E9Q5F9 (E9Q5F9_MOUSE) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Protein Setd2 Ensembl ENSMUSP00000116313

Gene names

Name:

Setd2 Ensembl ENSMUSP00000116313 MGI 1918177

Organism

Mus musculus (Mouse) [Reference proteome] Ensembl ENSMUSP00000116313

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	2537 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone]. SAAS SAAS001214
Sequence similarities	Contains 1 SET domain. RuleBase RU004538 Contains 1 post-SET domain. RuleBase RU004541 SAAS SAAS001214
Caution	The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data. Ensembl ENSMUSP00000116313

Ontologies

Keywords
Cellular component	Nucleus SAAS SAAS003616
Molecular function	Methyltransferase RuleBase RU004541 SAAS SAAS001214 Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	angiogenesis Inferred from mutant phenotype PubMed 20133625. Source: MGI cell migration involved in vasculogenesis Inferred from mutant phenotype PubMed 20133625. Source: MGI coronary vasculature morphogenesis Inferred from mutant phenotype PubMed 20133625. Source: MGI embryonic cranial skeleton morphogenesis Inferred from mutant phenotype PubMed 20133625. Source: MGI embryonic placenta morphogenesis Inferred from mutant phenotype PubMed 20133625. Source: MGI forebrain development Inferred from mutant phenotype PubMed 20133625. Source: MGI histone H3-K36 methylation Inferred from mutant phenotype PubMed 18157086PubMed 20133625. Source: MGI mesoderm morphogenesis Inferred from mutant phenotype PubMed 20133625. Source: MGI morphogenesis of a branching structure Inferred from mutant phenotype PubMed 20133625. Source: MGI neural tube closure Inferred from mutant phenotype PubMed 20133625. Source: MGI peptidyl-lysine trimethylation Inferred from mutant phenotype PubMed 18157086PubMed 20133625. Source: MGI pericardium development Inferred from mutant phenotype PubMed 20133625. Source: MGI regulation of gene expression Inferred from mutant phenotype PubMed 20133625. Source: MGI regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: InterPro stem cell development Inferred from mutant phenotype PubMed 20133625. Source: MGI
Cellular_component	chromosome Inferred from electronic annotation. Source: InterPro nucleus Inferred from direct assay PubMed 18157086. Source: MGI
Molecular_function	histone-lysine N-methyltransferase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	E9Q5F9 [UniParc]. Last modified April 5, 2011. Version 1. Checksum: 4ED47D778291DA9D	FASTA	2,537	285,663
