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Protein
Submitted name:

Interleukin-1 receptor accessory protein

Gene

Il1rap

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
Interleukin-1 receptor accessory proteinImported
Gene namesi
Name:Il1rapImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:104975 Il1rap

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei363 – 383HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_500324446421 – 640Sequence analysisAdd BLAST620

Proteomic databases

MaxQBiE9Q6I2
PaxDbiE9Q6I2
PeptideAtlasiE9Q6I2

Expressioni

Gene expression databases

BgeeiENSMUSG00000022514
ExpressionAtlasiE9Q6I2 baseline and differential
GenevisibleiE9Q6I2 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000093843

Structurei

3D structure databases

ProteinModelPortaliE9Q6I2
SMRiE9Q6I2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini158 – 230Ig-likeInterPro annotationAdd BLAST73
Domaini243 – 348Ig-likeInterPro annotationAdd BLAST106
Domaini403 – 547TIRInterPro annotationAdd BLAST145

Keywords - Domaini

RepeatSAAS annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG410IEPH Eukaryota
ENOG410ZRCQ LUCA
GeneTreeiENSGT00760000119071

Family and domain databases

Gene3Di2.60.40.10, 3 hits
3.40.50.10140, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR015621 IL-1_rcpt_fam
IPR004074 IL-1_rcpt_I/II-typ
IPR000157 TIR_dom
IPR035897 Toll_tir_struct_dom_sf
PANTHERiPTHR11890 PTHR11890, 1 hit
PfamiView protein in Pfam
PF13895 Ig_2, 1 hit
PF01582 TIR, 1 hit
PRINTSiPR01536 INTRLKN1R12F
SMARTiView protein in SMART
SM00409 IG, 3 hits
SM00255 TIR, 1 hit
SUPFAMiSSF48726 SSF48726, 3 hits
SSF52200 SSF52200, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 2 hits
PS50104 TIR, 1 hit

Sequencei

Sequence statusi: Complete.

E9Q6I2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLLWYLMSL SFYGILQSHA SERCDDWGLD TMRQIQVFED EPARIKCPLF
60 70 80 90 100
EHFLKYNYST AHSSGLTLIW YWTRQDRDLE EPINFRLPEN RISKEKDVLW
110 120 130 140 150
FRPTLLNDTG NYTCMLRNTT YCSKVAFPLE VVQKDSCFNS AMRFPVHKMY
160 170 180 190 200
IEHGIHKITC PNVDGYFPSS VKPSVTWYKG CTEIVDFHNV LPEGMNLSFF
210 220 230 240 250
IPLVSNNGNY TCVVTYPENG RLFHLTRTVT VKVVGSPKDA LPPQIYSPND
260 270 280 290 300
RVVYEKEPGE ELVIPCKVYF SFIMDSHNEV WWTIDGKKPD DVTVDITINE
310 320 330 340 350
SVSYSSTEDE TRTQILSIKK VTPEDLRRNY VCHARNTKGE AEQAAKVKQK
360 370 380 390 400
VIPPRYTVEL ACGFGATVFL VVVLIVVYHV YWLEMVLFYR AHFGTDETIL
410 420 430 440 450
DGKEYDIYVS YARNVEEEEF VLLTLRGVLE NEFGYKLCIF DRDSLPGGNT
460 470 480 490 500
VEAVFDFIQR SRRMIVVLSP DYVTEKSISM LEFKLGVMCQ NSIATKLIVV
510 520 530 540 550
EYRPLEQPHP GIMQLKESVS FVSWKGEKSK HSGSKFWKAL RLALPLRSLS
560 570 580 590 600
ASSGWNESCS SQSDISLDHV QRRSRLKEPP ELRSSERVSG AEPAPGTMSK
610 620 630 640
HRGKPSAACR CCVTYCEGES HLRSKSRAEM HTHPQWETHL
Length:640
Mass (Da):73,517
Last modified:April 5, 2011 - v1
Checksum:iF21C567FDC79B0C3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC154234 Genomic DNA No translation available.
AC154601 Genomic DNA No translation available.
CT009561 Genomic DNA No translation available.
RefSeqiNP_001152789.1, NM_001159317.1
UniGeneiMm.253424

Genome annotation databases

EnsembliENSMUST00000166294; ENSMUSP00000128100; ENSMUSG00000022514
GeneIDi16180
UCSCiuc007yvf.2 mouse

Similar proteinsi

Entry informationi

Entry nameiE9Q6I2_MOUSE
AccessioniPrimary (citable) accession number: E9Q6I2
Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: April 25, 2018
This is version 60 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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Main funding by: National Institutes of Health