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Protein
Submitted name:

Receptor-type tyrosine-protein phosphatase O

Gene

Ptpro

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.SAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei1118Phosphocysteine intermediatePROSITE-ProRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Protein phosphataseSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Receptor-type tyrosine-protein phosphatase OImported
Gene namesi
Name:PtproImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1097152 Ptpro

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei830 – 854HelicalSequence analysisAdd BLAST25

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Sequence analysisAdd BLAST29
ChainiPRO_500324569530 – 1198Sequence analysisAdd BLAST1169

Proteomic databases

MaxQBiE9Q4I1
PRIDEiE9Q4I1

Expressioni

Gene expression databases

BgeeiENSMUSG00000030223
ExpressionAtlasiE9Q4I1 baseline and differential
GenevisibleiE9Q4I1 MM

Structurei

3D structure databases

ProteinModelPortaliE9Q4I1
SMRiE9Q4I1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini339 – 435Fibronectin type-IIIInterPro annotationAdd BLAST97
Domaini445 – 541Fibronectin type-IIIInterPro annotationAdd BLAST97
Domaini542 – 638Fibronectin type-IIIInterPro annotationAdd BLAST97
Domaini641 – 734Fibronectin type-IIIInterPro annotationAdd BLAST94
Domaini735 – 827Fibronectin type-IIIInterPro annotationAdd BLAST93
Domaini920 – 1177Tyrosine-protein phosphataseInterPro annotationAdd BLAST258
Domaini1094 – 1168TYR_PHOSPHATASE_2InterPro annotationAdd BLAST75

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG0791 Eukaryota
COG5599 LUCA
GeneTreeiENSGT00900000140785

Family and domain databases

CDDicd00063 FN3, 3 hits
Gene3Di2.60.40.10, 3 hits
3.90.190.10, 1 hit
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR013783 Ig-like_fold
IPR029021 Prot-tyrosine_phosphatase-like
IPR000242 PTPase_domain
IPR016130 Tyr_Pase_AS
IPR003595 Tyr_Pase_cat
IPR000387 TYR_PHOSPHATASE_dom
PfamiView protein in Pfam
PF00041 fn3, 2 hits
PF00102 Y_phosphatase, 1 hit
PRINTSiPR00700 PRTYPHPHTASE
SMARTiView protein in SMART
SM00060 FN3, 4 hits
SM00194 PTPc, 1 hit
SM00404 PTPc_motif, 1 hit
SUPFAMiSSF49265 SSF49265, 2 hits
SSF52799 SSF52799, 1 hit
PROSITEiView protein in PROSITE
PS50853 FN3, 5 hits
PS00383 TYR_PHOSPHATASE_1, 1 hit
PS50056 TYR_PHOSPHATASE_2, 1 hit
PS50055 TYR_PHOSPHATASE_PTP, 1 hit

Sequencei

Sequence statusi: Complete.

E9Q4I1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGHLPRGTLG GRRLLPLLGL FVLLKIVTTF HVAVQDDNNI VVSLEASDIV
60 70 80 90 100
SPASVYVVRV AGESKNYFFE FEEFNSTLPP PVVFKATYHG LYYIITLVVV
110 120 130 140 150
NGNVVTKPSR SITVLTKPLP VTSVSIYDYK PSPETGVLFE IHYPEKYNVF
160 170 180 190 200
SRVNISYWEG RDFRTMLYKD FFKGKTVFNH WLPGLCYSNI TFQLVSEATF
210 220 230 240 250
NKSTLVEYSG VSHEPKQHRT APYPPRNISV RFVNLNKNNW EEPSGSFPED
260 270 280 290 300
SFIKPPQDSI GRDRRFHFPE ETPETPPSNV SSGSPPSNVS SAWPDPNSTD
310 320 330 340 350
YESTSQPFWW DSASAAPENE EDFVSALPAD YDTETTLDRT EKPTADPFSA
360 370 380 390 400
FPVQMTLSWL PPKPPTAFDG FNILIEREEN FTDYLTVDEE AHEFVAELKE
410 420 430 440 450
PGKYKLSVTT FSSSGACETR KSQSAKSLSF YISPTGEWIE ELTEKPQHVS
460 470 480 490 500
VHVLSSTTAL MSWTSSQENY NSTIVSVVSL TCQKQKESQR LEKQYCTQVN
510 520 530 540 550
SSKPVIENLV PGAQYQVVMY LRKGPLIGPP SDPVTFAIVP TGIKDLMLYP
560 570 580 590 600
LGPTAVVLSW TRPILGVFRK YVVEMFYFNP TTMTSEWTTY YEIAATVSLT
610 620 630 640 650
ASVRIASLLP AWYYNFRVTM VTWGDPELSC CDSSTISFIT APVAPEITSV
660 670 680 690 700
EYFNSLLYIS WTYGDATTDL SHSRMLHWMV VAEGRKKIKK SVTRNVMTAI
710 720 730 740 750
LSLPPGDIYN LSVTACTERG SNTSLPRLVK LEPAPPKSLF AVNKTQTSVT
760 770 780 790 800
LLWVEEGVAD FFEVFCQQLG SGHNGKLQEP VAVSSHVVTI SSLLPATAYN
810 820 830 840 850
CSVTSFSHDT PSVPTFIAVS TMVTEVNPNV VVISVLAILS TLLIGLLLVT
860 870 880 890 900
LVILRKKHLQ MARECGAGTF VNFASLEREG KLPYSWSKNG LKKRKLTNPV
910 920 930 940 950
QLDDFDSYIK DMAKDSDYKF SLQFEELKLI GLDIPHFAAD LPLNRCKNRY
960 970 980 990 1000
TNILPYDFSR VRLVSMNEEE GADYINANYI PGYNSPQEYI ATQGPLPETR
1010 1020 1030 1040 1050
NDFWKMVLQQ KSHIIVMLTQ CNEKRRVKCD HYWPFTEEPI AYGDITVEMV
1060 1070 1080 1090 1100
SEEEEEDWAS RHFRINYADE AQDVMHFNYT AWPDHGVPPA NAAESILQFV
1110 1120 1130 1140 1150
FTVRQQAAKS KGPMIIHCSA GVGRTGTFIA LDRLLQHIRD HEFVDILGLV
1160 1170 1180 1190
SEMRSYRMSM VQTEEQYIFI HQCVQLMWLR KKQQFCISDV IYENVSKS
Length:1,198
Mass (Da):135,234
Last modified:April 5, 2011 - v1
Checksum:iAF080558978EC924
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC093120 Genomic DNA No translation available.
AC144767 Genomic DNA No translation available.
AC163627 Genomic DNA No translation available.
RefSeqiNP_001157873.1, NM_001164401.1
UniGeneiMm.186361
Mm.491536

Genome annotation databases

EnsembliENSMUST00000167679; ENSMUSP00000127112; ENSMUSG00000030223
GeneIDi19277
UCSCiuc009emw.2 mouse

Similar proteinsi

Entry informationi

Entry nameiE9Q4I1_MOUSE
AccessioniPrimary (citable) accession number: E9Q4I1
Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: May 23, 2018
This is version 69 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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