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Protein
Submitted name:

Neural cell adhesion molecule 1

Gene

Ncam1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-MMU-375165. NCAM signaling for neurite out-growth.
R-MMU-419037. NCAM1 interactions.
R-MMU-445144. Signal transduction by L1.
R-MMU-5673001. RAF/MAP kinase cascade.

Names & Taxonomyi

Protein namesi
Submitted name:
Neural cell adhesion molecule 1Imported
Gene namesi
Name:Ncam1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:97281. Ncam1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence analysisAdd
BLAST
Chaini20 – 725706Sequence analysisPRO_5003245739Add
BLAST

Proteomic databases

PaxDbiE9Q589.
PeptideAtlasiE9Q589.
PRIDEiE9Q589.

Expressioni

Gene expression databases

BgeeiE9Q589.
ExpressionAtlasiE9Q589. baseline and differential.
GenevisibleiE9Q589. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000130668.

Structurei

3D structure databases

ProteinModelPortaliE9Q589.
SMRiE9Q589. Positions 20-696.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini20 – 11192Ig-like (immunoglobulin-like)InterPro annotationAdd
BLAST
Domaini116 – 18974Ig-like (immunoglobulin-like)InterPro annotationAdd
BLAST
Domaini212 – 30291Ig-like (immunoglobulin-like)InterPro annotationAdd
BLAST
Domaini309 – 40496Ig-like (immunoglobulin-like)InterPro annotationAdd
BLAST
Domaini407 – 49286Ig-like (immunoglobulin-like)InterPro annotationAdd
BLAST
Domaini500 – 599100Fibronectin type-IIIInterPro annotationAdd
BLAST
Domaini601 – 69696Fibronectin type-IIIInterPro annotationAdd
BLAST

Keywords - Domaini

RepeatSAAS annotation, SignalSequence analysis

Phylogenomic databases

eggNOGiENOG410IQJI. Eukaryota.
ENOG410XTGB. LUCA.
GeneTreeiENSGT00840000129722.

Family and domain databases

Gene3Di2.60.40.10. 7 hits.
InterProiIPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
IPR033019. Ncam1.
IPR009138. Neural_cell_adh.
[Graphical view]
PANTHERiPTHR10489:SF34. PTHR10489:SF34. 1 hit.
PfamiPF00041. fn3. 2 hits.
PF07679. I-set. 3 hits.
[Graphical view]
PRINTSiPR01838. NCAMFAMILY.
SMARTiSM00060. FN3. 2 hits.
SM00409. IG. 5 hits.
SM00408. IGc2. 5 hits.
SM00406. IGv. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 5 hits.
SSF49265. SSF49265. 1 hit.
PROSITEiPS50853. FN3. 2 hits.
PS50835. IG_LIKE. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E9Q589-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRTKDLIWT LFFLGTAVSL QVDIVPSQGE ISVGESKFFL CQVAGDAKDK
60 70 80 90 100
DISWFSPNGE KLSPNQQRIS VVWNDDDSST LTIYNANIDD AGIYKCVVTA
110 120 130 140 150
EDGTQSEATV NVKIFQKLMF KNAPTPQEFK EGEDAVIVCD VVSSLPPTII
160 170 180 190 200
WKHKGRDVIL KKDVRFIVLS NNYLQIRGIK KTDEGTYRCE GRILARGEIN
210 220 230 240 250
FKDIQVIVNV PPTVQARQSI VNATANLGQS VTLVCDADGF PEPTMSWTKD
260 270 280 290 300
GEPIENEEED DEKHIFSDDS SELTIRNVDK NDEAEYVCIA ENKAGEQDAS
310 320 330 340 350
IHLKVFAKPK ITYVENQTAM ELEEQVTLTC EASGDPIPSI TWRTSTRNIS
360 370 380 390 400
SEEKTLDGHM VVRSHARVSS LTLKSIQYTD AGEYICTASN TIGQDSQSMY
410 420 430 440 450
LEVQYAPKLQ GPVAVYTWEG NQVNITCEVF AYPSATISWF RDGQLLPSSN
460 470 480 490 500
YSNIKIYNTP SASYLEVTPD SENDFGNYNC TAVNRIGQES LEFILVQADT
510 520 530 540 550
PSSPSIDRVE PYSSTAQVQF DEPEATGGVP ILKYKAEWKS LGEESWHFKW
560 570 580 590 600
YDAKEANMEG IVTIMGLKPE TRYSVRLAAL NGKGLGEISA ATEFKTQPVR
610 620 630 640 650
EPSAPKLEGQ MGEDGNSIKV NLIKQDDGGS PIRHYLVKYR ALASEWKPEI
660 670 680 690 700
RLPSGSDHVM LKSLDWNAEY EVYVVAENQQ GKSKAAHFVF RTSAQPTAIP
710 720
ATLGGSSTSY TLVSLLFSAV TLLLL
Length:725
Mass (Da):80,358
Last modified:April 5, 2011 - v1
Checksum:iE08F947CD65FF22C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC117630 Genomic DNA. No translation available.
AC140447 Genomic DNA. No translation available.
CT025676 Genomic DNA. No translation available.
RefSeqiNP_035005.2. NM_010875.3.
UniGeneiMm.439182.
Mm.4974.

Genome annotation databases

EnsembliENSMUST00000114476; ENSMUSP00000110120; ENSMUSG00000039542.
GeneIDi17967.
UCSCiuc009pjh.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC117630 Genomic DNA. No translation available.
AC140447 Genomic DNA. No translation available.
CT025676 Genomic DNA. No translation available.
RefSeqiNP_035005.2. NM_010875.3.
UniGeneiMm.439182.
Mm.4974.

3D structure databases

ProteinModelPortaliE9Q589.
SMRiE9Q589. Positions 20-696.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000130668.

Proteomic databases

PaxDbiE9Q589.
PeptideAtlasiE9Q589.
PRIDEiE9Q589.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000114476; ENSMUSP00000110120; ENSMUSG00000039542.
GeneIDi17967.
UCSCiuc009pjh.1. mouse.

Organism-specific databases

CTDi4684.
MGIiMGI:97281. Ncam1.

Phylogenomic databases

eggNOGiENOG410IQJI. Eukaryota.
ENOG410XTGB. LUCA.
GeneTreeiENSGT00840000129722.

Enzyme and pathway databases

ReactomeiR-MMU-375165. NCAM signaling for neurite out-growth.
R-MMU-419037. NCAM1 interactions.
R-MMU-445144. Signal transduction by L1.
R-MMU-5673001. RAF/MAP kinase cascade.

Miscellaneous databases

ChiTaRSiNcam1. mouse.
SOURCEiSearch...

Gene expression databases

BgeeiE9Q589.
ExpressionAtlasiE9Q589. baseline and differential.
GenevisibleiE9Q589. MM.

Family and domain databases

Gene3Di2.60.40.10. 7 hits.
InterProiIPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
IPR033019. Ncam1.
IPR009138. Neural_cell_adh.
[Graphical view]
PANTHERiPTHR10489:SF34. PTHR10489:SF34. 1 hit.
PfamiPF00041. fn3. 2 hits.
PF07679. I-set. 3 hits.
[Graphical view]
PRINTSiPR01838. NCAMFAMILY.
SMARTiSM00060. FN3. 2 hits.
SM00409. IG. 5 hits.
SM00408. IGc2. 5 hits.
SM00406. IGv. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 5 hits.
SSF49265. SSF49265. 1 hit.
PROSITEiPS50853. FN3. 2 hits.
PS50835. IG_LIKE. 5 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  3. Ensembl
    Submitted (MAY-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiE9Q589_MOUSE
AccessioniPrimary (citable) accession number: E9Q589
Entry historyi
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: July 6, 2016
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.