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Protein

Caspase

Gene

Casp12

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

  1. cysteine-type endopeptidase activity Source: GO_Central

GO - Biological processi

  1. apoptotic process Source: MGI
  2. endoplasmic reticulum unfolded protein response Source: MGI
  3. intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol proteaseUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
CaspaseUniRule annotation
Gene namesi
Name:Casp12Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 9

Organism-specific databases

MGIiMGI:1312922. Casp12.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: GO_Central
  2. endoplasmic reticulum Source: MGI
Complete GO annotation...

PTM / Processingi

Keywords - PTMi

ZymogenUniRule annotation

Expressioni

Gene expression databases

BgeeiE9Q575.
ExpressionAtlasiE9Q575. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliE9Q575.
SMRiE9Q575. Positions 69-349.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase C14A family.UniRule annotation

Phylogenomic databases

GeneTreeiENSGT00760000118912.
KOiK04741.

Family and domain databases

Gene3Di3.40.50.1460. 1 hit.
InterProiIPR029030. Caspase-like_dom.
IPR017350. Caspase_ICE-type.
IPR011600. Pept_C14_caspase.
IPR001309. Pept_C14_ICE_p20.
IPR016129. Pept_C14_ICE_p20_AS.
IPR002138. Pept_C14_p10.
IPR015917. Pept_C14A_p45_core.
[Graphical view]
PfamiPF00656. Peptidase_C14. 1 hit.
[Graphical view]
PIRSFiPIRSF038001. Caspase_ICE. 1 hit.
PRINTSiPR00376. IL1BCENZYME.
SMARTiSM00115. CASc. 1 hit.
[Graphical view]
PROSITEiPS01122. CASPASE_CYS. 1 hit.
PS01121. CASPASE_HIS. 1 hit.
PS50207. CASPASE_P10. 1 hit.
PS50208. CASPASE_P20. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E9Q575-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAARRTHERD PIYKIKEFSN DEDDGPQKIC TPSSPSESKR KVEDDEMEVN
60 70 80 90 100
AGLAHESHLM LTAPHGLQSS EVQDTLKLCP RDQFCKIKTE RAKEIYPVME
110 120 130 140 150
KEGRTRLALI ICNKKFDYLF DRDNADTDIL NMQELLENLG YSVVLKENLT
160 170 180 190 200
AQEMETELMQ FAGRPEHQSS DSTFLVFMSH GILEGICGVK HRNKKPDVLH
210 220 230 240 250
DDTIFKIFNN SNCRSLRNKP KILIMQACRG RYNGTIWVST NKGIATADTD
260 270 280 290 300
EERVLSCKWN NSITKAHVET DFIAFKSSTP HNISWKVGKT GSLFISKLID
310 320 330 340
CFKKYCWCYH LEEIFRKVQH SFEVPGELTQ MPTIERVSMT RYFYLFPGN
Length:349
Mass (Da):40,250
Last modified:April 5, 2011 - v1
Checksum:i5DE0DC1FFF7D27A7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC104914 Genomic DNA. No translation available.
AC141637 Genomic DNA. No translation available.
RefSeqiXP_006509903.1. XM_006509840.1.
UniGeneiMm.42163.

Genome annotation databases

EnsembliENSMUST00000151332; ENSMUSP00000122201; ENSMUSG00000025887.
GeneIDi12364.
KEGGimmu:12364.
UCSCiuc012gno.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC104914 Genomic DNA. No translation available.
AC141637 Genomic DNA. No translation available.
RefSeqiXP_006509903.1. XM_006509840.1.
UniGeneiMm.42163.

3D structure databases

ProteinModelPortaliE9Q575.
SMRiE9Q575. Positions 69-349.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000151332; ENSMUSP00000122201; ENSMUSG00000025887.
GeneIDi12364.
KEGGimmu:12364.
UCSCiuc012gno.1. mouse.

Organism-specific databases

CTDi100506742.
MGIiMGI:1312922. Casp12.

Phylogenomic databases

GeneTreeiENSGT00760000118912.
KOiK04741.

Miscellaneous databases

NextBioi35555203.
SOURCEiSearch...

Gene expression databases

BgeeiE9Q575.
ExpressionAtlasiE9Q575. baseline and differential.

Family and domain databases

Gene3Di3.40.50.1460. 1 hit.
InterProiIPR029030. Caspase-like_dom.
IPR017350. Caspase_ICE-type.
IPR011600. Pept_C14_caspase.
IPR001309. Pept_C14_ICE_p20.
IPR016129. Pept_C14_ICE_p20_AS.
IPR002138. Pept_C14_p10.
IPR015917. Pept_C14A_p45_core.
[Graphical view]
PfamiPF00656. Peptidase_C14. 1 hit.
[Graphical view]
PIRSFiPIRSF038001. Caspase_ICE. 1 hit.
PRINTSiPR00376. IL1BCENZYME.
SMARTiSM00115. CASc. 1 hit.
[Graphical view]
PROSITEiPS01122. CASPASE_CYS. 1 hit.
PS01121. CASPASE_HIS. 1 hit.
PS50207. CASPASE_P10. 1 hit.
PS50208. CASPASE_P20. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  2. Ensembl
    Submitted (MAY-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiE9Q575_MOUSE
AccessioniPrimary (citable) accession number: E9Q575
Entry historyi
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: February 4, 2015
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.