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Protein

Cytochrome P450 2W1

Gene

Cyp2w1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Seems to have broad catalytic activity towards several chemicals, including polycyclic aromatic hydrocarbon dihydrodiols and aromatic amines. Actives also in the metabolism of indoline substrates and is able to activate aflatoxin B1 into cytotoxic products. Furthermore, it seems to be involved in the oxydation of lysophospholipids and fatty acids.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi436 – 4361Iron (heme axial ligand)By similarity

GO - Molecular functioni

  1. heme binding Source: GO_Central
  2. iron ion binding Source: InterPro
  3. oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen Source: GO_Central
  4. oxygen binding Source: GO_Central
  5. steroid hydroxylase activity Source: GO_Central

GO - Biological processi

  1. aflatoxin B1 metabolic process Source: UniProtKB
  2. exogenous drug catabolic process Source: GO_Central
  3. organic acid metabolic process Source: GO_Central
  4. oxidation-reduction process Source: GO_Central
  5. xenobiotic metabolic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_216259. Miscellaneous substrates.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 2W1 (EC:1.14.14.-)
Gene namesi
Name:Cyp2w1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 5

Organism-specific databases

MGIiMGI:3616076. Cyp2w1.

Subcellular locationi

Membrane By similarity. Endoplasmic reticulum lumen By similarity. Cell membrane By similarity

GO - Cellular componenti

  1. cell surface Source: UniProtKB
  2. cytoplasm Source: GO_Central
  3. endoplasmic reticulum lumen Source: UniProtKB
  4. intracellular membrane-bounded organelle Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence AnalysisAdd
BLAST
Chaini24 – 493470Cytochrome P450 2W1Sequence AnalysisPRO_0000431705Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi180 – 1801N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Expressioni

Tissue specificityi

Detected in colon, ileum, and testes.1 Publication

Gene expression databases

BgeeiE9Q816.

Structurei

3D structure databases

ProteinModelPortaliE9Q816.
SMRiE9Q816. Positions 33-492.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.UniRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

GeneTreeiENSGT00760000118775.
InParanoidiE9Q816.
KOiK07423.
OMAiWAPCNIT.
OrthoDBiEOG7RBZ85.
PhylomeDBiE9Q816.
TreeFamiTF352043.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

E9Q816-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MALLLLGVWG ILLLLGLWGL LQGCTRSPSL APRWPPGPRP LPFLGNLHLL
60 70 80 90 100
GVTQQDRALM ELSERYGPMF TIHLGSQKTV VLSGYEVVRE ALVGTGHELA
110 120 130 140 150
DRPPIPIFQH IQRGGGIFFS SGARWRAGRQ FTVRTLQSLG VQQPSMVGKV
160 170 180 190 200
LQELACLKGQ LDSYGGQPLP LALLGWAPCN ITFTLLFGQR FDYQDPVFVS
210 220 230 240 250
LLSLIDQVMV LLGSPGIQLF NTFPRLGAFL RLHRPVLSKI EEVRTILRTL
260 270 280 290 300
LETRRPPLPT GGPAQSYVEA LLQQGQEDDP EDMFGEANVL ACTLDMVMAG
310 320 330 340 350
TETTAATLQW AVFLMVKHPH VQGRVQEELD RVLGPGQLPQ PEHQRALPYT
360 370 380 390 400
SAVLHEVQRY ITLLPHVPRC TAADIQLGGY LLPKGTPVIP LLTSVLLDKT
410 420 430 440 450
QWETPSQFNP NHFLDAKGRF MKRGAFLPFS AGRRVCVGKS LARTELFLLF
460 470 480 490
AGLLQRYRLL PPPGLSPADL DLRPAPAFTM RPPAQTLCVV PRS
Length:493
Mass (Da):54,438
Last modified:April 5, 2011 - v1
Checksum:iBFD0F2958C443F62
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC161058 Genomic DNA. No translation available.
RefSeqiNP_001153737.1. NM_001160265.1.
UniGeneiMm.482474.

Genome annotation databases

EnsembliENSMUST00000031521; ENSMUSP00000031521; ENSMUSG00000029541.
GeneIDi545817.
KEGGimmu:545817.
UCSCiuc012efv.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC161058 Genomic DNA. No translation available.
RefSeqiNP_001153737.1. NM_001160265.1.
UniGeneiMm.482474.

3D structure databases

ProteinModelPortaliE9Q816.
SMRiE9Q816. Positions 33-492.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000031521; ENSMUSP00000031521; ENSMUSG00000029541.
GeneIDi545817.
KEGGimmu:545817.
UCSCiuc012efv.1. mouse.

Organism-specific databases

CTDi54905.
MGIiMGI:3616076. Cyp2w1.

Phylogenomic databases

GeneTreeiENSGT00760000118775.
InParanoidiE9Q816.
KOiK07423.
OMAiWAPCNIT.
OrthoDBiEOG7RBZ85.
PhylomeDBiE9Q816.
TreeFamiTF352043.

Enzyme and pathway databases

ReactomeiREACT_216259. Miscellaneous substrates.

Miscellaneous databases

NextBioi413022.
SOURCEiSearch...

Gene expression databases

BgeeiE9Q816.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. "Tissue distribution and gender-divergent expression of 78 cytochrome P450 mRNAs in mice."
    Renaud H.J., Cui J.Y., Khan M., Klaassen C.D.
    Toxicol. Sci. 124:261-277(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiCP2W1_MOUSE
AccessioniPrimary (citable) accession number: E9Q816
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 4, 2015
Last sequence update: April 5, 2011
Last modified: February 4, 2015
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.