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E9Q876

- E9Q876_MOUSE

UniProt

E9Q876 - E9Q876_MOUSE

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Protein
Submitted name:

Protein Abca12

Gene

Abca12

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 4 out of 5- Protein inferred from homologyi

Functioni

GO - Molecular functioni

  1. ATPase activity Source: InterPro
  2. ATP binding Source: UniProtKB-KW
  3. lipid transporter activity Source: Ensembl

GO - Biological processi

  1. ceramide transport Source: MGI
  2. establishment of skin barrier Source: MGI
  3. keratinization Source: MGI
  4. keratinocyte differentiation Source: MGI
  5. lipid homeostasis Source: MGI
  6. lung alveolus development Source: MGI
  7. phospholipid efflux Source: Ensembl
  8. positive regulation of cholesterol efflux Source: MGI
  9. positive regulation of protein localization to cell surface Source: MGI
  10. protein localization to plasma membrane Source: Ensembl
  11. regulated secretory pathway Source: Ensembl
  12. surfactant homeostasis Source: MGI
Complete GO annotation...

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Protein Abca12Imported
Gene namesi
Name:Abca12Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 1

Organism-specific databases

MGIiMGI:2676312. Abca12.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: MGI
  2. epidermal lamellar body Source: Ensembl
  3. mitochondrial inner membrane Source: MGI
  4. plasma membrane Source: Ensembl
Complete GO annotation...

Expressioni

Gene expression databases

BgeeiE9Q876.

Family & Domainsi

Sequence similaritiesi

Belongs to the ABC transporter superfamily.UniRule annotation

Phylogenomic databases

GeneTreeiENSGT00760000118965.
InParanoidiE9Q876.
KOiK05646.
OMAiGMAAPWY.
OrthoDBiEOG78D7J6.
PhylomeDBiE9Q876.
TreeFamiTF105191.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR026082. ABC_A.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR19229. PTHR19229. 1 hit.
PfamiPF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E9Q876-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MASQFHQLRI LVWKNWLGVK RQPLWTLVLI LWPVIIFIIL AITRTKFPPT
60 70 80 90 100
AKPTCYLAPR NLPSAGFFPF LQTLLCDTDS KCKDTPYGPR DLLRRKGIDG
110 120 130 140 150
PLFKESEILK KPSNPKRDSN LSLRSTQVPE RSHTSLATVP PRPSYDLEGT
160 170 180 190 200
GTENFNGSQL LTRILGLEKL LKQNSTPEDI RRELCESYPG YTADYAFSWV
210 220 230 240 250
TLGKNVFNKF CLSNMTLLES SLQELKYQVS QMSSDPDNQK RVFRGLVQVL
260 270 280 290 300
SFFSQVQQQR EVWQLLSSLP DVFQNGTSLS SLFGVLQKAN RVLLVVQKVY
310 320 330 340 350
PRVQTDEGFS TLQKSVKHLL NTLDSPMQGD NSTHAWSDDD EQTLSPSSLA
360 370 380 390 400
AQLLILENFE DAILNISSNS PYSPYLACVR NMTDNLAKGS PDNLKLLQST
410 420 430 440 450
IHFRKSFLQN GSSEDSFPPF LEILKSKLSQ LRNLTELLCE SETFSSIKKS
460 470 480 490 500
CQFSNMSFER LCEDHAFHVQ LIEAAELGTD LTTGLLYHDN IISAKLRGLL
510 520 530 540 550
TGDPSKINLN VDWLLEQALQ MNYLENITRL IPTVEAMLHV NTSADASEKP
560 570 580 590 600
GQLREMFKNI DLLKEDLRAI GMSNTSIDKL LAIPIPDNRA EIISRVFWLH
610 620 630 640 650
SCDTNVTNPK LEDAMKEFCK LPLPERSHQS YLIGLTLLHY LDIYNFTYKV
660 670 680 690 700
FFPRKDQKPM ERMMELFIKL REILNQLASG THPLLDKMRS LRQMHLPRSV
710 720 730 740 750
PLTQAMYRNT RMNSPAGSFS TISQALCSQG ITTEYLTAML PSSQKPKGNH
760 770 780 790 800
TKDFLTYKLT KEEIASKYGI PLNATPFCFS LYKDIINMPA GPVIWAFLKP
810 820 830 840 850
MLLGKILYSP YNPTTKAIME KSNVTLRQLA ELREKSQEWM DKSPIFMNSF
860 870 880 890 900
HLLNQTIPML QNTLRNPFVQ VFVKFSVGLD AVELLKQIDD LDVLRLKLVN
910 920 930 940 950
NIDIIDQLNT LSSLTVNISS CVLYDRIQAS DTVEEMETVA EQLYKSNELF
960 970 980 990 1000
GSVIFKLPSN GSLHRGFDPE KVSLPPIVRY TIRMSLKTAQ TTRSIRTKIW
1010 1020 1030 1040 1050
APGPHNSPSH NQIYGRAFIY LQDSIERAII ELQTGRNSQE VAVQVQAVPY
1060 1070 1080 1090 1100
PCFMKDNFLT SVSYSLPIVL MVAWVVFIAA FVKKLVYEKD LRLHEYMKMM
1110 1120 1130 1140 1150
GVNSCSHFFA WLIESIGFLL VTIAILIVIL KFGNILPKTN GFILFLYFSD
1160 1170 1180 1190 1200
YSFSVIAMSY LISVFFNNTN IAALIGSLIY VIAFFPFIVL VTVEDELSYV
1210 1220 1230 1240 1250
IKVFMSLLSP TAFSYASQYI ARYEEQGVGL QWENMYKSPV QDDTTSFGWL
1260 1270 1280 1290 1300
CCLILADSFI YFFIAWYVRN VFPGTYGMAA PWYFPILPSY WKERFGCAEV
1310 1320 1330 1340 1350
KHEKSNGLMF TNIMMQNTNP SASKTSPDCA FPSNIEPEPK DLQVGVALHG
1360 1370 1380 1390 1400
VTKIYGSKTA VENLNLNFYE GHITSLLGPN GAGKTTTISM LTGLFGATAG
1410 1420 1430 1440 1450
TIFVYGKDIK TDLNTVRKNM GVCMQHDVLF SYLTTKEHLL LYGSIKVPHW
1460 1470 1480 1490 1500
TKTQLHEEVK RTLKDTGLYS HRHKRVGTLS GGMKRKLSIS IALIGGSRVV
1510 1520 1530 1540 1550
ILDEPSTGVD PCSRRSIWDV ISKNKTARTI ILSTHHLDEA EVLSDRIAFL
1560 1570 1580 1590 1600
EQGGLRCCGS PFYLKEAFGD GYHLTLTKKK SPNLDTNAIC DTVAVTAMIQ
1610 1620 1630 1640 1650
SHLPEAYLKE DIGGELVYVL PPFSTKVSGA YLSLLRALDK GMGKLNIGCY
1660 1670 1680 1690 1700
GISDTTVEEV FLNLTKDSQK SSNMSLEHLT QRKVGNPSAN GTSTPDDLSV
1710 1720 1730 1740 1750
SSSNFTDRDD KVLTRSEKLE GFGLLLKKIM AILIKRFHHT RRNWKGLIAQ
1760 1770 1780 1790 1800
VILPIVFVAT AMGLGTLRDS SNSYPEIMIS PSIYGTSEQT AFYANFDPST
1810 1820 1830 1840 1850
SGLVSALWNF PGIDNVCLNT SDLQCLKKDD LGKWNTSGEA IDNFGVCSCS
1860 1870 1880 1890 1900
DNVQECPKFN YHPPHRRTYS SQVIYNLTGK HMENYLITTA NHFVQKRYGG
1910 1920 1930 1940 1950
WSFGMKLTND LRFDVTAVPD NRTLAKVWYD PEGYHSLPAY LNSLNNFLLR
1960 1970 1980 1990 2000
VNMSEYDAAR HGIIMYSHPY PGVQDQEQAT ISSLIDILVA LSILMGYSVT
2010 2020 2030 2040 2050
TASFVTYIVR EHQTKAKQLQ HISGIGVTCY WVTNFIYDMV FYLVPVAFSI
2060 2070 2080 2090 2100
GVIAIFKLPA FYSGNNLGAV SLLLLLFGYA TFSWMYLLAG LFHETGMAFI
2110 2120 2130 2140 2150
TYVCVNLFFG INSIVSLSVV YFLSKEKPND PTLELISETL KRIFLIFPQF
2160 2170 2180 2190 2200
CFGYGLIELS QQQAVLDFLK AYGVEYPSET FEMDKLGAMF VALVSQGTMF
2210 2220 2230 2240 2250
FLLRLLINEW LIKKLRLFFR KFTSSPIMET VDEDEDVRAE RFRVESGAAE
2260 2270 2280 2290 2300
FDLVQLHRLT KTYQLIHKKI IAVNNISLGI PAGECFGLLG VNGAGKTTIF
2310 2320 2330 2340 2350
KMLTGDIIPS SGNILIRNKS GSLGHVDSHS SLVGYCPQED ALDDLVTVEE
2360 2370 2380 2390 2400
HLYFYARVHG IPEKDIKDTV HKLLRRLHLM AYKDRSTSMC SYGTKRKLST
2410 2420 2430 2440 2450
ALALIGKPSI LLLDEPSSGM DPKSKRHLWR IISEEVQNKC SVILTSHSME
2460 2470 2480 2490 2500
ECEALCTRLA IMVNGRFQCI GSLQHIKSRF GRGFTVKVHL KNNKVSMETL
2510 2520 2530 2540 2550
TKFMQLHFPK TYLKDQHLSM LEYHVPVTAG GVANIFDLLE TNKTALNITN
2560 2570 2580 2590
FLVSQTTLEE VFINFAKDQK SYENVDTSSQ GSTISVDSQE DQLDS
Length:2,595
Mass (Da):292,592
Last modified:April 5, 2011 - v1
Checksum:i17D651731EC35D05
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC107789 Genomic DNA. No translation available.
AC138589 Genomic DNA. No translation available.
RefSeqiNP_780419.2. NM_175210.3.
UniGeneiMm.159251.

