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Protein

Fanconi anemia group F protein

Gene

Fancf

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability.1 Publication

GO - Biological processi

  • cellular response to DNA damage stimulus Source: MGI
  • DNA repair Source: UniProtKB-KW
  • mitophagy in response to mitochondrial depolarization Source: MGI
  • ovarian follicle development Source: MGI
  • protein ubiquitination Source: MGI
  • spermatogenesis Source: MGI
Complete GO annotation...

Keywords - Biological processi

DNA damage, DNA repair

Enzyme and pathway databases

ReactomeiR-MMU-6783310. Fanconi Anemia Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Fanconi anemia group F proteinBy similarity
Short name:
Protein FACFBy similarity
Gene namesi
Name:FancfImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:3689889. Fancf.

Subcellular locationi

  • Nucleus By similarity

GO - Cellular componenti

  • Fanconi anaemia nuclear complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

Viable with no gross developmental abnormalities or significant growth retardation. Gonad defects are present in both male and female mice. Testes are devoid of germ cells. Ovaries show premature depletion of primordial follicles with almost complete loss by 14 weeks of age, and aberrant estrous cycle. Significantly increased incidence of tumors, particularly ovarian tumors.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 343343Fanconi anemia group F proteinPRO_0000436204Add
BLAST

Proteomic databases

PaxDbiE9Q5Z5.
PRIDEiE9Q5Z5.

PTM databases

iPTMnetiE9Q5Z5.

Expressioni

Gene expression databases

BgeeiE9Q5Z5.
GenevisibleiE9Q5Z5. MM.

Interactioni

Subunit structurei

Belongs to the multisubunit FA complex composed of FANCA, FANCB, FANCC, FANCE, FANCF, FANCG, FANCL/PHF9 and FANCM. In complex with FANCA, FANCG and FANCL, but not with FANCC, nor FANCE, interacts with HES1; this interaction may be essential for the stability and nuclear localization of FA core complex proteins.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000125812.

Structurei

3D structure databases

ProteinModelPortaliE9Q5Z5.
SMRiE9Q5Z5. Positions 147-339.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IKQV. Eukaryota.
ENOG4111WMC. LUCA.
GeneTreeiENSGT00390000005623.
InParanoidiE9Q5Z5.
KOiK10893.
OMAiWARYLRH.
OrthoDBiEOG7S4X6V.
PhylomeDBiE9Q5Z5.
TreeFamiTF332957.

Family and domain databases

InterProiIPR025825. FANCF.
[Graphical view]
ProDomiPD321645. PD321645. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

E9Q5Z5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPLVQQTER FSELLAVSCG SLVSTWDAEK VRRALQWARY LLHVYRRFAG
60 70 80 90 100
RGRVREALER RLPARGGPLG LRSFAALESG DARLALRLLR NRALAPAAAR
110 120 130 140 150
ALPSLLFPGP AADHRDDVPQ SRLVLLARRG SALRLLCRLG GDAPRSALLR
160 170 180 190 200
THAELLDARL HELGGADSAA ARKLLDTLWT RGPREHVLDV TAEALLLREE
210 220 230 240 250
DPEPAQATDP AGADETQKLL RWLLESPEVL AAFCRHLPAK RLASVAGCHH
260 270 280 290 300
ALSRAYLDLL TTWATRLHYD LQKGAWVPTQ MEDMPWEELC LRLQSLCHAQ
310 320 330 340
PFLQEEVLVT LRSRKALDGD FEVPGMSIWT DLLVVLECGI VLE
Length:343
Mass (Da):38,224
Last modified:April 5, 2011 - v1
Checksum:iAB6794BF903F4FB6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC158345 Genomic DNA. No translation available.
CCDSiCCDS52261.1.
RefSeqiNP_001108559.1. NM_001115087.1.
UniGeneiMm.322643.
Mm.392015.

Genome annotation databases

EnsembliENSMUST00000169357; ENSMUSP00000125812; ENSMUSG00000092118.
GeneIDi100040608.
KEGGimmu:100040608.
UCSCiuc012flg.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC158345 Genomic DNA. No translation available.
CCDSiCCDS52261.1.
RefSeqiNP_001108559.1. NM_001115087.1.
UniGeneiMm.322643.
Mm.392015.

3D structure databases

ProteinModelPortaliE9Q5Z5.
SMRiE9Q5Z5. Positions 147-339.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000125812.

PTM databases

iPTMnetiE9Q5Z5.

Proteomic databases

PaxDbiE9Q5Z5.
PRIDEiE9Q5Z5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000169357; ENSMUSP00000125812; ENSMUSG00000092118.
GeneIDi100040608.
KEGGimmu:100040608.
UCSCiuc012flg.2. mouse.

Organism-specific databases

CTDi2188.
MGIiMGI:3689889. Fancf.

Phylogenomic databases

eggNOGiENOG410IKQV. Eukaryota.
ENOG4111WMC. LUCA.
GeneTreeiENSGT00390000005623.
InParanoidiE9Q5Z5.
KOiK10893.
OMAiWARYLRH.
OrthoDBiEOG7S4X6V.
PhylomeDBiE9Q5Z5.
TreeFamiTF332957.

Enzyme and pathway databases

ReactomeiR-MMU-6783310. Fanconi Anemia Pathway.

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

BgeeiE9Q5Z5.
GenevisibleiE9Q5Z5. MM.

Family and domain databases

InterProiIPR025825. FANCF.
[Graphical view]
ProDomiPD321645. PD321645. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  2. Cited for: FUNCTION, DISRUPTION PHENOTYPE.

Entry informationi

Entry nameiFANCF_MOUSE
AccessioniPrimary (citable) accession number: E9Q5Z5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 11, 2016
Last sequence update: April 5, 2011
Last modified: July 6, 2016
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.