM LEYHVPVTAG GVANIFDLLE TNKTALNITN
2560 2570 2580 2590
FLVSQTTLEE VFINFAKDQK SYENVDTSSQ GSTISVDSQE DQLDS
Length:2,595
Mass (Da):292,592
Last modified:April 5, 2011 - v1
Checksum:i17D651731EC35D05
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC107789 Genomic DNA No translation available.
AC138589 Genomic DNA No translation available.
RefSeqiNP_780419.2, NM_175210.3
UniGeneiMm.159251

Genome annotation databases

EnsembliENSMUST00000087268; ENSMUSP00000084523; ENSMUSG00000050296
GeneIDi74591
KEGGimmu:74591
UCSCiuc011wmq.1 mouse

Similar proteinsi

Entry informationi

Entry nameiE9Q876_MOUSE
AccessioniPrimary (citable) accession number: E9Q876
Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: March 28, 2018
This is version 59 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health