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E9Q612

- PTPRO_MOUSE

UniProt

E9Q612 - PTPRO_MOUSE

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Protein

Receptor-type tyrosine-protein phosphatase O

Gene

Ptpro

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Possesses tyrosine phosphatase activity. Plays a role in regulating the glomerular pressure/filtration rate relationship through an effect on podocyte structure and function.1 Publication

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei1112 – 11121SubstrateBy similarity
Active sitei1146 – 11461Phosphocysteine intermediatePROSITE-ProRule annotation
Binding sitei1190 – 11901SubstrateBy similarity

GO - Molecular functioni

  1. protein homodimerization activity Source: UniProtKB
  2. protein tyrosine phosphatase activity Source: UniProtKB
  3. Wnt-protein binding Source: UniProtKB

GO - Biological processi

  1. axon guidance Source: UniProtKB
  2. cell morphogenesis Source: UniProtKB
  3. glomerular visceral epithelial cell differentiation Source: UniProtKB
  4. glomerulus development Source: UniProtKB
  5. lamellipodium assembly Source: UniProtKB
  6. monocyte chemotaxis Source: UniProtKB
  7. negative regulation of canonical Wnt signaling pathway Source: UniProtKB
  8. negative regulation of glomerular filtration Source: UniProtKB
  9. peptidyl-tyrosine dephosphorylation Source: UniProtKB
  10. regulation of glomerular filtration Source: UniProtKB
  11. slit diaphragm assembly Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase, Receptor

Names & Taxonomyi

Protein namesi
Recommended name:
Receptor-type tyrosine-protein phosphatase O (EC:3.1.3.48)
Short name:
R-PTP-O
Alternative name(s):
Glomerular epithelial protein 1
Protein tyrosine phosphatase U2
Short name:
PTP-U2
Short name:
PTPase U2
Gene namesi
Name:Ptpro
Synonyms:GLEPP1, Ptpn15, PTPU2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 6

Organism-specific databases

MGIiMGI:1097152. Ptpro.

Subcellular locationi

Membrane By similarity; Single-pass type I membrane protein By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini30 – 832803ExtracellularSequence AnalysisAdd
BLAST
Transmembranei833 – 85321HelicalSequence AnalysisAdd
BLAST
Topological domaini854 – 1226373CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. apical plasma membrane Source: UniProtKB
  2. dendritic spine Source: UniProtKB
  3. extracellular vesicular exosome Source: Ensembl
  4. integral component of membrane Source: UniProtKB-KW
  5. lateral plasma membrane Source: UniProtKB
  6. plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Disruption phenotypei

Modification of podocyte structure such that the normal octopoid podocyte is simplified to a more amoeboid structure and that the foot processes are shorter and broader than normal. These changes are associated with altered distribution of the podocyte intermediate cytoskeletal protein vimentin/VIM. Mutant animals have a reduced glomerular filtration rate and reduced glomerular nephrin (NPHS1) content. However, there is no evidence of proteinuria. After removal of one or more kidneys, Ptpro-null animals have higher blood pressure than does their wild-type littermates.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2929Sequence AnalysisAdd
BLAST
Chaini30 – 12261197Receptor-type tyrosine-protein phosphatase OPRO_0000414059Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi75 – 751N-linked (GlcNAc...)Sequence Analysis
Glycosylationi154 – 1541N-linked (GlcNAc...)Sequence Analysis
Glycosylationi227 – 2271N-linked (GlcNAc...)Sequence Analysis
Glycosylationi279 – 2791N-linked (GlcNAc...)Sequence Analysis
Glycosylationi471 – 4711N-linked (GlcNAc...)Sequence Analysis
Glycosylationi500 – 5001N-linked (GlcNAc...)Sequence Analysis
Glycosylationi710 – 7101N-linked (GlcNAc...)Sequence Analysis
Glycosylationi743 – 7431N-linked (GlcNAc...)Sequence Analysis
Glycosylationi800 – 8001N-linked (GlcNAc...)Sequence Analysis
Modified residuei875 – 8751Phosphoserine1 Publication

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiE9Q612.
PRIDEiE9Q612.

PTM databases

PhosphoSiteiE9Q612.

Expressioni

Gene expression databases

BgeeiE9Q612.
ExpressionAtlasiE9Q612. baseline and differential.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
Wnt3aP274672EBI-8183885,EBI-2899665

Protein-protein interaction databases

IntActiE9Q612. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliE9Q612.
SMRiE9Q612. Positions 926-1218.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini30 – 11586Fibronectin type-III 1PROSITE-ProRule annotationAdd
BLAST
Domaini339 – 43597Fibronectin type-III 2PROSITE-ProRule annotationAdd
BLAST
Domaini445 – 54197Fibronectin type-III 3PROSITE-ProRule annotationAdd
BLAST
Domaini542 – 63897Fibronectin type-III 4PROSITE-ProRule annotationAdd
BLAST
Domaini641 – 73494Fibronectin type-III 5PROSITE-ProRule annotationAdd
BLAST
Domaini735 – 82793Fibronectin type-III 6PROSITE-ProRule annotationAdd
BLAST
Domaini948 – 1205258Tyrosine-protein phosphatasePROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1146 – 11527Substrate bindingBy similarity

Sequence similaritiesi

Contains 6 fibronectin type-III domains.PROSITE-ProRule annotation
Contains 1 tyrosine-protein phosphatase domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00770000120452.
HOGENOMiHOG000115792.
HOVERGENiHBG053763.
InParanoidiE9Q612.
KOiK18035.
OMAiSTMVTEM.
OrthoDBiEOG7PCJFZ.
TreeFamiTF351926.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
3.90.190.10. 1 hit.
InterProiIPR003961. Fibronectin_type3.
IPR013783. Ig-like_fold.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view]
PfamiPF00041. fn3. 2 hits.
PF00102. Y_phosphatase. 1 hit.
[Graphical view]
PRINTSiPR00700. PRTYPHPHTASE.
SMARTiSM00060. FN3. 4 hits.
SM00194. PTPc. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 3 hits.
SSF52799. SSF52799. 1 hit.
PROSITEiPS50853. FN3. 5 hits.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

E9Q612-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGHLPRGTLG GRRLLPLLGL FVLLKIVTTF HVAVQDDNNI VVSLEASDIV
60 70 80 90 100
SPASVYVVRV AGESKNYFFE FEEFNSTLPP PVVFKATYHG LYYIITLVVV
110 120 130 140 150
NGNVVTKPSR SITVLTKPLP VTSVSIYDYK PSPETGVLFE IHYPEKYNVF
160 170 180 190 200
SRVNISYWEG RDFRTMLYKD FFKGKTVFNH WLPGLCYSNI TFQLVSEATF
210 220 230 240 250
NKSTLVEYSG VSHEPKQHRT APYPPRNISV RFVNLNKNNW EEPSGSFPED
260 270 280 290 300
SFIKPPQDSI GRDRRFHFPE ETPETPPSNV SSGSPPSNVS SAWPDPNSTD
310 320 330 340 350
YESTSQPFWW DSASAAPENE EDFVSALPAD YDTETTLDRT EKPTADPFSA
360 370 380 390 400
FPVQMTLSWL PPKPPTAFDG FNILIEREEN FTDYLTVDEE AHEFVAELKE
410 420 430 440 450
PGKYKLSVTT FSSSGACETR KSQSAKSLSF YISPTGEWIE ELTEKPQHVS
460 470 480 490 500
VHVLSSTTAL MSWTSSQENY NSTIVSVVSL TCQKQKESQR LEKQYCTQVN
510 520 530 540 550
SSKPVIENLV PGAQYQVVMY LRKGPLIGPP SDPVTFAIVP TGIKDLMLYP
560 570 580 590 600
LGPTAVVLSW TRPILGVFRK YVVEMFYFNP TTMTSEWTTY YEIAATVSLT
610 620 630 640 650
ASVRIASLLP AWYYNFRVTM VTWGDPELSC CDSSTISFIT APVAPEITSV
660 670 680 690 700
EYFNSLLYIS WTYGDATTDL SHSRMLHWMV VAEGRKKIKK SVTRNVMTAI
710 720 730 740 750
LSLPPGDIYN LSVTACTERG SNTSLPRLVK LEPAPPKSLF AVNKTQTSVT
760 770 780 790 800
LLWVEEGVAD FFEVFCQQLG SGHNGKLQEP VAVSSHVVTI SSLLPATAYN
810 820 830 840 850
CSVTSFSHDT PSVPTFIAVS TMVTEVNPNV VVISVLAILS TLLIGLLLVT
860 870 880 890 900
LVILRKKHLQ MARECGAGTF VNFASLEREG KLPYSWRRSV FALLTLLPSC
910 920 930 940 950
LWTDYLLAFY INPWSKNGLK KRKLTNPVQL DDFDSYIKDM AKDSDYKFSL
960 970 980 990 1000
QFEELKLIGL DIPHFAADLP LNRCKNRYTN ILPYDFSRVR LVSMNEEEGA
1010 1020 1030 1040 1050
DYINANYIPG YNSPQEYIAT QGPLPETRND FWKMVLQQKS HIIVMLTQCN
1060 1070 1080 1090 1100
EKRRVKCDHY WPFTEEPIAY GDITVEMVSE EEEEDWASRH FRINYADEAQ
1110 1120 1130 1140 1150
DVMHFNYTAW PDHGVPPANA AESILQFVFT VRQQAAKSKG PMIIHCSAGV
1160 1170 1180 1190 1200
GRTGTFIALD RLLQHIRDHE FVDILGLVSE MRSYRMSMVQ TEEQYIFIHQ
1210 1220
CVQLMWLRKK QQFCISDVIY ENVSKS
Length:1,226
Mass (Da):138,589
Last modified:April 5, 2011 - v1
Checksum:i3FF0BE298354BC32
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1184 – 11841Y → H in AAH52743. (PubMed:15489334)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC093120 Genomic DNA. No translation available.
AC144767 Genomic DNA. No translation available.
AC163627 Genomic DNA. No translation available.
BC052743 mRNA. Translation: AAH52743.1.
CCDSiCCDS20664.1.
RefSeqiNP_035346.3. NM_011216.3.
UniGeneiMm.186361.
Mm.491536.

Genome annotation databases

EnsembliENSMUST00000077115; ENSMUSP00000076364; ENSMUSG00000030223.
GeneIDi19277.
KEGGimmu:19277.
UCSCiuc009emv.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC093120 Genomic DNA. No translation available.
AC144767 Genomic DNA. No translation available.
AC163627 Genomic DNA. No translation available.
BC052743 mRNA. Translation: AAH52743.1 .
CCDSi CCDS20664.1.
RefSeqi NP_035346.3. NM_011216.3.
UniGenei Mm.186361.
Mm.491536.

3D structure databases

ProteinModelPortali E9Q612.
SMRi E9Q612. Positions 926-1218.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi E9Q612. 1 interaction.

PTM databases

PhosphoSitei E9Q612.

Proteomic databases

MaxQBi E9Q612.
PRIDEi E9Q612.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000077115 ; ENSMUSP00000076364 ; ENSMUSG00000030223 .
GeneIDi 19277.
KEGGi mmu:19277.
UCSCi uc009emv.2. mouse.

Organism-specific databases

CTDi 5800.
MGIi MGI:1097152. Ptpro.

Phylogenomic databases

GeneTreei ENSGT00770000120452.
HOGENOMi HOG000115792.
HOVERGENi HBG053763.
InParanoidi E9Q612.
KOi K18035.
OMAi STMVTEM.
OrthoDBi EOG7PCJFZ.
TreeFami TF351926.

Miscellaneous databases

NextBioi 296184.
PROi E9Q612.
SOURCEi Search...

Gene expression databases

Bgeei E9Q612.
ExpressionAtlasi E9Q612. baseline and differential.

Family and domain databases

Gene3Di 2.60.40.10. 3 hits.
3.90.190.10. 1 hit.
InterProi IPR003961. Fibronectin_type3.
IPR013783. Ig-like_fold.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view ]
Pfami PF00041. fn3. 2 hits.
PF00102. Y_phosphatase. 1 hit.
[Graphical view ]
PRINTSi PR00700. PRTYPHPHTASE.
SMARTi SM00060. FN3. 4 hits.
SM00194. PTPc. 1 hit.
[Graphical view ]
SUPFAMi SSF49265. SSF49265. 3 hits.
SSF52799. SSF52799. 1 hit.
PROSITEi PS50853. FN3. 5 hits.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "Altered podocyte structure in GLEPP1 (Ptpro)-deficient mice associated with hypertension and low glomerular filtration rate."
    Wharram B.L., Goyal M., Gillespie P.J., Wiggins J.E., Kershaw D.B., Holzman L.B., Dysko R.C., Saunders T.L., Samuelson L.C., Wiggins R.C.
    J. Clin. Invest. 106:1281-1290(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DISRUPTION PHENOTYPE.
  4. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-875, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiPTPRO_MOUSE
AccessioniPrimary (citable) accession number: E9Q612
Secondary accession number(s): Q7TSY7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 14, 2011
Last sequence update: April 5, 2011
Last modified: November 26, 2014
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3