Fibroblast growth factor receptor 2

Contribute

Send feedback

Read comments (?) or add your own

E9Q7E6 (E9Q7E6_MOUSE) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 22. History...

Clusters with 100%, 90%, 50% identity |

Third-party data

text xml rdf/xml gff fasta

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info Customize order

Names and origin

Protein names

Submitted name:
Fibroblast growth factor receptor 2 Ensembl ENSMUSP00000113187

Gene names

Name:

Fgfr2 Ensembl ENSMUSP00000113187 MGI 95523

Organism

Mus musculus (Mouse) [Reference proteome] Ensembl ENSMUSP00000113187

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	608 AA.
Sequence status	Fragment.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. SAAS SAAS008266
Sequence similarities	Contains 1 protein kinase domain. SAAS SAAS008266
Caution	The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data. Ensembl ENSMUSP00000113187

Ontologies

Keywords
Cellular component	Membrane
Domain	Immunoglobulin domain SAAS SAAS008266 Repeat SAAS SAAS008266 Transmembrane Transmembrane helix SAAS SAAS008266
Ligand	ATP-binding SAAS SAAS008266 Nucleotide-binding
Molecular function	Kinase Receptor SAAS SAAS008266 Transferase Tyrosine-protein kinase SAAS SAAS008266
PTM	Phosphoprotein SAAS SAAS008266
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	angiogenesis Inferred from genetic interaction PubMed 16778080. Source: MGI axonogenesis Inferred from mutant phenotype PubMed 17951031. Source: MGI bone mineralization Inferred from mutant phenotype PubMed 12756187. Source: MGI branch elongation involved in salivary gland morphogenesis Inferred from mutant phenotype PubMed 15972105. Source: MGI branching involved in labyrinthine layer morphogenesis Inferred from mutant phenotype PubMed 9435295. Source: MGI branching morphogenesis of a nerve Inferred from mutant phenotype PubMed 17951031. Source: MGI bud elongation involved in lung branching Inferred from mutant phenotype PubMed 16989802. Source: MGI cell fate commitment Inferred from direct assay PubMed 15509736. Source: MGI coronal suture morphogenesis Inferred from mutant phenotype PubMed 19389359. Source: MGI embryonic digestive tract morphogenesis Inferred from mutant phenotype PubMed 16618415 PubMed 21550054. Source: MGI embryonic pattern specification Inferred from mutant phenotype PubMed 16618415. Source: MGI endodermal digestive tract morphogenesis Inferred from mutant phenotype PubMed 21550054. Source: MGI epithelial cell proliferation involved in salivary gland morphogenesis Inferred from mutant phenotype PubMed 15972105. Source: MGI fibroblast growth factor receptor signaling pathway involved in mammary gland specification Inferred from mutant phenotype PubMed 16720875. Source: MGI hair follicle morphogenesis Inferred from mutant phenotype PubMed 14530295. Source: MGI lacrimal gland development Inferred from mutant phenotype PubMed 10821755. Source: MGI lateral sprouting from an epithelium Inferred from mutant phenotype PubMed 12666202. Source: MGI lens fiber cell development Inferred from genetic interaction PubMed 18455718. Source: MGI limb bud formation Inferred from mutant phenotype PubMed 10518547 PubMed 9435295. Source: MGI lung alveolus development Inferred from mutant phenotype PubMed 16989802. Source: MGI lung lobe morphogenesis Inferred from mutant phenotype PubMed 16989802. Source: MGI lung-associated mesenchyme development Inferred from mutant phenotype PubMed 16989802. Source: MGI mammary gland bud formation Inferred from mutant phenotype PubMed 11782400. Source: MGI membranous septum morphogenesis Inferred from mutant phenotype PubMed 16687131. Source: MGI mesenchymal cell differentiation involved in lung development Inferred from genetic interaction PubMed 16989802. Source: MGI mesenchymal cell proliferation involved in lung development Inferred from mutant phenotype PubMed 16989802. Source: MGI midbrain development Inferred from genetic interaction PubMed 17687036. Source: MGI multicellular organism growth Inferred from mutant phenotype PubMed 16989802. Source: MGI negative regulation of cell proliferation Inferred from genetic interaction PubMed 18455718. Source: MGI negative regulation of mitosis Inferred from genetic interaction PubMed 18455718. Source: MGI negative regulation of transcription from RNA polymerase II promoter Inferred from mutant phenotype PubMed 16989802. Source: MGI neuromuscular junction development Inferred from mutant phenotype PubMed 17418794. Source: MGI odontogenesis Inferred from mutant phenotype PubMed 17951031. Source: MGI organ growth Inferred from mutant phenotype PubMed 16618415. Source: MGI otic vesicle formation Inferred from mutant phenotype PubMed 9435295. Source: MGI outflow tract septum morphogenesis Inferred from mutant phenotype PubMed 16687131. Source: MGI positive regulation of ERK1 and ERK2 cascade Inferred from genetic interaction PubMed 17202188. Source: MGI positive regulation of canonical Wnt receptor signaling pathway Inferred from mutant phenotype PubMed 16720875. Source: MGI positive regulation of cardiac muscle cell proliferation Inferred from genetic interaction PubMed 15621532. Source: MGI positive regulation of cell division Inferred from mutant phenotype PubMed 14530295. Source: MGI positive regulation of epithelial cell proliferation involved in lung morphogenesis Inferred from mutant phenotype PubMed 16989802. Source: MGI positive regulation of mesenchymal cell proliferation Inferred from genetic interaction PubMed 16540513. Source: MGI positive regulation of transcription from RNA polymerase II promoter Inferred from mutant phenotype PubMed 16989802. Source: MGI post-embryonic development Inferred from mutant phenotype PubMed 16989802. Source: MGI prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis Inferred from mutant phenotype PubMed 17215304. Source: MGI prostate epithelial cord elongation Inferred from mutant phenotype PubMed 17215304. Source: MGI regulation of branching involved in prostate gland morphogenesis Inferred from mutant phenotype PubMed 17202188. Source: MGI regulation of cell fate commitment Inferred from mutant phenotype PubMed 16989802. Source: MGI regulation of fibroblast growth factor receptor signaling pathway Inferred from mutant phenotype PubMed 16989802. Source: MGI regulation of multicellular organism growth Inferred from mutant phenotype PubMed 9435295. Source: MGI regulation of smooth muscle cell differentiation Inferred from mutant phenotype PubMed 16989802. Source: MGI regulation of smoothened signaling pathway Inferred from mutant phenotype PubMed 16618415. Source: MGI squamous basal epithelial stem cell differentiation involved in prostate gland acinus development Inferred from mutant phenotype PubMed 17215304. Source: MGI synaptic vesicle transport Inferred from mutant phenotype PubMed 17418794. Source: MGI ureteric bud development Inferred from genetic interaction PubMed 16442091. Source: MGI ventricular cardiac muscle tissue morphogenesis Inferred from mutant phenotype PubMed 16687131. Source: MGI
Cellular_component	extracellular region Traceable author statement PubMed 12024206. Source: MGI integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW nucleus Inferred from direct assay PubMed 15229180 PubMed 15944199. Source: MGI
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW fibroblast growth factor binding Inferred from direct assay PubMed 9435295. Source: MGI protein tyrosine kinase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Experimental info

Non-terminal residue

Ensembl ENSMUSP00000113187

Sequences

Sequence

Length

Mass (Da)

Tools

E9Q7E6 [UniParc].

Last modified April 5, 2011. Version 1.
Checksum: FD45882921EEBE80
Show »

FASTA

608

68,290

        10         20         30         40         50         60 
MVSWGRFICL VLVTMATLSL ARPSFSLVED TTLEPEERSP HRPILQAGLP ANASTVVGGD 

        70         80         90        100        110        120 
VEFVCKVYSD AQPHIQWIKH VEKNGSKYGP DGLPYLKVLK AAGVNTTDKE IEVLYIRNVT 

       130        140        150        160        170        180 
FEDAGEYTCL AGNSIGISFH SAWLTVLPAP VREKEITASP DYLEIAIYCI GVFLIACMVV 

       190        200        210        220        230        240 
TVIFCRMKTT TKKPDFSSQP AVHKLTKRIP LRRQVTVSAE SSSSMNSNTP LVRITTRLSS 

       250        260        270        280        290        300 
TADTPMLAGV SEYELPEDPK WEFPRDKLTL GKPLGEGCFG QVVMAEAVGI DKDKPKEAVT 

       310        320        330        340        350        360 
VAVKMLKDDA TEKDLSDLVS EMEMMKMIGK HKNIINLLGA CTQDGPLYVI VEYASKGNLR 

       370        380        390        400        410        420 
EYLRARRPPG MEYSYDINRV PEEQMTFKDL VSCTYQLARG MEYLASQKCI HRDLAARNVL 

       430        440        450        460        470        480 
VTENNVMKIA DFGLARDINN IDYYKKTTNG RLPVKWMAPE ALFDRVYTHQ SDVWSFGVLM 

       490        500        510        520        530        540 
WEIFTLGGSP YPGIPVEELF KLLKEGHRMD KPTNCTNELY MMMRDCWHAV PSQRPTFKQL 

       550        560        570        580        590        600 
VEDLDRILTL TTNEEYLDLT QPLEQYSPSY PDTRSSCSSG DDSVFSPDPM PYEPCLPQYP 


HINGSVKT

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J Ensembl ENSMUSP00000113187.
[2]	Ensembl Submitted (MAY-2011) to UniProtKB Cited for: IDENTIFICATION. Strain: C57BL/6J Ensembl ENSMUSP00000113187.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC087063 Genomic DNA. No translation available. AC099609 Genomic DNA. No translation available. AC099627 Genomic DNA. No translation available. AC100735 Genomic DNA. No translation available. AC101690 Genomic DNA. No translation available. AC101762 Genomic DNA. No translation available. AC105062 Genomic DNA. No translation available. AC110885 Genomic DNA. No translation available. AC111058 Genomic DNA. No translation available. AC115697 Genomic DNA. No translation available. AC119806 Genomic DNA. No translation available. AC122258 Genomic DNA. No translation available. AC126688 Genomic DNA. No translation available. AC138624 Genomic DNA. No translation available. AC145294 Genomic DNA. No translation available. AC149596 Genomic DNA. No translation available. AC156606 Genomic DNA. No translation available. AC157606 Genomic DNA. No translation available. AC158113 Genomic DNA. No translation available. AC158314 Genomic DNA. No translation available. AC159994 Genomic DNA. No translation available. AC175034 Genomic DNA. No translation available. AC238818 Genomic DNA. No translation available.
IPI	IPI00828828.
3D structure databases
ProteinModelPortal	E9Q7E6.
SMR	E9Q7E6. Positions 33-150, 254-591.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000117754; ENSMUSP00000113187; ENSMUSG00000030849.
Organism-specific databases
MGI	MGI:95523. Fgfr2.
Phylogenomic databases
GeneTree	ENSGT00670000097694.
Gene expression databases
ArrayExpress	E9Q7E6.
Bgee	E9Q7E6.
Family and domain databases
Gene3D	2.60.40.10. 1 hit.
InterPro	IPR007110. Ig-like_dom. IPR013783. Ig-like_fold. IPR013098. Ig_I-set. IPR003598. Ig_sub2. IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR001245. Ser-Thr/Tyr_kinase_cat_dom. IPR008266. Tyr_kinase_AS. IPR020635. Tyr_kinase_cat_dom. [Graphical view]
Pfam	PF07679. I-set. 1 hit. PF07714. Pkinase_Tyr. 1 hit. [Graphical view]
PRINTS	PR00109. TYRKINASE.
SMART	SM00408. IGc2. 1 hit. SM00219. TyrKc. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
PROSITE	PS50835. IG_LIKE. 1 hit. PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00109. PROTEIN_KINASE_TYR. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	FGFR2. mouse.
NextBio	35555482.
SOURCE	Search...

Entry information

Entry name

E9Q7E6_MOUSE

Accession

Primary (citable) accession number: E9Q7E6

Entry history

Integrated into UniProtKB/TrEMBL:	April 5, 2011
Last sequence update:	April 5, 2011
Last modified:	May 1, 2013
This is version 22 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information