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E9Q575

- E9Q575_MOUSE

UniProt

E9Q575 - E9Q575_MOUSE

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Protein

Caspase

Gene

Casp12

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei180 – 1801UniRule annotation
Active sitei228 – 2281UniRule annotation

GO - Molecular functioni

  1. cysteine-type endopeptidase activity Source: RefGenome

GO - Biological processi

  1. apoptotic process Source: MGI
  2. endoplasmic reticulum unfolded protein response Source: MGI
  3. intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol proteaseUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
CaspaseUniRule annotation
Gene namesi
Name:Casp12Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 9

Organism-specific databases

MGIiMGI:1312922. Casp12.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: RefGenome
  2. endoplasmic reticulum Source: MGI
Complete GO annotation...

PTM / Processingi

Keywords - PTMi

ZymogenUniRule annotation

Expressioni

Gene expression databases

BgeeiE9Q575.
ExpressionAtlasiE9Q575. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliE9Q575.
SMRiE9Q575. Positions 69-349.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase C14A family.UniRule annotation

Phylogenomic databases

GeneTreeiENSGT00760000118912.
KOiK04741.

Family and domain databases

Gene3Di3.40.50.1460. 1 hit.
InterProiIPR029030. Caspase-like_dom.
IPR017350. Caspase_ICE-type.
IPR011600. Pept_C14_caspase.
IPR001309. Pept_C14_ICE_p20.
IPR016129. Pept_C14_ICE_p20_AS.
IPR002138. Pept_C14_p10.
IPR015917. Pept_C14A_p45_core.
[Graphical view]
PfamiPF00656. Peptidase_C14. 1 hit.
[Graphical view]
PIRSFiPIRSF038001. Caspase_ICE. 1 hit.
PRINTSiPR00376. IL1BCENZYME.
SMARTiSM00115. CASc. 1 hit.
[Graphical view]
PROSITEiPS01122. CASPASE_CYS. 1 hit.
PS01121. CASPASE_HIS. 1 hit.
PS50207. CASPASE_P10. 1 hit.
PS50208. CASPASE_P20. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E9Q575-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAARRTHERD PIYKIKEFSN DEDDGPQKIC TPSSPSESKR KVEDDEMEVN
60 70 80 90 100
AGLAHESHLM LTAPHGLQSS EVQDTLKLCP RDQFCKIKTE RAKEIYPVME
110 120 130 140 150
KEGRTRLALI ICNKKFDYLF DRDNADTDIL NMQELLENLG YSVVLKENLT
160 170 180 190 200
AQEMETELMQ FAGRPEHQSS DSTFLVFMSH GILEGICGVK HRNKKPDVLH
210 220 230 240 250
DDTIFKIFNN SNCRSLRNKP KILIMQACRG RYNGTIWVST NKGIATADTD
260 270 280 290 300
EERVLSCKWN NSITKAHVET DFIAFKSSTP HNISWKVGKT GSLFISKLID
310 320 330 340
CFKKYCWCYH LEEIFRKVQH SFEVPGELTQ MPTIERVSMT RYFYLFPGN
Length:349
Mass (Da):40,250
Last modified:April 5, 2011 - v1
Checksum:i5DE0DC1FFF7D27A7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC104914 Genomic DNA. No translation available.
AC141637 Genomic DNA. No translation available.
RefSeqiXP_006509903.1. XM_006509840.1.
UniGeneiMm.42163.

Genome annotation databases

EnsembliENSMUST00000151332; ENSMUSP00000122201; ENSMUSG00000025887.
GeneIDi12364.
KEGGimmu:12364.
UCSCiuc012gno.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC104914 Genomic DNA. No translation available.
AC141637 Genomic DNA. No translation available.
RefSeqi XP_006509903.1. XM_006509840.1.
UniGenei Mm.42163.

3D structure databases

ProteinModelPortali E9Q575.
SMRi E9Q575. Positions 69-349.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000151332 ; ENSMUSP00000122201 ; ENSMUSG00000025887 .
GeneIDi 12364.
KEGGi mmu:12364.
UCSCi uc012gno.1. mouse.

Organism-specific databases

CTDi 100506742.
MGIi MGI:1312922. Casp12.

Phylogenomic databases

GeneTreei ENSGT00760000118912.
KOi K04741.

Miscellaneous databases

NextBioi 35555203.
SOURCEi Search...

Gene expression databases

Bgeei E9Q575.
ExpressionAtlasi E9Q575. baseline and differential.

Family and domain databases

Gene3Di 3.40.50.1460. 1 hit.
InterProi IPR029030. Caspase-like_dom.
IPR017350. Caspase_ICE-type.
IPR011600. Pept_C14_caspase.
IPR001309. Pept_C14_ICE_p20.
IPR016129. Pept_C14_ICE_p20_AS.
IPR002138. Pept_C14_p10.
IPR015917. Pept_C14A_p45_core.
[Graphical view ]
Pfami PF00656. Peptidase_C14. 1 hit.
[Graphical view ]
PIRSFi PIRSF038001. Caspase_ICE. 1 hit.
PRINTSi PR00376. IL1BCENZYME.
SMARTi SM00115. CASc. 1 hit.
[Graphical view ]
PROSITEi PS01122. CASPASE_CYS. 1 hit.
PS01121. CASPASE_HIS. 1 hit.
PS50207. CASPASE_P10. 1 hit.
PS50208. CASPASE_P20. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  2. Ensembl
    Submitted (MAY-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiE9Q575_MOUSE
AccessioniPrimary (citable) accession number: E9Q575
Entry historyi
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: October 29, 2014
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3