E9Q876 (E9Q876_MOUSE) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Protein Abca12 Ensembl ENSMUSP00000084523

Gene names

Name:

Abca12 Ensembl ENSMUSP00000084523 MGI 2676312

Organism

Mus musculus (Mouse) [Reference proteome] Ensembl ENSMUSP00000084523

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	2595 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Sequence similarities	Belongs to the ABC transporter superfamily. RuleBase RU000684
Caution	The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data. Ensembl ENSMUSP00000084523

Ontologies

Keywords
Ligand	ATP-binding RuleBase RU003299 Nucleotide-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	ATP catabolic process Inferred from electronic annotation. Source: GOC ceramide transport Inferred from mutant phenotype PubMed 18957418. Source: MGI establishment of skin barrier Inferred from mutant phenotype PubMed 18632686PubMed 18802465PubMed 18957418. Source: MGI keratinization Inferred from mutant phenotype PubMed 18632686PubMed 18802465PubMed 18957418. Source: MGI lipid homeostasis Inferred from mutant phenotype PubMed 18802465. Source: MGI lung alveolus development Inferred from mutant phenotype PubMed 18632686. Source: MGI surfactant homeostasis Inferred from mutant phenotype PubMed 18632686. Source: MGI
Cellular_component	cytosol Inferred from direct assay PubMed 18632686. Source: MGI mitochondrial inner membrane Inferred from direct assay PubMed 12865426. Source: MGI
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ATPase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	E9Q876 [UniParc]. Last modified April 5, 2011. Version 1. Checksum: 17D651731EC35D05	FASTA	2,595	292,592
	10 20 30 40 50 60 MASQFHQLRI LVWKNWLGVK RQPLWTLVLI LWPVIIFIIL AITRTKFPPT AKPTCYLAPR 70 80 90 100 110 120 NLPSAGFFPF LQTLLCDTDS KCKDTPYGPR DLLRRKGIDG PLFKESEILK KPSNPKRDSN 130 140 150 160 170 180 LSLRSTQVPE RSHTSLATVP PRPSYDLEGT GTENFNGSQL LTRILGLEKL LKQNSTPEDI 190 200 210 220 230 240 RRELCESYPG YTADYAFSWV TLGKNVFNKF CLSNMTLLES SLQELKYQVS QMSSDPDNQK 250 260 270 280 290 300 RVFRGLVQVL SFFSQVQQQR EVWQLLSSLP DVFQNGTSLS SLFGVLQKAN RVLLVVQKVY 310 320 330 340 350 360 PRVQTDEGFS TLQKSVKHLL NTLDSPMQGD NSTHAWSDDD EQTLSPSSLA AQLLILENFE 370 380 390 400 410 420 DAILNISSNS PYSPYLACVR NMTDNLAKGS PDNLKLLQST IHFRKSFLQN GSSEDSFPPF 430 440 450 460 470 480 LEILKSKLSQ LRNLTELLCE SETFSSIKKS CQFSNMSFER LCEDHAFHVQ LIEAAELGTD 490 500 510 520 530 540 LTTGLLYHDN IISAKLRGLL TGDPSKINLN VDWLLEQALQ MNYLENITRL IPTVEAMLHV 550 560 570 580 590 600 NTSADASEKP GQLREMFKNI DLLKEDLRAI GMSNTSIDKL LAIPIPDNRA EIISRVFWLH 610 620 630 640 650 660 SCDTNVTNPK LEDAMKEFCK LPLPERSHQS YLIGLTLLHY LDIYNFTYKV FFPRKDQKPM 670 680 690 700 710 720 ERMMELFIKL REILNQLASG THPLLDKMRS LRQMHLPRSV PLTQAMYRNT RMNSPAGSFS 730 740 750 760 770 780 TISQALCSQG ITTEYLTAML PSSQKPKGNH TKDFLTYKLT KEEIASKYGI PLNATPFCFS 790 800 810 820 830 840 LYKDIINMPA GPVIWAFLKP MLLGKILYSP YNPTTKAIME KSNVTLRQLA ELREKSQEWM 850 860 870 880 890 900 DKSPIFMNSF HLLNQTIPML QNTLRNPFVQ VFVKFSVGLD AVELLKQIDD LDVLRLKLVN 910 920 930 940 950 960 NIDIIDQLNT LSSLTVNISS CVLYDRIQAS DTVEEMETVA EQLYKSNELF GSVIFKLPSN 970 980 990 1000 1010 1020 GSLHRGFDPE KVSLPPIVRY TIRMSLKTAQ TTRSIRTKIW APGPHNSPSH NQIYGRAFIY 1030 1040 1050 1060 1070 1080 LQDSIERAII ELQTGRNSQE VAVQVQAVPY PCFMKDNFLT SVSYSLPIVL MVAWVVFIAA 1090 1100 1110 1120 1130 1140 FVKKLVYEKD LRLHEYMKMM GVNSCSHFFA WLIESIGFLL VTIAILIVIL KFGNILPKTN 1150 1160 1170 1180 1190 1200 GFILFLYFSD YSFSVIAMSY LISVFFNNTN IAALIGSLIY VIAFFPFIVL VTVEDELSYV 1210 1220 1230 1240 1250 1260 IKVFMSLLSP TAFSYASQYI ARYEEQGVGL QWENMYKSPV QDDTTSFGWL CCLILADSFI 1270 1280 1290 1300 1310 1320 YFFIAWYVRN VFPGTYGMAA PWYFPILPSY WKERFGCAEV KHEKSNGLMF TNIMMQNTNP 1330 1340 1350 1360 1370 1380 SASKTSPDCA FPSNIEPEPK DLQVGVALHG VTKIYGSKTA VENLNLNFYE GHITSLLGPN 1390 1400 1410 1420 1430 1440 GAGKTTTISM LTGLFGATAG TIFVYGKDIK TDLNTVRKNM GVCMQHDVLF SYLTTKEHLL 1450 1460 1470 1480 1490 1500 LYGSIKVPHW TKTQLHEEVK RTLKDTGLYS HRHKRVGTLS GGMKRKLSIS IALIGGSRVV 1510 1520 1530 1540 1550 1560 ILDEPSTGVD PCSRRSIWDV ISKNKTARTI ILSTHHLDEA EVLSDRIAFL EQGGLRCCGS 1570 1580 1590 1600 1610 1620 PFYLKEAFGD GYHLTLTKKK SPNLDTNAIC DTVAVTAMIQ SHLPEAYLKE DIGGELVYVL 1630 1640 1650 1660 1670 1680 PPFSTKVSGA YLSLLRALDK GMGKLNIGCY GISDTTVEEV FLNLTKDSQK SSNMSLEHLT 1690 1700 1710 1720 1730 1740 QRKVGNPSAN GTSTPDDLSV SSSNFTDRDD KVLTRSEKLE GFGLLLKKIM AILIKRFHHT 1750 1760 1770 1780 1790 1800 RRNWKGLIAQ VILPIVFVAT AMGLGTLRDS SNSYPEIMIS PSIYGTSEQT AFYANFDPST 1810 1820 1830 1840 1850 1860 SGLVSALWNF PGIDNVCLNT SDLQCLKKDD LGKWNTSGEA IDNFGVCSCS DNVQECPKFN 1870 1880 1890 1900 1910 1920 YHPPHRRTYS SQVIYNLTGK HMENYLITTA NHFVQKRYGG WSFGMKLTND LRFDVTAVPD 1930 1940 1950 1960 1970 1980 NRTLAKVWYD PEGYHSLPAY LNSLNNFLLR VNMSEYDAAR HGIIMYSHPY PGVQDQEQAT 1990 2000 2010 2020 2030 2040 ISSLIDILVA LSILMGYSVT TASFVTYIVR EHQTKAKQLQ HISGIGVTCY WVTNFIYDMV 2050 2060 2070 2080 2090 2100 FYLVPVAFSI GVIAIFKLPA FYSGNNLGAV SLLLLLFGYA TFSWMYLLAG LFHETGMAFI 2110 2120 2130 2140 2150 2160 TYVCVNLFFG INSIVSLSVV YFLSKEKPND PTLELISETL KRIFLIFPQF CFGYGLIELS 2170 2180 2190 2200 2210 2220 QQQAVLDFLK AYGVEYPSET FEMDKLGAMF VALVSQGTMF FLLRLLINEW LIKKLRLFFR 2230 2240 2250 2260 2270 2280 KFTSSPIMET VDEDEDVRAE RFRVESGAAE FDLVQLHRLT KTYQLIHKKI IAVNNISLGI 2290 2300 2310 2320 2330 2340 PAGECFGLLG VNGAGKTTIF KMLTGDIIPS SGNILIRNKS GSLGHVDSHS SLVGYCPQED 2350 2360 2370 2380 2390 2400 ALDDLVTVEE HLYFYARVHG IPEKDIKDTV HKLLRRLHLM AYKDRSTSMC SYGTKRKLST 2410 2420 2430 2440 2450 2460 ALALIGKPSI LLLDEPSSGM DPKSKRHLWR IISEEVQNKC SVILTSHSME ECEALCTRLA 2470 2480 2490 2500 2510 2520 IMVNGRFQCI GSLQHIKSRF GRGFTVKVHL KNNKVSMETL TKFMQLHFPK TYLKDQHLSM 2530 2540 2550 2560 2570 2580 LEYHVPVTAG GVANIFDLLE TNKTALNITN FLVSQTTLEE VFINFAKDQK SYENVDTSSQ 2590 GSTISVDSQE DQLDS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J Ensembl ENSMUSP00000084523.
[2]	Ensembl Submitted (MAY-2011) to UniProtKB Cited for: IDENTIFICATION. Strain: C57BL/6J Ensembl ENSMUSP00000084523.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC107789 Genomic DNA. No translation available. AC138589 Genomic DNA. No translation available.
IPI	IPI00624357.
RefSeq	NP_780419.2. NM_175210.3.
UniGene	Mm.159251.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000087268; ENSMUSP00000084523; ENSMUSG00000050296.
GeneID	74591.
KEGG	mmu:74591.
Organism-specific databases
CTD	26154.
MGI	MGI:2676312. Abca12.
Phylogenomic databases
GeneTree	ENSGT00700000104262.
KO	K05646.
OMA	VCSCSEN.
Gene expression databases
Bgee	E9Q876.
Family and domain databases
InterPro	IPR003593. AAA+_ATPase. IPR026082. ABC_A. IPR003439. ABC_transporter-like. IPR017871. ABC_transporter_CS. [Graphical view]
PANTHER	PTHR19229. PTHR19229. 1 hit.
Pfam	PF00005. ABC_tran. 2 hits. [Graphical view]
SMART	SM00382. AAA. 2 hits. [Graphical view]
PROSITE	PS00211. ABC_TRANSPORTER_1. 1 hit. PS50893. ABC_TRANSPORTER_2. 2 hits. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	ABCA12. mouse.
NextBio	341173.
SOURCE	Search...

Entry information

Entry name

E9Q876_MOUSE

Accession

Primary (citable) accession number: E9Q876

Entry history

Integrated into UniProtKB/TrEMBL:	April 5, 2011
Last sequence update:	April 5, 2011
Last modified:	March 6, 2013
This is version 18 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)