Genome annotation databases

EnsembliENSMUST00000087268; ENSMUSP00000084523; ENSMUSG00000050296.
GeneIDi74591.
KEGGimmu:74591.
UCSCiuc011wmq.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC107789 Genomic DNA. No translation available.
AC138589 Genomic DNA. No translation available.
RefSeqi NP_780419.2. NM_175210.3.
UniGenei Mm.159251.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000087268 ; ENSMUSP00000084523 ; ENSMUSG00000050296 .
GeneIDi 74591.
KEGGi mmu:74591.
UCSCi uc011wmq.1. mouse.

Organism-specific databases

CTDi 26154.
MGIi MGI:2676312. Abca12.

Phylogenomic databases

GeneTreei ENSGT00760000118965.
InParanoidi E9Q876.
KOi K05646.
OMAi GMAAPWY.
OrthoDBi EOG78D7J6.
PhylomeDBi E9Q876.
TreeFami TF105191.

Miscellaneous databases

ChiTaRSi Abca12. mouse.
NextBioi 341173.
PROi E9Q876.
SOURCEi Search...

Gene expression databases

Bgeei E9Q876.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
InterProi IPR003593. AAA+_ATPase.
IPR026082. ABC_A.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
PANTHERi PTHR19229. PTHR19229. 1 hit.
Pfami PF00005. ABC_tran. 2 hits.
[Graphical view ]
SMARTi SM00382. AAA. 2 hits.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 2 hits.
PROSITEi PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  2. Ensembl
    Submitted (MAY-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiE9Q876_MOUSE
AccessioniPrimary (citable) accession number: E9Q876
Entry historyi
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: November 26, 2014
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3