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Protein

Receptor protein-tyrosine kinase

Gene

Fgfr2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei627Proton acceptorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, ReceptorSAAS annotation, Transferase, Tyrosine-protein kinaseSAAS annotation

Enzyme and pathway databases

ReactomeiR-MMU-109704. PI3K Cascade.
R-MMU-1257604. PIP3 activates AKT signaling.
R-MMU-190375. FGFR2c ligand binding and activation.
R-MMU-190377. FGFR2b ligand binding and activation.
R-MMU-5654221. Phospholipase C-mediated cascade, FGFR2.
R-MMU-5654693. FRS-mediated FGFR1 signaling.
R-MMU-5654695. PI-3K cascade:FGFR2.
R-MMU-5654699. SHC-mediated cascade:FGFR2.
R-MMU-5654700. FRS-mediated FGFR2 signaling.
R-MMU-5654706. FRS-mediated FGFR3 signaling.
R-MMU-5654712. FRS-mediated FGFR4 signaling.
R-MMU-5654727. Negative regulation of FGFR2 signaling.
R-MMU-5673001. RAF/MAP kinase cascade.
R-MMU-6811558. PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Receptor protein-tyrosine kinaseSAAS annotation (EC:2.7.10.1SAAS annotation)
Gene namesi
Name:Fgfr2Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:95523. Fgfr2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei379 – 399HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_500324597422 – 822Receptor protein-tyrosine kinaseSequence analysisAdd BLAST801

Keywords - PTMi

Disulfide bondSAAS annotation

Proteomic databases

MaxQBiE9Q7E8.
PaxDbiE9Q7E8.

Expressioni

Gene expression databases

BgeeiENSMUSG00000030849.
ExpressionAtlasiE9Q7E8. baseline and differential.

Structurei

3D structure databases

SMRiE9Q7E8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini39 – 125Ig-likeInterPro annotationAdd BLAST87
Domaini154 – 247Ig-likeInterPro annotationAdd BLAST94
Domaini256 – 356Ig-likeInterPro annotationAdd BLAST101
Domaini482 – 771Protein kinaseInterPro annotationAdd BLAST290

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family.SAAS annotation

Keywords - Domaini

Immunoglobulin domainSAAS annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG0200. Eukaryota.
COG0515. LUCA.
GeneTreeiENSGT00760000118923.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiView protein in InterPro
IPR016248. FGF_rcpt_fam.
IPR007110. Ig-like_dom.
IPR036179. Ig-like_dom_sf.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR011009. Kinase-like_dom_sf.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
PfamiView protein in Pfam
PF07679. I-set. 2 hits.
PF07714. Pkinase_Tyr. 1 hit.
PIRSFiPIRSF000628. FGFR. 1 hit.
PRINTSiPR00109. TYRKINASE.
SMARTiView protein in SMART
SM00409. IG. 3 hits.
SM00408. IGc2. 3 hits.
SM00219. TyrKc. 1 hit.
SUPFAMiSSF48726. SSF48726. 3 hits.
SSF56112. SSF56112. 1 hit.
PROSITEiView protein in PROSITE
PS50835. IG_LIKE. 3 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.

Sequencei

Sequence statusi: Fragment.

E9Q7E8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVSWGRFICL VLVTMATLSL ARPSFSLVED TTLEPEEPPT KYQISQPEAY
60 70 80 90 100
VVAPGESLEL QCMLKDAAVI SWTKDGVHLG PNNRTVLIGE YLQIKGATPR
110 120 130 140 150
DSGLYACTAA RTVDSETWYF MVNVTDAISS GDDEDDTDSS EDVVSENRSN
160 170 180 190 200
QRAPYWTNTE KMEKRLHAVP AANTVKFRCP AGGNPTPTMR WLKNGKEFKQ
210 220 230 240 250
EHRIGGYKVR NQHWSLIMES VVPSDKGNYT CLVENEYGSI NHTYHLDVVE
260 270 280 290 300
RSPHRPILQA GLPANASTVV GGDVEFVCKV YSDAQPHIQW IKHVEKNGSK
310 320 330 340 350
YGPDGLPYLK VLKHSGINSS NAEVLALFNV TEMDAGEYIC KVSNYIGQAN
360 370 380 390 400
QSAWLTVLPK QQAPVREKEI TASPDYLEIA IYCIGVFLIA CMVVTVIFCR
410 420 430 440 450
MKTTTKKPDF SSQPAVHKLT KRIPLRRQVT VSAESSSSMN SNTPLVRITT
460 470 480 490 500
RLSSTADTPM LAGVSEYELP EDPKWEFPRD KLTLGKPLGE GCFGQVVMAE
510 520 530 540 550
AVGIDKDKPK EAVTVAVKML KDDATEKDLS DLVSEMEMMK MIGKHKNIIN
560 570 580 590 600
LLGACTQDGP LYVIVEYASK GNLREYLRAR RPPGMEYSYD INRVPEEQMT
610 620 630 640 650
FKDLVSCTYQ LARGMEYLAS QKCIHRDLAA RNVLVTENNV MKIADFGLAR
660 670 680 690 700
DINNIDYYKK TTNGRLPVKW MAPEALFDRV YTHQSDVWSF GVLMWEIFTL
710 720 730 740 750
GGSPYPGIPV EELFKLLKEG HRMDKPTNCT NELYMMMRDC WHAVPSQRPT
760 770 780 790 800
FKQLVEDLDR ILTLTTNEEY LDLTQPLEQY SPSYPDTRSS CSSGDDSVFS
810 820
PDPMPYEPCL PQYPHINGSV KT
Length:822
Mass (Da):92,311
Last modified:April 5, 2011 - v1
Checksum:iB0D14F509CAC3471
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC087063 Genomic DNA. No translation available.
AC110885 Genomic DNA. No translation available.
AC111058 Genomic DNA. No translation available.
AC115697 Genomic DNA. No translation available.
AC122258 Genomic DNA. No translation available.
AC145294 Genomic DNA. No translation available.
AC149596 Genomic DNA. No translation available.
AC157606 Genomic DNA. No translation available.
AC158113 Genomic DNA. No translation available.
AC175034 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSMUST00000117691; ENSMUSP00000113180; ENSMUSG00000030849.

Similar proteinsi

Entry informationi

Entry nameiE9Q7E8_MOUSE
AccessioniPrimary (citable) accession number: E9Q7E8
Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: November 22, 2017
This is version 64 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported