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Protein

Protein-tyrosine-phosphatase

Gene

Ptpro

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.SAAS annotation

GO - Molecular functioni

  1. protein tyrosine phosphatase activity Source: MGI

GO - Biological processi

  1. glomerulus development Source: MGI
  2. monocyte chemotaxis Source: MGI
  3. peptidyl-tyrosine dephosphorylation Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphataseSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Protein-tyrosine-phosphataseSAAS annotation (EC:3.1.3.48SAAS annotation)
Gene namesi
Name:PtproImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 6

Organism-specific databases

MGIiMGI:1097152. Ptpro.

Subcellular locationi

GO - Cellular componenti

  1. extracellular vesicular exosome Source: MGI
Complete GO annotation...

Expressioni

Gene expression databases

BgeeiE9Q4I1.
ExpressionAtlasiE9Q4I1. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliE9Q4I1.
SMRiE9Q4I1. Positions 221-247, 898-1190.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00770000120452.
KOiK18035.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
3.90.190.10. 1 hit.
InterProiIPR003961. FN3_dom.
IPR013783. Ig-like_fold.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view]
PfamiPF00041. fn3. 2 hits.
PF00102. Y_phosphatase. 1 hit.
[Graphical view]
PRINTSiPR00700. PRTYPHPHTASE.
SMARTiSM00060. FN3. 4 hits.
SM00194. PTPc. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 2 hits.
SSF52799. SSF52799. 1 hit.
PROSITEiPS50853. FN3. 5 hits.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E9Q4I1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGHLPRGTLG GRRLLPLLGL FVLLKIVTTF HVAVQDDNNI VVSLEASDIV
60 70 80 90 100
SPASVYVVRV AGESKNYFFE FEEFNSTLPP PVVFKATYHG LYYIITLVVV
110 120 130 140 150
NGNVVTKPSR SITVLTKPLP VTSVSIYDYK PSPETGVLFE IHYPEKYNVF
160 170 180 190 200
SRVNISYWEG RDFRTMLYKD FFKGKTVFNH WLPGLCYSNI TFQLVSEATF
210 220 230 240 250
NKSTLVEYSG VSHEPKQHRT APYPPRNISV RFVNLNKNNW EEPSGSFPED
260 270 280 290 300
SFIKPPQDSI GRDRRFHFPE ETPETPPSNV SSGSPPSNVS SAWPDPNSTD
310 320 330 340 350
YESTSQPFWW DSASAAPENE EDFVSALPAD YDTETTLDRT EKPTADPFSA
360 370 380 390 400
FPVQMTLSWL PPKPPTAFDG FNILIEREEN FTDYLTVDEE AHEFVAELKE
410 420 430 440 450
PGKYKLSVTT FSSSGACETR KSQSAKSLSF YISPTGEWIE ELTEKPQHVS
460 470 480 490 500
VHVLSSTTAL MSWTSSQENY NSTIVSVVSL TCQKQKESQR LEKQYCTQVN
510 520 530 540 550
SSKPVIENLV PGAQYQVVMY LRKGPLIGPP SDPVTFAIVP TGIKDLMLYP
560 570 580 590 600
LGPTAVVLSW TRPILGVFRK YVVEMFYFNP TTMTSEWTTY YEIAATVSLT
610 620 630 640 650
ASVRIASLLP AWYYNFRVTM VTWGDPELSC CDSSTISFIT APVAPEITSV
660 670 680 690 700
EYFNSLLYIS WTYGDATTDL SHSRMLHWMV VAEGRKKIKK SVTRNVMTAI
710 720 730 740 750
LSLPPGDIYN LSVTACTERG SNTSLPRLVK LEPAPPKSLF AVNKTQTSVT
760 770 780 790 800
LLWVEEGVAD FFEVFCQQLG SGHNGKLQEP VAVSSHVVTI SSLLPATAYN
810 820 830 840 850
CSVTSFSHDT PSVPTFIAVS TMVTEVNPNV VVISVLAILS TLLIGLLLVT
860 870 880 890 900
LVILRKKHLQ MARECGAGTF VNFASLEREG KLPYSWSKNG LKKRKLTNPV
910 920 930 940 950
QLDDFDSYIK DMAKDSDYKF SLQFEELKLI GLDIPHFAAD LPLNRCKNRY
960 970 980 990 1000
TNILPYDFSR VRLVSMNEEE GADYINANYI PGYNSPQEYI ATQGPLPETR
1010 1020 1030 1040 1050
NDFWKMVLQQ KSHIIVMLTQ CNEKRRVKCD HYWPFTEEPI AYGDITVEMV
1060 1070 1080 1090 1100
SEEEEEDWAS RHFRINYADE AQDVMHFNYT AWPDHGVPPA NAAESILQFV
1110 1120 1130 1140 1150
FTVRQQAAKS KGPMIIHCSA GVGRTGTFIA LDRLLQHIRD HEFVDILGLV
1160 1170 1180 1190
SEMRSYRMSM VQTEEQYIFI HQCVQLMWLR KKQQFCISDV IYENVSKS
Length:1,198
Mass (Da):135,234
Last modified:April 5, 2011 - v1
Checksum:iAF080558978EC924
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC093120 Genomic DNA. No translation available.
AC144767 Genomic DNA. No translation available.
AC163627 Genomic DNA. No translation available.
RefSeqiNP_001157873.1. NM_001164401.1.
UniGeneiMm.186361.
Mm.491536.

Genome annotation databases

EnsembliENSMUST00000167679; ENSMUSP00000127112; ENSMUSG00000030223.
GeneIDi19277.
KEGGimmu:19277.
UCSCiuc009emw.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC093120 Genomic DNA. No translation available.
AC144767 Genomic DNA. No translation available.
AC163627 Genomic DNA. No translation available.
RefSeqiNP_001157873.1. NM_001164401.1.
UniGeneiMm.186361.
Mm.491536.

3D structure databases

ProteinModelPortaliE9Q4I1.
SMRiE9Q4I1. Positions 221-247, 898-1190.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000167679; ENSMUSP00000127112; ENSMUSG00000030223.
GeneIDi19277.
KEGGimmu:19277.
UCSCiuc009emw.2. mouse.

Organism-specific databases

CTDi5800.
MGIiMGI:1097152. Ptpro.

Phylogenomic databases

GeneTreeiENSGT00770000120452.
KOiK18035.

Miscellaneous databases

NextBioi296184.
SOURCEiSearch...

Gene expression databases

BgeeiE9Q4I1.
ExpressionAtlasiE9Q4I1. baseline and differential.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
3.90.190.10. 1 hit.
InterProiIPR003961. FN3_dom.
IPR013783. Ig-like_fold.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view]
PfamiPF00041. fn3. 2 hits.
PF00102. Y_phosphatase. 1 hit.
[Graphical view]
PRINTSiPR00700. PRTYPHPHTASE.
SMARTiSM00060. FN3. 4 hits.
SM00194. PTPc. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 2 hits.
SSF52799. SSF52799. 1 hit.
PROSITEiPS50853. FN3. 5 hits.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  3. Ensembl
    Submitted (MAY-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiE9Q4I1_MOUSE
AccessioniPrimary (citable) accession number: E9Q4I1
Entry historyi
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: February 4, 2015
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.