ID   E9Q4I1_MOUSE            Unreviewed;      1198 AA.
AC   E9Q4I1;
DT   05-APR-2011, integrated into UniProtKB/TrEMBL.
DT   05-APR-2011, sequence version 1.
DT   27-MAR-2024, entry version 102.
DE   RecName: Full=protein-tyrosine-phosphatase {ECO:0000256|ARBA:ARBA00013064};
DE            EC=3.1.3.48 {ECO:0000256|ARBA:ARBA00013064};
GN   Name=Ptpro {ECO:0000313|Ensembl:ENSMUSP00000127112.2,
GN   ECO:0000313|MGI:MGI:1097152};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000127112.2, ECO:0000313|Proteomes:UP000000589};
RN   [1] {ECO:0007829|PubMed:19144319}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=19144319; DOI=10.1016/j.immuni.2008.11.006;
RA   Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,
RA   Thibault P.;
RT   "The phagosomal proteome in interferon-gamma-activated macrophages.";
RL   Immunity 30:143-154(2009).
RN   [2] {ECO:0000313|Ensembl:ENSMUSP00000127112.2, ECO:0000313|Proteomes:UP000000589}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000127112.2,
RC   ECO:0000313|Proteomes:UP000000589};
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [3] {ECO:0007829|PubMed:21183079}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
RN   [4] {ECO:0000313|Ensembl:ENSMUSP00000127112.2}
RP   IDENTIFICATION.
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000127112.2};
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] +
CC         phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC         COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858,
CC         ChEBI:CHEBI:82620; EC=3.1.3.48;
CC         Evidence={ECO:0000256|ARBA:ARBA00001490};
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DR   RefSeq; NP_001157873.1; NM_001164401.1.
DR   AlphaFoldDB; E9Q4I1; -.
DR   SMR; E9Q4I1; -.
DR   jPOST; E9Q4I1; -.
DR   MaxQB; E9Q4I1; -.
DR   ProteomicsDB; 345368; -.
DR   Antibodypedia; 23718; 116 antibodies from 22 providers.
DR   DNASU; 19277; -.
DR   Ensembl; ENSMUST00000167679.8; ENSMUSP00000127112.2; ENSMUSG00000030223.15.
DR   GeneID; 19277; -.
DR   UCSC; uc009emw.2; mouse.
DR   AGR; MGI:1097152; -.
DR   CTD; 5800; -.
DR   MGI; MGI:1097152; Ptpro.
DR   VEuPathDB; HostDB:ENSMUSG00000030223; -.
DR   GeneTree; ENSGT00940000154814; -.
DR   OrthoDB; 5395787at2759; -.
DR   BioGRID-ORCS; 19277; 2 hits in 72 CRISPR screens.
DR   Proteomes; UP000000589; Chromosome 6.
DR   Bgee; ENSMUSG00000030223; Expressed in cortical plate and 190 other cell types or tissues.
DR   ExpressionAtlas; E9Q4I1; baseline and differential.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-EC.
DR   GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR   CDD; cd00063; FN3; 3.
DR   CDD; cd14614; R-PTPc-O; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 3.
DR   Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 1.
DR   InterPro; IPR003961; FN3_dom.
DR   InterPro; IPR036116; FN3_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR   InterPro; IPR000242; PTP_cat.
DR   InterPro; IPR042996; PTPRO.
DR   InterPro; IPR016130; Tyr_Pase_AS.
DR   InterPro; IPR003595; Tyr_Pase_cat.
DR   InterPro; IPR000387; Tyr_Pase_dom.
DR   PANTHER; PTHR47028; RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE O; 1.
DR   PANTHER; PTHR47028:SF1; RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE O; 1.
DR   Pfam; PF00041; fn3; 2.
DR   Pfam; PF00102; Y_phosphatase; 1.
DR   PRINTS; PR00700; PRTYPHPHTASE.
DR   SMART; SM00060; FN3; 4.
DR   SMART; SM00194; PTPc; 1.
DR   SMART; SM00404; PTPc_motif; 1.
DR   SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR   SUPFAM; SSF49265; Fibronectin type III; 2.
DR   PROSITE; PS50853; FN3; 4.
DR   PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
DR   PROSITE; PS50056; TYR_PHOSPHATASE_2; 1.
DR   PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 1.
DR   Genevisible; E9Q4I1; MM.
PE   1: Evidence at protein level;
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Protein phosphatase {ECO:0000256|ARBA:ARBA00022912};
KW   Proteomics identification {ECO:0007829|MaxQB:E9Q4I1,
KW   ECO:0007829|ProteomicsDB:E9Q4I1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..29
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           30..1198
FT                   /note="protein-tyrosine-phosphatase"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5003245695"
FT   TRANSMEM        830..854
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          339..435
FT                   /note="Fibronectin type-III"
FT                   /evidence="ECO:0000259|PROSITE:PS50853"
FT   DOMAIN          445..541
FT                   /note="Fibronectin type-III"
FT                   /evidence="ECO:0000259|PROSITE:PS50853"
FT   DOMAIN          641..734
FT                   /note="Fibronectin type-III"
FT                   /evidence="ECO:0000259|PROSITE:PS50853"
FT   DOMAIN          735..827
FT                   /note="Fibronectin type-III"
FT                   /evidence="ECO:0000259|PROSITE:PS50853"
FT   DOMAIN          920..1177
FT                   /note="Tyrosine-protein phosphatase"
FT                   /evidence="ECO:0000259|PROSITE:PS50055"
FT   DOMAIN          1094..1168
FT                   /note="Tyrosine specific protein phosphatases"
FT                   /evidence="ECO:0000259|PROSITE:PS50056"
FT   REGION          242..305
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        256..271
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        274..305
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1198 AA;  135234 MW;  AF080558978EC924 CRC64;
     MGHLPRGTLG GRRLLPLLGL FVLLKIVTTF HVAVQDDNNI VVSLEASDIV SPASVYVVRV
     AGESKNYFFE FEEFNSTLPP PVVFKATYHG LYYIITLVVV NGNVVTKPSR SITVLTKPLP
     VTSVSIYDYK PSPETGVLFE IHYPEKYNVF SRVNISYWEG RDFRTMLYKD FFKGKTVFNH
     WLPGLCYSNI TFQLVSEATF NKSTLVEYSG VSHEPKQHRT APYPPRNISV RFVNLNKNNW
     EEPSGSFPED SFIKPPQDSI GRDRRFHFPE ETPETPPSNV SSGSPPSNVS SAWPDPNSTD
     YESTSQPFWW DSASAAPENE EDFVSALPAD YDTETTLDRT EKPTADPFSA FPVQMTLSWL
     PPKPPTAFDG FNILIEREEN FTDYLTVDEE AHEFVAELKE PGKYKLSVTT FSSSGACETR
     KSQSAKSLSF YISPTGEWIE ELTEKPQHVS VHVLSSTTAL MSWTSSQENY NSTIVSVVSL
     TCQKQKESQR LEKQYCTQVN SSKPVIENLV PGAQYQVVMY LRKGPLIGPP SDPVTFAIVP
     TGIKDLMLYP LGPTAVVLSW TRPILGVFRK YVVEMFYFNP TTMTSEWTTY YEIAATVSLT
     ASVRIASLLP AWYYNFRVTM VTWGDPELSC CDSSTISFIT APVAPEITSV EYFNSLLYIS
     WTYGDATTDL SHSRMLHWMV VAEGRKKIKK SVTRNVMTAI LSLPPGDIYN LSVTACTERG
     SNTSLPRLVK LEPAPPKSLF AVNKTQTSVT LLWVEEGVAD FFEVFCQQLG SGHNGKLQEP
     VAVSSHVVTI SSLLPATAYN CSVTSFSHDT PSVPTFIAVS TMVTEVNPNV VVISVLAILS
     TLLIGLLLVT LVILRKKHLQ MARECGAGTF VNFASLEREG KLPYSWSKNG LKKRKLTNPV
     QLDDFDSYIK DMAKDSDYKF SLQFEELKLI GLDIPHFAAD LPLNRCKNRY TNILPYDFSR
     VRLVSMNEEE GADYINANYI PGYNSPQEYI ATQGPLPETR NDFWKMVLQQ KSHIIVMLTQ
     CNEKRRVKCD HYWPFTEEPI AYGDITVEMV SEEEEEDWAS RHFRINYADE AQDVMHFNYT
     AWPDHGVPPA NAAESILQFV FTVRQQAAKS KGPMIIHCSA GVGRTGTFIA LDRLLQHIRD
     HEFVDILGLV SEMRSYRMSM VQTEEQYIFI HQCVQLMWLR KKQQFCISDV IYENVSKS
//