ID   E9Q575_MOUSE            Unreviewed;       349 AA.
AC   E9Q575;
DT   05-APR-2011, integrated into UniProtKB/TrEMBL.
DT   05-APR-2011, sequence version 1.
DT   27-MAR-2024, entry version 95.
DE   SubName: Full=Caspase 12 {ECO:0000313|Ensembl:ENSMUSP00000122201.2};
GN   Name=Casp12 {ECO:0000313|Ensembl:ENSMUSP00000122201.2,
GN   ECO:0000313|MGI:MGI:1312922};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000122201.2, ECO:0000313|Proteomes:UP000000589};
RN   [1] {ECO:0000313|Ensembl:ENSMUSP00000122201.2, ECO:0000313|Proteomes:UP000000589}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000122201.2,
RC   ECO:0000313|Proteomes:UP000000589};
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [2] {ECO:0000313|Ensembl:ENSMUSP00000122201.2}
RP   IDENTIFICATION.
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000122201.2};
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the peptidase C14A family.
CC       {ECO:0000256|ARBA:ARBA00010134, ECO:0000256|RuleBase:RU003971}.
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DR   RefSeq; XP_006509903.1; XM_006509840.2.
DR   AlphaFoldDB; E9Q575; -.
DR   SMR; E9Q575; -.
DR   MaxQB; E9Q575; -.
DR   ProteomicsDB; 309905; -.
DR   Antibodypedia; 8737; 614 antibodies from 42 providers.
DR   DNASU; 12364; -.
DR   Ensembl; ENSMUST00000151332.2; ENSMUSP00000122201.2; ENSMUSG00000025887.11.
DR   GeneID; 12364; -.
DR   UCSC; uc012gno.1; mouse.
DR   AGR; MGI:1312922; -.
DR   CTD; 100506742; -.
DR   MGI; MGI:1312922; Casp12.
DR   VEuPathDB; HostDB:ENSMUSG00000025887; -.
DR   GeneTree; ENSGT00940000162555; -.
DR   HOGENOM; CLU_036904_0_1_1; -.
DR   OrthoDB; 2873736at2759; -.
DR   BioGRID-ORCS; 12364; 4 hits in 76 CRISPR screens.
DR   Proteomes; UP000000589; Chromosome 9.
DR   Bgee; ENSMUSG00000025887; Expressed in temporalis muscle and 135 other cell types or tissues.
DR   ExpressionAtlas; E9Q575; baseline and differential.
DR   GO; GO:0004197; F:cysteine-type endopeptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   CDD; cd00032; CASc; 1.
DR   Gene3D; 3.40.50.1460; -; 1.
DR   Gene3D; 3.30.70.1470; Caspase-like; 1.
DR   InterPro; IPR029030; Caspase-like_dom_sf.
DR   InterPro; IPR033139; Caspase_cys_AS.
DR   InterPro; IPR016129; Caspase_his_AS.
DR   InterPro; IPR011600; Pept_C14_caspase.
DR   InterPro; IPR002138; Pept_C14_p10.
DR   InterPro; IPR001309; Pept_C14_p20.
DR   InterPro; IPR015917; Pept_C14A.
DR   PANTHER; PTHR47901; CASPASE RECRUITMENT DOMAIN-CONTAINING PROTEIN 18; 1.
DR   PANTHER; PTHR47901:SF6; CASPASE-12; 1.
DR   Pfam; PF00656; Peptidase_C14; 1.
DR   PIRSF; PIRSF038001; Caspase_ICE; 1.
DR   PRINTS; PR00376; IL1BCENZYME.
DR   SMART; SM00115; CASc; 1.
DR   SUPFAM; SSF52129; Caspase-like; 1.
DR   PROSITE; PS01122; CASPASE_CYS; 1.
DR   PROSITE; PS01121; CASPASE_HIS; 1.
DR   PROSITE; PS50207; CASPASE_P10; 1.
DR   PROSITE; PS50208; CASPASE_P20; 1.
PE   1: Evidence at protein level;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Protease {ECO:0000256|ARBA:ARBA00022670};
KW   Proteomics identification {ECO:0007829|MaxQB:E9Q575,
KW   ECO:0007829|ProteomicsDB:E9Q575};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW   Thiol protease {ECO:0000256|ARBA:ARBA00022807};
KW   Zymogen {ECO:0000256|ARBA:ARBA00023145}.
FT   DOMAIN          104..232
FT                   /note="Caspase family p20"
FT                   /evidence="ECO:0000259|PROSITE:PS50208"
FT   DOMAIN          262..347
FT                   /note="Caspase family p10"
FT                   /evidence="ECO:0000259|PROSITE:PS50207"
FT   REGION          1..42
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..24
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   349 AA;  40250 MW;  5DE0DC1FFF7D27A7 CRC64;
     MAARRTHERD PIYKIKEFSN DEDDGPQKIC TPSSPSESKR KVEDDEMEVN AGLAHESHLM
     LTAPHGLQSS EVQDTLKLCP RDQFCKIKTE RAKEIYPVME KEGRTRLALI ICNKKFDYLF
     DRDNADTDIL NMQELLENLG YSVVLKENLT AQEMETELMQ FAGRPEHQSS DSTFLVFMSH
     GILEGICGVK HRNKKPDVLH DDTIFKIFNN SNCRSLRNKP KILIMQACRG RYNGTIWVST
     NKGIATADTD EERVLSCKWN NSITKAHVET DFIAFKSSTP HNISWKVGKT GSLFISKLID
     CFKKYCWCYH LEEIFRKVQH SFEVPGELTQ MPTIERVSMT RYFYLFPGN
//