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Protein

Tyrosine-protein kinase

Gene

Lck

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase, Tyrosine-protein kinaseUniRule annotation
LigandATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein kinaseUniRule annotation (EC:2.7.10.2UniRule annotation)
Gene namesi
Name:LckImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:96756 Lck

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

MaxQBiE9Q696
PeptideAtlasiE9Q696
PRIDEiE9Q696

Expressioni

Gene expression databases

BgeeiENSMUSG00000000409
ExpressionAtlasiE9Q696 baseline and differential
GenevisibleiE9Q696 MM

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliE9Q696
SMRiE9Q696
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini72 – 132SH3InterPro annotationAdd BLAST61
Domaini138 – 235SH2InterPro annotationAdd BLAST98
Domaini256 – 509Protein kinaseInterPro annotationAdd BLAST254

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family.UniRule annotation

Keywords - Domaini

SH2 domainPROSITE-ProRule annotation, SH3 domainPROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0197 Eukaryota
COG0515 LUCA
GeneTreeiENSGT00760000118938
OMAiNPEDDWM
OrthoDBiEOG091G0D46

Family and domain databases

CDDicd10362 SH2_Src_Lck, 1 hit
cd12005 SH3_Lck, 1 hit
Gene3Di3.30.505.10, 1 hit
InterProiView protein in InterPro
IPR035850 Lck_SH2
IPR035749 Lck_SH3
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR001452 SH3_domain
IPR008266 Tyr_kinase_AS
IPR020635 Tyr_kinase_cat_dom
PfamiView protein in Pfam
PF07714 Pkinase_Tyr, 1 hit
PF00017 SH2, 1 hit
PF00018 SH3_1, 1 hit
PRINTSiPR00401 SH2DOMAIN
PR00452 SH3DOMAIN
PR00109 TYRKINASE
SMARTiView protein in SMART
SM00252 SH2, 1 hit
SM00326 SH3, 1 hit
SM00219 TyrKc, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit
PS50001 SH2, 1 hit
PS50002 SH3, 1 hit

Sequencei

Sequence statusi: Complete.

E9Q696-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGASELTISG IMGCVCSSNP EDDWMENIDV CENCHYPIVP LDSKISLPIR
60 70 80 90 100
NGSEVRDPLV TYEGSLPPAS PLQDNLVIAL HSYEPSHDGD LGFEKGEQLR
110 120 130 140 150
ILEQSGEWWK AQSLTTGQEG FIPFNFVAKA NSLEPEPWFF KNLSRKDAER
160 170 180 190 200
QLLAPGNTHG SFLIRESEST AGSFSLSVRD FDQNQGEVVK HYKIRNLDNG
210 220 230 240 250
GFYISPRITF PGLHDLVRHY TNASDGLCTK LSRPCQTQKP QKPWWEDEWE
260 270 280 290 300
VPRETLKLVE RLGAGQFGEV WMGYYNGHTK VAVKSLKQGS MSPDAFLAEA
310 320 330 340 350
NLMKQLQHPR LVRLYAVVTQ EPIYIITEYM ENGSLVDFLK TPSGIKLNVN
360 370 380 390 400
KLLDMAAQIA EGMAFIEEQN YIHRDLRAAN ILVSDTLSCK IADFGLARLI
410 420 430 440 450
EDNEYTAREG AKFPIKWTAP EAINYGTFTI KSDVWSFGIL LTEIVTHGRI
460 470 480 490 500
PYPGMTNPEV IQNLERGYRM VRPDNCPEEL YHLMMLCWKE RPEDRPTFDY
510 520
LRSVLDDFFT ATEGQYQPQP
Length:520
Mass (Da):59,003
Last modified:April 5, 2011 - v1
Checksum:i76DC69BEF5907FCC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL606921 Genomic DNA No translation available.
AL671759 Genomic DNA No translation available.
RefSeqiNP_001155904.1, NM_001162432.1
UniGeneiMm.293753

Genome annotation databases

EnsembliENSMUST00000167288; ENSMUSP00000125777; ENSMUSG00000000409
GeneIDi16818
UCSCiuc012dlq.1 mouse

Similar proteinsi

Entry informationi

Entry nameiE9Q696_MOUSE
AccessioniPrimary (citable) accession number: E9Q696
Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: March 28, 2018
This is version 60 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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Main funding by: National Institutes of Health