Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Fanconi anemia group F protein

Gene

Fancf

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability.1 Publication

GO - Biological processi

  • cellular response to DNA damage stimulus Source: MGI
  • DNA repair Source: UniProtKB-KW
  • ovarian follicle development Source: MGI
  • protein ubiquitination Source: MGI
  • spermatogenesis Source: MGI

Keywordsi

Biological processDNA damage, DNA repair

Enzyme and pathway databases

ReactomeiR-MMU-6783310 Fanconi Anemia Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Fanconi anemia group F proteinBy similarity
Short name:
Protein FACFBy similarity
Gene namesi
Name:FancfImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:3689889 Fancf

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

Viable with no gross developmental abnormalities or significant growth retardation. Gonad defects are present in both male and female mice. Testes are devoid of germ cells. Ovaries show premature depletion of primordial follicles with almost complete loss by 14 weeks of age, and aberrant estrous cycle. Significantly increased incidence of tumors, particularly ovarian tumors.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004362041 – 343Fanconi anemia group F proteinAdd BLAST343

Proteomic databases

MaxQBiE9Q5Z5
PaxDbiE9Q5Z5
PRIDEiE9Q5Z5

PTM databases

iPTMnetiE9Q5Z5
PhosphoSitePlusiE9Q5Z5

Expressioni

Gene expression databases

BgeeiENSMUSG00000092118
GenevisibleiE9Q5Z5 MM

Interactioni

Subunit structurei

Belongs to the multisubunit FA complex composed of FANCA, FANCB, FANCC, FANCE, FANCF, FANCG, FANCL/PHF9 and FANCM. In complex with FANCA, FANCG and FANCL, but not with FANCC, nor FANCE, interacts with HES1; this interaction may be essential for the stability and nuclear localization of FA core complex proteins.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000125812

Structurei

3D structure databases

ProteinModelPortaliE9Q5Z5
SMRiE9Q5Z5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IKQV Eukaryota
ENOG4111WMC LUCA
GeneTreeiENSGT00390000005623
InParanoidiE9Q5Z5
KOiK10893
OMAiWARYLRH
OrthoDBiEOG091G18J8
PhylomeDBiE9Q5Z5
TreeFamiTF332957

Family and domain databases

Gene3Di1.25.40.490, 1 hit
InterProiView protein in InterPro
IPR035428 FANCF
IPR038505 FANCF_C_sf
IPR025825 FANCF_met
PANTHERiPTHR14449 PTHR14449, 1 hit
PfamiView protein in Pfam
PF11107 FANCF, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD321645 PD321645, 1 hit

Sequencei

Sequence statusi: Complete.

E9Q5Z5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPLVQQTER FSELLAVSCG SLVSTWDAEK VRRALQWARY LLHVYRRFAG
60 70 80 90 100
RGRVREALER RLPARGGPLG LRSFAALESG DARLALRLLR NRALAPAAAR
110 120 130 140 150
ALPSLLFPGP AADHRDDVPQ SRLVLLARRG SALRLLCRLG GDAPRSALLR
160 170 180 190 200
THAELLDARL HELGGADSAA ARKLLDTLWT RGPREHVLDV TAEALLLREE
210 220 230 240 250
DPEPAQATDP AGADETQKLL RWLLESPEVL AAFCRHLPAK RLASVAGCHH
260 270 280 290 300
ALSRAYLDLL TTWATRLHYD LQKGAWVPTQ MEDMPWEELC LRLQSLCHAQ
310 320 330 340
PFLQEEVLVT LRSRKALDGD FEVPGMSIWT DLLVVLECGI VLE
Length:343
Mass (Da):38,224
Last modified:April 5, 2011 - v1
Checksum:iAB6794BF903F4FB6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC158345 Genomic DNA No translation available.
CCDSiCCDS52261.1
RefSeqiNP_001108559.1, NM_001115087.1
UniGeneiMm.322643
Mm.392015

Genome annotation databases

EnsembliENSMUST00000169357; ENSMUSP00000125812; ENSMUSG00000092118
GeneIDi100040608
KEGGimmu:100040608
UCSCiuc012flg.2 mouse

Similar proteinsi

Entry informationi

Entry nameiFANCF_MOUSE
AccessioniPrimary (citable) accession number: E9Q5Z5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 11, 2016
Last sequence update: April 5, 2011
Last modified: May 23, 2018
This is version 50 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health