Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Cullin-3

Gene

Cul3

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

  1. cyclin binding Source: MGI
  2. POZ domain binding Source: MGI
  3. protein heterodimerization activity Source: MGI
  4. protein homodimerization activity Source: MGI

GO - Biological processi

  1. cell migration Source: MGI
  2. cell morphogenesis Source: MGI
  3. COPII vesicle coating Source: MGI
  4. ER to Golgi vesicle-mediated transport Source: MGI
  5. fibroblast apoptotic process Source: MGI
  6. gastrulation Source: MGI
  7. in utero embryonic development Source: MGI
  8. liver morphogenesis Source: MGI
  9. mitotic cell cycle Source: MGI
  10. mitotic metaphase plate congression Source: MGI
  11. negative regulation of cyclin-dependent protein serine/threonine kinase by cyclin degradation Source: MGI
  12. negative regulation of Rho protein signal transduction Source: MGI
  13. negative regulation of transcription from RNA polymerase II promoter Source: MGI
  14. positive regulation of cytokinesis Source: MGI
  15. positive regulation of mitotic metaphase/anaphase transition Source: MGI
  16. proteasome-mediated ubiquitin-dependent protein catabolic process Source: MGI
  17. protein monoubiquitination Source: MGI
  18. protein polyubiquitination Source: MGI
  19. protein ubiquitination Source: MGI
  20. regulation of transcription from RNA polymerase II promoter Source: MGI
  21. stress fiber assembly Source: MGI
  22. trophectodermal cellular morphogenesis Source: MGI
  23. Wnt signaling pathway Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Cullin-3Imported
Gene namesi
Name:Cul3Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1347360. Cul3.

Subcellular locationi

GO - Cellular componenti

  1. Cul3-RING ubiquitin ligase complex Source: MGI
  2. cytoplasm Source: MGI
  3. extracellular vesicular exosome Source: MGI
  4. Golgi apparatus Source: MGI
  5. Golgi membrane Source: MGI
  6. membrane Source: MGI
  7. nucleus Source: MGI
  8. polar microtubule Source: MGI
Complete GO annotation...

Expressioni

Gene expression databases

BgeeiE9Q4T8.
ExpressionAtlasiE9Q4T8. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliE9Q4T8.
SMRiE9Q4T8. Positions 21-702.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cullin family.UniRule annotation

Phylogenomic databases

GeneTreeiENSGT00760000119212.

Family and domain databases

Gene3Di1.10.10.10. 2 hits.
InterProiIPR016157. Cullin_CS.
IPR016158. Cullin_homology.
IPR001373. Cullin_N.
IPR019559. Cullin_neddylation_domain.
IPR016159. Cullin_repeat-like_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00888. Cullin. 1 hit.
PF10557. Cullin_Nedd8. 1 hit.
[Graphical view]
SMARTiSM00182. CULLIN. 1 hit.
SM00884. Cullin_Nedd8. 1 hit.
[Graphical view]
SUPFAMiSSF74788. SSF74788. 1 hit.
SSF75632. SSF75632. 1 hit.
PROSITEiPS01256. CULLIN_1. 1 hit.
PS50069. CULLIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E9Q4T8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNLSKGTGS RKDTKMRIRA FPVREDVLNS LNNNFLQTLN QAWNDHQTAM
60 70 80 90 100
VMIRDILMYM DRVYVQQNNV ENVYNLGLII FRDQVVRYGC IRDHLRQTLL
110 120 130 140 150
DMIARERKGE VVDRGAIRNA CQMLMILGLE GRSVYEEDFE APFLEMSAEF
160 170 180 190 200
FQMESQKFLA ENSASVYIKK VEARINEEIE RVMHCLDKST EEPIVKVVER
210 220 230 240 250
ELISKHMKTI VEMENSGLVH MLKNGKTEDL ACMYKLFSRV PNGLKTMCEC
260 270 280 290 300
MSCYLREQGK ALVSEEGEGK NPVDYIQGLL DLKSRFDRFL QESFNNDRLF
310 320 330 340 350
KQTIAGDFEY FLNLNSRSPE YLSLFIDDKL KKGVKGLTEQ EVETILDKAM
360 370 380 390 400
VLFRFMQEKD VFERYYKQHL ARRLLTNKSV SDDSEKNMIS KLKTECGCQF
410 420 430 440 450
TSKLEGMFRD MSISNTTMDE FRQHLQATGV SLGGVDLTVR VLTTGYWPTQ
460 470 480 490 500
SATPKCNIPP APRHAFEIFR RFYLAKHSGR QLTLQHHMGS ADLNATFYGP
510 520 530 540 550
VKKEDGSEVG VGGAQVTGSN TRKHILQVST FQMTILMLFN NREKYTFEEI
560 570 580 590 600
QQETDIPERE LVRALQSLAC GKPTQRVLTK EPKSKEIESG HIFTVNDQFT
610 620 630 640 650
SKLHRVKIQT VAAKQGESDP ERKETRQKVD DDRKHEIEAA IVRIMKSRKK
660 670 680 690 700
MQHNVLVAEV TQQLKARFLP SPVVIKKRIE GLIEREYLAR TPEDRKVYTY

VA
Length:702
Mass (Da):81,111
Last modified:April 5, 2011 - v1
Checksum:i09608E18C7E70FB0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC161416 Genomic DNA. No translation available.
AC166157 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSMUST00000164108; ENSMUSP00000131891; ENSMUSG00000004364.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC161416 Genomic DNA. No translation available.
AC166157 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortaliE9Q4T8.
SMRiE9Q4T8. Positions 21-702.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000164108; ENSMUSP00000131891; ENSMUSG00000004364.

Organism-specific databases

MGIiMGI:1347360. Cul3.

Phylogenomic databases

GeneTreeiENSGT00760000119212.

Miscellaneous databases

ChiTaRSiCul3. mouse.
NextBioi35555159.
SOURCEiSearch...

Gene expression databases

BgeeiE9Q4T8.
ExpressionAtlasiE9Q4T8. baseline and differential.

Family and domain databases

Gene3Di1.10.10.10. 2 hits.
InterProiIPR016157. Cullin_CS.
IPR016158. Cullin_homology.
IPR001373. Cullin_N.
IPR019559. Cullin_neddylation_domain.
IPR016159. Cullin_repeat-like_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00888. Cullin. 1 hit.
PF10557. Cullin_Nedd8. 1 hit.
[Graphical view]
SMARTiSM00182. CULLIN. 1 hit.
SM00884. Cullin_Nedd8. 1 hit.
[Graphical view]
SUPFAMiSSF74788. SSF74788. 1 hit.
SSF75632. SSF75632. 1 hit.
PROSITEiPS01256. CULLIN_1. 1 hit.
PS50069. CULLIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  2. Ensembl
    Submitted (JAN-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiE9Q4T8_MOUSE
AccessioniPrimary (citable) accession number: E9Q4T8
Entry historyi
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: March 4, 2015
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.