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E9Q4T8

- E9Q4T8_MOUSE

UniProt

E9Q4T8 - E9Q4T8_MOUSE

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Protein
Submitted name: Cullin-3
Gene
Cul3
Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

GO - Molecular functioni

  1. cyclin binding Source: MGI
  2. protein binding Source: MGI
  3. protein heterodimerization activity Source: MGI
  4. protein homodimerization activity Source: MGI

GO - Biological processi

  1. Wnt signaling pathway Source: MGI
  2. cell morphogenesis Source: MGI
  3. cyclin catabolic process Source: MGI
  4. gastrulation Source: MGI
  5. in utero embryonic development Source: MGI
  6. proteasome-mediated ubiquitin-dependent protein catabolic process Source: MGI
  7. trophectodermal cellular morphogenesis Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Cullin-3Imported
Gene namesi
Name:Cul3Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 1

Organism-specific databases

MGIiMGI:1347360. Cul3.

Subcellular locationi

GO - Cellular componenti

  1. Golgi apparatus Source: MGI
  2. cullin-RING ubiquitin ligase complex Source: InterPro
  3. nucleus Source: MGI
Complete GO annotation...

Expressioni

Gene expression databases

ArrayExpressiE9Q4T8.
BgeeiE9Q4T8.

Structurei

3D structure databases

ProteinModelPortaliE9Q4T8.
SMRiE9Q4T8. Positions 21-702.

Family & Domainsi

Sequence similaritiesi

Belongs to the cullin family.UniRule annotation

Phylogenomic databases

GeneTreeiENSGT00730000110449.

Family and domain databases

Gene3Di1.10.10.10. 2 hits.
InterProiIPR016157. Cullin_CS.
IPR016158. Cullin_homology.
IPR001373. Cullin_N.
IPR019559. Cullin_neddylation_domain.
IPR016159. Cullin_repeat-like_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00888. Cullin. 1 hit.
PF10557. Cullin_Nedd8. 1 hit.
[Graphical view]
SMARTiSM00182. CULLIN. 1 hit.
SM00884. Cullin_Nedd8. 1 hit.
[Graphical view]
SUPFAMiSSF74788. SSF74788. 1 hit.
SSF75632. SSF75632. 1 hit.
PROSITEiPS01256. CULLIN_1. 1 hit.
PS50069. CULLIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E9Q4T8-1 [UniParc]FASTAAdd to Basket

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MSNLSKGTGS RKDTKMRIRA FPVREDVLNS LNNNFLQTLN QAWNDHQTAM    50
VMIRDILMYM DRVYVQQNNV ENVYNLGLII FRDQVVRYGC IRDHLRQTLL 100
DMIARERKGE VVDRGAIRNA CQMLMILGLE GRSVYEEDFE APFLEMSAEF 150
FQMESQKFLA ENSASVYIKK VEARINEEIE RVMHCLDKST EEPIVKVVER 200
ELISKHMKTI VEMENSGLVH MLKNGKTEDL ACMYKLFSRV PNGLKTMCEC 250
MSCYLREQGK ALVSEEGEGK NPVDYIQGLL DLKSRFDRFL QESFNNDRLF 300
KQTIAGDFEY FLNLNSRSPE YLSLFIDDKL KKGVKGLTEQ EVETILDKAM 350
VLFRFMQEKD VFERYYKQHL ARRLLTNKSV SDDSEKNMIS KLKTECGCQF 400
TSKLEGMFRD MSISNTTMDE FRQHLQATGV SLGGVDLTVR VLTTGYWPTQ 450
SATPKCNIPP APRHAFEIFR RFYLAKHSGR QLTLQHHMGS ADLNATFYGP 500
VKKEDGSEVG VGGAQVTGSN TRKHILQVST FQMTILMLFN NREKYTFEEI 550
QQETDIPERE LVRALQSLAC GKPTQRVLTK EPKSKEIESG HIFTVNDQFT 600
SKLHRVKIQT VAAKQGESDP ERKETRQKVD DDRKHEIEAA IVRIMKSRKK 650
MQHNVLVAEV TQQLKARFLP SPVVIKKRIE GLIEREYLAR TPEDRKVYTY 700
VA 702
Length:702
Mass (Da):81,111
Last modified:April 5, 2011 - v1
Checksum:i09608E18C7E70FB0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC161416 Genomic DNA. No translation available.
AC166157 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSMUST00000164108; ENSMUSP00000131891; ENSMUSG00000004364.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC161416 Genomic DNA. No translation available.
AC166157 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortali E9Q4T8.
SMRi E9Q4T8. Positions 21-702.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000164108 ; ENSMUSP00000131891 ; ENSMUSG00000004364 .

Organism-specific databases

MGIi MGI:1347360. Cul3.

Phylogenomic databases

GeneTreei ENSGT00730000110449.

Miscellaneous databases

ChiTaRSi CUL3. mouse.
NextBioi 35555159.
SOURCEi Search...

Gene expression databases

ArrayExpressi E9Q4T8.
Bgeei E9Q4T8.

Family and domain databases

Gene3Di 1.10.10.10. 2 hits.
InterProi IPR016157. Cullin_CS.
IPR016158. Cullin_homology.
IPR001373. Cullin_N.
IPR019559. Cullin_neddylation_domain.
IPR016159. Cullin_repeat-like_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
Pfami PF00888. Cullin. 1 hit.
PF10557. Cullin_Nedd8. 1 hit.
[Graphical view ]
SMARTi SM00182. CULLIN. 1 hit.
SM00884. Cullin_Nedd8. 1 hit.
[Graphical view ]
SUPFAMi SSF74788. SSF74788. 1 hit.
SSF75632. SSF75632. 1 hit.
PROSITEi PS01256. CULLIN_1. 1 hit.
PS50069. CULLIN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  2. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiE9Q4T8_MOUSE
AccessioniPrimary (citable) accession number: E9Q4T8
Entry historyi
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: July 9, 2014
This is version 25 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

Similar proteinsi