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Protein
Submitted name:

Protein Numa1

Gene

Numa1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • establishment of mitotic spindle orientation Source: MGI
  • lung epithelial cell differentiation Source: MGI
  • meiotic cell cycle Source: Ensembl
Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-MMU-380320. Recruitment of NuMA to mitotic centrosomes.

Names & Taxonomyi

Protein namesi
Submitted name:
Protein Numa1Imported
Gene namesi
Name:Numa1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:2443665. Numa1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Proteomic databases

EPDiE9Q7G0.
MaxQBiE9Q7G0.
PaxDbiE9Q7G0.
PRIDEiE9Q7G0.

Expressioni

Gene expression databases

BgeeiE9Q7G0.
ExpressionAtlasiE9Q7G0. baseline and differential.
GenevisibleiE9Q7G0. MM.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiE9Q7G0. 1 interaction.
STRINGi10090.ENSMUSP00000081912.

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili276 – 31742Sequence analysisAdd
BLAST
Coiled coili332 – 39867Sequence analysisAdd
BLAST
Coiled coili413 – 44735Sequence analysisAdd
BLAST
Coiled coili452 – 48938Sequence analysisAdd
BLAST
Coiled coili501 – 57878Sequence analysisAdd
BLAST
Coiled coili586 – 64560Sequence analysisAdd
BLAST
Coiled coili653 – 810158Sequence analysisAdd
BLAST
Coiled coili861 – 90949Sequence analysisAdd
BLAST
Coiled coili979 – 104567Sequence analysisAdd
BLAST
Coiled coili1053 – 108735Sequence analysisAdd
BLAST
Coiled coili1118 – 114528Sequence analysisAdd
BLAST
Coiled coili1181 – 127191Sequence analysisAdd
BLAST
Coiled coili1276 – 133156Sequence analysisAdd
BLAST
Coiled coili1363 – 140139Sequence analysisAdd
BLAST
Coiled coili1405 – 143935Sequence analysisAdd
BLAST
Coiled coili1458 – 150750Sequence analysisAdd
BLAST
Coiled coili1512 – 154635Sequence analysisAdd
BLAST
Coiled coili1554 – 1675122Sequence analysisAdd
BLAST

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiENOG410IFJ8. Eukaryota.
ENOG41125FF. LUCA.
GeneTreeiENSGT00730000111158.
InParanoidiE9Q7G0.
KOiK16808.
OMAiQQRCISE.
OrthoDBiEOG7MH0X7.
TreeFamiTF334442.

Family and domain databases

InterProiIPR026650. NUMA1.
[Graphical view]
PANTHERiPTHR18902:SF24. PTHR18902:SF24. 7 hits.

Sequencei

Sequence statusi: Complete.

E9Q7G0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLHATRAAT LLSWVNSLHV ADPVETVLQL QDCSIFIKII NTIHDTKEGQ
60 70 80 90 100
QILQQPLPER LDFVCSFLQK NRKHPSSTQC LVSVQKVIEG SEMELAKMIM
110 120 130 140 150
LFLYQSTMSS RNLRDWEQFE YGVQAELAVI LKFMLDHEES LNLTEDLESF
160 170 180 190 200
LEKVPYTHAS TLSEELSPPS HQTKRKIRFL EIQRIASSSS ENNFLSGSPS
210 220 230 240 250
SPMGDILQTP QFQMRRLKKQ LADERSNRDD LELELSESLK LLTEKDAQIA
260 270 280 290 300
MMQQRIDHLA LLNEKQAASS QEPSELEELR GKNESLTVRL HETLKQCQNL
310 320 330 340 350
KTEKSQMDRK ISQLSEENGD LSFKVREFAN HLQQLQGAFN DLIEEHSKAS
360 370 380 390 400
QEWAEKQARL ENELSTALQD KKCLEEKNEI LQGKLSQLED QATRLQESPA
410 420 430 440 450
PEKGEVLGDA LQLDTLKQEA AKLATDNTQL QTRVETLECE RGKQEAQLLA
460 470 480 490 500
ERSRFEDEKQ QLASLIADLQ SSVSNLSQAK EELEQASQAQ GAQLTAQLTS
510 520 530 540 550
MTGLNATLQQ RDQELASLKE QAKKEQAQML QTMQEQEQAA QGLRQQVEQL
560 570 580 590 600
SSSLKLKEQQ LEEAAKEQEA TRQDHAQQLA IVAEAREASL RERDTARQQL
610 620 630 640 650
ETVEKEKDAK LESLQQQLQA ANDARDNAQT SVTQAQQEKA ELSQKIGELH
660 670 680 690 700
ACIEASHQEQ RQVQARVTEL EAQLKAEQQK TTEREKVVQE KAQLQEQLRA
710 720 730 740 750
LEESLKITKG SLEEEKRRAA DALKEQQCRA TEMEAESRSL MEQREREQKE
760 770 780 790 800
LEQEKAGRKG LEARIQQLEE AHQAETEALR HELAEATASQ HRAESECERL
810 820 830 840 850
IREVESRQKR FEARQQEEAR YGAMFQEQLM ALKGEKTGQE VQEEAVEIHS
860 870 880 890 900
EGQPGQQQSQ LAQLHASLAK AIQQVQEKEV RAQKLVDDLS ALQEKMAATN
910 920 930 940 950
KEVACLKTLV LKAGEQQETA SLELLKEPPR AANRASDQLG EQQGRPFSST
960 970 980 990 1000
HAAVKAMERE AEQMGGELER LRAALIKSQG QQQEERGQQE REVARLTQER
1010 1020 1030 1040 1050
GQAQADLAQE KAAKAELEMR LQNTLNEQRV EFAALQEALA HALTEKEGTD
1060 1070 1080 1090 1100
QELAKLRGQE AAQRTELKEL QQTLEQLKIQ LVKKEKEHPA GGASGEDASG
1110 1120 1130 1140 1150
PGTQSETAGK TDAPGPELQA LRAEISKLEQ QCQQQQQQVE GLTHSLKSER
1160 1170 1180 1190 1200
ACRAEQDKAL ETLQGQLEEK ARELGHNQAA SASAQRELQA LRAKAQDHSK
1210 1220 1230 1240 1250
AEEEWKAQVA RGQQEAERKS SLISSLEEEV SILNRQVLEK EGESKELKRL
1260 1270 1280 1290 1300
VVAESEKSQK LEERLRLLQV ETASNSARAA ERSSALREEV QSLREEVEKQ
1310 1320 1330 1340 1350
RVVSENSRQE LASQAERAEE LGQELKAWQE KFFQKEQALS ALQLEHTSTQ
1360 1370 1380 1390 1400
ALVSELLPAK HLCQQLQAEQ AAAEKRFREE LEQSKQAAGG LQAELMRAQR
1410 1420 1430 1440 1450
ELGELGSLRQ KIVEQERAAQ QLRAEKASYA EQLSMLKKAH GLLAEENRGL
1460 1470 1480 1490 1500
GERANLGRQF LEVELDQARE KYVQELAAVR TDAETHLAEM RQEAQSTSRE
1510 1520 1530 1540 1550
LEVMTAKYEG AKVKVLEERQ RFQEERQKLT AQVEELSKKL TEHDQASKVQ
1560 1570 1580 1590 1600
QQKLKAFQAQ RGESQQEVQR LQTQLNELQA QLSQKEQAAE HYKLQMEKAK
1610 1620 1630 1640 1650
THYDAKKQQN QKLQEQLQDL EELQKENKEL RSEAERLGRE LQQAGLKTKE
1660 1670 1680 1690 1700
AEQTCRHLTA QVRSLEAQVA HADQQLRDLG KFQVATDALK SREPQVKPQL
1710 1720 1730 1740 1750
DLSIDSLDLS LEEGTPCSVA SKLPRTQPDG TSVPGEPASP ISQRLPPKVE
1760 1770 1780 1790 1800
SLESLYFTPT PARGQAPLET SLDSLGDAFP DSGRKTRSAR RRTTQIINIT
1810 1820 1830 1840 1850
MTKKLELEEP DSANSSFYST QSAPASQANL RATSSTQSLA RLGSPDDGNS
1860 1870 1880 1890 1900
ALLSLPGYRP TTRSSARRSQ ARMSSGAPQG RNSFYMGTCQ DEPEQLDDWN
1910 1920 1930 1940 1950
RIAELQQRNR VCPPHLKTCY PLESRPTLSL ATITDEEMKT GDPRETLRRA
1960 1970 1980 1990 2000
SMQPAQIAEG VGITTRQQRK RVSSETHQGP GTPESKKATS CFPRPMTPRD
2010 2020 2030 2040 2050
RHEGRKQSST ADTQKKAAPV LKQADRRQSM AFSILNTPKK LGNSLLRRGA
2060 2070 2080 2090
SKKTPAKVSP NPRSGTRRSP RIATTTTGTA TVATTPRAKG KVKH
Length:2,094
Mass (Da):235,630
Last modified:April 5, 2011 - v1
Checksum:i09074ACC3A6A1046
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC167240 Genomic DNA. No translation available.
RefSeqiNP_598708.3. NM_133947.3.
XP_006507240.1. XM_006507177.1.
UniGeneiMm.27259.

Genome annotation databases

EnsembliENSMUST00000084852; ENSMUSP00000081912; ENSMUSG00000066306.
GeneIDi101706.
KEGGimmu:101706.
UCSCiuc009ipz.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC167240 Genomic DNA. No translation available.
RefSeqiNP_598708.3. NM_133947.3.
XP_006507240.1. XM_006507177.1.
UniGeneiMm.27259.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiE9Q7G0. 1 interaction.
STRINGi10090.ENSMUSP00000081912.

Proteomic databases

EPDiE9Q7G0.
MaxQBiE9Q7G0.
PaxDbiE9Q7G0.
PRIDEiE9Q7G0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000084852; ENSMUSP00000081912; ENSMUSG00000066306.
GeneIDi101706.
KEGGimmu:101706.
UCSCiuc009ipz.1. mouse.

Organism-specific databases

CTDi4926.
MGIiMGI:2443665. Numa1.

Phylogenomic databases

eggNOGiENOG410IFJ8. Eukaryota.
ENOG41125FF. LUCA.
GeneTreeiENSGT00730000111158.
InParanoidiE9Q7G0.
KOiK16808.
OMAiQQRCISE.
OrthoDBiEOG7MH0X7.
TreeFamiTF334442.

Enzyme and pathway databases

ReactomeiR-MMU-380320. Recruitment of NuMA to mitotic centrosomes.

Miscellaneous databases

ChiTaRSiNuma1. mouse.
NextBioi355078.
SOURCEiSearch...

Gene expression databases

BgeeiE9Q7G0.
ExpressionAtlasiE9Q7G0. baseline and differential.
GenevisibleiE9Q7G0. MM.

Family and domain databases

InterProiIPR026650. NUMA1.
[Graphical view]
PANTHERiPTHR18902:SF24. PTHR18902:SF24. 7 hits.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  2. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  5. Ensembl
    Submitted (MAY-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.
  6. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
    Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
    Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiE9Q7G0_MOUSE
AccessioniPrimary (citable) accession number: E9Q7G0
Entry historyi
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: March 16, 2016
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.