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Protein

E3 ubiquitin-protein ligase RNF213

Gene

Rnf213

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

E3 ubiquitin-protein ligase involved in angiogenesis. Involved in the non-canonical Wnt signaling pathway in vascular development: acts by mediating ubiquitination and degradation of FLNA and NFATC2 downstream of RSPO3, leading to inhibit the non-canonical Wnt signaling pathway and promoting vessel regression. Also has ATPase activity.By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.By similarity
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri3947 – 398640RING-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Ligase

Keywords - Biological processi

Angiogenesis, Ubl conjugation pathway

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-983168. Antigen processing: Ubiquitination & Proteasome degradation.
UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
E3 ubiquitin-protein ligase RNF213 (EC:3.6.4.-By similarity, EC:6.3.2.-By similarity)
Alternative name(s):
Mysterin1 Publication
RING finger protein 213Curated
Gene namesi
Name:Rnf213Imported
Synonyms:Mystr1 Publication
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1289196. Rnf213.

Subcellular locationi

  • Cytoplasmcytosol By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Disruption phenotypei

No visible phenotype. Males and female are fertile and produce normal-sized litters (PubMed:23410753, PubMed:24440776). Mice do not spontaneously develop Moyamoya disease, a chronic occlusive cerebrovascular disease (PubMed:24440776). Mice show elevated expression of MMP9 (PubMed:25383461).3 Publications

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi4757 – 47571R → K: Knockin mice grow normally and do not show any visible phenotype. Slightly impaired angiogenesis. 2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 51525152E3 ubiquitin-protein ligase RNF213PRO_0000415918Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei196 – 1961PhosphoserineBy similarity
Cross-linki1128 – 1128Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei2234 – 22341PhosphoserineBy similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiE9Q555.
MaxQBiE9Q555.
PaxDbiE9Q555.
PeptideAtlasiE9Q555.
PRIDEiE9Q555.

Expressioni

Gene expression databases

BgeeiE9Q555.
ExpressionAtlasiE9Q555. baseline and differential.
GenevisibleiE9Q555. MM.

Interactioni

Subunit structurei

Homooligomer; probably forms homohexamers.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000091429.

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili3435 – 346531Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the AAA ATPase family.Curated
Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri3947 – 398640RING-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiENOG410IHNB. Eukaryota.
ENOG410XTAN. LUCA.
GeneTreeiENSGT00630000089884.
InParanoidiE9Q555.
OrthoDBiEOG7S21WZ.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
3.40.50.300. 3 hits.
InterProiIPR003593. AAA+_ATPase.
IPR027417. P-loop_NTPase.
IPR031248. RNF213.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PANTHERiPTHR22605:SF5. PTHR22605:SF5. 1 hit.
SMARTiSM00382. AAA. 2 hits.
SM00184. RING. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E9Q555-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MECPQCGHVS SEKAPKFCSE CGQKLPSAAT VQGDLKNDNT LVVSSTPEGK
60 70 80 90 100
TEQGAVLREE EVLLSSTDPG KELEKPEESD SNASWTTQMS KKEKRRRKRQ
110 120 130 140 150
GTISSSEAPS SGLWSLDMPP SPGSHNSALP QNQAQQGGAA SQPGHPLDTE
160 170 180 190 200
NMPMEDGFVH TEGSGSPLQG QAAERTDAQS NLAPSDLAEV KDLNTSKPSV
210 220 230 240 250
DKGLPLDGGP ALSAFKGHPK MTDASQKAPL PESKGETSGQ EKKVPPIDAA
260 270 280 290 300
ASPVKTAGKE TGEDVRKPKP SPVSPVASKH GDQEAELKGK LATPVRKSNE
310 320 330 340 350
GGNTQPEDQR KPGEGRNFAA AVKTQQAAAP QQAAAPEPTS AFNPRDTVTV
360 370 380 390 400
YFHAIVSRHF GFNPEEHKVY VRGGEGLGQK GWTDACEMYC TQDLHDLGSL
410 420 430 440 450
VEGKMDIPRQ SLDKPIPYKY VIHRGGSSKD TVEYEFIYEQ AQKKGEHVNR
460 470 480 490 500
CLRVVSTSLG NGDWHQYDDI ICMRSTGFFQ QAKNRILDST RKELLKGKKQ
510 520 530 540 550
AAVVMLDRIF SVLQPWSDIN LQSFMTQFLQ FYSVVREPMI HDGRARKWTS
560 570 580 590 600
LQYEEKEVWT NLWEHVKKQM APFLEGKSGE SLPADCPVRS KLTLGLSILF
610 620 630 640 650
MVEAAEFTVP KKDLDSLCYL LIPSAGSPEA LHSDLSPVLR IRQRWRIYLT
660 670 680 690 700
NLCLRCIDER CDRWLGILPL LHTCMQKSPP KKNSKSQPED TWAGLEGISF
710 720 730 740 750
SEFRDKAPTR SQPLQFMQSK MALLRVDEYL FRSWLSVVPL ESLSSYLENS
760 770 780 790 800
IDYLSDVPVR VLDCLQGISY RLPGLRKISN QNMKKDVENV FKMLMHLVDI
810 820 830 840 850
YQHRIFGENL LQIYLTECLT LHETVCNITA NHQFFEIPAL SAELICKLLE
860 870 880 890 900
LSPPGHTDEG LPEKSYEDLV TSTLQEALAT TRNWLRSLFK SRMLSISSAY
910 920 930 940 950
VRLTYSEEMA VWRRLVEIGF PEKHGWKGSL LGDMEGRLKQ EPPRLQISFF
960 970 980 990 1000
