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E9Q557

- DESP_MOUSE

UniProt

E9Q557 - DESP_MOUSE

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Protein
Desmoplakin
Gene
Dsp
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Major high molecular weight protein of desmosomes. Involved in the organization of the desmosomal cadherin-plakoglobin complexes into discrete plasma membrane domains and in the anchoring of intermediate filaments to the desmosomes.

GO - Molecular functioni

  1. protein binding Source: UniProtKB
  2. structural molecule activity Source: Ensembl

GO - Biological processi

  1. adherens junction organization Source: MGI
  2. bundle of His cell to Purkinje myocyte communication Source: Ensembl
  3. desmosome organization Source: BHF-UCL
  4. intermediate filament cytoskeleton organization Source: MGI
  5. intermediate filament organization Source: BHF-UCL
  6. keratinocyte differentiation Source: Ensembl
  7. peptide cross-linking Source: Ensembl
  8. protein localization to adherens junction Source: BHF-UCL
  9. regulation of heart rate by cardiac conduction Source: Ensembl
  10. single organismal cell-cell adhesion Source: MGI
  11. skin development Source: MGI
  12. ventricular cardiac muscle cell action potential Source: Ensembl
  13. ventricular compact myocardium morphogenesis Source: BHF-UCL
  14. wound healing Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Desmoplakin
Short name:
DP
Gene namesi
Name:Dsp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 13

Organism-specific databases

MGIiMGI:109611. Dsp.

Subcellular locationi

Cell junctiondesmosome By similarity. Cytoplasmcytoskeleton By similarity
Note: Innermost portion of the desmosomal plaque. Colocalizes with epidermal KRT5-KRT14 and simple KRT8-KRT18 keratins and VIM intermediate filaments network By similarity.

GO - Cellular componenti

  1. basolateral plasma membrane Source: MGI
  2. cell-cell junction Source: MGI
  3. cornified envelope Source: Ensembl
  4. desmosome Source: MGI
  5. fascia adherens Source: Ensembl
  6. intercalated disc Source: MGI
  7. membrane Source: MGI
  8. mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cytoplasm, Cytoskeleton

Pathology & Biotechi

Keywords - Diseasei

Cardiomyopathy

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 28832883Desmoplakin
PRO_0000410831Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei22 – 221Phosphoserine By similarity
Modified residuei177 – 1771Phosphoserine By similarity
Modified residuei178 – 1781Phosphoserine By similarity
Modified residuei188 – 1881Phosphoserine By similarity
Modified residuei2036 – 20361Phosphoserine By similarity
Modified residuei2219 – 22191Phosphoserine By similarity
Modified residuei2221 – 22211Phosphoserine By similarity
Lipidationi2492 – 24921Omega-hydroxyceramide glutamate ester By similarity
Modified residuei2827 – 28271Phosphoserine By similarity
Modified residuei2832 – 28321Phosphoserine By similarity
Modified residuei2836 – 28361Phosphoserine1 Publication
Modified residuei2860 – 28601Phosphoserine By similarity
Modified residuei2864 – 28641Phosphothreonine By similarity
Modified residuei2879 – 28791Phosphoserine By similarity

Post-translational modificationi

Ser-2860 is probably phosphorylated by a cAMP-dependent protein kinase. Phosphorylation on Ser-2860 probably affects its association with epidermal, simple cytokeratins and VIM intermediate filaments By similarity.
Substrate of transglutaminase. Some glutamines and lysines are cross-linked to other desmoplakin molecules, to other proteins such as keratin, envoplakin, periplakin and involucrin, and to lipids like omega-hydroxyceramide By similarity.

Keywords - PTMi

Lipoprotein, Phosphoprotein

Proteomic databases

MaxQBiE9Q557.
PRIDEiE9Q557.

Expressioni

Gene expression databases

ArrayExpressiE9Q557.
BgeeiE9Q557.

Interactioni

Subunit structurei

Homodimer. Interacts with COL17A1 (via cytoplasmic region). Associates (via C-terminal) with KRT5-KRT14 (via rod region), KRT8-KRT18 and VIM intermediate filaments. Interacts with PKP2 By similarity.

Protein-protein interaction databases

BioGridi224908. 3 interactions.
IntActiE9Q557. 4 interactions.

Structurei

3D structure databases

ProteinModelPortaliE9Q557.
SMRiE9Q557. Positions 190-639, 2221-2460, 2625-2820.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati190 – 28394Spectrin 1
Add
BLAST
Repeati284 – 387104Spectrin 2
Add
BLAST
Repeati388 – 45871Spectrin 3a
Add
BLAST
Domaini459 – 52769SH3
Add
BLAST
Repeati528 – 55730Spectrin 3b
Add
BLAST
Repeati558 – 63982Spectrin 4
Add
BLAST
Repeati666 – 781116Spectrin 5
Add
BLAST
Repeati782 – 895114Spectrin 6
Add
BLAST
Repeati2021 – 205737Plectin 1
Add
BLAST
Repeati2058 – 209538Plectin 2
Add
BLAST
Repeati2096 – 213338Plectin 3
Add
BLAST
Repeati2134 – 217138Plectin 4
Add
BLAST
Repeati2175 – 220935Plectin 5
Add
BLAST
Repeati2210 – 224536Plectin 6
Add
BLAST
Repeati2263 – 230038Plectin 7
Add
BLAST
Repeati2301 – 233838Plectin 8
Add
BLAST
Repeati2339 – 237638Plectin 9
Add
BLAST
Repeati2377 – 241438Plectin 10
Add
BLAST
Repeati2418 – 245235Plectin 11
Add
BLAST
Repeati2468 – 250538Plectin 12
Add
BLAST
Repeati2519 – 255638Plectin 13
Add
BLAST
Repeati2622 – 265938Plectin 14
Add
BLAST
Repeati2660 – 269738Plectin 15
Add
BLAST
Repeati2736 – 277338Plectin 16
Add
BLAST
Repeati2774 – 281138Plectin 17
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 10681068Globular 1
Add
BLAST
Regioni1 – 596596Interacts with plakophilin 1 and junction plakoglobin By similarity
Add
BLAST
Regioni1069 – 1957889Central fibrous rod domain
Add
BLAST
Regioni1958 – 2882925Globular 2
Add
BLAST
Regioni1972 – 22202494.5 X 38 AA tandem repeats (Domain A)
Add
BLAST
Regioni2256 – 24582034.5 X 38 AA tandem repeats (Domain B)
Add
BLAST
Regioni2621 – 28332134.5 X 38 AA tandem repeats (Domain C)
Add
BLAST
Regioni2835 – 2858246 X 4 AA tandem repeats of G-S-R-[SR]
Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili1034 – 1956923 Reviewed prediction
Add
BLAST

Domaini

Its association with epidermal and simple keratins is dependent on the tertiary structure induced by heterodimerization of these intermediate filaments proteins and most likely involves recognition sites located in the rod domain of these keratins By similarity.
The N-terminal region is required for localization to the desmosomal plaque and interacts with the N-terminal region of plakophilin 1 By similarity.
The three tandem plakin repeat regions in the C-terminus mediate binding to intermediate filaments By similarity.

Sequence similaritiesi

Contains 17 plectin repeats.
Contains 1 SH3 domain.
Contains 6 spectrin repeats.

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

GeneTreeiENSGT00720000108730.
KOiK10381.
OMAiKRSMSFQ.
TreeFamiTF106435.

Family and domain databases

Gene3Di3.90.1290.10. 4 hits.
InterProiIPR028462. Desmoplakin.
IPR001101. Plectin_repeat.
IPR018159. Spectrin/alpha-actinin.
[Graphical view]
PANTHERiPTHR11915:SF234. PTHR11915:SF234. 1 hit.
PfamiPF00681. Plectin. 8 hits.
[Graphical view]
SMARTiSM00250. PLEC. 18 hits.
SM00150. SPEC. 2 hits.
[Graphical view]
SUPFAMiSSF75399. SSF75399. 5 hits.

Sequencei

Sequence statusi: Complete.

E9Q557-1 [UniParc]FASTAAdd to Basket

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MSCNGGSHPR INTLGRMTRA ESGPDLRYEM TYSGGGGGGG GGGGGGTSRT     50
FYSHSRRCTV NDQNSDGYCQ TGTMSRHQNQ NTIQEMLQNC SDCLMRAELI 100
AQPELKFGEG MQLAWNRELD EYFTQANDQM EIIDGLIREM RQMGQPCDAY 150
QKRLLQLQEQ MRALYKAISV PRVRRASSKG AGGYTCQSGS GWDEFTKRLT 200
GECLGWMRQQ REEMDLMAWG VDAGSVEQHI NSHRSIHNTI GDYRWQLDKI 250
KADLREKSAI YQLEEEYENL LKASFERMDH LRQLQNIIQA TSREIMWIND 300
CEEEELLYDW SDKNTNIAQK QEAFSIRMSQ LEVKEKELNK LKQESDQLVL 350
NQHPASDKIE AYMDTLQTQW SWILQITKCI DVHLKENAAY FQFFEEAQST 400
EAYLKGLQDS IRKKYPCDKN MPLQHLLEQI KELEKEREKI IEYKRQVQNL 450
VNKSKKIVQL KPRNPDYRSN KPIILRALCD YKQDQKIVHK GDECILKDNN 500
ERSKWYVTGP GGVDMLVPSV GLIIPPPNPL AVDLSCKIEQ YYEAILALWN 550
QLYINMKSLV SWHYCMIDIE KIRAMTIAKL KTMRQEDYMK TIEDLELHYQ 600
DFIKNSQGSE MFGDDDKRRM QSQFTDAQKH YQTLVIQLPG HPQHQTVTKT 650
EITHLGTCQD VNHNKVIETN RENDKQETWL LMELQKIRRQ MEHCEARMTL 700
KNLLLAEQGS THHITVKINE LKSVQNDSQA LAEVLNQLKD MLANFRGSEK 750
YCYLQNEIFG LFQKLENING VSDGYLNSLC SVRALLQAIL QTEDMLKVYE 800
ARLTEEETVC LDLDKVEAYR CGLKKIKNDL NLKKSLLATM KTELQKAQQI 850
HSQSSQQYPL YDLDLGKFTE KVTQLTDRWQ KIDKQIDFRL WDLEKQIKQL 900
RNYRDNYQSF CKWLYDAKRR QDSLESMKFG DSNTVMRFLN EQKNLHSEIS 950
GKRDKSEEVH KIAELCANSI KDYELQLASY TSGLETLLNI PIKRTMVQSP 1000
SGVILQEAAD IHARYIELLT RSGDYYRFLS EMLKSLEDLK LKNTKIEVLE 1050
EELRLARDAN SENCNKNKFL DQNLQKYQAE CSQFKAKLVS LEELKRQAEL 1100
DGKSAKQNLD KCYGQIKELN EKITRLTYEI EDEKRRRKTV EDRFDQQKND 1150
YDQLQKARQC EKENLSWQKL ESEKAIKEKE YEIERLRVLL QEEGARKREY 1200
ENELAKVRNH YNEEMSNLRN KYETEINITK TTIKEISMQK EDDSKNLRNQ 1250
MDRLSRENRD LKDEIVRLND SILQATEQRR RAEENALQQK ACGSETMQKK 1300
QRLEIELKQV IQQRSEDNAR HKQSLEEAAK TIQDKNKEIE RLKAEYQEEA 1350
KRRWEYENEL SKVRNSYDEE IISLKNQFET EINITKTTIH QLTMQKEEDT 1400
SGYRAQIDNL TRENRSLCEE VKRLKNTLAQ TTENLRRVEE NAQQQKATGS 1450
EMSQRKQQLE IELRQVTQMR TEESMRYKQS LDDAAKTIQD KNKEIERLKQ 1500
LVDKETNERK CLEDENSKLQ RVQYDLQKAN NSATEAMSKL KVQEQELTRL 1550
RIDYERVSQE RTVKDQDITR IQSSLKDLQL QKQKAEEELS RLKRTASDES 1600
SKRKMLEEEL EAMRRSLKEQ AVKITNLTQQ LEQASIVKKR SEDDLRQQRD 1650
VLDGHVREKQ RTQEELRRLS LDVEALRRQL VQEQENVKQA HLRNEHFQKA 1700
IEDKSRSLNE SKIEIERLQS LTENLTKEHL MLEEELRNLR LEYDDLRRGR 1750
SEADSDKNST ISELRSQLQI SNNRTLELQG LINDLQRERE NLRQEIEKFQ 1800
KQALEASNRI QESKSQCTQV VQERESLLVK IKVLEQDKAR LQRLEDELNR 1850
AKATLEAESR VKQRLECEKQ QIQNDLNQWK TQYSRKEETI RKIESEREKS 1900
EREKNSLRSE IERLQAEIKR IEERCRRKLE DSSRETQSQL ESERCRLQKE 1950
IEKLRQRPYG SHRETQTEYE WTVDSSKLVF DGLRKKVTAM QLYECQLIDK 2000
TTLDKLLKGK KSVEEVASEI QPFLRGAGAI AGASASPKEK YSLVEAKRKK 2050
FITPESTVML LEAQAATGGI IDPHRNEKLT VDNAVARDLI DFDDRQQIYT 2100
AEKAITGFDD PFSGKTVSVS EAIKKNLIDR ETGMRLLEAQ LASGGVVDPV 2150
NSVFLPKDVA LARGLIDRDL YRSLNDPRDS QKNFVDPITK KKVSYMQLRE 2200
RCRIEPHTGL LLLSVQKRSM SFQGIRQPVT VTELVDSGIL RPSTVNELES 2250
GQISYDEVGE RIKDFLQGSS CIAGIYNETT KQKLGIYEAM KIGLVRPGTA 2300
LELLEAQAAT GFIVDPVSNL RLPVEEAYKR GLVGIEFKEK LLSAERAVTG 2350
YNDPETGNII SLFQAMNKEL IEKGHGIRLL EAQIATGGII DPKESHRLPV 2400
DMAYKRGYFN EELSEILSDP SDDTKGFFDP NTEENLTYLQ LKERCIKDEE 2450
TGLCLLPLKE KKKQVQTSQK NTLRKRRVVI VDPETNKEMS VQEAYKKGLI 2500
DYDTFKELCE QECEWEEITI TGSDGSTRVV LVDRKTGSQY DIQDAIDKGL 2550
VDRKFFDQYR SGSLSLTQFA DMISLKNGVG NSSGLGGSVN DDVFSSSRHD 2600
SVSKISTISS VRNLTIRSSS LSDPLEESSP IAAIFDTENL EKISIAEGIE 2650
RGIVDSITGQ RLLEAQACTG GIIHPTTGQK LSLQDAVNQG LIDQDMATRL 2700
KPAQKAFIGF EGVKGKKKMS AAEAVKEKWL PYEAGQRFLE FQFLTGGLVD 2750
PEVHGRISTE EAIRKGFIDG RAAQRLQDIS SYAKILTCPK TKLKISYKDA 2800
MNRSMVEDIT GLRLLEAASV SSKGLPSPYN MSAPGSRSGS RSGSRSGSRS 2850
GSRSGSRRGS FDATGNSSYS YSYSFSSSSI GGY 2883
Length:2,883
Mass (Da):332,912
Last modified:April 5, 2011 - v1
Checksum:i1D8B68788D519940
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC140331 Genomic DNA. No translation available.
CCDSiCCDS49239.1.
RefSeqiNP_076331.2. NM_023842.2.
UniGeneiMm.355327.

Genome annotation databases

EnsembliENSMUST00000124830; ENSMUSP00000115062; ENSMUSG00000054889.
GeneIDi109620.
KEGGimmu:109620.
UCSCiuc007qdk.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC140331 Genomic DNA. No translation available.
CCDSi CCDS49239.1.
RefSeqi NP_076331.2. NM_023842.2.
UniGenei Mm.355327.

3D structure databases

ProteinModelPortali E9Q557.
SMRi E9Q557. Positions 190-639, 2221-2460, 2625-2820.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 224908. 3 interactions.
IntActi E9Q557. 4 interactions.

Proteomic databases

MaxQBi E9Q557.
PRIDEi E9Q557.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000124830 ; ENSMUSP00000115062 ; ENSMUSG00000054889 .
GeneIDi 109620.
KEGGi mmu:109620.
UCSCi uc007qdk.2. mouse.

Organism-specific databases

CTDi 1832.
MGIi MGI:109611. Dsp.

Phylogenomic databases

GeneTreei ENSGT00720000108730.
KOi K10381.
OMAi KRSMSFQ.
TreeFami TF106435.

Miscellaneous databases

ChiTaRSi DSP. mouse.
NextBioi 362451.
PROi E9Q557.
SOURCEi Search...

Gene expression databases

ArrayExpressi E9Q557.
Bgeei E9Q557.

Family and domain databases

Gene3Di 3.90.1290.10. 4 hits.
InterProi IPR028462. Desmoplakin.
IPR001101. Plectin_repeat.
IPR018159. Spectrin/alpha-actinin.
[Graphical view ]
PANTHERi PTHR11915:SF234. PTHR11915:SF234. 1 hit.
Pfami PF00681. Plectin. 8 hits.
[Graphical view ]
SMARTi SM00250. PLEC. 18 hits.
SM00150. SPEC. 2 hits.
[Graphical view ]
SUPFAMi SSF75399. SSF75399. 5 hits.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2836, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiDESP_MOUSE
AccessioniPrimary (citable) accession number: E9Q557
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 28, 2011
Last sequence update: April 5, 2011
Last modified: July 9, 2014
This is version 28 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi