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Protein

Fibroblast growth factor receptor

Gene

Fgfr2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei531Proton acceptorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, ReceptorUniRule annotationSAAS annotation, Transferase, Tyrosine-protein kinaseUniRule annotationSAAS annotation

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-109704. PI3K Cascade.
R-MMU-1257604. PIP3 activates AKT signaling.
R-MMU-190375. FGFR2c ligand binding and activation.
R-MMU-190377. FGFR2b ligand binding and activation.
R-MMU-5654221. Phospholipase C-mediated cascade, FGFR2.
R-MMU-5654695. PI-3K cascade:FGFR2.
R-MMU-5654699. SHC-mediated cascade:FGFR2.
R-MMU-5654700. FRS-mediated FGFR2 signaling.
R-MMU-5654727. Negative regulation of FGFR2 signaling.
R-MMU-5673001. RAF/MAP kinase cascade.
R-MMU-6811558. PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Fibroblast growth factor receptorUniRule annotation (EC:2.7.10.1UniRule annotation)
Gene namesi
Name:Fgfr2Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:95523. Fgfr2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei20 – 40HelicalSequence analysisAdd BLAST21
Transmembranei280 – 302HelicalSequence analysisAdd BLAST23

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Keywords - PTMi

Disulfide bondSAAS annotation

Proteomic databases

MaxQBiE9Q7C7.
PaxDbiE9Q7C7.

Expressioni

Gene expression databases

BgeeiENSMUSG00000030849.
ExpressionAtlasiE9Q7C7. baseline and differential.
GenevisibleiE9Q7C7. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000112430.

Structurei

3D structure databases

ProteinModelPortaliE9Q7C7.
SMRiE9Q7C7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini42 – 151Ig-like (immunoglobulin-like)InterPro annotationAdd BLAST110
Domaini160 – 260Ig-like (immunoglobulin-like)InterPro annotationAdd BLAST101
Domaini386 – 675Protein kinaseInterPro annotationAdd BLAST290

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.UniRule annotation

Keywords - Domaini

Immunoglobulin domainSAAS annotation, RepeatSAAS annotation, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG0200. Eukaryota.
COG0515. LUCA.
GeneTreeiENSGT00760000118923.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR016248. FGF_rcpt_fam.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PfamiPF07679. I-set. 2 hits.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PIRSFiPIRSF000628. FGFR. 1 hit.
PRINTSiPR00109. TYRKINASE.
SMARTiSM00409. IG. 2 hits.
SM00408. IGc2. 2 hits.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
SSF56112. SSF56112. 1 hit.
PROSITEiPS50835. IG_LIKE. 2 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E9Q7C7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLPSTWRYG RGPGIGTVTM VSWGRFICLV LVTMATLSLA RPSFSLVEDT
60 70 80 90 100
TLEPEGAPYW TNTEKMEKRL HAVPAANTVK FRCPAGGNPT PTMRWLKNGK
110 120 130 140 150
EFKQEHRIGG YKVRNQHWSL IMESVVPSDK GNYTCLVENE YGSINHTYHL
160 170 180 190 200
DVVERSPHRP ILQAGLPANA STVVGGDVEF VCKVYSDAQP HIQWIKHVEK
210 220 230 240 250
NGSKYGPDGL PYLKVLKHSG INSSNAEVLA LFNVTEMDAG EYICKVSNYI
260 270 280 290 300
GQANQSAWLT VLPKQQAPVR EKEITASPDY LEIAIYCIGV FLIACMVVTV
310 320 330 340 350
IFCRMKTTTK KPDFSSQPAV HKLTKRIPLR RQVTVSAESS SSMNSNTPLV
360 370 380 390 400
RITTRLSSTA DTPMLAGVSE YELPEDPKWE FPRDKLTLGK PLGEGCFGQV
410 420 430 440 450
VMAEAVGIDK DKPKEAVTVA VKMLKDDATE KDLSDLVSEM EMMKMIGKHK
460 470 480 490 500
NIINLLGACT QDGPLYVIVE YASKGNLREY LRARRPPGME YSYDINRVPE
510 520 530 540 550
EQMTFKDLVS CTYQLARGME YLASQKCIHR DLAARNVLVT ENNVMKIADF
560 570 580 590 600
GLARDINNID YYKKTTNGRL PVKWMAPEAL FDRVYTHQSD VWSFGVLMWE
610 620 630 640 650
IFTLGGSPYP GIPVEELFKL LKEGHRMDKP TNCTNELYMM MRDCWHAVPS
660 670 680 690 700
QRPTFKQLVE DLDRILTLTT NEEYLDLTQP LEQYSPSYPD TRSSCSSGDD
710 720
SVFSPDPMPY EPCLPQYPHI NGSVKT
Length:726
Mass (Da):81,644
Last modified:April 5, 2011 - v1
Checksum:i620C7DCB586B1D29
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC087063 Genomic DNA. No translation available.
AC110885 Genomic DNA. No translation available.
AC111058 Genomic DNA. No translation available.
AC115697 Genomic DNA. No translation available.
AC122258 Genomic DNA. No translation available.
AC145294 Genomic DNA. No translation available.
AC149596 Genomic DNA. No translation available.
AC157606 Genomic DNA. No translation available.
AC158113 Genomic DNA. No translation available.
AC175034 Genomic DNA. No translation available.
RefSeqiNP_963895.2. NM_201601.2.
UniGeneiMm.16340.

Genome annotation databases

EnsembliENSMUST00000120187; ENSMUSP00000113248; ENSMUSG00000030849.
GeneIDi14183.
UCSCiuc033jck.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC087063 Genomic DNA. No translation available.
AC110885 Genomic DNA. No translation available.
AC111058 Genomic DNA. No translation available.
AC115697 Genomic DNA. No translation available.
AC122258 Genomic DNA. No translation available.
AC145294 Genomic DNA. No translation available.
AC149596 Genomic DNA. No translation available.
AC157606 Genomic DNA. No translation available.
AC158113 Genomic DNA. No translation available.
AC175034 Genomic DNA. No translation available.
RefSeqiNP_963895.2. NM_201601.2.
UniGeneiMm.16340.

3D structure databases

ProteinModelPortaliE9Q7C7.
SMRiE9Q7C7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000112430.

Proteomic databases

MaxQBiE9Q7C7.
PaxDbiE9Q7C7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000120187; ENSMUSP00000113248; ENSMUSG00000030849.
GeneIDi14183.
UCSCiuc033jck.1. mouse.

Organism-specific databases

CTDi2263.
MGIiMGI:95523. Fgfr2.

Phylogenomic databases

eggNOGiKOG0200. Eukaryota.
COG0515. LUCA.
GeneTreeiENSGT00760000118923.

Enzyme and pathway databases

ReactomeiR-MMU-109704. PI3K Cascade.
R-MMU-1257604. PIP3 activates AKT signaling.
R-MMU-190375. FGFR2c ligand binding and activation.
R-MMU-190377. FGFR2b ligand binding and activation.
R-MMU-5654221. Phospholipase C-mediated cascade, FGFR2.
R-MMU-5654695. PI-3K cascade:FGFR2.
R-MMU-5654699. SHC-mediated cascade:FGFR2.
R-MMU-5654700. FRS-mediated FGFR2 signaling.
R-MMU-5654727. Negative regulation of FGFR2 signaling.
R-MMU-5673001. RAF/MAP kinase cascade.
R-MMU-6811558. PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.

Miscellaneous databases

ChiTaRSiFgfr2. mouse.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000030849.
ExpressionAtlasiE9Q7C7. baseline and differential.
GenevisibleiE9Q7C7. MM.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR016248. FGF_rcpt_fam.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PfamiPF07679. I-set. 2 hits.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PIRSFiPIRSF000628. FGFR. 1 hit.
PRINTSiPR00109. TYRKINASE.
SMARTiSM00409. IG. 2 hits.
SM00408. IGc2. 2 hits.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
SSF56112. SSF56112. 1 hit.
PROSITEiPS50835. IG_LIKE. 2 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiE9Q7C7_MOUSE
AccessioniPrimary (citable) accession number: E9Q7C7
Entry historyi
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: November 30, 2016
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.