Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Hexokinase-2

Gene

Hk2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinaseSAAS annotation, Transferase
Biological processGlycolysisSAAS annotation
LigandATP-bindingSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Hexokinase-2Imported
Gene namesi
Name:Hk2Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1315197. Hk2.

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Proteomic databases

MaxQBiE9Q5B5.
PaxDbiE9Q5B5.
PeptideAtlasiE9Q5B5.
PRIDEiE9Q5B5.

Expressioni

Gene expression databases

BgeeiENSMUSG00000000628.
ExpressionAtlasiE9Q5B5. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliE9Q5B5.
SMRiE9Q5B5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 191Hexokinase_1InterPro annotationAdd BLAST191
Domaini197 – 431Hexokinase_2InterPro annotationAdd BLAST235
Domaini443 – 639Hexokinase_1InterPro annotationAdd BLAST197
Domaini645 – 879Hexokinase_2InterPro annotationAdd BLAST235

Sequence similaritiesi

Belongs to the hexokinase family.SAAS annotation

Phylogenomic databases

eggNOGiKOG1369. Eukaryota.
COG5026. LUCA.
GeneTreeiENSGT00390000017159.

Family and domain databases

InterProiView protein in InterPro
IPR001312. Hexokinase.
IPR019807. Hexokinase_BS.
IPR022673. Hexokinase_C.
IPR022672. Hexokinase_N.
PANTHERiPTHR19443. PTHR19443. 1 hit.
PfamiView protein in Pfam
PF00349. Hexokinase_1. 2 hits.
PF03727. Hexokinase_2. 2 hits.
PROSITEiView protein in PROSITE
PS00378. HEXOKINASE_1. 2 hits.
PS51748. HEXOKINASE_2. 2 hits.

Sequencei

Sequence statusi: Complete.

E9Q5B5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLSDETLLE ISRRFRKEME KGLGATTHPT AAVKMLPTFV RSTPDGTEHG
60 70 80 90 100
EFLALDLGGT NFRVLRVRVT DNGLQRVEME NQIYAIPEDI MRGSGTQLFD
110 120 130 140 150
HIAECLANFM DKLQIKEKKL PLGFTFSFPC HQTKLDESFL VSWTKGFKSS
160 170 180 190 200
GVEGRDVVDL IRKAIQRRGD FDIDIVAVVN DTVGTMMTCG YDDQNCEIGL
210 220 230 240 250
IVGTGSNACY MEEMRHIDMV EGDEGRMCIN MEWGAFGDDG TLNDIRTEFD
260 270 280 290 300
REIDMGSLNP GKQLFEKMIS GMYMGELVRL ILVKMAKAEL LFQGKLSPEL
310 320 330 340 350
LTTGSFETKD VSDIEDDKDG IQKAYQILVR LGLSPLQEDC VATHRICQIV
360 370 380 390 400
STRSASLCAA TLAAVLWRIK ENKGEERLRS TIGVDGSVYK KHPHFAKRLH
410 420 430 440 450
KAVRRLVPDC DVRFLRSEDG SGKGAAMVTA VAYRLADQHR ARQKTLESLK
460 470 480 490 500
LSHEQLLEVK RRMKVEMEQG LSKETHEAAP VKMLPTYVCA TPDGTEKGDF
510 520 530 540 550
LALDLGGTNF RVLLVRVRNG KRRGVEMHNK IYSIPQEVMH GTGEELFDHI
560 570 580 590 600
VQCIADFLEY MGMKGVSLPL GFTFSFPCQQ NSLDQSILLK WTKGFKASGC
610 620 630 640 650
EGEDVVTLLK EAIRRREEFD LDVVAVVNDT VGTMMTCGYE DPHCEVGLIV
660 670 680 690 700
GTGSNACYME EMRNVELVDG EEGRMCVNME WGAFGDNGCL DDLRTVFDVA
710 720 730 740 750
VDELSLNPGK QRFEKMISGM YLGEIVRNIL IDFTKRGLLF RGRISERLKT
760 770 780 790 800
RGIFETKFLS QIESDCLALL QVRAILRHLG LESTCDDSII VKEVCTVVAR
810 820 830 840 850
RAAQLCGAGM AAVVDKIREN RGLDNLKVTV GVDGTLYKLH PHFAKVMHET
860 870 880
VRDLAPKCDV SFLESEDGSG KGAALITAVA CRIREAGQR
Length:889
Mass (Da):99,214
Last modified:April 5, 2011 - v1
Checksum:iE0EAFE160AF0206A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC116811 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSMUST00000170833; ENSMUSP00000125986; ENSMUSG00000000628.

Similar proteinsi

Entry informationi

Entry nameiE9Q5B5_MOUSE
AccessioniPrimary (citable) accession number: E9Q5B5
Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: August 30, 2017
This is version 49 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported