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Protein

Fibroblast growth factor receptor

Gene

Fgfr2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei528Proton acceptorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, ReceptorUniRule annotationSAAS annotation, Transferase, Tyrosine-protein kinaseUniRule annotationSAAS annotation
LigandATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-109704 PI3K Cascade
R-MMU-1257604 PIP3 activates AKT signaling
R-MMU-190375 FGFR2c ligand binding and activation
R-MMU-190377 FGFR2b ligand binding and activation
R-MMU-5654221 Phospholipase C-mediated cascade, FGFR2
R-MMU-5654693 FRS-mediated FGFR1 signaling
R-MMU-5654695 PI-3K cascade:FGFR2
R-MMU-5654699 SHC-mediated cascade:FGFR2
R-MMU-5654700 FRS-mediated FGFR2 signaling
R-MMU-5654706 FRS-mediated FGFR3 signaling
R-MMU-5654712 FRS-mediated FGFR4 signaling
R-MMU-5654727 Negative regulation of FGFR2 signaling
R-MMU-5673001 RAF/MAP kinase cascade
R-MMU-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Fibroblast growth factor receptorUniRule annotation (EC:2.7.10.1UniRule annotation)
Gene namesi
Name:Fgfr2Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:95523 Fgfr2

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei20 – 40HelicalSequence analysisAdd BLAST21
Transmembranei279 – 301HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Membrane

PTM / Processingi

Keywords - PTMi

Disulfide bondSAAS annotation

Proteomic databases

MaxQBiE9Q5C2
PRIDEiE9Q5C2

Expressioni

Gene expression databases

BgeeiENSMUSG00000030849
ExpressionAtlasiE9Q5C2 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliE9Q5C2
SMRiE9Q5C2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini42 – 151Ig-likeInterPro annotationAdd BLAST110
Domaini160 – 262Ig-likeInterPro annotationAdd BLAST103
Domaini383 – 672Protein kinaseInterPro annotationAdd BLAST290

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.UniRule annotation

Keywords - Domaini

Immunoglobulin domainSAAS annotation, RepeatSAAS annotation, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG0200 Eukaryota
COG0515 LUCA
GeneTreeiENSGT00760000118923

Family and domain databases

Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR016248 FGF_rcpt_fam
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR008266 Tyr_kinase_AS
IPR020635 Tyr_kinase_cat_dom
PfamiView protein in Pfam
PF07679 I-set, 2 hits
PF07714 Pkinase_Tyr, 1 hit
PIRSFiPIRSF000628 FGFR, 1 hit
PRINTSiPR00109 TYRKINASE
SMARTiView protein in SMART
SM00409 IG, 2 hits
SM00408 IGc2, 2 hits
SM00219 TyrKc, 1 hit
SUPFAMiSSF48726 SSF48726, 2 hits
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 2 hits
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit

Sequencei

Sequence statusi: Complete.

E9Q5C2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLPSTWRYG RGPGIGTVTM VSWGRFICLV LVTMATLSLA RPSFSLVEDT
60 70 80 90 100
TLEPEGAPYW TNTEKMEKRL HAVPAANTVK FRCPAGGNPT PTMRWLKNGK
110 120 130 140 150
EFKQEHRIGG YKVRNQHWSL IMESVVPSDK GNYTCLVENE YGSINHTYHL
160 170 180 190 200
DVVERSPHRP ILQAGLPANA STVVGGDVEF VCKVYSDAQP HIQWIKHVEK
210 220 230 240 250
NGSKYGPDGL PYLKVLKAAG VNTTDKEIEV LYIRNVTFED AGEYTCLAGN
260 270 280 290 300
SIGISFHSAW LTVLPAPVRE KEITASPDYL EIAIYCIGVF LIACMVVTVI
310 320 330 340 350
FCRMKTTTKK PDFSSQPAVH KLTKRIPLRR QVSAESSSSM NSNTPLVRIT
360 370 380 390 400
TRLSSTADTP MLAGVSEYEL PEDPKWEFPR DKLTLGKPLG EGCFGQVVMA
410 420 430 440 450
EAVGIDKDKP KEAVTVAVKM LKDDATEKDL SDLVSEMEMM KMIGKHKNII
460 470 480 490 500
NLLGACTQDG PLYVIVEYAS KGNLREYLRA RRPPGMEYSY DINRVPEEQM
510 520 530 540 550
TFKDLVSCTY QLARGMEYLA SQKCIHRDLA ARNVLVTENN VMKIADFGLA
560 570 580 590 600
RDINNIDYYK KTTNGRLPVK WMAPEALFDR VYTHQSDVWS FGVLMWEIFT
610 620 630 640 650
LGGSPYPGIP VEELFKLLKE GHRMDKPTNC TNELYMMMRD CWHAVPSQRP
660 670 680 690 700
TFKQLVEDLD RILTLTTNEE YLDLTQPLEQ YSPSYPDTRS SCSSGDDSVF
710 720
SPDPMPYEPC LPQYPHINGS VKT
Length:723
Mass (Da):81,290
Last modified:April 5, 2011 - v1
Checksum:i70333D95639EE58F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC087063 Genomic DNA No translation available.
AC110885 Genomic DNA No translation available.
AC111058 Genomic DNA No translation available.
AC115697 Genomic DNA No translation available.
AC122258 Genomic DNA No translation available.
AC145294 Genomic DNA No translation available.
AC149596 Genomic DNA No translation available.
AC157606 Genomic DNA No translation available.
AC158113 Genomic DNA No translation available.
AC175034 Genomic DNA No translation available.
RefSeqiNP_001334567.1, NM_001347638.1
UniGeneiMm.16340

Genome annotation databases

EnsembliENSMUST00000117872; ENSMUSP00000113994; ENSMUSG00000030849
GeneIDi14183
UCSCiuc009jzv.1 mouse

Similar proteinsi

Entry informationi

Entry nameiE9Q5C2_MOUSE
AccessioniPrimary (citable) accession number: E9Q5C2
Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: March 28, 2018
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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