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E9Q612

- PTPRO_MOUSE

UniProt

E9Q612 - PTPRO_MOUSE

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Protein
Receptor-type tyrosine-protein phosphatase O
Gene
Ptpro, GLEPP1, Ptpn15, PTPU2
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Possesses tyrosine phosphatase activity. Plays a role in regulating the glomerular pressure/filtration rate relationship through an effect on podocyte structure and function.1 Publication

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei1112 – 11121Substrate By similarity
Active sitei1146 – 11461Phosphocysteine intermediate By similarity
Binding sitei1190 – 11901Substrate By similarity

GO - Molecular functioni

  1. Wnt-protein binding Source: UniProtKB
  2. protein binding Source: UniProtKB
  3. protein homodimerization activity Source: UniProtKB
  4. protein tyrosine phosphatase activity Source: UniProtKB

GO - Biological processi

  1. axon guidance Source: UniProtKB
  2. cell morphogenesis Source: UniProtKB
  3. glomerular visceral epithelial cell differentiation Source: UniProtKB
  4. glomerulus development Source: UniProtKB
  5. lamellipodium assembly Source: UniProtKB
  6. monocyte chemotaxis Source: UniProtKB
  7. negative regulation of canonical Wnt signaling pathway Source: UniProtKB
  8. negative regulation of glomerular filtration Source: UniProtKB
  9. peptidyl-tyrosine dephosphorylation Source: UniProtKB
  10. regulation of glomerular filtration Source: UniProtKB
  11. slit diaphragm assembly Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase, Receptor

Names & Taxonomyi

Protein namesi
Recommended name:
Receptor-type tyrosine-protein phosphatase O (EC:3.1.3.48)
Short name:
R-PTP-O
Alternative name(s):
Glomerular epithelial protein 1
Protein tyrosine phosphatase U2
Short name:
PTP-U2
Short name:
PTPase U2
Gene namesi
Name:Ptpro
Synonyms:GLEPP1, Ptpn15, PTPU2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 6

Organism-specific databases

MGIiMGI:1097152. Ptpro.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini30 – 832803Extracellular Reviewed prediction
Add
BLAST
Transmembranei833 – 85321Helical; Reviewed prediction
Add
BLAST
Topological domaini854 – 1226373Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. apical plasma membrane Source: UniProtKB
  2. dendritic spine Source: UniProtKB
  3. integral component of membrane Source: UniProtKB-KW
  4. lateral plasma membrane Source: UniProtKB
  5. plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Disruption phenotypei

Modification of podocyte structure such that the normal octopoid podocyte is simplified to a more amoeboid structure and that the foot processes are shorter and broader than normal. These changes are associated with altered distribution of the podocyte intermediate cytoskeletal protein vimentin/VIM. Mutant animals have a reduced glomerular filtration rate and reduced glomerular nephrin (NPHS1) content. However, there is no evidence of proteinuria. After removal of one or more kidneys, Ptpro-null animals have higher blood pressure than does their wild-type littermates.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2929 Reviewed prediction
Add
BLAST
Chaini30 – 12261197Receptor-type tyrosine-protein phosphatase O
PRO_0000414059Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi75 – 751N-linked (GlcNAc...) Reviewed prediction
Glycosylationi154 – 1541N-linked (GlcNAc...) Reviewed prediction
Glycosylationi227 – 2271N-linked (GlcNAc...) Reviewed prediction
Glycosylationi279 – 2791N-linked (GlcNAc...) Reviewed prediction
Glycosylationi471 – 4711N-linked (GlcNAc...) Reviewed prediction
Glycosylationi500 – 5001N-linked (GlcNAc...) Reviewed prediction
Glycosylationi710 – 7101N-linked (GlcNAc...) Reviewed prediction
Glycosylationi743 – 7431N-linked (GlcNAc...) Reviewed prediction
Glycosylationi800 – 8001N-linked (GlcNAc...) Reviewed prediction
Modified residuei875 – 8751Phosphoserine1 Publication

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PRIDEiE9Q612.

PTM databases

PhosphoSiteiE9Q612.

Expressioni

Gene expression databases

BgeeiE9Q612.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
Wnt3aP274672EBI-8183885,EBI-2899665

Protein-protein interaction databases

IntActiE9Q612. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliE9Q612.
SMRiE9Q612. Positions 926-1218.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini30 – 11586Fibronectin type-III 1
Add
BLAST
Domaini339 – 43597Fibronectin type-III 2
Add
BLAST
Domaini445 – 54197Fibronectin type-III 3
Add
BLAST
Domaini542 – 63897Fibronectin type-III 4
Add
BLAST
Domaini641 – 73494Fibronectin type-III 5
Add
BLAST
Domaini735 – 82793Fibronectin type-III 6
Add
BLAST
Domaini948 – 1205258Tyrosine-protein phosphatase
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1146 – 11527Substrate binding By similarity

Sequence similaritiesi

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00750000117631.
HOGENOMiHOG000115792.
HOVERGENiHBG053763.
InParanoidiQ7TSY7.
KOiK18035.
OMAiSTMVTEM.
OrthoDBiEOG7PCJFZ.
TreeFamiTF351926.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
3.90.190.10. 1 hit.
InterProiIPR003961. Fibronectin_type3.
IPR013783. Ig-like_fold.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view]
PfamiPF00041. fn3. 2 hits.
PF00102. Y_phosphatase. 1 hit.
[Graphical view]
PRINTSiPR00700. PRTYPHPHTASE.
SMARTiSM00060. FN3. 4 hits.
SM00194. PTPc. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 3 hits.
SSF52799. SSF52799. 1 hit.
PROSITEiPS50853. FN3. 5 hits.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

E9Q612-1 [UniParc]FASTAAdd to Basket

« Hide

MGHLPRGTLG GRRLLPLLGL FVLLKIVTTF HVAVQDDNNI VVSLEASDIV     50
SPASVYVVRV AGESKNYFFE FEEFNSTLPP PVVFKATYHG LYYIITLVVV 100
NGNVVTKPSR SITVLTKPLP VTSVSIYDYK PSPETGVLFE IHYPEKYNVF 150
SRVNISYWEG RDFRTMLYKD FFKGKTVFNH WLPGLCYSNI TFQLVSEATF 200
NKSTLVEYSG VSHEPKQHRT APYPPRNISV RFVNLNKNNW EEPSGSFPED 250
SFIKPPQDSI GRDRRFHFPE ETPETPPSNV SSGSPPSNVS SAWPDPNSTD 300
YESTSQPFWW DSASAAPENE EDFVSALPAD YDTETTLDRT EKPTADPFSA 350
FPVQMTLSWL PPKPPTAFDG FNILIEREEN FTDYLTVDEE AHEFVAELKE 400
PGKYKLSVTT FSSSGACETR KSQSAKSLSF YISPTGEWIE ELTEKPQHVS 450
VHVLSSTTAL MSWTSSQENY NSTIVSVVSL TCQKQKESQR LEKQYCTQVN 500
SSKPVIENLV PGAQYQVVMY LRKGPLIGPP SDPVTFAIVP TGIKDLMLYP 550
LGPTAVVLSW TRPILGVFRK YVVEMFYFNP TTMTSEWTTY YEIAATVSLT 600
ASVRIASLLP AWYYNFRVTM VTWGDPELSC CDSSTISFIT APVAPEITSV 650
EYFNSLLYIS WTYGDATTDL SHSRMLHWMV VAEGRKKIKK SVTRNVMTAI 700
LSLPPGDIYN LSVTACTERG SNTSLPRLVK LEPAPPKSLF AVNKTQTSVT 750
LLWVEEGVAD FFEVFCQQLG SGHNGKLQEP VAVSSHVVTI SSLLPATAYN 800
CSVTSFSHDT PSVPTFIAVS TMVTEVNPNV VVISVLAILS TLLIGLLLVT 850
LVILRKKHLQ MARECGAGTF VNFASLEREG KLPYSWRRSV FALLTLLPSC 900
LWTDYLLAFY INPWSKNGLK KRKLTNPVQL DDFDSYIKDM AKDSDYKFSL 950
QFEELKLIGL DIPHFAADLP LNRCKNRYTN ILPYDFSRVR LVSMNEEEGA 1000
DYINANYIPG YNSPQEYIAT QGPLPETRND FWKMVLQQKS HIIVMLTQCN 1050
EKRRVKCDHY WPFTEEPIAY GDITVEMVSE EEEEDWASRH FRINYADEAQ 1100
DVMHFNYTAW PDHGVPPANA AESILQFVFT VRQQAAKSKG PMIIHCSAGV 1150
GRTGTFIALD RLLQHIRDHE FVDILGLVSE MRSYRMSMVQ TEEQYIFIHQ 1200
CVQLMWLRKK QQFCISDVIY ENVSKS 1226
Length:1,226
Mass (Da):138,589
Last modified:April 5, 2011 - v1
Checksum:i3FF0BE298354BC32
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1184 – 11841Y → H in AAH52743. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC093120 Genomic DNA. No translation available.
AC144767 Genomic DNA. No translation available.
AC163627 Genomic DNA. No translation available.
BC052743 mRNA. Translation: AAH52743.1.
CCDSiCCDS20664.1.
RefSeqiNP_035346.3. NM_011216.3.
UniGeneiMm.186361.
Mm.491536.

Genome annotation databases

EnsembliENSMUST00000077115; ENSMUSP00000076364; ENSMUSG00000030223.
GeneIDi19277.
KEGGimmu:19277.
UCSCiuc009emv.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC093120 Genomic DNA. No translation available.
AC144767 Genomic DNA. No translation available.
AC163627 Genomic DNA. No translation available.
BC052743 mRNA. Translation: AAH52743.1 .
CCDSi CCDS20664.1.
RefSeqi NP_035346.3. NM_011216.3.
UniGenei Mm.186361.
Mm.491536.

3D structure databases

ProteinModelPortali E9Q612.
SMRi E9Q612. Positions 926-1218.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi E9Q612. 1 interaction.

PTM databases

PhosphoSitei E9Q612.

Proteomic databases

PRIDEi E9Q612.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000077115 ; ENSMUSP00000076364 ; ENSMUSG00000030223 .
GeneIDi 19277.
KEGGi mmu:19277.
UCSCi uc009emv.2. mouse.

Organism-specific databases

CTDi 5800.
MGIi MGI:1097152. Ptpro.

Phylogenomic databases

GeneTreei ENSGT00750000117631.
HOGENOMi HOG000115792.
HOVERGENi HBG053763.
InParanoidi Q7TSY7.
KOi K18035.
OMAi STMVTEM.
OrthoDBi EOG7PCJFZ.
TreeFami TF351926.

Miscellaneous databases

NextBioi 296184.
PROi E9Q612.
SOURCEi Search...

Gene expression databases

Bgeei E9Q612.

Family and domain databases

Gene3Di 2.60.40.10. 3 hits.
3.90.190.10. 1 hit.
InterProi IPR003961. Fibronectin_type3.
IPR013783. Ig-like_fold.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view ]
Pfami PF00041. fn3. 2 hits.
PF00102. Y_phosphatase. 1 hit.
[Graphical view ]
PRINTSi PR00700. PRTYPHPHTASE.
SMARTi SM00060. FN3. 4 hits.
SM00194. PTPc. 1 hit.
[Graphical view ]
SUPFAMi SSF49265. SSF49265. 3 hits.
SSF52799. SSF52799. 1 hit.
PROSITEi PS50853. FN3. 5 hits.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "Altered podocyte structure in GLEPP1 (Ptpro)-deficient mice associated with hypertension and low glomerular filtration rate."
    Wharram B.L., Goyal M., Gillespie P.J., Wiggins J.E., Kershaw D.B., Holzman L.B., Dysko R.C., Saunders T.L., Samuelson L.C., Wiggins R.C.
    J. Clin. Invest. 106:1281-1290(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DISRUPTION PHENOTYPE.
  4. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-875, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiPTPRO_MOUSE
AccessioniPrimary (citable) accession number: E9Q612
Secondary accession number(s): Q7TSY7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 14, 2011
Last sequence update: April 5, 2011
Last modified: July 9, 2014
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi