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Protein
Submitted name:

Complement component 6

Gene

C6

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

  • immune response Source: InterPro
  • in utero embryonic development Source: MGI

Enzyme and pathway databases

ReactomeiR-MMU-166665. Terminal pathway of complement.
R-MMU-977606. Regulation of Complement cascade.

Names & Taxonomyi

Protein namesi
Submitted name:
Complement component 6Imported
Gene namesi
Name:C6Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:88233. C6.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_500324309322 – 931Sequence analysisAdd BLAST910

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi146 ↔ 164PROSITE-ProRule annotation
Disulfide bondi158 ↔ 173PROSITE-ProRule annotation
Disulfide bondi672 ↔ 699PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationSAAS annotation

Proteomic databases

MaxQBiE9Q6D8.
PaxDbiE9Q6D8.
PeptideAtlasiE9Q6D8.

Expressioni

Gene expression databases

BgeeiENSMUSG00000022181.
ExpressionAtlasiE9Q6D8. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliE9Q6D8.
SMRiE9Q6D8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini176 – 522MACPFInterPro annotationAdd BLAST347
Domaini642 – 701SushiInterPro annotationAdd BLAST60
Domaini702 – 763SushiInterPro annotationAdd BLAST62
Domaini779 – 836Kazal-likeInterPro annotationAdd BLAST58
Domaini878 – 931Kazal-likeInterPro annotationAdd BLAST54

Keywords - Domaini

SignalSequence analysis, SushiPROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IDXP. Eukaryota.
ENOG410YJ70. LUCA.
GeneTreeiENSGT00550000074478.
InParanoidiE9Q6D8.
OMAiCKNKFRC.
OrthoDBiEOG091G07LK.
TreeFamiTF330498.

Family and domain databases

CDDicd00033. CCP. 2 hits.
cd00112. LDLa. 1 hit.
Gene3Di2.20.100.10. 2 hits.
InterProiView protein in InterPro
IPR003884. FacI_MAC.
IPR002350. Kazal_dom.
IPR036055. LDL_receptor-like_sf.
IPR023415. LDLR_class-A_CS.
IPR002172. LDrepeatLR_classA_rpt.
IPR001862. MAC_perforin.
IPR020864. MACPF.
IPR020863. MACPF_CS.
IPR035976. Sushi/SCR/CCP_sf.
IPR000436. Sushi_SCR_CCP_dom.
IPR000884. TSP1_rpt.
IPR036383. TSP1_rpt_sf.
PfamiView protein in Pfam
PF00057. Ldl_recept_a. 1 hit.
PF01823. MACPF. 1 hit.
PF00084. Sushi. 2 hits.
PF00090. TSP_1. 3 hits.
PRINTSiPR00764. COMPLEMENTC9.
SMARTiView protein in SMART
SM00032. CCP. 2 hits.
SM00057. FIMAC. 2 hits.
SM00192. LDLa. 1 hit.
SM00457. MACPF. 1 hit.
SM00209. TSP1. 3 hits.
SUPFAMiSSF57424. SSF57424. 1 hit.
SSF57535. SSF57535. 2 hits.
SSF82895. SSF82895. 3 hits.
PROSITEiView protein in PROSITE
PS51465. KAZAL_2. 2 hits.
PS01209. LDLRA_1. 1 hit.
PS50068. LDLRA_2. 1 hit.
PS00279. MACPF_1. 1 hit.
PS51412. MACPF_2. 1 hit.
PS50923. SUSHI. 2 hits.
PS50092. TSP1. 3 hits.

Sequencei

Sequence statusi: Complete.

E9Q6D8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTRHLTLCFI LLVMLIDKSE ACFCDHYPWT HWSSCSKSCN SGTQSRQRQV
60 70 80 90 100
VVNDYYWKNL CDKLCIKQET RECNLQTCPI NCVLGDYGTW SDCDPCTEKQ
110 120 130 140 150
VKVKSVLRPS QFGGQPCTEP LVTFQPCVPS KLCKIEETNC KNKFLCDSGR
160 170 180 190 200
CIPSKLECNG ENDCGDNSDE RNCGRTKPVC TRIYTPIPSV QLMGTGFHFL
210 220 230 240 250
AGEPRGEVLD NSFTGGICKL VKTSRASNPY RVSANLENVN FEVQTIEDDL
260 270 280 290 300
KTEFYKNLIS FEKNKNEDSL SVDERTKFFP IPIFHFSEKN EHSHYSSAFN
310 320 330 340 350
KVIKASHKKD SSFIRIHKLI KVLNFTMKAT DLQLSDVFLK ALVHLPLEYN
360 370 380 390 400
SAVYSRIFDD FGTHYFTSGS LGGKYDLIYQ FSRQELQNSG LTEEEAQNCV
410 420 430 440 450
QYETKKLKFL YMEIHKEDTC TKNKLSEKYG GSFLQGSEKS ISLVQGGRSQ
460 470 480 490 500
QAAALAWEKG TSGPEENVYS EWLESVKENP AVVDYKLAPI TDLVRNIPCA
510 520 530 540 550
VTKRNNLRRA LQEYAAKFDP CQCAPCPNNG RPRLSGTECL CVCQSGTYGE
560 570 580 590 600
NCERRSPGYK SDAVDGNWGC WSSWSACNAA YRRSRTRECN NPAPQRGGQS
610 620 630 640 650
CGGKDQQEED CTVSIMENVG QPCINDDEEM KEVDLAEPEA ESGCSQPPLP
660 670 680 690 700
ENAFTWNEKK LYSVGEEVEI SCLTGFTAVG FQYLRCLPDR TWSQGDVECQ
710 720 730 740 750
RTSCLKPVVQ DVLTISPFQR VYQIGESIEL TCPRGFVVAG PSRYTCKEDS
760 770 780 790 800
WTPPISNSLT CEQGEQIFAW TCHLHVLSAL RPNTCFPSSD SAYSEDLCIF
810 820 830 840 850
DGGSSQYFTS SACKFLAGKC LNNTQSHFVH SGSCQEGLQL EWGLERLKLA
860 870 880 890 900
VNSTKRVSCG YNTCYDWENC SAHTSNCVCL LPPQCSKDEN QLYCVKIGSS
910 920 930
MREKTVNICT LGAVRCANIK VEILNPGRCP D
Length:931
Mass (Da):104,457
Last modified:April 5, 2011 - v1
Checksum:i513A49FCB652D071
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC102033 Genomic DNA. No translation available.
AC117588 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSMUST00000162350; ENSMUSP00000125693; ENSMUSG00000022181.

Similar proteinsi

Entry informationi

Entry nameiE9Q6D8_MOUSE
AccessioniPrimary (citable) accession number: E9Q6D8
Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: October 25, 2017
This is version 55 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation
The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported