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Protein
Submitted name:

Complement component 6

Gene

C6

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Biological processi

  • complement activation Source: InterPro
  • in utero embryonic development Source: MGI

Enzyme and pathway databases

ReactomeiR-MMU-166665. Terminal pathway of complement.
R-MMU-977606. Regulation of Complement cascade.

Names & Taxonomyi

Protein namesi
Submitted name:
Complement component 6Imported
Gene namesi
Name:C6Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:88233. C6.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_501416187022 – 934Sequence analysisAdd BLAST913

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationSAAS annotation

Proteomic databases

MaxQBiE9Q6D8.
PeptideAtlasiE9Q6D8.

Expressioni

Gene expression databases

BgeeiENSMUSG00000022181.
ExpressionAtlasiE9Q6D8. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliE9Q6D8.
SMRiE9Q6D8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini176 – 522MACPFInterPro annotationAdd BLAST347
Domaini642 – 701SushiInterPro annotationAdd BLAST60
Domaini702 – 763SushiInterPro annotationAdd BLAST62
Domaini785 – 839Kazal-likeInterPro annotationAdd BLAST55
Domaini881 – 934Kazal-likeInterPro annotationAdd BLAST54

Keywords - Domaini

SignalSequence analysis, SushiPROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IDXP. Eukaryota.
ENOG410YJ70. LUCA.
GeneTreeiENSGT00550000074478.
InParanoidiE9Q6D8.
OMAiCKNKFRC.
OrthoDBiEOG091G07LK.
TreeFamiTF330498.

Family and domain databases

CDDicd00033. CCP. 2 hits.
cd00112. LDLa. 1 hit.
Gene3Di2.20.100.10. 3 hits.
InterProiView protein in InterPro
IPR037563. Complement_C6.
IPR003884. FacI_MAC.
IPR002350. Kazal_dom.
IPR036055. LDL_receptor-like_sf.
IPR023415. LDLR_class-A_CS.
IPR002172. LDrepeatLR_classA_rpt.
IPR001862. MAC_perforin.
IPR020864. MACPF.
IPR020863. MACPF_CS.
IPR035976. Sushi/SCR/CCP_sf.
IPR000436. Sushi_SCR_CCP_dom.
IPR000884. TSP1_rpt.
IPR036383. TSP1_rpt_sf.
PANTHERiPTHR19325:SF23. PTHR19325:SF23. 1 hit.
PfamiView protein in Pfam
PF00057. Ldl_recept_a. 1 hit.
PF01823. MACPF. 1 hit.
PF00084. Sushi. 2 hits.
PF00090. TSP_1. 3 hits.
PRINTSiPR00764. COMPLEMENTC9.
SMARTiView protein in SMART
SM00032. CCP. 2 hits.
SM00057. FIMAC. 2 hits.
SM00192. LDLa. 1 hit.
SM00457. MACPF. 1 hit.
SM00209. TSP1. 3 hits.
SUPFAMiSSF57424. SSF57424. 1 hit.
SSF57535. SSF57535. 2 hits.
SSF82895. SSF82895. 3 hits.
PROSITEiView protein in PROSITE
PS51465. KAZAL_2. 2 hits.
PS01209. LDLRA_1. 1 hit.
PS50068. LDLRA_2. 1 hit.
PS00279. MACPF_1. 1 hit.
PS51412. MACPF_2. 1 hit.
PS50923. SUSHI. 2 hits.
PS50092. TSP1. 3 hits.

Sequencei

Sequence statusi: Complete.

E9Q6D8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTRHLTLCFI LLVMLIDKSE ACFCDHYPWT HWSSCSKSCN SGTQSRQRQV
60 70 80 90 100
VVNDYYWKNL CDKLCIKQET RECNLQTCPI NCVLGDYGTW SDCDPCTEKQ
110 120 130 140 150
VKVKSVLRPS QFGGQPCTEP LVTFQPCVPS KLCKIEETNC KNKFLCDSGR
160 170 180 190 200
CIPSKLECNG ENDCGDNSDE RNCGRTKPVC TRIYTPIPSV QLMGTGFHFL
210 220 230 240 250
AGEPRGEVLD NSFTGGICKL VKTSRASNPY RVSANLENVN FEVQTIEDDL
260 270 280 290 300
KTEFYKNLIS FEKNKNEDSL SVDERTKFFP IPIFHFSEKN EHSHYSSAFN
310 320 330 340 350
KVIKASHKKD SSFIRIHKLI KVLNFTMKAT DLQLSDVFLK ALVHLPLEYN
360 370 380 390 400
SAVYSRIFDD FGTHYFTSGS LGGKYDLIYQ FSRQELQNSG LTEEEAQNCV
410 420 430 440 450
QYETKKLKFL YMEIHKEDTC TKNKLSEKYG GSFLQGSEKS ISLVQGGRSQ
460 470 480 490 500
QAAALAWEKG TSGPEENVYS EWLESVKENP AVVDYKLAPI TDLVRNIPCA
510 520 530 540 550
VTKRNNLRRA LQEYAAKFDP CQCAPCPNNG RPRLSGTECL CVCQSGTYGE
560 570 580 590 600
NCERRSPGYK SDAVDGNWGC WSSWSACNAA YRRSRTRECN NPAPQRGGQS
610 620 630 640 650
CGGKDQQEED CTVSIMENVG QPCINDDEEM KEVDLAEPEA ESGCSQPPLP
660 670 680 690 700
ENAFTWNEKK LYSVGEEVEI SCLTGFTAVG FQYLRCLPDR TWSQGDVECQ
710 720 730 740 750
RTSCLKPVVQ DVLTISPFQR VYQIGESIEL TCPRGFVVAG PSRYTCKEDS
760 770 780 790 800
WTPPISNSLT CEQAILTKSK DLCPPGQKQS GSKCICMSPE EDCSAYSEDL
810 820 830 840 850
CIFDGGSSQY FTSSACKFLA GKCLNNTQSH FVHSGSCQEG LQLEWGLERL
860 870 880 890 900
KLAVNSTKRV SCGYNTCYDW ENCSAHTSNC VCLLPPQCSK DENQLYCVKI
910 920 930
GSSMREKTVN ICTLGAVRCA NIKVEILNPG RCPD
Length:934
Mass (Da):104,624
Last modified:February 28, 2018 - v2
Checksum:i196CDCB42AD0392A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC102033 Genomic DNA. No translation available.
AC117588 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSMUST00000162350; ENSMUSP00000125693; ENSMUSG00000022181.

Similar proteinsi

Entry informationi

Entry nameiE9Q6D8_MOUSE
AccessioniPrimary (citable) accession number: E9Q6D8
Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: February 28, 2018
Last modified: March 28, 2018
This is version 58 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported