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Protein

Voltage-dependent T-type calcium channel subunit alpha

Gene

Cacna1i

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite negative potentials, and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes.UniRule annotation

GO - Molecular functioni

GO - Biological processi

  • calcium ion import Source: InterPro
  • calcium ion transport Source: MGI
  • flagellated sperm motility Source: InterPro
  • membrane depolarization during action potential Source: GO_Central
  • neuronal action potential Source: MGI
  • positive regulation of calcium ion-dependent exocytosis Source: GO_Central
  • regulation of membrane potential Source: MGI
  • sleep Source: MGI

Keywordsi

Molecular functionCalcium channelUniRule annotation, Ion channel, Voltage-gated channelUniRule annotation
Biological processCalcium transport, Ion transport, Transport
LigandCalcium

Names & Taxonomyi

Protein namesi
Recommended name:
Voltage-dependent T-type calcium channel subunit alphaUniRule annotation
Gene namesi
Name:Cacna1iImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:2178051. Cacna1i.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei119 – 139HelicalSequence analysisAdd BLAST21
Transmembranei206 – 230HelicalSequence analysisAdd BLAST25
Transmembranei343 – 364HelicalSequence analysisAdd BLAST22
Transmembranei370 – 395HelicalSequence analysisAdd BLAST26
Transmembranei720 – 742HelicalSequence analysisAdd BLAST23
Transmembranei762 – 778HelicalSequence analysisAdd BLAST17
Transmembranei798 – 820HelicalSequence analysisAdd BLAST23
Transmembranei1130 – 1148HelicalSequence analysisAdd BLAST19
Transmembranei1168 – 1189HelicalSequence analysisAdd BLAST22
Transmembranei1201 – 1227HelicalSequence analysisAdd BLAST27
Transmembranei1265 – 1287HelicalSequence analysisAdd BLAST23
Transmembranei1366 – 1390HelicalSequence analysisAdd BLAST25
Transmembranei1446 – 1463HelicalSequence analysisAdd BLAST18
Transmembranei1483 – 1502HelicalSequence analysisAdd BLAST20
Transmembranei1581 – 1600HelicalSequence analysisAdd BLAST20
Transmembranei1667 – 1689HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

MaxQBiE9Q7P2.
PaxDbiE9Q7P2.
PRIDEiE9Q7P2.

PTM databases

iPTMnetiE9Q7P2.
PhosphoSitePlusiE9Q7P2.

Expressioni

Gene expression databases

BgeeiENSMUSG00000022416.
ExpressionAtlasiE9Q7P2. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000125063.

Structurei

3D structure databases

ProteinModelPortaliE9Q7P2.
SMRiE9Q7P2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini76 – 406Ion_transInterPro annotationAdd BLAST331
Domaini598 – 825Ion_transInterPro annotationAdd BLAST228
Domaini1128 – 1400Ion_transInterPro annotationAdd BLAST273
Domaini1446 – 1699Ion_transInterPro annotationAdd BLAST254

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili1399 – 1426Sequence analysisAdd BLAST28

Sequence similaritiesi

Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. [View classification]UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG2302. Eukaryota.
COG1226. LUCA.
GeneTreeiENSGT00830000128242.
InParanoidiE9Q7P2.
KOiK04856.
OMAiSPSVNCT.
OrthoDBiEOG091G02L1.
TreeFamiTF313555.

Family and domain databases

InterProiView protein in InterPro
IPR030162. CACNA1I.
IPR005821. Ion_trans_dom.
IPR005445. VDCC_T_a1.
IPR002077. VDCCAlpha1.
PANTHERiPTHR10037:SF209. PTHR10037:SF209. 1 hit.
PfamiView protein in Pfam
PF00520. Ion_trans. 4 hits.
PRINTSiPR00167. CACHANNEL.
PR01629. TVDCCALPHA1.

Sequencei

Sequence statusi: Complete.

