E9Q575 (E9Q575_MOUSE) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Caspase PIRNR PIRNR038001

Gene names

Name:

Casp12 Ensembl ENSMUSP00000122201 MGI 1312922

Organism

Mus musculus (Mouse) [Reference proteome] Ensembl ENSMUSP00000122201

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	349 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities	Belongs to the peptidase C14A family. PIRNR PIRNR038001 RuleBase RU003971
Caution	The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data. Ensembl ENSMUSP00000122201

Ontologies

Keywords
Molecular function	Hydrolase Protease Thiol protease RuleBase RU003972
PTM	Zymogen RuleBase RU003972
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	endoplasmic reticulum unfolded protein response Inferred from direct assay PubMed 10882126. Source: MGI intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress Inferred from genetic interaction PubMed 12847083. Source: MGI proteolysis Inferred from electronic annotation. Source: UniProtKB-KW virus-infected cell apoptotic process Inferred from direct assay PubMed 15542627. Source: MGI
Cellular_component	endoplasmic reticulum Traceable author statement PubMed 14561754. Source: MGI
Molecular_function	cysteine-type endopeptidase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	180	1	By similarity PIRSR PIRSR038001-1
	Active site	228	1	By similarity PIRSR PIRSR038001-1

Sequences

	Sequence		Length	Mass (Da)
	E9Q575 [UniParc]. Last modified April 5, 2011. Version 1. Checksum: 5DE0DC1FFF7D27A7	FASTA	349	40,250
	10 20 30 40 50 60 MAARRTHERD PIYKIKEFSN DEDDGPQKIC TPSSPSESKR KVEDDEMEVN AGLAHESHLM 70 80 90 100 110 120 LTAPHGLQSS EVQDTLKLCP RDQFCKIKTE RAKEIYPVME KEGRTRLALI ICNKKFDYLF 130 140 150 160 170 180 DRDNADTDIL NMQELLENLG YSVVLKENLT AQEMETELMQ FAGRPEHQSS DSTFLVFMSH 190 200 210 220 230 240 GILEGICGVK HRNKKPDVLH DDTIFKIFNN SNCRSLRNKP KILIMQACRG RYNGTIWVST 250 260 270 280 290 300 NKGIATADTD EERVLSCKWN NSITKAHVET DFIAFKSSTP HNISWKVGKT GSLFISKLID 310 320 330 340 CFKKYCWCYH LEEIFRKVQH SFEVPGELTQ MPTIERVSMT RYFYLFPGN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J Ensembl ENSMUSP00000122201.
[2]	Ensembl Submitted (MAY-2011) to UniProtKB Cited for: IDENTIFICATION. Strain: C57BL/6J Ensembl ENSMUSP00000122201.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC104914 Genomic DNA. No translation available. AC141637 Genomic DNA. No translation available.
IPI	IPI00928000.
3D structure databases
ProteinModelPortal	E9Q575.
SMR	E9Q575. Positions 69-349.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000151332; ENSMUSP00000122201; ENSMUSG00000025887.
Organism-specific databases
MGI	MGI:1312922. Casp12.
Phylogenomic databases
GeneTree	ENSGT00700000104134.
Gene expression databases
ArrayExpress	E9Q575.
Bgee	E9Q575.
Family and domain databases
InterPro	IPR017350. Caspase_IL-1_beta. IPR011600. Pept_C14_cat. IPR001309. Pept_C14_ICE_p20. IPR016129. Pept_C14_ICE_p20_AS. IPR002138. Pept_C14_p10. IPR002398. Pept_C14_p45. IPR015917. Pept_C14_p45_core. [Graphical view]
PANTHER	PTHR10454. PTHR10454. 1 hit.
Pfam	PF00656. Peptidase_C14. 1 hit. [Graphical view]
PIRSF	PIRSF038001. Caspase_ICE. 1 hit.
PRINTS	PR00376. IL1BCENZYME.
SMART	SM00115. CASc. 1 hit. [Graphical view]
PROSITE	PS01122. CASPASE_CYS. 1 hit. PS01121. CASPASE_HIS. 1 hit. PS50207. CASPASE_P10. 1 hit. PS50208. CASPASE_P20. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	35555203.
SOURCE	Search...

Entry information

Entry name

E9Q575_MOUSE

Accession

Primary (citable) accession number: E9Q575

Entry history

Integrated into UniProtKB/TrEMBL:	April 5, 2011
Last sequence update:	April 5, 2011
Last modified:	May 1, 2013
This is version 19 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)