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E9Q4I1

- E9Q4I1_MOUSE

UniProt

E9Q4I1 - E9Q4I1_MOUSE

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Protein
Submitted name: Receptor-type tyrosine-protein phosphatase O
Gene
Ptpro
Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 1 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.SAAS annotations

GO - Molecular functioni

  1. protein tyrosine phosphatase activity Source: InterPro
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Hydrolase, Protein phosphataseSAAS annotations

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Receptor-type tyrosine-protein phosphatase OImported
    Gene namesi
    Name:PtproImported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 6

    Organism-specific databases

    MGIiMGI:1097152. Ptpro.

    Expressioni

    Gene expression databases

    BgeeiE9Q4I1.

    Structurei

    3D structure databases

    ProteinModelPortaliE9Q4I1.
    SMRiE9Q4I1. Positions 221-257, 350-421, 640-821, 898-1190.

    Family & Domainsi

    Phylogenomic databases

    GeneTreeiENSGT00750000117631.
    KOiK18035.

    Family and domain databases

    Gene3Di2.60.40.10. 3 hits.
    3.90.190.10. 1 hit.
    InterProiIPR003961. Fibronectin_type3.
    IPR013783. Ig-like_fold.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    IPR000242. Tyr_Pase_rcpt/non-rcpt.
    [Graphical view]
    PfamiPF00041. fn3. 2 hits.
    PF00102. Y_phosphatase. 1 hit.
    [Graphical view]
    PRINTSiPR00700. PRTYPHPHTASE.
    SMARTiSM00060. FN3. 4 hits.
    SM00194. PTPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF49265. SSF49265. 2 hits.
    SSF52799. SSF52799. 1 hit.
    PROSITEiPS50853. FN3. 6 hits.
    PS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 1 hit.
    PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    E9Q4I1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGHLPRGTLG GRRLLPLLGL FVLLKIVTTF HVAVQDDNNI VVSLEASDIV     50
    SPASVYVVRV AGESKNYFFE FEEFNSTLPP PVVFKATYHG LYYIITLVVV 100
    NGNVVTKPSR SITVLTKPLP VTSVSIYDYK PSPETGVLFE IHYPEKYNVF 150
    SRVNISYWEG RDFRTMLYKD FFKGKTVFNH WLPGLCYSNI TFQLVSEATF 200
    NKSTLVEYSG VSHEPKQHRT APYPPRNISV RFVNLNKNNW EEPSGSFPED 250
    SFIKPPQDSI GRDRRFHFPE ETPETPPSNV SSGSPPSNVS SAWPDPNSTD 300
    YESTSQPFWW DSASAAPENE EDFVSALPAD YDTETTLDRT EKPTADPFSA 350
    FPVQMTLSWL PPKPPTAFDG FNILIEREEN FTDYLTVDEE AHEFVAELKE 400
    PGKYKLSVTT FSSSGACETR KSQSAKSLSF YISPTGEWIE ELTEKPQHVS 450
    VHVLSSTTAL MSWTSSQENY NSTIVSVVSL TCQKQKESQR LEKQYCTQVN 500
    SSKPVIENLV PGAQYQVVMY LRKGPLIGPP SDPVTFAIVP TGIKDLMLYP 550
    LGPTAVVLSW TRPILGVFRK YVVEMFYFNP TTMTSEWTTY YEIAATVSLT 600
    ASVRIASLLP AWYYNFRVTM VTWGDPELSC CDSSTISFIT APVAPEITSV 650
    EYFNSLLYIS WTYGDATTDL SHSRMLHWMV VAEGRKKIKK SVTRNVMTAI 700
    LSLPPGDIYN LSVTACTERG SNTSLPRLVK LEPAPPKSLF AVNKTQTSVT 750
    LLWVEEGVAD FFEVFCQQLG SGHNGKLQEP VAVSSHVVTI SSLLPATAYN 800
    CSVTSFSHDT PSVPTFIAVS TMVTEVNPNV VVISVLAILS TLLIGLLLVT 850
    LVILRKKHLQ MARECGAGTF VNFASLEREG KLPYSWSKNG LKKRKLTNPV 900
    QLDDFDSYIK DMAKDSDYKF SLQFEELKLI GLDIPHFAAD LPLNRCKNRY 950
    TNILPYDFSR VRLVSMNEEE GADYINANYI PGYNSPQEYI ATQGPLPETR 1000
    NDFWKMVLQQ KSHIIVMLTQ CNEKRRVKCD HYWPFTEEPI AYGDITVEMV 1050
    SEEEEEDWAS RHFRINYADE AQDVMHFNYT AWPDHGVPPA NAAESILQFV 1100
    FTVRQQAAKS KGPMIIHCSA GVGRTGTFIA LDRLLQHIRD HEFVDILGLV 1150
    SEMRSYRMSM VQTEEQYIFI HQCVQLMWLR KKQQFCISDV IYENVSKS 1198
    Length:1,198
    Mass (Da):135,234
    Last modified:April 5, 2011 - v1
    Checksum:iAF080558978EC924
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC093120 Genomic DNA. No translation available.
    AC144767 Genomic DNA. No translation available.
    AC163627 Genomic DNA. No translation available.
    RefSeqiNP_001157873.1. NM_001164401.1.
    UniGeneiMm.186361.
    Mm.491536.

    Genome annotation databases

    EnsembliENSMUST00000167679; ENSMUSP00000127112; ENSMUSG00000030223.
    GeneIDi19277.
    KEGGimmu:19277.
    UCSCiuc009emw.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC093120 Genomic DNA. No translation available.
    AC144767 Genomic DNA. No translation available.
    AC163627 Genomic DNA. No translation available.
    RefSeqi NP_001157873.1. NM_001164401.1.
    UniGenei Mm.186361.
    Mm.491536.

    3D structure databases

    ProteinModelPortali E9Q4I1.
    SMRi E9Q4I1. Positions 221-257, 350-421, 640-821, 898-1190.
    ModBasei Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000167679 ; ENSMUSP00000127112 ; ENSMUSG00000030223 .
    GeneIDi 19277.
    KEGGi mmu:19277.
    UCSCi uc009emw.2. mouse.

    Organism-specific databases

    CTDi 5800.
    MGIi MGI:1097152. Ptpro.

    Phylogenomic databases

    GeneTreei ENSGT00750000117631.
    KOi K18035.

    Miscellaneous databases

    NextBioi 296184.
    SOURCEi Search...

    Gene expression databases

    Bgeei E9Q4I1.

    Family and domain databases

    Gene3Di 2.60.40.10. 3 hits.
    3.90.190.10. 1 hit.
    InterProi IPR003961. Fibronectin_type3.
    IPR013783. Ig-like_fold.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    IPR000242. Tyr_Pase_rcpt/non-rcpt.
    [Graphical view ]
    Pfami PF00041. fn3. 2 hits.
    PF00102. Y_phosphatase. 1 hit.
    [Graphical view ]
    PRINTSi PR00700. PRTYPHPHTASE.
    SMARTi SM00060. FN3. 4 hits.
    SM00194. PTPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49265. SSF49265. 2 hits.
    SSF52799. SSF52799. 1 hit.
    PROSITEi PS50853. FN3. 6 hits.
    PS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 1 hit.
    PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    « Hide 'large scale' publications
    1. "The phagosomal proteome in interferon-gamma-activated macrophages."
      Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
      Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6JImported.
    3. Ensembl
      Submitted (MAY-2011) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: C57BL/6JImported.

    Entry informationi

    Entry nameiE9Q4I1_MOUSE
    AccessioniPrimary (citable) accession number: E9Q4I1
    Entry historyi
    Integrated into UniProtKB/TrEMBL: April 5, 2011
    Last sequence update: April 5, 2011
    Last modified: June 11, 2014
    This is version 30 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Caution

    The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

    Keywords - Technical termi

    Complete proteome, Reference proteome

    External Data

    Dasty 3

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