	10 20 30 40 50 60 MKPLPSQQPP PKMGDFYDPE HPTPEEEENE AKIENVQKTG FIKGPVFKGV ASSRFLPKGT 70 80 90 100 110 120 KTKVNLEEQG RQKVSFSFSF TKKTLQNRFL TALSNEKQSD SPNSPAPPLQ VDSNPKVKMD 130 140 150 160 170 180 AGDTFPATEE SSPPKSRVEL GRIHFKKHLL HVTSRPQLAA STTAASPLPP TTQLPAVLAE 190 200 210 220 230 240 SMIDSPPSSP PPPPPPPQAS SPSPPAQISE PVALPQPPAT ALMTSPPGPL PGDVAVRAQK 250 260 270 280 290 300 ESPVKSGPEV LEVDTKQDIV SNSLEEHTVQ TLKEQADHLL QKEDSHIGKE EEVSDGSKIS 310 320 330 340 350 360 LSSKKASSKK KSSQFEGTFL GSESDEDSVR TSSSQRSHDL KSSTSIDKER DFKKSSAPSK 370 380 390 400 410 420 SEDLGKSSRS KTERDDRYCS YSKLERDTRY VSSRCRSERD RRRSRSRSRS DRASRTSLSY 430 440 450 460 470 480 SRSERSHYYD SERRYHRSSP YRERTRYSRP YTDNRARESS DSEDEYKKTY PRRTSAHSYR 490 500 510 520 530 540 DLRTSSSYSK FDRDCKTETS YLEMERRGKY TSKLERESKR TSEHETIKRC CSPPNELGFR 550 560 570 580 590 600 RGSSYSKHDN STSRYKSALS KSISKNDKFK NSFCCTELNE ENKQSHSFSL QTPCSKGSEL 610 620 630 640 650 660 RTINKISERE KTGSPTPSNQ LNDSPTFKKL DESPVLKPEF IGHDGRESIK ELELSKVKND 670 680 690 700 710 720 QLRNFCSIEL NVNGSPETEA DVATFCTSKT DAISMTSDDS VTGSEVSPLI KACMLSSNGF 730 740 750 760 770 780 QNVGRCRERD SDDTCRQHNT SKSPFREMEP LLSPHHDKLM SLPVKTIDYP KTLIKEPVDK 790 800 810 820 830 840 RHSCCKTKDS DIYCSPNENP EAENAEPSAM TISSHSFVNV HLESKTVICD NREPTDRHSE 850 860 870 880 890 900 NTCDEYKQSI GSTSSASHNH FDGLYEPIGS SGISSLQSPP SGIRCEENTS PTLDAVESKK 910 920 930 940 950 960 GIDFLKYARK ETDVGSALPD SGKGFSWENR HNNVLSGQSL QEAQEEGNSI LHERRGRPEI 970 980 990 1000 1010 1020 PLDEEQRGHT HISDDSEVVF PYDLNLTMED SDGITYTLKC DSSGNAPEIV STVHEDYSGS 1030 1040 1050 1060 1070 1080 SASSSDESDS EDTESDDSSI PRNRLQSVVV VPKNSTLPME ETSPCSSRSS QSYKHYSDRW 1090 1100 1110 1120 1130 1140 EDGLETRRHA YEEEYESKGC SQTEKYFLHK GTERSAESCY SQFGRKADNH LPDIAHAQSD 1150 1160 1170 1180 1190 1200 GVDSTSQTDS RSDHLGHLNP EDTLRAKTSR PQELPVYSDD FEDLPNKSRQ QMIFSNRPDS 1210 1220 1230 1240 1250 1260 SRLGKTELSF SSSCDISRMD GLHSSEELRN LGWDFSQQER PTTTYQQPDS SYGTCGTHKY 1270 1280 1290 1300 1310 1320 QQSTEHYGGT HNYWQGNGYW DPRSAGRPPG TGLAYDRIQG QVPDSLTDDR EEEEHWDQRS 1330 1340 1350 1360 1370 1380 GSHFSSPSNK FFFHQKDKGS VQAPEISSNS IKDALVMNER KDFSKNFEKN DIKERGPPKK 1390 1400 1410 1420 1430 1440 RRQELESDSE SDGELQARKK VRVEMEQGES SVPQHSELMG PSCAMDDFRD PQRWKEFAKL 1450 1460 1470 1480 1490 1500 GKMPCYFDLI EENVYLTERK KNKSHRDIKR MQCECTPLSK DERAQGEVAC GEDCLNRLLM 1510 1520 1530 1540 1550 1560 IECSSRCPNG DYCSNRRFQR KQHADVEVIL TEKKGWGLRA AKDLPSNTFV LEYCGEVLDH 1570 1580 1590 1600 1610 1620 KEFKARVKEY ARNKNIHYYF MALKNDEIID ATQKGNCSRF MNHSCEPNCE TQKWTVNGQL 1630 1640 1650 1660 1670 1680 RVGFFTTKLV PSGSELTFDY QFQRYGKEAQ KCFCGSANCR GYLGGENRVS IRAAGGKMKK 1690 1700 1710 1720 1730 1740 ERSRKKDSVD GELEALMENG EGLSDKNQVL SLSRLMVRIE TLEQKLTCLK LIQNTHSQSC 1750 1760 1770 1780 1790 1800 LKSFLERHGL SLLWIWMAEL GDGRESNQKL QEEIIKTLEH LPIPTKNMLE ESKVLPIIQR 1810 1820 1830 1840 1850 1860 WSQTKTAVPQ LSEGDGYSSE NTSRAHTPLN TPDPSAKPST EMDTDTPKKL IFRRLKIISE 1870 1880 1890 1900 1910 1920 NSMDSAVSDV TSELECKDGK EDLDQLETVT VEEDEELQSQ QLLPQQLCES KVESEATIEV 1930 1940 1950 1960 1970 1980 SKLPTSEPEA DTETEPKDSN GTKLEETIAE ETPSQDEEEG VSDVESERSQ EPPDKTVDIS 1990 2000 2010 2020 2030 2040 DLATKLLDSW KDLKEVYRIP KKSQTEKEST VAERGRDAAA FRDQTAPKTP NRSRERDPDK 2050 2060 2070 2080 2090 2100 QSQNKEKRKR RGSLSPPSSA YERGTKRPDD RYDTPTSKKK VRIKDRNKLS TEERRKLFEQ 2110 2120 2130 2140 2150 2160 EVAQREAQKQ QQQMQNLGMT SPLPFDSLGY NASHHPFAGY PPGYPMQAYV DPSNPNAGKV 2170 2180 2190 2200 2210 2220 LLPTPSMDPV CSPAPYDHAQ PLVGHSTESL AAPPSVPVVP HVAASVEVSS SQYVAQNESV 2230 2240 2250 2260 2270 2280 VHQDSNVPVM PVQAPGPVQG QNYNVWESNQ QSVSVQQQYS PAQSQTTIYY QGQTCSTVYS 2290 2300 2310 2320 2330 2340 VTSPYSQTTP PIVQSYAQPS LQYIQGQQIF TAHPQGVVVQ PTAAVTSIVA PGQPQSLQPP 2350 2360 2370 2380 2390 2400 EMVVTNNLLD LPPPSPPKPK TIVLPPNWKT ARDPEGKIYY YHVITRQTQW DPPTWESPGD 2410 2420 2430 2440 2450 2460 DASLEHEAEM DLGTPTYDEN PMKTSKKPKT AEADTSSELA KKSKEVFRKE MSQFIVQCLN 2470 2480 2490 2500 2510 2520 PYRKPDCKVG RITTTEDFKH LARKLTHGVM NKELKYCKNP EDLECNENVK HKTKEYIKKY 2530 MQKFGAVYKP KEDTELE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J Ensembl ENSMUSP00000116313.
[2]	Ensembl Submitted (MAY-2011) to UniProtKB Cited for: IDENTIFICATION. Strain: C57BL/6J Ensembl ENSMUSP00000116313.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC132103 Genomic DNA. No translation available.
IPI	IPI00462466.
RefSeq	NP_001074809.2. NM_001081340.2.
UniGene	Mm.288949.
3D structure databases
ProteinModelPortal	E9Q5F9.
SMR	E9Q5F9. Positions 1421-1665, 2435-2534.
ModBase	Search...
Proteomic databases
PRIDE	E9Q5F9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000153838; ENSMUSP00000116313; ENSMUSG00000044791.
GeneID	235626.
KEGG	mmu:235626.
Organism-specific databases
CTD	29072.
MGI	MGI:1918177. Setd2.
Phylogenomic databases
GeneTree	ENSGT00700000104009.
KO	K11423.
OMA	VMDDFRD.
Gene expression databases
ArrayExpress	E9Q5F9.
Bgee	E9Q5F9.
Family and domain databases
InterPro	IPR006560. AWS. IPR003616. Post-SET_dom. IPR001214. SET_dom. IPR013257. SRI. IPR001202. WW_dom. [Graphical view]
Pfam	PF00856. SET. 1 hit. PF08236. SRI. 1 hit. PF00397. WW. 1 hit. [Graphical view]
SMART	SM00570. AWS. 1 hit. SM00508. PostSET. 1 hit. SM00317. SET. 1 hit. SM00456. WW. 1 hit. [Graphical view]
SUPFAM	SSF51045. WW_Rsp5_WWP. 1 hit.
PROSITE	PS51215. AWS. 1 hit. PS50868. POST_SET. 1 hit. PS50280. SET. 1 hit. PS01159. WW_DOMAIN_1. 1 hit. PS50020. WW_DOMAIN_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	382803.
SOURCE	Search...

Entry information

Entry name

E9Q5F9_MOUSE

Accession

Primary (citable) accession number: E9Q5F9

Entry history

Integrated into UniProtKB/TrEMBL:	April 5, 2011
Last sequence update:	April 5, 2011
Last modified:	May 1, 2013
This is version 21 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)