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Protein

Tyrosine-protein kinase

Gene

Lck

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase, Tyrosine-protein kinaseUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein kinaseUniRule annotation (EC:2.7.10.2UniRule annotation)
Gene namesi
Name:LckImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:96756. Lck.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Proteomic databases

MaxQBiE9Q696.
PaxDbiE9Q696.
PeptideAtlasiE9Q696.
PRIDEiE9Q696.

Expressioni

Gene expression databases

BgeeiENSMUSG00000000409.
ExpressionAtlasiE9Q696. baseline and differential.
GenevisibleiE9Q696. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000125777.

Structurei

3D structure databases

ProteinModelPortaliE9Q696.
SMRiE9Q696.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini72 – 132SH3InterPro annotationAdd BLAST61
Domaini138 – 235SH2InterPro annotationAdd BLAST98
Domaini256 – 509Protein kinaseInterPro annotationAdd BLAST254

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family.UniRule annotation
Contains 1 SH2 domain.UniRule annotation
Contains 1 SH3 domain.UniRule annotation
Contains 1 protein kinase domain.UniRule annotation

Keywords - Domaini

SH3 domainUniRule annotation

Phylogenomic databases

eggNOGiKOG0197. Eukaryota.
COG0515. LUCA.
GeneTreeiENSGT00760000118938.
OMAiHTKVAIK.
OrthoDBiEOG091G0D46.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR001452. SH3_domain.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PfamiPF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
PRINTSiPR00401. SH2DOMAIN.
PR00452. SH3DOMAIN.
PR00109. TYRKINASE.
SMARTiSM00252. SH2. 1 hit.
SM00326. SH3. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E9Q696-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGASELTISG IMGCVCSSNP EDDWMENIDV CENCHYPIVP LDSKISLPIR
60 70 80 90 100
NGSEVRDPLV TYEGSLPPAS PLQDNLVIAL HSYEPSHDGD LGFEKGEQLR
110 120 130 140 150
ILEQSGEWWK AQSLTTGQEG FIPFNFVAKA NSLEPEPWFF KNLSRKDAER
160 170 180 190 200
QLLAPGNTHG SFLIRESEST AGSFSLSVRD FDQNQGEVVK HYKIRNLDNG
210 220 230 240 250
GFYISPRITF PGLHDLVRHY TNASDGLCTK LSRPCQTQKP QKPWWEDEWE
260 270 280 290 300
VPRETLKLVE RLGAGQFGEV WMGYYNGHTK VAVKSLKQGS MSPDAFLAEA
310 320 330 340 350
NLMKQLQHPR LVRLYAVVTQ EPIYIITEYM ENGSLVDFLK TPSGIKLNVN
360 370 380 390 400
KLLDMAAQIA EGMAFIEEQN YIHRDLRAAN ILVSDTLSCK IADFGLARLI
410 420 430 440 450
EDNEYTAREG AKFPIKWTAP EAINYGTFTI KSDVWSFGIL LTEIVTHGRI
460 470 480 490 500
PYPGMTNPEV IQNLERGYRM VRPDNCPEEL YHLMMLCWKE RPEDRPTFDY
510 520
LRSVLDDFFT ATEGQYQPQP
Length:520
Mass (Da):59,003
Last modified:April 5, 2011 - v1
Checksum:i76DC69BEF5907FCC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL606921 Genomic DNA. No translation available.
AL671759 Genomic DNA. No translation available.
RefSeqiNP_001155904.1. NM_001162432.1.
UniGeneiMm.293753.

Genome annotation databases

EnsembliENSMUST00000167288; ENSMUSP00000125777; ENSMUSG00000000409.
GeneIDi16818.
UCSCiuc012dlq.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL606921 Genomic DNA. No translation available.
AL671759 Genomic DNA. No translation available.
RefSeqiNP_001155904.1. NM_001162432.1.
UniGeneiMm.293753.

3D structure databases

ProteinModelPortaliE9Q696.
SMRiE9Q696.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000125777.

Proteomic databases

MaxQBiE9Q696.
PaxDbiE9Q696.
PeptideAtlasiE9Q696.
PRIDEiE9Q696.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000167288; ENSMUSP00000125777; ENSMUSG00000000409.
GeneIDi16818.
UCSCiuc012dlq.1. mouse.

Organism-specific databases

CTDi3932.
MGIiMGI:96756. Lck.

Phylogenomic databases

eggNOGiKOG0197. Eukaryota.
COG0515. LUCA.
GeneTreeiENSGT00760000118938.
OMAiHTKVAIK.
OrthoDBiEOG091G0D46.

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000000409.
ExpressionAtlasiE9Q696. baseline and differential.
GenevisibleiE9Q696. MM.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR001452. SH3_domain.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PfamiPF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
PRINTSiPR00401. SH2DOMAIN.
PR00452. SH3DOMAIN.
PR00109. TYRKINASE.
SMARTiSM00252. SH2. 1 hit.
SM00326. SH3. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiE9Q696_MOUSE
AccessioniPrimary (citable) accession number: E9Q696
Entry historyi
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: November 30, 2016
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.