E9Q7P2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADSNLPPSS SAAPDPEPGI TEQPGPRSPP PSPPGLEEPL DGTNPDVPHP
60 70 80 90 100
DLAPVAFFCL RQTTSPRNWC IKMVCNPWFE CVSMLVILLN CVTLGMYQPC
110 120 130 140 150
DDMECLSDRC KILQVFDDFI FIFFAMEMVL KMVALGIFGK KCYLGDTWNR
160 170 180 190 200
LDFFIVMAGM VEYSLDLQNI NLSAIRTVRV LRPLKAINRV PSMRILVNLL
210 220 230 240 250
LDTLPMLGNV LLLCFFVFFI FGIIGVQLWA GLLRNRCFLE ENFTIQGDVA
260 270 280 290 300
LPPYYQPEED DEMPFICSLS GDNGIMGCHE IPPLKEQGRE CCLSKDDMYD
310 320 330 340 350
FGAGRQDLNA SGLCVNWNRY YNVCRTGNAN PHKGAINFDN IGYAWIVIFQ
360 370 380 390 400
VITLEGWVEI MYYVMDAHSF YNFIYFILLI IVGSFFMINL CLVVIATQFS
410 420 430 440 450
ETKQREHRLM LEQRQRYLSS STVASYAEPG DCYEEIFQYV CHILRKAKRR
460 470 480 490 500
ALGLYQALQN RRQATGPGTP APAKPGPHAK EPSHCKLCPR HSPLDTTPHT
510 520 530 540 550
LVQPISAILA SDPSSCPRCQ HEAGRRPSGL GSTDSGQEGS GSGGSAEAEA
560 570 580 590 600
NGDGPQSSED GVSSGLGKEE EQEDGAARLC GDVWRETRAK LRGIVDSKYF
610 620 630 640 650
NRGIMMAILV NTVSMGIEHH EQPEELTNIL EICNVVFTSM FALEMILKLA
660 670 680 690 700
AFGLFDYLRN PYNIFDSIIV IISIWEIVGQ ADGGLSVLRT FRLLRVLKLV
710 720 730 740 750
RFMPALRRQL VVLMKTMDNV ATFCMLLMLF IFIFSILGMH IFGCKFSLRT
760 770 780 790 800
DTGDTVPDRK NFDSLLWAIV TVFQILTQED WNVVLYNGMA STTPWASLYF
810 820 830 840 850
VALMTFGNYV LFNLLVAILV EGFQAEGDAN RSYSDEDQSS SNLEELDKLP
860 870 880 890 900
EGLDSSRDLK LCPIPMTPNG HLDPSLPLGG HLGPAGAMGA APRLSLQPDP
910 920 930 940 950
VLVALESRKS SVMSLGRMSY DQRSLSSSRS SYYGPWGRSG TWASRRSSWN
960 970 980 990 1000
SLKHKPPSAE HESLLSGERG GSCVRACEGA REDAPPRAAP LHAPHTHHAH
1010 1020 1030 1040 1050
HGPHLAHRHR HHRRTLSLDT RDSVDLAELV PVVGAHSRAA WRAAGQAPGH
1060 1070 1080 1090 1100
EDCNGRMPNI AKDVFTKMDD RRDRGEDEEE IDYTLCFRVR KMIDVYKPDW
1110 1120 1130 1140 1150
CEVREDWSVY LFSPENKFRI LCQTIIAHKL FDYVVLAFIF LNCITIALER
1160 1170 1180 1190 1200
PQIEAGSTER IFLTVSNYIF TAIFVGEMTL KVVSLGLYFG EQAYLRSSWN
1210 1220 1230 1240 1250
VLDGFLVFVS IIDIVVSVAS AGGAKILGVL RVLRLLRTLR PLRVISRAPG
1260 1270 1280 1290 1300
LKLVVETLIS SLKPIGNIVL ICCAFFIIFG ILGVQLFKGK FYHCLGVDTR
1310 1320 1330 1340 1350
NITNRSDCVA ANYRWVHHKY NFDNLGQALM SLFVLASKDG WVNIMYNGLD
1360 1370 1380 1390 1400
AVAVDQQPVT NHNPWMLLYF ISFLLIVSFF VLNMFVGVVV ENFHKCRQHQ
1410 1420 1430 1440 1450
EAEEARRREE KRLRRLEKKR RKAQRLPYYA TYCPTRLLIH SMCTSHYLDI
1460 1470 1480 1490 1500
FITFIICLNV VTMSLEHYNQ PTSLETALKY CNYMFTTVFV LEAVLKLVAF
1510 1520 1530 1540 1550
GLRRFFKDRW NQLDLAIVLL SVMGITLEEI EINAALPINP TIIRIMRVLR
1560 1570 1580 1590 1600
IARVLKLLKM ATGMRALLDT VVQALPQVGN LGLLFMLLFF IYAALGVELF
1610 1620 1630 1640 1650
GKLVCNDENP CEGMSRHATF ENFGMAFLTL FQVSTGDNWN GIMKDTLRDC
1660 1670 1680 1690 1700
THDERSCLSS LQFVSPLYFV SFVLTAQFVL INVVVAVLMK HLDDSNKEAQ
1710 1720 1730 1740 1750
EDAEMDAEIE LEMAHGLGPG PGPCPCPCPC PCPCPCPGPR MPTSSPGAPG
1760 1770 1780 1790 1800
RGSGGAGVGG DTESHLCRHC YSPAQETLWL DSVSLIIKDS LEGELTIIDN
1810 1820 1830 1840 1850
LSGSIFHHYS SPAGCDKCHH DKQEVQLAET EAFSLNSDRS SSVLLGDDLS
1860 1870 1880 1890 1900
LEDPTACPQG PKESKGELEP PEPMQAGDLD ECFFPFAGEP VSAGPESLLC
1910 1920 1930 1940 1950
EMGAIPFNPV QSWLKHESNQ APPSPFSPDG SSPLLQMPAE FFHPAVSASQ
1960 1970 1980 1990 2000
KGQEPGMSSG TLPKIALQGS WASLRSPSVN CTLLRQATVS DTSLDASPSS
2010 2020 2030 2040 2050
SAGSLQTTLE DSLTLSDSPR RALGPPVQVP GPRASLSPAT RRRLSLRGRG
2060 2070 2080 2090 2100
LFSLRGLRAH QRSHSSGGST SPGCTYHDSM DPSDEEGRGG AGGGGAGSEH
2110 2120 2130 2140 2150
SETLSSLSLT SLFCLPPTLP PPGLTPARKF SSTSSLAAGP GRPGATVSVR
2160 2170 2180 2190
GLARSPSWAA DRSKDPPGQA QLASGFGSSA PEPQPPPGES TDAASKRKR
Length:2,199
Mass (Da):242,894
Last modified:April 5, 2011 - v1
Checksum:i232626040672E989
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC155313 Genomic DNA. No translation available.
RefSeqiNP_001037773.2. NM_001044308.2.
UniGeneiMm.291058.

Genome annotation databases

EnsembliENSMUST00000160424; ENSMUSP00000125063; ENSMUSG00000022416.
GeneIDi239556.
KEGGimmu:239556.
UCSCiuc009var.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiE9Q7P2_MOUSE
AccessioniPrimary (citable) accession number: E9Q7P2
Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: October 25, 2017
This is version 59 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported