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E9Q575

- E9Q575_MOUSE

UniProt

E9Q575 - E9Q575_MOUSE

Protein

Caspase

Gene

Casp12

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 31 (01 Oct 2014)
      Sequence version 1 (05 Apr 2011)
      Previous versions | rss
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    Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei180 – 1801UniRule annotation
    Active sitei228 – 2281UniRule annotation

    GO - Molecular functioni

    1. cysteine-type endopeptidase activity Source: RefGenome
    2. protein binding Source: MGI

    GO - Biological processi

    1. apoptotic process Source: MGI
    2. endoplasmic reticulum unfolded protein response Source: MGI
    3. intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress Source: MGI

    Keywords - Molecular functioni

    Hydrolase, Protease, Thiol proteaseUniRule annotation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    CaspaseUniRule annotation
    Gene namesi
    Name:Casp12Imported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 9

    Organism-specific databases

    MGIiMGI:1312922. Casp12.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: RefGenome
    2. endoplasmic reticulum Source: MGI

    PTM / Processingi

    Keywords - PTMi

    ZymogenUniRule annotation

    Expressioni

    Gene expression databases

    ArrayExpressiE9Q575.
    BgeeiE9Q575.

    Structurei

    3D structure databases

    ProteinModelPortaliE9Q575.
    SMRiE9Q575. Positions 69-349.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase C14A family.UniRule annotation

    Phylogenomic databases

    GeneTreeiENSGT00700000104134.
    KOiK04741.

    Family and domain databases

    Gene3Di3.40.50.1460. 1 hit.
    InterProiIPR029030. Caspase-like_dom.
    IPR017350. Caspase_ICE-type.
    IPR011600. Pept_C14_caspase.
    IPR001309. Pept_C14_ICE_p20.
    IPR016129. Pept_C14_ICE_p20_AS.
    IPR002138. Pept_C14_p10.
    IPR015917. Pept_C14A_p45_core.
    [Graphical view]
    PfamiPF00656. Peptidase_C14. 1 hit.
    [Graphical view]
    PIRSFiPIRSF038001. Caspase_ICE. 1 hit.
    PRINTSiPR00376. IL1BCENZYME.
    SMARTiSM00115. CASc. 1 hit.
    [Graphical view]
    PROSITEiPS01122. CASPASE_CYS. 1 hit.
    PS01121. CASPASE_HIS. 1 hit.
    PS50207. CASPASE_P10. 1 hit.
    PS50208. CASPASE_P20. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    E9Q575-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAARRTHERD PIYKIKEFSN DEDDGPQKIC TPSSPSESKR KVEDDEMEVN    50
    AGLAHESHLM LTAPHGLQSS EVQDTLKLCP RDQFCKIKTE RAKEIYPVME 100
    KEGRTRLALI ICNKKFDYLF DRDNADTDIL NMQELLENLG YSVVLKENLT 150
    AQEMETELMQ FAGRPEHQSS DSTFLVFMSH GILEGICGVK HRNKKPDVLH 200
    DDTIFKIFNN SNCRSLRNKP KILIMQACRG RYNGTIWVST NKGIATADTD 250
    EERVLSCKWN NSITKAHVET DFIAFKSSTP HNISWKVGKT GSLFISKLID 300
    CFKKYCWCYH LEEIFRKVQH SFEVPGELTQ MPTIERVSMT RYFYLFPGN 349
    Length:349
    Mass (Da):40,250
    Last modified:April 5, 2011 - v1
    Checksum:i5DE0DC1FFF7D27A7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC104914 Genomic DNA. No translation available.
    AC141637 Genomic DNA. No translation available.
    RefSeqiXP_006509903.1. XM_006509840.1.
    UniGeneiMm.42163.

    Genome annotation databases

    EnsembliENSMUST00000151332; ENSMUSP00000122201; ENSMUSG00000025887.
    GeneIDi12364.
    KEGGimmu:12364.
    UCSCiuc012gno.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC104914 Genomic DNA. No translation available.
    AC141637 Genomic DNA. No translation available.
    RefSeqi XP_006509903.1. XM_006509840.1.
    UniGenei Mm.42163.

    3D structure databases

    ProteinModelPortali E9Q575.
    SMRi E9Q575. Positions 69-349.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000151332 ; ENSMUSP00000122201 ; ENSMUSG00000025887 .
    GeneIDi 12364.
    KEGGi mmu:12364.
    UCSCi uc012gno.1. mouse.

    Organism-specific databases

    CTDi 100506742.
    MGIi MGI:1312922. Casp12.

    Phylogenomic databases

    GeneTreei ENSGT00700000104134.
    KOi K04741.

    Miscellaneous databases

    NextBioi 35555203.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi E9Q575.
    Bgeei E9Q575.

    Family and domain databases

    Gene3Di 3.40.50.1460. 1 hit.
    InterProi IPR029030. Caspase-like_dom.
    IPR017350. Caspase_ICE-type.
    IPR011600. Pept_C14_caspase.
    IPR001309. Pept_C14_ICE_p20.
    IPR016129. Pept_C14_ICE_p20_AS.
    IPR002138. Pept_C14_p10.
    IPR015917. Pept_C14A_p45_core.
    [Graphical view ]
    Pfami PF00656. Peptidase_C14. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF038001. Caspase_ICE. 1 hit.
    PRINTSi PR00376. IL1BCENZYME.
    SMARTi SM00115. CASc. 1 hit.
    [Graphical view ]
    PROSITEi PS01122. CASPASE_CYS. 1 hit.
    PS01121. CASPASE_HIS. 1 hit.
    PS50207. CASPASE_P10. 1 hit.
    PS50208. CASPASE_P20. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6JImported.
    2. Ensembl
      Submitted (MAY-2011) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: C57BL/6JImported.

    Entry informationi

    Entry nameiE9Q575_MOUSE
    AccessioniPrimary (citable) accession number: E9Q575
    Entry historyi
    Integrated into UniProtKB/TrEMBL: April 5, 2011
    Last sequence update: April 5, 2011
    Last modified: October 1, 2014
    This is version 31 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Caution

    The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3