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E9Q557

- DESP_MOUSE

UniProt

E9Q557 - DESP_MOUSE

Protein

Desmoplakin

Gene

Dsp

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 29 (01 Oct 2014)
      Sequence version 1 (05 Apr 2011)
      Previous versions | rss
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    Functioni

    Major high molecular weight protein of desmosomes. Involved in the organization of the desmosomal cadherin-plakoglobin complexes into discrete plasma membrane domains and in the anchoring of intermediate filaments to the desmosomes.

    GO - Molecular functioni

    1. protein binding Source: UniProtKB
    2. structural molecule activity Source: Ensembl

    GO - Biological processi

    1. adherens junction organization Source: MGI
    2. bundle of His cell to Purkinje myocyte communication Source: Ensembl
    3. desmosome organization Source: BHF-UCL
    4. intermediate filament cytoskeleton organization Source: MGI
    5. intermediate filament organization Source: BHF-UCL
    6. keratinocyte differentiation Source: Ensembl
    7. peptide cross-linking Source: Ensembl
    8. protein localization to adherens junction Source: BHF-UCL
    9. regulation of heart rate by cardiac conduction Source: Ensembl
    10. single organismal cell-cell adhesion Source: MGI
    11. skin development Source: MGI
    12. ventricular cardiac muscle cell action potential Source: Ensembl
    13. ventricular compact myocardium morphogenesis Source: BHF-UCL
    14. wound healing Source: Ensembl

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Desmoplakin
    Short name:
    DP
    Gene namesi
    Name:Dsp
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 13

    Organism-specific databases

    MGIiMGI:109611. Dsp.

    Subcellular locationi

    Cell junctiondesmosome By similarity. Cytoplasmcytoskeleton By similarity
    Note: Innermost portion of the desmosomal plaque. Colocalizes with epidermal KRT5-KRT14 and simple KRT8-KRT18 keratins and VIM intermediate filaments network By similarity.By similarity

    GO - Cellular componenti

    1. basolateral plasma membrane Source: MGI
    2. cell-cell junction Source: MGI
    3. cornified envelope Source: Ensembl
    4. desmosome Source: MGI
    5. fascia adherens Source: Ensembl
    6. intercalated disc Source: MGI
    7. membrane Source: MGI
    8. mitochondrion Source: MGI

    Keywords - Cellular componenti

    Cell junction, Cytoplasm, Cytoskeleton

    Pathology & Biotechi

    Keywords - Diseasei

    Cardiomyopathy

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 28832883DesmoplakinPRO_0000410831Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei22 – 221PhosphoserineBy similarity
    Modified residuei177 – 1771PhosphoserineBy similarity
    Modified residuei178 – 1781PhosphoserineBy similarity
    Modified residuei188 – 1881PhosphoserineBy similarity
    Modified residuei2036 – 20361PhosphoserineBy similarity
    Modified residuei2219 – 22191PhosphoserineBy similarity
    Modified residuei2221 – 22211PhosphoserineBy similarity
    Lipidationi2492 – 24921Omega-hydroxyceramide glutamate esterBy similarity
    Modified residuei2827 – 28271PhosphoserineBy similarity
    Modified residuei2832 – 28321PhosphoserineBy similarity
    Modified residuei2836 – 28361Phosphoserine1 Publication
    Modified residuei2860 – 28601PhosphoserineBy similarity
    Modified residuei2864 – 28641PhosphothreonineBy similarity
    Modified residuei2879 – 28791PhosphoserineBy similarity

    Post-translational modificationi

    Ser-2860 is probably phosphorylated by a cAMP-dependent protein kinase. Phosphorylation on Ser-2860 probably affects its association with epidermal, simple cytokeratins and VIM intermediate filaments By similarity.By similarity
    Substrate of transglutaminase. Some glutamines and lysines are cross-linked to other desmoplakin molecules, to other proteins such as keratin, envoplakin, periplakin and involucrin, and to lipids like omega-hydroxyceramide By similarity.By similarity

    Keywords - PTMi

    Lipoprotein, Phosphoprotein

    Proteomic databases

    MaxQBiE9Q557.
    PRIDEiE9Q557.

    Expressioni

    Gene expression databases

    ArrayExpressiE9Q557.
    BgeeiE9Q557.

