Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Receptor-type tyrosine-protein phosphatase delta

Gene

Ptprd

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.SAAS annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphataseSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Receptor-type tyrosine-protein phosphatase deltaImported
Gene namesi
Name:PtprdImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:97812. Ptprd.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei846 – 86924HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence analysisAdd
BLAST
Chaini21 – 15051485Sequence analysisPRO_5003243119Add
BLAST

Proteomic databases

PaxDbiE9Q7I7.
PeptideAtlasiE9Q7I7.

Expressioni

Gene expression databases

BgeeiE9Q7I7.
ExpressionAtlasiE9Q7I7. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000133468.

Structurei

3D structure databases

ProteinModelPortaliE9Q7I7.
SMRiE9Q7I7. Positions 21-595, 924-1499.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini24 – 11491Ig-like (immunoglobulin-like)InterPro annotationAdd
BLAST
Domaini126 – 21893Ig-like (immunoglobulin-like)InterPro annotationAdd
BLAST
Domaini226 – 30883Ig-like (immunoglobulin-like)InterPro annotationAdd
BLAST
Domaini315 – 40591Fibronectin type-IIIInterPro annotationAdd
BLAST
Domaini410 – 50697Fibronectin type-IIIInterPro annotationAdd
BLAST
Domaini508 – 59790Fibronectin type-IIIInterPro annotationAdd
BLAST
Domaini599 – 68587Fibronectin type-IIIInterPro annotationAdd
BLAST
Domaini950 – 1205256Tyrosine-protein phosphataseInterPro annotationAdd
BLAST
Domaini1125 – 119672TYR_PHOSPHATASE_2InterPro annotationAdd
BLAST
Domaini1237 – 1496260Tyrosine-protein phosphataseInterPro annotationAdd
BLAST
Domaini1414 – 148774TYR_PHOSPHATASE_2InterPro annotationAdd
BLAST

Keywords - Domaini

RepeatSAAS annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG4228. Eukaryota.
COG5599. LUCA.
GeneTreeiENSGT00760000118900.

Family and domain databases

Gene3Di2.60.40.10. 7 hits.
3.90.190.10. 2 hits.
InterProiIPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000242. PTPase_domain.
IPR016130. Tyr_Pase_AS.
IPR003595. Tyr_Pase_cat.
IPR000387. TYR_PHOSPHATASE_dom.
[Graphical view]
PfamiPF00041. fn3. 3 hits.
PF07679. I-set. 2 hits.
PF00102. Y_phosphatase. 2 hits.
[Graphical view]
PRINTSiPR00700. PRTYPHPHTASE.
SMARTiSM00060. FN3. 4 hits.
SM00409. IG. 4 hits.
SM00408. IGc2. 3 hits.
SM00194. PTPc. 2 hits.
SM00404. PTPc_motif. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
SSF49265. SSF49265. 4 hits.
SSF52799. SSF52799. 2 hits.
PROSITEiPS50853. FN3. 4 hits.
PS50835. IG_LIKE. 3 hits.
PS00383. TYR_PHOSPHATASE_1. 2 hits.
PS50056. TYR_PHOSPHATASE_2. 2 hits.
PS50055. TYR_PHOSPHATASE_PTP. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E9Q7I7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVPVARPLSL LLTFFLCACA ETPPRFTRTP VDQTGVSGGV ASFICQATGD
60 70 80 90 100
PRPKIVWNKK GKKVSNQRFE VIEFDDGSGS VLRIQPLRTP RDEAIYECVA
110 120 130 140 150
SNNVGEISVS TRLTVLREDQ IPRGFPTIDM GPQLKVVERT RTATMLCAAS
160 170 180 190 200
GNPDPEITWF KDFLPVDTSN NNGRIKQLRS ESIGALQIEQ SEESDQGKYE
210 220 230 240 250
CVATNSAGTR YSAPANLYVR VRRVPPRFSI PPTNHEIMPG GSVNITCVAV
260 270 280 290 300
GSPMPYVKWM LGAEDLTPED DMPIGRNVLE LNDVRQSANY TCVAMSTLGV
310 320 330 340 350
IEAIAQITVK ALPKPPGTPV VTESTATSIT LTWDSGNPEP VSYYIIQHKP
360 370 380 390 400
KNSEEPYKEI DGIATTRYSV AGLSPYSDYE FRVVAVNNIG RGPASEPVLT
410 420 430 440 450
QTSEQAPSSA PRDVQARMLS STTILVQWKE PEEPNGQIQG YRVYYTMDPT
460 470 480 490 500
QHVNNWMKHN VADSQITTIG NLVPQKTYSV KVLAFTSIGD GPLSSDIQVI
510 520 530 540 550
TQTGVPGQPL NFKAEPESET SILLSWTPPR SDTIASYELV YRDGDQGEEQ
560 570 580 590 600
RITIEPGTSY RLQGLKPNSL YYFRLSARSP QGLGASTAEI SARTMQSMFA
610 620 630 640 650
KNFHVKAVMK TSVLLSWEIP ENYNSAMPFK ILYDDGKMVE EVDGRATQKL
660 670 680 690 700
IVNLKPEKSY SFVLTNRGNS AGGLQHRVTA KTAPDVLRTK PAFIGKTNLD
710 720 730 740 750
GMITVQLPDV PANENIKGYY IIIVPLKKSR GKFIKPWESP DEMELDELLK
760 770 780 790 800
EISRKRRSIR YGREVELKPY IAAHFDVLPT EFTLGDDKHY GGFTNKQLQS
810 820 830 840 850
GQEYVFFVLA VMDHAESKMY ATSPYSDPVV SMDLDPQPIT DEEEGLIWVV
860 870 880 890 900
GPVLAVVFII CIVIAILLYK RKRAESESRK SSLPNSKEVP SHHPTDPVEL
910 920 930 940 950
RRLNFQTPGS DDSGYPGNLH FSSMASHPPI PILELADHIE RLKANDNLKF
960 970 980 990 1000
SQEYESIDPG QQFTWEHSNL EVNKPKNRYA NVIAYDHSRV LLSAIEGIPG
1010 1020 1030 1040 1050
SDYVNANYID GYRKQNAYIA TQGSLPETFG DFWRMIWEQR SATVVMMTKL
1060 1070 1080 1090 1100
EERSRVKCDQ YWPSRGTETH GLVQVTLLDT VELATYCVRT FALYKNGSSE
1110 1120 1130 1140 1150
KREVRQFQFT AWPDHGVPEH PTPFLAFLRR VKTCNPPDAG PMVVHCSAGV
1160 1170 1180 1190 1200
GRTGCFIVID AMLERIKHEK TVDIYGHVTL MRAQRNYMVQ TEDQYIFIHD
1210 1220 1230 1240 1250
ALLEAVTCGN TEVPARNLYA YIQKLTQIET GENVTGMELE FKRLASSKAH
1260 1270 1280 1290 1300
TSRFISANLP CNKFKNRLVN IMPYESTRVC LQPIRGVEGS DYINASFLDG
1310 1320 1330 1340 1350
YRQQKAYIAT QGPLAETTED FWRMLWEHNS TIVVMLTKLR EMGREKCHQY
1360 1370 1380 1390 1400
WPAERSARYQ YFVVDPMAEY NMPQYILREF KVTDARDGQS RTVRQFQFTD
1410 1420 1430 1440 1450
WPEQGVPKSG EGFIDFIGQV HKTKEQFGQD GPISVHCSAG VGRTGVFITL
1460 1470 1480 1490 1500
SIVLERMRYE GVVDIFQTVK MLRTQRPAMV QTEDQYQFCY RAALEYLGSF

DHYAT
Length:1,505
Mass (Da):169,283
Last modified:November 16, 2011 - v2
Checksum:i2001DD2B9A5BA92A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL844848 Genomic DNA. No translation available.
AL845158 Genomic DNA. No translation available.
AL845333 Genomic DNA. No translation available.
AL845335 Genomic DNA. No translation available.
AL845508 Genomic DNA. No translation available.
AL845517 Genomic DNA. No translation available.
AL929181 Genomic DNA. No translation available.
AL929553 Genomic DNA. No translation available.
AL954675 Genomic DNA. No translation available.
BX296523 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSMUST00000050757; ENSMUSP00000058466; ENSMUSG00000028399.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL844848 Genomic DNA. No translation available.
AL845158 Genomic DNA. No translation available.
AL845333 Genomic DNA. No translation available.
AL845335 Genomic DNA. No translation available.
AL845508 Genomic DNA. No translation available.
AL845517 Genomic DNA. No translation available.
AL929181 Genomic DNA. No translation available.
AL929553 Genomic DNA. No translation available.
AL954675 Genomic DNA. No translation available.
BX296523 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortaliE9Q7I7.
SMRiE9Q7I7. Positions 21-595, 924-1499.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000133468.

Proteomic databases

PaxDbiE9Q7I7.
PeptideAtlasiE9Q7I7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000050757; ENSMUSP00000058466; ENSMUSG00000028399.

Organism-specific databases

MGIiMGI:97812. Ptprd.

Phylogenomic databases

eggNOGiKOG4228. Eukaryota.
COG5599. LUCA.
GeneTreeiENSGT00760000118900.

Miscellaneous databases

ChiTaRSiPtprd. mouse.
SOURCEiSearch...

Gene expression databases

BgeeiE9Q7I7.
ExpressionAtlasiE9Q7I7. baseline and differential.

Family and domain databases

Gene3Di2.60.40.10. 7 hits.
3.90.190.10. 2 hits.
InterProiIPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000242. PTPase_domain.
IPR016130. Tyr_Pase_AS.
IPR003595. Tyr_Pase_cat.
IPR000387. TYR_PHOSPHATASE_dom.
[Graphical view]
PfamiPF00041. fn3. 3 hits.
PF07679. I-set. 2 hits.
PF00102. Y_phosphatase. 2 hits.
[Graphical view]
PRINTSiPR00700. PRTYPHPHTASE.
SMARTiSM00060. FN3. 4 hits.
SM00409. IG. 4 hits.
SM00408. IGc2. 3 hits.
SM00194. PTPc. 2 hits.
SM00404. PTPc_motif. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
SSF49265. SSF49265. 4 hits.
SSF52799. SSF52799. 2 hits.
PROSITEiPS50853. FN3. 4 hits.
PS50835. IG_LIKE. 3 hits.
PS00383. TYR_PHOSPHATASE_1. 2 hits.
PS50056. TYR_PHOSPHATASE_2. 2 hits.
PS50055. TYR_PHOSPHATASE_PTP. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  3. Ensembl
    Submitted (MAY-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiE9Q7I7_MOUSE
AccessioniPrimary (citable) accession number: E9Q7I7
Entry historyi
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: November 16, 2011
Last modified: July 6, 2016
This is version 43 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.