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Protein
Submitted name:

Protein C6

Gene

C6

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

  • immune response Source: InterPro
  • in utero embryonic development Source: MGI
Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-MMU-166665. Terminal pathway of complement.
R-MMU-977606. Regulation of Complement cascade.

Names & Taxonomyi

Protein namesi
Submitted name:
Protein C6Imported
Gene namesi
Name:C6Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:88233. C6.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_500324309322 – 931Sequence analysisAdd BLAST910

Keywords - PTMi

Disulfide bondSAAS annotation

Proteomic databases

MaxQBiE9Q6D8.
PaxDbiE9Q6D8.
PeptideAtlasiE9Q6D8.

Expressioni

Gene expression databases

BgeeiENSMUSG00000022181.
ExpressionAtlasiE9Q6D8. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000022788.

Structurei

3D structure databases

ProteinModelPortaliE9Q6D8.
SMRiE9Q6D8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini176 – 522MACPFInterPro annotationAdd BLAST347
Domaini642 – 701Sushi (CCP/SCR)InterPro annotationAdd BLAST60
Domaini702 – 763Sushi (CCP/SCR)InterPro annotationAdd BLAST62
Domaini779 – 836Kazal-likeInterPro annotationAdd BLAST58
Domaini878 – 931Kazal-likeInterPro annotationAdd BLAST54

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiENOG410IDXP. Eukaryota.
ENOG410YJ70. LUCA.
GeneTreeiENSGT00550000074478.
InParanoidiE9Q6D8.
OMAiCVCQSGT.
OrthoDBiEOG091G07LK.
TreeFamiTF330498.

Family and domain databases

CDDicd00033. CCP. 2 hits.
InterProiIPR003884. FacI_MAC.
IPR002350. Kazal_dom.
IPR023415. LDLR_class-A_CS.
IPR002172. LDrepeatLR_classA_rpt.
IPR001862. MAC_perforin.
IPR020864. MACPF.
IPR020863. MACPF_CS.
IPR000436. Sushi_SCR_CCP_dom.
IPR000884. TSP1_rpt.
[Graphical view]
PfamiPF00057. Ldl_recept_a. 1 hit.
PF01823. MACPF. 1 hit.
PF00084. Sushi. 2 hits.
PF00090. TSP_1. 3 hits.
[Graphical view]
PRINTSiPR00764. COMPLEMENTC9.
SMARTiSM00032. CCP. 2 hits.
SM00057. FIMAC. 2 hits.
SM00192. LDLa. 1 hit.
SM00457. MACPF. 1 hit.
SM00209. TSP1. 3 hits.
[Graphical view]
SUPFAMiSSF57424. SSF57424. 1 hit.
SSF57535. SSF57535. 2 hits.
SSF82895. SSF82895. 3 hits.
PROSITEiPS51465. KAZAL_2. 2 hits.
PS01209. LDLRA_1. 1 hit.
PS50068. LDLRA_2. 1 hit.
PS00279. MACPF_1. 1 hit.
PS51412. MACPF_2. 1 hit.
PS50923. SUSHI. 2 hits.
PS50092. TSP1. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E9Q6D8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTRHLTLCFI LLVMLIDKSE ACFCDHYPWT HWSSCSKSCN SGTQSRQRQV
60 70 80 90 100
VVNDYYWKNL CDKLCIKQET RECNLQTCPI NCVLGDYGTW SDCDPCTEKQ
110 120 130 140 150
VKVKSVLRPS QFGGQPCTEP LVTFQPCVPS KLCKIEETNC KNKFLCDSGR
160 170 180 190 200
CIPSKLECNG ENDCGDNSDE RNCGRTKPVC TRIYTPIPSV QLMGTGFHFL
210 220 230 240 250
AGEPRGEVLD NSFTGGICKL VKTSRASNPY RVSANLENVN FEVQTIEDDL
260 270 280 290 300
KTEFYKNLIS FEKNKNEDSL SVDERTKFFP IPIFHFSEKN EHSHYSSAFN
310 320 330 340 350
KVIKASHKKD SSFIRIHKLI KVLNFTMKAT DLQLSDVFLK ALVHLPLEYN
360 370 380 390 400
SAVYSRIFDD FGTHYFTSGS LGGKYDLIYQ FSRQELQNSG LTEEEAQNCV
410 420 430 440 450
QYETKKLKFL YMEIHKEDTC TKNKLSEKYG GSFLQGSEKS ISLVQGGRSQ
460 470 480 490 500
QAAALAWEKG TSGPEENVYS EWLESVKENP AVVDYKLAPI TDLVRNIPCA
510 520 530 540 550
VTKRNNLRRA LQEYAAKFDP CQCAPCPNNG RPRLSGTECL CVCQSGTYGE
560 570 580 590 600
NCERRSPGYK SDAVDGNWGC WSSWSACNAA YRRSRTRECN NPAPQRGGQS
610 620 630 640 650
CGGKDQQEED CTVSIMENVG QPCINDDEEM KEVDLAEPEA ESGCSQPPLP
660 670 680 690 700
ENAFTWNEKK LYSVGEEVEI SCLTGFTAVG FQYLRCLPDR TWSQGDVECQ
710 720 730 740 750
RTSCLKPVVQ DVLTISPFQR VYQIGESIEL TCPRGFVVAG PSRYTCKEDS
760 770 780 790 800
WTPPISNSLT CEQGEQIFAW TCHLHVLSAL RPNTCFPSSD SAYSEDLCIF
810 820 830 840 850
DGGSSQYFTS SACKFLAGKC LNNTQSHFVH SGSCQEGLQL EWGLERLKLA
860 870 880 890 900
VNSTKRVSCG YNTCYDWENC SAHTSNCVCL LPPQCSKDEN QLYCVKIGSS
910 920 930
MREKTVNICT LGAVRCANIK VEILNPGRCP D
Length:931
Mass (Da):104,457
Last modified:April 5, 2011 - v1
Checksum:i513A49FCB652D071
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC102033 Genomic DNA. No translation available.
AC117588 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSMUST00000162350; ENSMUSP00000125693; ENSMUSG00000022181.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC102033 Genomic DNA. No translation available.
AC117588 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortaliE9Q6D8.
SMRiE9Q6D8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000022788.

Proteomic databases

MaxQBiE9Q6D8.
PaxDbiE9Q6D8.
PeptideAtlasiE9Q6D8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000162350; ENSMUSP00000125693; ENSMUSG00000022181.

Organism-specific databases

MGIiMGI:88233. C6.

Phylogenomic databases

eggNOGiENOG410IDXP. Eukaryota.
ENOG410YJ70. LUCA.
GeneTreeiENSGT00550000074478.
InParanoidiE9Q6D8.
OMAiCVCQSGT.
OrthoDBiEOG091G07LK.
TreeFamiTF330498.

Enzyme and pathway databases

ReactomeiR-MMU-166665. Terminal pathway of complement.
R-MMU-977606. Regulation of Complement cascade.

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000022181.
ExpressionAtlasiE9Q6D8. baseline and differential.

Family and domain databases

CDDicd00033. CCP. 2 hits.
InterProiIPR003884. FacI_MAC.
IPR002350. Kazal_dom.
IPR023415. LDLR_class-A_CS.
IPR002172. LDrepeatLR_classA_rpt.
IPR001862. MAC_perforin.
IPR020864. MACPF.
IPR020863. MACPF_CS.
IPR000436. Sushi_SCR_CCP_dom.
IPR000884. TSP1_rpt.
[Graphical view]
PfamiPF00057. Ldl_recept_a. 1 hit.
PF01823. MACPF. 1 hit.
PF00084. Sushi. 2 hits.
PF00090. TSP_1. 3 hits.
[Graphical view]
PRINTSiPR00764. COMPLEMENTC9.
SMARTiSM00032. CCP. 2 hits.
SM00057. FIMAC. 2 hits.
SM00192. LDLa. 1 hit.
SM00457. MACPF. 1 hit.
SM00209. TSP1. 3 hits.
[Graphical view]
SUPFAMiSSF57424. SSF57424. 1 hit.
SSF57535. SSF57535. 2 hits.
SSF82895. SSF82895. 3 hits.
PROSITEiPS51465. KAZAL_2. 2 hits.
PS01209. LDLRA_1. 1 hit.
PS50068. LDLRA_2. 1 hit.
PS00279. MACPF_1. 1 hit.
PS51412. MACPF_2. 1 hit.
PS50923. SUSHI. 2 hits.
PS50092. TSP1. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiE9Q6D8_MOUSE
AccessioniPrimary (citable) accession number: E9Q6D8
Entry historyi
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: November 30, 2016
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.