CSSQCRDGGL HDSVSRSFEK CVIEAVSSAC QSQTSVLEGL SCQDLQKFGT
1010 1020 1030 1040 1050
LLSAVITKSW PVHNGEPVFD VDEIFKYLLK WPDVRQLFEL CGTNEKIIDN
1060 1070 1080 1090 1100
ITEEGRQLMA TAESVFQKVA GELENGTIVV GQLELILEHQ SQFLDIWNLN
1110 1120 1130 1140 1150
RRRLPSQEKA CDVRSLLKRR RDDLLFLKQE KRYVESLLRQ LGRVKHLVQV
1160 1170 1180 1190 1200
DFGNIEIIHS QDLSNKKLNE AVIKLPNSSS YKRETHYCLS PDIREMASKL
1210 1220 1230 1240 1250
DSLKDSHIFQ DFWQETAESL NTLDKDPREL KVSLPEVLEY LYNPCYDNFY
1260 1270 1280 1290 1300
TLYENLKSGK ITFAEVDAIF KDFVDKYDEL KNDLKFMCTM NPQDQKGWIS
1310 1320 1330 1340 1350
ERVGQIKEYH TLHQAVSSAK VILQVRRALG VTGDFSVLNP LLNFADSFED
1360 1370 1380 1390 1400
FGNEKLDQIS PQFIKAKQLL QDISEPRQRC LEELARQTEL VAWLHKALED
1410 1420 1430 1440 1450
INELKVFVDL ASISAGENDI DVDRVACFHD AVQGYASLLY KMDERTNFSD
1460 1470 1480 1490 1500
FMNHLQELWR ALDNDQHLPD KLKDSARNLE WLKTVKESHG SVELSSLSLA
1510 1520 1530 1540 1550
TAINSRGVYV IEAPKDGQKI SPDTVLRLLL PDGHGYPEAL RTYSTEELKE
1560 1570 1580 1590 1600
LLNKLMLMSG KKDHNSNTEV EKFSEVFSNM QRLVHVFIKL HCAGNMLFRT
1610 1620 1630 1640 1650
WTAKVYCCPD GGIFMNFGLE LLSQLTEKGD VIQLLGALCR QMEDFLDNWK
1660 1670 1680 1690 1700
TVVAQKRAEH FYLNFYTAEQ LVYLSSELRK PRPSEAALMM LSFIKGKCTV
1710 1720 1730 1740 1750
QDLVQATSAC ESKADRYCLR EVMKKLPQQL LSEPSLMGKL QVIMMQSLVY
1760 1770 1780 1790 1800
MSAFLPHCLD LDALGRCLAH LATMGGTPVE RPLPKGLQAG QPNLILCGHS
1810 1820 1830 1840 1850
EVLPAALAIY MQAPRQPLPT FDEVLLCTPA TTIEEVELLL RRCLTSGSQG
1860 1870 1880 1890 1900
HKVYSLLFAD QLSYEVGCQA EEFFQSLCTR AHREDYQLVI LCDAAREHCY
1910 1920 1930 1940 1950
IPSTFSQYKV PLVPQAPLPN IQAYLQSHYQ VPKRLLSAAT VFRDGLCVGI
1960 1970 1980 1990 2000
VTSERAGVGK SLYVNTLHTK LKAKLRDETV PLKIIRLTEP HLDENQVLSA
2010 2020 2030 2040 2050
LLPFLKEKYQ KMPVIFHIDI STSVQTGIPI FLFKLLILQY LMDINGKIWR
2060 2070 2080 2090 2100
RSPGHLYLVE IPQGLSVQPK RSSKLNARAP LFKFLDLFPK VTCRPPKEVI
2110 2120 2130 2140 2150
DMELTPERSH TDPAMDPVEF CSEAFQRPYQ YLKRFHQQQN LDTFQYEKGS
2160 2170 2180 2190 2200
VEGSPEECLQ HFLIYCGLIN PSWSELRNFA WFLNCQLKDC EASIFCKSAF
2210 2220 2230 2240 2250
TGDTLRGFKN FVVTFMILMA RDFATPTLHT SDQSPGRQSV TIGEVVEEDL
2260 2270 2280 2290 2300
APFSLRKRWE SEPHPYVFFN GDHMTMTFIG FHLETNNNGY VDAINPSNGK
2310 2320 2330 2340 2350
VIKKDVMTKE LFDGLRLQRV PFNIDFDNLP RYEKLERLCL ALGIEWPIDP
2360 2370 2380 2390 2400
DETYELTTDN MLKILAIEMR FRCGIPVIIM GETGCGKTRL IKFLSDLKRG
2410 2420 2430 2440 2450
SVEAETMKLV KVHGGTTPSM IYSKVKEAER TAFSNKAQHK LDTILFFDEA
2460 2470 2480 2490 2500
NTTEAVSCIK EILCDRTVDG EHLHEDSGLH IIAACNPYRK HSQEMILRLE
2510 2520 2530 2540 2550
SAGLGYRVSA EETADRLGSI PLRQLVYRVH ALPPSLIPLV WDFGQLNDSA
2560 2570 2580 2590 2600
EKLYIQQIVQ RLVDSVSVNP SETCVIADVL SASQMFMRKR ENECGFVSLR
2610 2620 2630 2640 2650
DVERCVKVFR WFHDHSDMLL KELDKFLHES SDSTHTFERD PVLWSLVMAI
2660 2670 2680 2690 2700
GVCYHASLEE KASYRTAIAR CFPKPYNSSR AILDEVTHVQ DLFLRGAPIR
2710 2720 2730 2740 2750
TNIARNLALK ENVFMMVICI ELKIPLFLVG KPGSSKSLAK IIVADAMQGQ
2760 2770 2780 2790 2800
AAFSELFRCL KQVHLVSFQC SPHSTPQGII STFKQCARFQ QGKDLGQYVS
2810 2820 2830 2840 2850
VVVLDEVGLA EDSPKMPLKT LHPLLEDGCI EDDPAPYKKV GFVGISNWAL
2860 2870 2880 2890 2900
DPAKMNRGIF VSRGSPNEKE LIESAEGICS SDRLVQDKIR GYFAPFAKAY
2910 2920 2930 2940 2950
ETVCQKQDKE FFGLRDYYSL IKMVFAKAKA SKRGLSPQDI THAVLRNFSG
2960 2970 2980 2990 3000
KDNIQALSIF TASLPEARYK EEVSTVELIK QNIYPGPQAS SRGLDGAESR
3010 3020 3030 3040 3050
YLLVLTRNYV ALQILQQTFF EGQQPEIIFG SSFPQDQEYT QICRNINRVK
3060 3070 3080 3090 3100
ICMETGKMVV LLNLQNLYES LYDALNQYYV YLGGQKYVDL GLGTHRVKCR
3110 3120 3130 3140 3150
VHTAFRLIVI EEKDVVYKQF PVPLINRLEK HYLDMNTVLQ PWQKSIVQEL
3160 3170 3180 3190 3200
QQWAHEFADV KADQFIARHK YSPADVFIGY HSDACASVVL QAVERQGCRD
3210 3220 3230 3240 3250
LTEELYRKVS EEARSILLDC ATPDAVVRLS GSSLGSFTAK QLSQEYYYAQ
3260 3270 3280 3290 3300
QHNSFVDFLQ AHLRMTHHEC RAVFTEITTF SRLLTGNDCD VLASELRGLA
3310 3320 3330 3340 3350
SKPVVLSLQQ YDTEYSFLKD VRSWLTNPGK RKVLVIQADF DDGTRSAQLV
3360 3370 3380 3390 3400
ASAKYTAINE INKTQGTKDF VFVYFVTKLS RMGSGTSYVG FHGGLWRSVH
3410 3420 3430 3440 3450
IDDLRRSTIM ASDVTKLQNV TISQLFKPED KPEQEEMEIE TSQSKELAEE
3460 3470 3480 3490 3500
QMEVEDSEEM KKASDPRSCD CSQFLDTTRL VQSCVQGAVG MLRDQNESCA
3510 3520 3530 3540 3550
RNMRRVTILL DLLNEDNTRN ASFLRESKMR LHVLLNKQEE NQVRSLKEWV
3560 3570 3580 3590 3600
TREAANQDAL QEAGTFRHTL WKRVQDVVTP ILASMIAHID RDGNLELLAQ
3610 3620 3630 3640 3650
PDSPAWVQDL WMFIYSDIKF LNISLVLNNT RSNSEMSFIL VQSHMNLLKD
3660 3670 3680 3690 3700
AYNAVPFSWR IRDYLEELWV QAQYITDTEG LSKKFVEIFQ KTPLGVFLAQ
3710 3720 3730 3740 3750
FPVAQQQKLL QSYLKDFLLL TMKVSSREEL MFLQMALWSC LRELQEASGT
3760 3770 3780 3790 3800
PDETYKFPLS LPWVHLAFQH FRTRLQNFSR ILTIHPQVLS SLSQAAEKHS
3810 3820 3830 3840 3850
LAGCEMTLDA FAAMACAEML KGDLLKPSPK AWLQLVKNLS TPLELVCSEG
3860 3870 3880 3890 3900
YLCDSGSMTR SVIQEVRALW NRIFSIALFV EHVLLGTESH IPELSPLVTT
3910 3920 3930 3940 3950
YVSLLDKCLE EDSNLKTCRP FVAVMTTLCD CKDKASKKFS RFGIQPCFIC
3960 3970 3980 3990 4000
HGDAQDPVCL PCDHVYCLRC IQTWLIPGQM MCPYCLTDLP DKFSPTVSQD
4010 4020 4030 4040 4050
HRKAIEKHAQ FRHMCNSFFV DLVSTMCFKD NTPPEKSVID TLLSLLFVQK
4060 4070 4080 4090 4100
ELLRDASQKH REHTKSLSPF DDVVDQTPVI RSVLLKLLLK YSFHEVKDYI
4110 4120 4130 4140 4150
QNYLTQLEKK AFLTEDKTEL YLLFISCLED SVHQKTSAGC RNLEQVLREE
4160 4170 4180 4190 4200
GHFLRTYSPG LQGQEPVRIA SVEYLQEVAR VRLCLDLAAD FLSELQEGSE
4210 4220 4230 4240 4250
LAEDKRRFLK HVEEFCTRVN NDWHRVYLVR KLSSQRGMEF VQSFSKQGHP
4260 4270 4280 4290 4300
CQWVFPRKVI AQQVRNRKDH VSLMDRYLVH GNEYKAVRDA TAKAVLECKT
4310 4320 4330 4340 4350
LDIGNALMAC RSPKPQQTAY LLLALYTEVA ALYRSPNGSL HPEAKQLEAV
4360 4370 4380 4390 4400
NKFIKESKIL SDPNIRCFAR SLVDNTLPLL KIRSANSILK GTVTEMAVHV
4410 4420 4430 4440 4450
ATILLCGHNQ ILKPLRNLAF YPVNMANAFL PTMPEDLLVH ARTWRGLENV
4460 4470 4480 4490 4500
TWYTCPRGHP CSVGECGRPM QESTCLDCGL PVGGLNHTPH EGFSAIRNNE
4510 4520 4530 4540 4550
DRTQTGHVLG SPQSSGVAEV SDRGQSPVVF ILTRLLTHLA MLVGATHNPQ
4560 4570 4580 4590 4600
ALTVIIKPWV QDPQGFLQQH IQRDLEQLTK MLGRSADETI HVVHLILSSL
4610 4620 4630 4640 4650
LRVQSHGVLN FNAELSTKGC RNNWEKHFET LLLRELKHLD KNLPAINALI
4660 4670 4680 4690 4700
SQDERISSNP VTKIIYGDPA TFLPHLPQKS IIHCSKIWSC RRKITVEYLQ
4710 4720 4730 4740 4750
HIVEQKNGKE TVPVLWHFLQ KEAELRLVKF LPEILALQRD LVKQFQNVSR
4760 4770 4780 4790 4800
VEYSSIRGFI HSHSSDGLRK LLHDRITIFL STWNALRRSL ETNGEIKLPK
4810 4820 4830 4840 4850
DYCCSDLDLD AEFEVILPRR QGLGLCGTAL VSYLISLHNN MVYTVQKFSN
4860 4870 4880 4890 4900
EDNSYSVDIS EVADLHVISY EVERDLNPLI LSNCQYQVQQ GGETSQEFDL
4910 4920 4930 4940 4950
EKIQRQISSR FLQGKPRLTL KGIPTLVYRR DWNYEHLFMD IKNKMAQSSL
4960 4970 4980 4990 5000
PNLAISTISG QLQSYSDACE ALSIIEITLG FLSTAGGDPG MDLNVYIEEV
5010 5020 5030 5040 5050
LRMCDQTAQV LKAFSRCQLR HIIALWQFLS AHKSEQRLRL NKELFREIDV
5060 5070 5080 5090 5100
QYKEELSTQH QRLLGTFLNE AGLDAFLLEL HEMIVLKLKG PRAANSFNPN
5110 5120 5130 5140 5150
WSLKDTLVSY METKDSDILS EVESQFPEEI LMSSCISVWK IAATRKWDRQ

SR
Length:5,152
Mass (Da):584,784
Last modified:March 16, 2016 - v2
Checksum:i306631B8DC82EBE4
GO

Sequence cautioni

The sequence BAC37048.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL645911 Genomic DNA. No translation available.
AK077880 mRNA. Translation: BAC37048.1. Different initiation.
UniGeneiMm.133342.
Mm.491338.

Genome annotation databases

EnsembliENSMUST00000093902; ENSMUSP00000091429; ENSMUSG00000070327.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL645911 Genomic DNA. No translation available.
AK077880 mRNA. Translation: BAC37048.1. Different initiation.
UniGeneiMm.133342.
Mm.491338.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000091429.

Proteomic databases

EPDiE9Q555.
MaxQBiE9Q555.
PaxDbiE9Q555.
PeptideAtlasiE9Q555.
PRIDEiE9Q555.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000093902; ENSMUSP00000091429; ENSMUSG00000070327.

Organism-specific databases

MGIiMGI:1289196. Rnf213.

Phylogenomic databases

eggNOGiENOG410IHNB. Eukaryota.
ENOG410XTAN. LUCA.
GeneTreeiENSGT00630000089884.
InParanoidiE9Q555.
OrthoDBiEOG7S21WZ.

Enzyme and pathway databases

UniPathwayiUPA00143.
ReactomeiR-MMU-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Miscellaneous databases

PROiE9Q555.
SOURCEiSearch...

Gene expression databases

BgeeiE9Q555.
ExpressionAtlasiE9Q555. baseline and differential.
GenevisibleiE9Q555. MM.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
3.40.50.300. 3 hits.
InterProiIPR003593. AAA+_ATPase.
IPR027417. P-loop_NTPase.
IPR031248. RNF213.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PANTHERiPTHR22605:SF5. PTHR22605:SF5. 1 hit.
SMARTiSM00382. AAA. 2 hits.
SM00184. RING. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 4811-5152.
    Strain: C57BL/6J.
    Tissue: Testis.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas, Spleen and Testis.
  4. Cited for: DISRUPTION PHENOTYPE.
  5. "Temporal profile of the vascular anatomy evaluated by 9.4-T magnetic resonance angiography and histopathological analysis in mice lacking RNF213: a susceptibility gene for moyamoya disease."
    Sonobe S., Fujimura M., Niizuma K., Nishijima Y., Ito A., Shimizu H., Kikuchi A., Arai-Ichinoi N., Kure S., Tominaga T.
    Brain Res. 1552:64-71(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISRUPTION PHENOTYPE.
  6. "Increased vascular MMP-9 in mice lacking RNF213: moyamoya disease susceptibility gene."
    Sonobe S., Fujimura M., Niizuma K., Fujimura T., Furudate S., Nishijima Y., Kure S., Tominaga T.
    NeuroReport 25:1442-1446(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISRUPTION PHENOTYPE.
  7. "Temporal profile of the vascular anatomy evaluated by 9.4-tesla magnetic resonance angiography and histological analysis in mice with the R4859K mutation of RNF213, the susceptibility gene for moyamoya disease."
    Kanoke A., Fujimura M., Niizuma K., Ito A., Sakata H., Sato-Maeda M., Morita-Fujimura Y., Kure S., Tominaga T.
    Brain Res. 1624:497-505(2015) [PubMed] [Europe PMC] [Abstract]
    Cited for: MUTAGENESIS OF ARG-4757.
  8. "Biochemical and functional characterization of RNF213 (Mysterin) R4810K, a susceptibility mutation of Moyamoya disease, in angiogenesis in vitro and in vivo."
    Kobayashi H., Matsuda Y., Hitomi T., Okuda H., Shioi H., Matsuda T., Imai H., Sone M., Taura D., Harada K.H., Habu T., Takagi Y., Miyamoto S., Koizumi A.
    J. Am. Heart. Assoc. 4:0-0(2015) [PubMed] [Europe PMC] [Abstract]
    Cited for: MUTAGENESIS OF ARG-4757.

Entry informationi

Entry nameiRN213_MOUSE
AccessioniPrimary (citable) accession number: E9Q555
Secondary accession number(s): F7A6H4, Q8BVK6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 21, 2012
Last sequence update: March 16, 2016
Last modified: July 6, 2016
This is version 42 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.