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E9Q555

- RN213_MOUSE

UniProt

E9Q555 - RN213_MOUSE

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Protein
E3 ubiquitin-protein ligase RNF213
Gene
Rnf213
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Probable E3 ubiquitin-protein ligase that may play a role in angiogenesis. May also have an ATPase activity By similarity.

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri3946 – 398540RING-type
Add
BLAST

GO - Molecular functioni

  1. ATPase activity Source: UniProtKB
  2. ligase activity Source: UniProtKB-KW
  3. nucleotide binding Source: InterPro
  4. ubiquitin-protein transferase activity Source: UniProtKB
  5. zinc ion binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. ATP catabolic process Source: UniProtKB
  2. protein autoubiquitination Source: UniProtKB
  3. protein ubiquitination Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Ubl conjugation pathway

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
E3 ubiquitin-protein ligase RNF213 (EC:6.3.2.-)
Gene namesi
Name:Rnf213
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:1289196. Rnf213.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 51505150E3 ubiquitin-protein ligase RNF213
PRO_0000415918Add
BLAST

Post-translational modificationi

Autoubiquitinates By similarity.

Keywords - PTMi

Ubl conjugation

Proteomic databases

MaxQBiE9Q555.
PRIDEiE9Q555.

Expressioni

Gene expression databases

ArrayExpressiE9Q555.
BgeeiE9Q555.

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili3434 – 346431 Reviewed prediction
Add
BLAST

Domaini

The RING-type zinc finger domain is required for the ubiquitin-protein ligase activity By similarity.

Sequence similaritiesi

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

GeneTreeiENSGT00630000089884.
OrthoDBiEOG7S21WZ.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
3.40.50.300. 3 hits.
InterProiIPR003593. AAA+_ATPase.
IPR027417. P-loop_NTPase.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
SM00184. RING. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E9Q555-1 [UniParc]FASTAAdd to Basket

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MECPQCGHVS SEKAPKFCSE CGQKLPSAAT VQGDLKNDNT LVVSSTPEGK     50
TEQGAVLREE EVLLSSTDPG KELEKPEESD SNASWTTQMS KKEKRRRKRQ 100
GTISSSEAPS SGLWSLDMPP SPGSHNSALP QNQAQQGGAA SQPGHPLDTE 150
NMPMEDGFVH TEGSGSPLQG QAAERTDAQS NLAPSDLAEV KDLNTSKPSV 200
DKGLPLDGGP ALSAFKGHPK MTDASQKAPL PESKGETSGQ EKKVPPIDAA 250
ASPVKTAGKE TGEDVRKPKP SPVSPVASKH GDQEAELKGK LATPVRKSNE 300
GGNTQPEDQR KPGEGRNFAA AVKTQQAAAP QQAAAPEPTS AFNPRDTVTV 350
YFHAIVSRHF GFNPEEHKVY VRGGEGLGQK GWTDACEMYC TQDLHDLGSL 400
VEGKMDIPRQ SLDKPIPYKY VIHRGGSSKD TVEYEFIYEQ AQKKGEHVNR 450
CLRVVSTSLG NGDWHQYDDI ICMRSTGFFQ QAKNRILDST RKELLKGKKQ 500
AAVVMLDRIF SVLQPWSDIN LQSFMTQFLQ FYSVVREPMI HDGRARKWTS 550
LQYEEKEVWT NLWEHVKKQM APFLEGKSGE SLPADCPVRS KLTLGLSILF 600
MVEAAEFTVP KKDLDSLCYL LIPSAGSPEA LHSDLSPVLR IRQRWRIYLT 650
NLCLRCIDER CDRWLGILPL LHTCMQKSPP KKNSKSQPED TWAGLEGISF 700
SEFRDKAPTS QPLQFMQSKM ALLRVDEYLF RSWLSVVPLE SLSSYLENSI 750
DYLSDVPVRV LDCLQGISYR LPGLRKISNQ NMKKDVENVF KMLMHLVDIY 800
QHRIFGENLL QIYLTECLTL HETVCNITAN HQFFEIPALS AELICKLLEL 850
SPPGHTDEGL PEKSYEDLVT STLQEALATT RNWLRSLFKS RMLSISSAYV 900
RLTYSEEMAV WRRLVEIGFP EKHGWKGSLL GDMEGRLKQE PPRLQISFFC 950
SSQCRDGGLH DSVSRSFEKC VIEAVSSACQ SQTSVLEGLS CQDLQKFGTL 1000
LSAVITKSWP VHNGEPVFDV DEIFKYLLKW PDVRQLFELC GTNEKIIDNI 1050
TEEGRQLMAT AESVFQKVAG ELENGTIVVG QLELILEHQS QFLDIWNLNR 1100
RRLPSQEKAC DVRSLLKRRR DDLLFLKQEK RYVESLLRQL GRVKHLVQVD 1150
FGNIEIIHSQ DLSNKKLNEA VIKLPNSSSY KRETHYCLSP DIREMASKLD 1200
SLKDSHIFQD FWQETAESLN TLDKDPRELK VSLPEVLEYL YNPCYDNFYT 1250
LYENLKSGKI TFAEVDAIFK DFVDKYDELK NDLKFMCTMN PQDQKGWISE 1300
RVGQIKEYHT LHQAVSSAKV ILQVRRALGV TGDFSVLNPL LNFADSFEDF 1350
GNEKLDQISP QFIKAKQLLQ DISEPRQRCL EELARQTELV AWLHKALEDI 1400
NELKVFVDLA SISAGENDID VDRVACFHDA VQGYASLLYK MDERTNFSDF 1450
MNHLQELWRA LDNDQHLPDK LKDSARNLEW LKTVKESHGS VELSSLSLAT 1500
AINSRGVYVI EAPKDGQKIS PDTVLRLLLP DGHGYPEALR TYSTEELKEL 1550
LNKLMLMSGK KDHNSNTEVE KFSEVFSNMQ RLVHVFIKLH CAGNMLFRTW 1600
TAKVYCCPDG GIFMNFGLEL LSQLTEKGDV IQLLGALCRQ MEDFLDNWKT 1650
VVAQKRAEHF YLNFYTAEQL VYLSSELRKP RPSEAALMML SFIKGKCTVQ 1700
DLVQATSACE SKADRYCLRE VMKKLPQQLL SEPSLMGKLQ VIMMQSLVYM 1750
SAFLPHCLDL DALGRCLAHL ATMGGTPVER PLPKGLQAGQ PNLILCGHSE 1800
VLPAALAIYM QAPRQPLPTF DEVLLCTPAT TIEEVELLLR RCLTSGSQGH 1850
KVYSLLFADQ LSYEVGCQAE EFFQSLCTRA HREDYQLVIL CDAAREHCYI 1900
PSTFSQYKVP LVPQAPLPNI QAYLQSHYQV PKRLLSAATV FRDGLCVGIV 1950
TSERAGVGKS LYVNTLHTKL KAKLRDETVP LKIIRLTEPH LDENQVLSAL 2000
LPFLKEKYQK MPVIFHIDIS TSVQTGIPIF LFKLLILQYL MDINGKIWRR 2050
SPGHLYLVEI PQGLSVQPKR SSKLNARAPL FKFLDLFPKV TCRPPKEVID 2100
MELTPERSHT DPAMDPVEFC SEAFQRPYQY LKRFHQQQNL DTFQYEKGSV 2150
EGSPEECLQH FLIYCGLINP SWSELRNFAW FLNCQLKDCE ASIFCKSAFT 2200
GDTLRGFKNF VVTFMILMAR DFATPTLHTS DQSPGRQSVT IGEVVEEDLA 2250
PFSLRKRWES EPHPYVFFNG DHMTMTFIGF HLETNNNGYV DAINPSNGKV 2300
IKKDVMTKEL FDGLRLQRVP FNIDFDNLPR YEKLERLCLA LGIEWPIDPD 2350
ETYELTTDNM LKILAIEMRF RCGIPVIIMG ETGCGKTRLI KFLSDLKRGS 2400
VEAETMKLVK VHGGTTPSMI YSKVKEAERT AFSNKAQHKL DTILFFDEAN 2450
TTEAVSCIKE ILCDRTVDGE HLHEDSGLHI IAACNPYRKH SQEMILRLES 2500
AGLGYRVSAE ETADRLGSIP LRQLVYRVHA LPPSLIPLVW DFGQLNDSAE 2550
KLYIQQIVQR LVDSVSVNPS ETCVIADVLS ASQMFMRKRE NECGFVSLRD 2600
VERCVKVFRW FHDHSDMLLK ELDKFLHESS DSTHTFERDP VLWSLVMAIG 2650
VCYHASLEEK ASYRTAIARC FPKPYNSSRA ILDEVTHVQD LFLRGAPIRT 2700
NIARNLALKE NVFMMVICIE LKIPLFLVGK PGSSKSLAKI IVADAMQGQA 2750
AFSELFRCLK QVHLVSFQCS PHSTPQGIIS TFKQCARFQQ GKDLGQYVSV 2800
VVLDEVGLAE DSPKMPLKTL HPLLEDGCIE DDPAPYKKVG FVGISNWALD 2850
PAKMNRGIFV SRGSPNEKEL IESAEGICSS DRLVQDKIRG YFAPFAKAYE 2900
TVCQKQDKEF FGLRDYYSLI KMVFAKAKAS KRGLSPQDIT HAVLRNFSGK 2950
DNIQALSIFT ASLPEARYKE EVSTVELIKQ NIYPGPQASS RGLDGAESRY 3000
LLVLTRNYVA LQILQQTFFE GQQPEIIFGS SFPQDQEYTQ ICRNINRVKI 3050
CMETGKMVVL LNLQNLYESL YDALNQYYVY LGGQKYVDLG LGTHRVKCRV 3100
HTAFRLIVIE EKDVVYKQFP VPLINRLEKH YLDMNTVLQP WQKSIVQELQ 3150
QWAHEFADVK ADQFIARHKY SPADVFIGYH SDACASVVLQ AVERQGCRDL 3200
TEELYRKVSE EARSILLDCA TPDAVVRLSG SSLGSFTAKQ LSQEYYYAQQ 3250
HNSFVDFLQA HLRMTHHECR AVFTEITTFS RLLTGNDCDV LASELRGLAS 3300
KPVVLSLQQY DTEYSFLKDV RSWLTNPGKR KVLVIQADFD DGTRSAQLVA 3350
SAKYTAINEI NKTQGTKDFV FVYFVTKLSR MGSGTSYVGF HGGLWRSVHI 3400
DDLRRSTIMA SDVTKLQNVT ISQLFKPEDK PEQEEMEIET SQSKELAEEQ 3450
MEVEDSEEMK KASDPRSCDC SQFLDTTRLV QSCVQGAVGM LRDQNESCAR 3500
NMRRVTILLD LLNEDNTRNA SFLRESKMRL HVLLNKQEEN QVRSLKEWVT 3550
REAANQDALQ EAGTFRHTLW KRVQDVVTPI LASMIAHIDR DGNLELLAQP 3600
DSPAWVQDLW MFIYSDIKFL NISLVLNNTR SNSEMSFILV QSHMNLLKDA 3650
YNAVPFSWRI RDYLEELWVQ AQYITDTEGL SKKFVEIFQK TPLGVFLAQF 3700
PVAQQQKLLQ SYLKDFLLLT MKVSSREELM FLQMALWSCL RELQEASGTP 3750
DETYKFPLSL PWVHLAFQHF RTRLQNFSRI LTIHPQVLSS LSQAAEKHSL 3800
AGCEMTLDAF AAMACAEMLK GDLLKPSPKA WLQLVKNLST PLELVCSEGY 3850
LCDSGSMTRS VIQEVRALWN RIFSIALFVE HVLLGTESHI PELSPLVTTY 3900
VSLLDKCLEE DSNLKTCRPF VAVMTTLCDC KDKASKKFSR FGIQPCFICH 3950
GDAQDPVCLP CDHVYCLRCI QTWLIPGQMM CPYCLTDLPD KFSPTVSQDH 4000
RKAIEKHAQF RHMCNSFFVD LVSTMCFKDN TPPEKSVIDT LLSLLFVQKE 4050
LLRDASQKHR EHTKSLSPFD DVVDQTPVIR SVLLKLLLKY SFHEVKDYIQ 4100
NYLTQLEKKA FLTEDKTELY LLFISCLEDS VHQKTSAGCR NLEQVLREEG 4150
HFLRTYSPGL QGQEPVRIAS VEYLQEVARV RLCLDLAADF LSELQEGSEL 4200
AEDKRRFLKH VEEFCTRVNN DWHRVYLVRK LSSQRGMEFV QSFSKQGHPC 4250
QWVFPRKVIA QQVRNRDHVS LMDRYLVHGN EYKAVRDATA KAVLECKTLD 4300
IGNALMACRS PKPQQTAYLL LALYTEVAAL YRSPNGSLHP EAKQLEAVNK 4350
FIKESKILSD PNIRCFARSL VDNTLPLLKI RSANSILKGT VTEMAVHVAT 4400
ILLCGHNQIL KPLRNLAFYP VNMANAFLPT MPEDLLVHAR TWRGLENVTW 4450
YTCPRGHPCS VGECGRPMQE STCLDCGLPV GGLNHTPHEG FSAIRNNEDR 4500
TQTGHVLGSP QSSGVAEVSD RGQSPVVFIL TRLLTHLAML VGATHNPQAL 4550
TVIIKPWVQD PQGFLQQHIQ RDLEQLTKML GRSADETIHV VHLILSSLLR 4600
VQSHGVLNFN AELSTKGCRN NWEKHFETLL LRELKHLDKN LPAINALISQ 4650
DERISSNPVT KIIYGDPATF LPHLPQKSII HCSKIWSCRR KITVEYLQHI 4700
VEQKNGKETV PVLWHFLQKE AELRLVKFLP EILALQRDLV KQFQNVSRVE 4750
YSSIRGFIHS HSSDGLRKLL HDRITIFLST WNALRRSLET NGEIKLPKDY 4800
CCSDLDLDAE FEVILPRRQG LGLCGTALVS YLISLHNNMV YTVQKFSNED 4850
NSYSVDISEV ADLHVISYEV ERDLNPLILS NCQYQVQQGG ETSQEFDLEK 4900
IQRQISSRFL QGKPRLTLKG IPTLVYRRDW NYEHLFMDIK NKMAQSSLPN 4950
LAISTISGQL QSYSDACEAL SIIEITLGFL STAGGDPGMD LNVYIEEVLR 5000
MCDQTAQVLK AFSRCQLRHI IALWQFLSAH KSEQRLRLNK ELFREIDVQY 5050
KEELSTQHQR LLGTFLNEAG LDAFLLELHE MIVLKLKGPR AANSFNPNWS 5100
LKDTLVSYME TKDSDILSEV ESQFPEEILM SSCISVWKIA ATRKWDRQSR 5150
Length:5,150
Mass (Da):584,499
Last modified:April 5, 2011 - v1
Checksum:i39FDE76554CC9D89
GO

Sequence cautioni

The sequence BAC37048.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL645911 Genomic DNA. No translation available.
AK077880 mRNA. Translation: BAC37048.1. Different initiation.
UniGeneiMm.133342.

Genome annotation databases

EnsembliENSMUST00000131035; ENSMUSP00000115063; ENSMUSG00000070327.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL645911 Genomic DNA. No translation available.
AK077880 mRNA. Translation: BAC37048.1 . Different initiation.
UniGenei Mm.133342.

3D structure databases

ModBasei Search...

Proteomic databases

MaxQBi E9Q555.
PRIDEi E9Q555.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000131035 ; ENSMUSP00000115063 ; ENSMUSG00000070327 .

Organism-specific databases

MGIi MGI:1289196. Rnf213.

Phylogenomic databases

GeneTreei ENSGT00630000089884.
OrthoDBi EOG7S21WZ.

Enzyme and pathway databases

UniPathwayi UPA00143 .

Miscellaneous databases

PROi E9Q555.
SOURCEi Search...

Gene expression databases

ArrayExpressi E9Q555.
Bgeei E9Q555.

Family and domain databases

Gene3Di 3.30.40.10. 1 hit.
3.40.50.300. 3 hits.
InterProi IPR003593. AAA+_ATPase.
IPR027417. P-loop_NTPase.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view ]
SMARTi SM00382. AAA. 2 hits.
SM00184. RING. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 2 hits.
PROSITEi PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 4809-5150.
    Strain: C57BL/6J.
    Tissue: Testis.

Entry informationi

Entry nameiRN213_MOUSE
AccessioniPrimary (citable) accession number: E9Q555
Secondary accession number(s): Q8BVK6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 21, 2012
Last sequence update: April 5, 2011
Last modified: September 3, 2014
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi