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Protein

NACHT, LRR and PYD domains-containing protein 12

Gene

Nlrp12

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

May mediate activation of CASP1 via ASC and promote activation of NF-kappa-B via IKK.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi217 – 224ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
NACHT, LRR and PYD domains-containing protein 12
Alternative name(s):
Monarch-1
PYRIN-containing APAF1-like protein 7
Short name:
PYPAF7
Gene namesi
Name:Nlrp12
Synonyms:NALP12
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:2676630. Nlrp12.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004197581 – 1054NACHT, LRR and PYD domains-containing protein 12Add BLAST1054

Proteomic databases

PaxDbiE9Q5R7.
PRIDEiE9Q5R7.

PTM databases

PhosphoSitePlusiE9Q5R7.

Expressioni

Gene expression databases

BgeeiENSMUSG00000078817.
GenevisibleiE9Q5R7. MM.

Interactioni

Subunit structurei

Binds to ASC with its pyrin domain. Interacts with FAF1 UBA domain via its pyrin domain (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000104293.

Structurei

3D structure databases

ProteinModelPortaliE9Q5R7.
SMRiE9Q5R7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 95PyrinPROSITE-ProRule annotationAdd BLAST95
Domaini211 – 528NACHTPROSITE-ProRule annotationAdd BLAST318
Repeati821 – 841LRR 1Add BLAST21
Repeati850 – 871LRR 2Add BLAST22
Repeati878 – 899LRR 3Add BLAST22
Repeati907 – 928LRR 4Add BLAST22
Repeati935 – 955LRR 5Add BLAST21
Repeati964 – 985LRR 6Add BLAST22
Repeati992 – 1013LRR 7Add BLAST22
Repeati1021 – 1042LRR 8Add BLAST22

Sequence similaritiesi

Belongs to the NLRP family.Curated
Contains 8 LRR (leucine-rich) repeats.Curated
Contains 1 NACHT domain.PROSITE-ProRule annotation
Contains 1 pyrin domain.PROSITE-ProRule annotation

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiENOG410IE5X. Eukaryota.
ENOG4111H3D. LUCA.
GeneTreeiENSGT00860000133669.
InParanoidiE9Q5R7.
OMAiKTHRRMA.
OrthoDBiEOG091G01CG.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
3.40.50.300. 1 hit.
3.80.10.10. 3 hits.
InterProiIPR004020. DAPIN.
IPR011029. DEATH-like_dom.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR029495. NACHT-assoc.
IPR007111. NACHT_NTPase.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF14484. FISNA. 1 hit.
PF13516. LRR_6. 5 hits.
PF02758. PYRIN. 1 hit.
[Graphical view]
SMARTiSM01288. FISNA. 1 hit.
SM01289. PYRIN. 1 hit.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
SSF52540. SSF52540. 2 hits.
PROSITEiPS50824. DAPIN. 1 hit.
PS51450. LRR. 6 hits.
PS50837. NACHT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E9Q5R7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLPSTARDGL YRLSTYLEEL EAGELKKFKL FLGIAEDLSQ DKIPWGRMEK
60 70 80 90 100
AGPLEMAQLM VAHMGTREAW LLALSTFQRI HRKDLWERGQ GEDLVRVTPN
110 120 130 140 150
NGLCLFESQS ACPLDVSPNA PRKDLQTTYK DYVRRKFQLM EDRNARLGEC
160 170 180 190 200
VNLSNRYTRL LLVKEHSNPI WTQQKFVDVE WERSRTRRHQ TSPIQMETLF
210 220 230 240 250
EPDEERPEPP HTVVLQGAAG MGKSMLAHKV MLDWADGRLF QGRFDYVFYI
260 270 280 290 300
SCRELNRSHT QCSVQDLISS CWPERGISLE DLMQAPDRLL FIIDGFDKLH
310 320 330 340 350
PSFHDAQGPW CLCWEEKQPT EVLLGSLIRR LLLPQVSLLI TTRPCALEKL
360 370 380 390 400
HGLLEHPRHV EILGFSEEAR KEYFYRYFHN TGQASRVLSF LMDYEPLFTM
410 420 430 440 450
CFVPMVSWVV CTCLKQQLES GELLRQTPRT TTAVYMFYLL SLMQPKPGTP
460 470 480 490 500
TFKVPANQRG LVSLAAEGLW NQKILFDEQD LGKHGLDGAD VSTFLNVNIF
510 520 530 540 550
QKGIKCEKFY SFIHLSFQEF FAAMYCALNG REAVRRALAE YGFSERNFLA
560 570 580 590 600
LTVHFLFGLL NEEMRCYLER NLGWSISPQV KEEVLAWIQN KAGSEGSTLQ
610 620 630 640 650
HGSLELLSCL YEVQEEDFIQ QALSHFQVVV VRSISTKMEH MVCSFCARYC
660 670 680 690 700
RSTEVLHLHG SAYSTGMEDD PPEPSGVQTQ STYLQERNML PDVYSAYLSA
710 720 730 740 750
AVCTNSNLIE LALYRNALGS QGVRLLCQGL RHASCKLQNL RLKRCQISGS
760 770 780 790 800
ACQDLAAAVI ANRNLIRLDL SDNSIGVPGL ELLCEGLQHP RCRLQMIQLR
810 820 830 840 850
KCLLEAAAGR SLASVLSNNS YLVELDLTGN PLEDSGLKLL CQGLRHPVCR
860 870 880 890 900
LRTLWLKICH LGQASCEDLA STLKMNQSLL ELDLGLNDLG DSGVLLLCEG
910 920 930 940 950
LSHPDCKLQT LRLGICRLGS VACVGIASVL QVNTCLQELD LSFNDLGDRG
960 970 980 990 1000
LQLLGEGLRH QTCRLQKLWL DNCGLTSKAC EDLSSILGIS QTLHELYLTN
1010 1020 1030 1040 1050
NALGDTGVCL LCKRLRHPGC KLRVLWLFGM DLNKKTHRRM AALRVTKPYL

DIGC
Length:1,054
Mass (Da):119,319
Last modified:April 5, 2011 - v1
Checksum:i3F17BEA78BA38621
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CAAA01093162 Genomic DNA. No translation available.
CAAA01093166 Genomic DNA. No translation available.
CAAA01193276 Genomic DNA. No translation available.
AK149454 mRNA. Translation: BAE28888.1.
CCDSiCCDS51963.1.
RefSeqiNP_001028603.1. NM_001033431.1.
UniGeneiMm.277152.

Genome annotation databases

EnsembliENSMUST00000108653; ENSMUSP00000104293; ENSMUSG00000078817.
ENSMUST00000181320; ENSMUSP00000137758; ENSMUSG00000097297.
GeneIDi378425.
KEGGimmu:378425.
UCSCiuc009eul.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CAAA01093162 Genomic DNA. No translation available.
CAAA01093166 Genomic DNA. No translation available.
CAAA01193276 Genomic DNA. No translation available.
AK149454 mRNA. Translation: BAE28888.1.
CCDSiCCDS51963.1.
RefSeqiNP_001028603.1. NM_001033431.1.
UniGeneiMm.277152.

3D structure databases

ProteinModelPortaliE9Q5R7.
SMRiE9Q5R7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000104293.

PTM databases

PhosphoSitePlusiE9Q5R7.

Proteomic databases

PaxDbiE9Q5R7.
PRIDEiE9Q5R7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000108653; ENSMUSP00000104293; ENSMUSG00000078817.
ENSMUST00000181320; ENSMUSP00000137758; ENSMUSG00000097297.
GeneIDi378425.
KEGGimmu:378425.
UCSCiuc009eul.2. mouse.

Organism-specific databases

CTDi91662.
MGIiMGI:2676630. Nlrp12.

Phylogenomic databases

eggNOGiENOG410IE5X. Eukaryota.
ENOG4111H3D. LUCA.
GeneTreeiENSGT00860000133669.
InParanoidiE9Q5R7.
OMAiKTHRRMA.
OrthoDBiEOG091G01CG.

Miscellaneous databases

PROiE9Q5R7.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000078817.
GenevisibleiE9Q5R7. MM.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
3.40.50.300. 1 hit.
3.80.10.10. 3 hits.
InterProiIPR004020. DAPIN.
IPR011029. DEATH-like_dom.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR029495. NACHT-assoc.
IPR007111. NACHT_NTPase.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF14484. FISNA. 1 hit.
PF13516. LRR_6. 5 hits.
PF02758. PYRIN. 1 hit.
[Graphical view]
SMARTiSM01288. FISNA. 1 hit.
SM01289. PYRIN. 1 hit.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
SSF52540. SSF52540. 2 hits.
PROSITEiPS50824. DAPIN. 1 hit.
PS51450. LRR. 6 hits.
PS50837. NACHT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNAL12_MOUSE
AccessioniPrimary (citable) accession number: E9Q5R7
Secondary accession number(s): Q3UEM3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2012
Last sequence update: April 5, 2011
Last modified: November 30, 2016
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.