    Interactioni

    Subunit structurei

    Homodimer. Interacts with COL17A1 (via cytoplasmic region). Associates (via C-terminal) with KRT5-KRT14 (via rod region), KRT8-KRT18 and VIM intermediate filaments. Interacts with PKP2 By similarity.By similarity

    Protein-protein interaction databases

    BioGridi224908. 3 interactions.
    IntActiE9Q557. 4 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliE9Q557.
    SMRiE9Q557. Positions 190-639, 2221-2460, 2625-2820.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati190 – 28394Spectrin 1Add
    BLAST
    Repeati284 – 387104Spectrin 2Add
    BLAST
    Repeati388 – 45871Spectrin 3aAdd
    BLAST
    Domaini459 – 52769SH3Add
    BLAST
    Repeati528 – 55730Spectrin 3bAdd
    BLAST
    Repeati558 – 63982Spectrin 4Add
    BLAST
    Repeati666 – 781116Spectrin 5Add
    BLAST
    Repeati782 – 895114Spectrin 6Add
    BLAST
    Repeati2021 – 205737Plectin 1Add
    BLAST
    Repeati2058 – 209538Plectin 2Add
    BLAST
    Repeati2096 – 213338Plectin 3Add
    BLAST
    Repeati2134 – 217138Plectin 4Add
    BLAST
    Repeati2175 – 220935Plectin 5Add
    BLAST
    Repeati2210 – 224536Plectin 6Add
    BLAST
    Repeati2263 – 230038Plectin 7Add
    BLAST
    Repeati2301 – 233838Plectin 8Add
    BLAST
    Repeati2339 – 237638Plectin 9Add
    BLAST
    Repeati2377 – 241438Plectin 10Add
    BLAST
    Repeati2418 – 245235Plectin 11Add
    BLAST
    Repeati2468 – 250538Plectin 12Add
    BLAST
    Repeati2519 – 255638Plectin 13Add
    BLAST
    Repeati2622 – 265938Plectin 14Add
    BLAST
    Repeati2660 – 269738Plectin 15Add
    BLAST
    Repeati2736 – 277338Plectin 16Add
    BLAST
    Repeati2774 – 281138Plectin 17Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 10681068Globular 1Add
    BLAST
    Regioni1 – 596596Interacts with plakophilin 1 and junction plakoglobinBy similarityAdd
    BLAST
    Regioni1069 – 1957889Central fibrous rod domainAdd
    BLAST
    Regioni1958 – 2882925Globular 2Add
    BLAST
    Regioni1972 – 22202494.5 X 38 AA tandem repeats (Domain A)Add
    BLAST
    Regioni2256 – 24582034.5 X 38 AA tandem repeats (Domain B)Add
    BLAST
    Regioni2621 – 28332134.5 X 38 AA tandem repeats (Domain C)Add
    BLAST
    Regioni2835 – 2858246 X 4 AA tandem repeats of G-S-R-[SR]Add
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili1034 – 1956923Sequence AnalysisAdd
    BLAST

    Domaini

    Its association with epidermal and simple keratins is dependent on the tertiary structure induced by heterodimerization of these intermediate filaments proteins and most likely involves recognition sites located in the rod domain of these keratins.By similarity
    The N-terminal region is required for localization to the desmosomal plaque and interacts with the N-terminal region of plakophilin 1.By similarity
    The three tandem plakin repeat regions in the C-terminus mediate binding to intermediate filaments.By similarity

    Sequence similaritiesi

    Belongs to the plakin or cytolinker family.Curated
    Contains 17 plectin repeats.Curated
    Contains 1 SH3 domain.Curated
    Contains 6 spectrin repeats.Curated

    Keywords - Domaini

    Coiled coil, Repeat

    Phylogenomic databases

    GeneTreeiENSGT00720000108730.
    KOiK10381.
    OMAiKRSMSFQ.
    TreeFamiTF106435.

    Family and domain databases

    Gene3Di3.90.1290.10. 4 hits.
    InterProiIPR028462. Desmoplakin.
    IPR001101. Plectin_repeat.
    IPR018159. Spectrin/alpha-actinin.
    [Graphical view]
    PANTHERiPTHR11915:SF234. PTHR11915:SF234. 1 hit.
    PfamiPF00681. Plectin. 8 hits.
    [Graphical view]
    SMARTiSM00250. PLEC. 18 hits.
    SM00150. SPEC. 2 hits.
    [Graphical view]
    SUPFAMiSSF75399. SSF75399. 5 hits.

    Sequencei

    Sequence statusi: Complete.

    E9Q557-1 [UniParc]FASTAAdd to Basket

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    MSCNGGSHPR INTLGRMTRA ESGPDLRYEM TYSGGGGGGG GGGGGGTSRT     50
    FYSHSRRCTV NDQNSDGYCQ TGTMSRHQNQ NTIQEMLQNC SDCLMRAELI 100
    AQPELKFGEG MQLAWNRELD EYFTQANDQM EIIDGLIREM RQMGQPCDAY 150
    QKRLLQLQEQ MRALYKAISV PRVRRASSKG AGGYTCQSGS GWDEFTKRLT 200
    GECLGWMRQQ REEMDLMAWG VDAGSVEQHI NSHRSIHNTI GDYRWQLDKI 250
    KADLREKSAI YQLEEEYENL LKASFERMDH LRQLQNIIQA TSREIMWIND 300
    CEEEELLYDW SDKNTNIAQK QEAFSIRMSQ LEVKEKELNK LKQESDQLVL 350
    NQHPASDKIE AYMDTLQTQW SWILQITKCI DVHLKENAAY FQFFEEAQST 400
    EAYLKGLQDS IRKKYPCDKN MPLQHLLEQI KELEKEREKI IEYKRQVQNL 450
    VNKSKKIVQL KPRNPDYRSN KPIILRALCD YKQDQKIVHK GDECILKDNN 500
    ERSKWYVTGP GGVDMLVPSV GLIIPPPNPL AVDLSCKIEQ YYEAILALWN 550
    QLYINMKSLV SWHYCMIDIE KIRAMTIAKL KTMRQEDYMK TIEDLELHYQ 600
    DFIKNSQGSE MFGDDDKRRM QSQFTDAQKH YQTLVIQLPG HPQHQTVTKT 650
    EITHLGTCQD VNHNKVIETN RENDKQETWL LMELQKIRRQ MEHCEARMTL 700
    KNLLLAEQGS THHITVKINE LKSVQNDSQA LAEVLNQLKD MLANFRGSEK 750
    YCYLQNEIFG LFQKLENING VSDGYLNSLC SVRALLQAIL QTEDMLKVYE 800
    ARLTEEETVC LDLDKVEAYR CGLKKIKNDL NLKKSLLATM KTELQKAQQI 850
    HSQSSQQYPL YDLDLGKFTE KVTQLTDRWQ KIDKQIDFRL WDLEKQIKQL 900
    RNYRDNYQSF CKWLYDAKRR QDSLESMKFG DSNTVMRFLN EQKNLHSEIS 950
    GKRDKSEEVH KIAELCANSI KDYELQLASY TSGLETLLNI PIKRTMVQSP 1000
    SGVILQEAAD IHARYIELLT RSGDYYRFLS EMLKSLEDLK LKNTKIEVLE 1050
    EELRLARDAN SENCNKNKFL DQNLQKYQAE CSQFKAKLVS LEELKRQAEL 1100
    DGKSAKQNLD KCYGQIKELN EKITRLTYEI EDEKRRRKTV EDRFDQQKND 1150
    YDQLQKARQC EKENLSWQKL ESEKAIKEKE YEIERLRVLL QEEGARKREY 1200
    ENELAKVRNH YNEEMSNLRN KYETEINITK TTIKEISMQK EDDSKNLRNQ 1250
    MDRLSRENRD LKDEIVRLND SILQATEQRR RAEENALQQK ACGSETMQKK 1300
    QRLEIELKQV IQQRSEDNAR HKQSLEEAAK TIQDKNKEIE RLKAEYQEEA 1350
    KRRWEYENEL SKVRNSYDEE IISLKNQFET EINITKTTIH QLTMQKEEDT 1400
    SGYRAQIDNL TRENRSLCEE VKRLKNTLAQ TTENLRRVEE NAQQQKATGS 1450
    EMSQRKQQLE IELRQVTQMR TEESMRYKQS LDDAAKTIQD KNKEIERLKQ 1500
    LVDKETNERK CLEDENSKLQ RVQYDLQKAN NSATEAMSKL KVQEQELTRL 1550
    RIDYERVSQE RTVKDQDITR IQSSLKDLQL QKQKAEEELS RLKRTASDES 1600
    SKRKMLEEEL EAMRRSLKEQ AVKITNLTQQ LEQASIVKKR SEDDLRQQRD 1650
    VLDGHVREKQ RTQEELRRLS LDVEALRRQL VQEQENVKQA HLRNEHFQKA 1700
    IEDKSRSLNE SKIEIERLQS LTENLTKEHL MLEEELRNLR LEYDDLRRGR 1750
    SEADSDKNST ISELRSQLQI SNNRTLELQG LINDLQRERE NLRQEIEKFQ 1800
    KQALEASNRI QESKSQCTQV VQERESLLVK IKVLEQDKAR LQRLEDELNR 1850
    AKATLEAESR VKQRLECEKQ QIQNDLNQWK TQYSRKEETI RKIESEREKS 1900
    EREKNSLRSE IERLQAEIKR IEERCRRKLE DSSRETQSQL ESERCRLQKE 1950
    IEKLRQRPYG SHRETQTEYE WTVDSSKLVF DGLRKKVTAM QLYECQLIDK 2000
    TTLDKLLKGK KSVEEVASEI QPFLRGAGAI AGASASPKEK YSLVEAKRKK 2050
    FITPESTVML LEAQAATGGI IDPHRNEKLT VDNAVARDLI DFDDRQQIYT 2100
    AEKAITGFDD PFSGKTVSVS EAIKKNLIDR ETGMRLLEAQ LASGGVVDPV 2150
    NSVFLPKDVA LARGLIDRDL YRSLNDPRDS QKNFVDPITK KKVSYMQLRE 2200
    RCRIEPHTGL LLLSVQKRSM SFQGIRQPVT VTELVDSGIL RPSTVNELES 2250
    GQISYDEVGE RIKDFLQGSS CIAGIYNETT KQKLGIYEAM KIGLVRPGTA 2300
    LELLEAQAAT GFIVDPVSNL RLPVEEAYKR GLVGIEFKEK LLSAERAVTG 2350
    YNDPETGNII SLFQAMNKEL IEKGHGIRLL EAQIATGGII DPKESHRLPV 2400
    DMAYKRGYFN EELSEILSDP SDDTKGFFDP NTEENLTYLQ LKERCIKDEE 2450
    TGLCLLPLKE KKKQVQTSQK NTLRKRRVVI VDPETNKEMS VQEAYKKGLI 2500
    DYDTFKELCE QECEWEEITI TGSDGSTRVV LVDRKTGSQY DIQDAIDKGL 2550
    VDRKFFDQYR SGSLSLTQFA DMISLKNGVG NSSGLGGSVN DDVFSSSRHD 2600
    SVSKISTISS VRNLTIRSSS LSDPLEESSP IAAIFDTENL EKISIAEGIE 2650
    RGIVDSITGQ RLLEAQACTG GIIHPTTGQK LSLQDAVNQG LIDQDMATRL 2700
    KPAQKAFIGF EGVKGKKKMS AAEAVKEKWL PYEAGQRFLE FQFLTGGLVD 2750
    PEVHGRISTE EAIRKGFIDG RAAQRLQDIS SYAKILTCPK TKLKISYKDA 2800
    MNRSMVEDIT GLRLLEAASV SSKGLPSPYN MSAPGSRSGS RSGSRSGSRS 2850
    GSRSGSRRGS FDATGNSSYS YSYSFSSSSI GGY 2883
    Length:2,883
    Mass (Da):332,912
    Last modified:April 5, 2011 - v1
    Checksum:i1D8B68788D519940
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC140331 Genomic DNA. No translation available.
    CCDSiCCDS49239.1.
    RefSeqiNP_076331.2. NM_023842.2.
    UniGeneiMm.355327.

    Genome annotation databases

    EnsembliENSMUST00000124830; ENSMUSP00000115062; ENSMUSG00000054889.
    GeneIDi109620.
    KEGGimmu:109620.
    UCSCiuc007qdk.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC140331 Genomic DNA. No translation available.
    CCDSi CCDS49239.1.
    RefSeqi NP_076331.2. NM_023842.2.
    UniGenei Mm.355327.

    3D structure databases

    ProteinModelPortali E9Q557.
    SMRi E9Q557. Positions 190-639, 2221-2460, 2625-2820.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 224908. 3 interactions.
    IntActi E9Q557. 4 interactions.

    Proteomic databases

    MaxQBi E9Q557.
    PRIDEi E9Q557.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000124830 ; ENSMUSP00000115062 ; ENSMUSG00000054889 .
    GeneIDi 109620.
    KEGGi mmu:109620.
    UCSCi uc007qdk.2. mouse.

    Organism-specific databases

    CTDi 1832.
    MGIi MGI:109611. Dsp.

    Phylogenomic databases

    GeneTreei ENSGT00720000108730.
    KOi K10381.
    OMAi KRSMSFQ.
    TreeFami TF106435.

    Miscellaneous databases

    ChiTaRSi DSP. mouse.
    NextBioi 362451.
    PROi E9Q557.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi E9Q557.
    Bgeei E9Q557.

    Family and domain databases

    Gene3Di 3.90.1290.10. 4 hits.
    InterProi IPR028462. Desmoplakin.
    IPR001101. Plectin_repeat.
    IPR018159. Spectrin/alpha-actinin.
    [Graphical view ]
    PANTHERi PTHR11915:SF234. PTHR11915:SF234. 1 hit.
    Pfami PF00681. Plectin. 8 hits.
    [Graphical view ]
    SMARTi SM00250. PLEC. 18 hits.
    SM00150. SPEC. 2 hits.
    [Graphical view ]
    SUPFAMi SSF75399. SSF75399. 5 hits.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    2. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2836, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.

    Entry informationi

    Entry nameiDESP_MOUSE
    AccessioniPrimary (citable) accession number: E9Q557
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 28, 2011
    Last sequence update: April 5, 2011
    Last modified: October 1, 2014
    This is version 29 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3