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Protein
Submitted name:

Hexokinase-2

Gene

Hk2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

KinaseSAAS annotation, Transferase

Keywords - Biological processi

GlycolysisSAAS annotation

Keywords - Ligandi

ATP-bindingSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Hexokinase-2Imported
Gene namesi
Name:Hk2Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1315197. Hk2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Proteomic databases

MaxQBiE9Q5B5.
PaxDbiE9Q5B5.

Expressioni

Gene expression databases

BgeeiE9Q5B5.
ExpressionAtlasiE9Q5B5. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000000642.

Structurei

3D structure databases

ProteinModelPortaliE9Q5B5.
SMRiE9Q5B5. Positions 1-885.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 191190Hexokinase_1InterPro annotationAdd
BLAST
Domaini197 – 431235Hexokinase_2InterPro annotationAdd
BLAST
Domaini443 – 639197Hexokinase_1InterPro annotationAdd
BLAST
Domaini645 – 879235Hexokinase_2InterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the hexokinase family.SAAS annotation

Phylogenomic databases

eggNOGiKOG1369. Eukaryota.
COG5026. LUCA.
GeneTreeiENSGT00390000017159.

Family and domain databases

InterProiIPR001312. Hexokinase.
IPR019807. Hexokinase_BS.
IPR022673. Hexokinase_C.
IPR022672. Hexokinase_N.
[Graphical view]
PANTHERiPTHR19443. PTHR19443. 1 hit.
PfamiPF00349. Hexokinase_1. 2 hits.
PF03727. Hexokinase_2. 2 hits.
[Graphical view]
PROSITEiPS00378. HEXOKINASE_1. 2 hits.
PS51748. HEXOKINASE_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E9Q5B5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLSDETLLE ISRRFRKEME KGLGATTHPT AAVKMLPTFV RSTPDGTEHG
60 70 80 90 100
EFLALDLGGT NFRVLRVRVT DNGLQRVEME NQIYAIPEDI MRGSGTQLFD
110 120 130 140 150
HIAECLANFM DKLQIKEKKL PLGFTFSFPC HQTKLDESFL VSWTKGFKSS
160 170 180 190 200
GVEGRDVVDL IRKAIQRRGD FDIDIVAVVN DTVGTMMTCG YDDQNCEIGL
210 220 230 240 250
IVGTGSNACY MEEMRHIDMV EGDEGRMCIN MEWGAFGDDG TLNDIRTEFD
260 270 280 290 300
REIDMGSLNP GKQLFEKMIS GMYMGELVRL ILVKMAKAEL LFQGKLSPEL
310 320 330 340 350
LTTGSFETKD VSDIEDDKDG IQKAYQILVR LGLSPLQEDC VATHRICQIV
360 370 380 390 400
STRSASLCAA TLAAVLWRIK ENKGEERLRS TIGVDGSVYK KHPHFAKRLH
410 420 430 440 450
KAVRRLVPDC DVRFLRSEDG SGKGAAMVTA VAYRLADQHR ARQKTLESLK
460 470 480 490 500
LSHEQLLEVK RRMKVEMEQG LSKETHEAAP VKMLPTYVCA TPDGTEKGDF
510 520 530 540 550
LALDLGGTNF RVLLVRVRNG KRRGVEMHNK IYSIPQEVMH GTGEELFDHI
560 570 580 590 600
VQCIADFLEY MGMKGVSLPL GFTFSFPCQQ NSLDQSILLK WTKGFKASGC
610 620 630 640 650
EGEDVVTLLK EAIRRREEFD LDVVAVVNDT VGTMMTCGYE DPHCEVGLIV
660 670 680 690 700
GTGSNACYME EMRNVELVDG EEGRMCVNME WGAFGDNGCL DDLRTVFDVA
710 720 730 740 750
VDELSLNPGK QRFEKMISGM YLGEIVRNIL IDFTKRGLLF RGRISERLKT
760 770 780 790 800
RGIFETKFLS QIESDCLALL QVRAILRHLG LESTCDDSII VKEVCTVVAR
810 820 830 840 850
RAAQLCGAGM AAVVDKIREN RGLDNLKVTV GVDGTLYKLH PHFAKVMHET
860 870 880
VRDLAPKCDV SFLESEDGSG KGAALITAVA CRIREAGQR
Length:889
Mass (Da):99,214
Last modified:April 5, 2011 - v1
Checksum:iE0EAFE160AF0206A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC116811 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSMUST00000170833; ENSMUSP00000125986; ENSMUSG00000000628.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC116811 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortaliE9Q5B5.
SMRiE9Q5B5. Positions 1-885.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000000642.

Proteomic databases

MaxQBiE9Q5B5.
PaxDbiE9Q5B5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000170833; ENSMUSP00000125986; ENSMUSG00000000628.

Organism-specific databases

MGIiMGI:1315197. Hk2.

Phylogenomic databases

eggNOGiKOG1369. Eukaryota.
COG5026. LUCA.
GeneTreeiENSGT00390000017159.

Miscellaneous databases

ChiTaRSiHk2. mouse.
SOURCEiSearch...

Gene expression databases

BgeeiE9Q5B5.
ExpressionAtlasiE9Q5B5. baseline and differential.

Family and domain databases

InterProiIPR001312. Hexokinase.
IPR019807. Hexokinase_BS.
IPR022673. Hexokinase_C.
IPR022672. Hexokinase_N.
[Graphical view]
PANTHERiPTHR19443. PTHR19443. 1 hit.
PfamiPF00349. Hexokinase_1. 2 hits.
PF03727. Hexokinase_2. 2 hits.
[Graphical view]
PROSITEiPS00378. HEXOKINASE_1. 2 hits.
PS51748. HEXOKINASE_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  3. Ensembl
    Submitted (MAY-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiE9Q5B5_MOUSE
AccessioniPrimary (citable) accession number: E9Q5B5
Entry historyi
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: June 8, 2016
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.