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E9Q418

- E9Q418_MOUSE

UniProt

E9Q418 - E9Q418_MOUSE

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Protein
Submitted name:

TGF-beta receptor type-1

Gene

Tgfbr1

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.SAAS annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. receptor signaling protein serine/threonine kinase activity Source: InterPro
  3. transforming growth factor beta-activated receptor activity Source: MGI
  4. transforming growth factor beta binding Source: MGI

GO - Biological processi

  1. angiogenesis Source: MGI
  2. anterior/posterior pattern specification Source: MGI
  3. artery morphogenesis Source: MGI
  4. blastocyst development Source: MGI
  5. collagen fibril organization Source: MGI
  6. embryonic cranial skeleton morphogenesis Source: MGI
  7. endothelial cell migration Source: MGI
  8. germ cell migration Source: MGI
  9. heart development Source: MGI
  10. in utero embryonic development Source: MGI
  11. kidney development Source: MGI
  12. lens development in camera-type eye Source: MGI
  13. male gonad development Source: MGI
  14. negative regulation of apoptotic process Source: MGI
  15. negative regulation of endothelial cell proliferation Source: MGI
  16. neuron fate commitment Source: MGI
  17. palate development Source: MGI
  18. parathyroid gland development Source: MGI
  19. pharyngeal system development Source: MGI
  20. positive regulation of filopodium assembly Source: MGI
  21. post-embryonic development Source: MGI
  22. regulation of gene expression Source: MGI
  23. regulation of protein binding Source: MGI
  24. skeletal system development Source: MGI
  25. skeletal system morphogenesis Source: MGI
  26. thymus development Source: MGI
  27. transforming growth factor beta receptor signaling pathway Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Kinase, ReceptorSAAS annotation, Serine/threonine-protein kinaseUniRule annotationSAAS annotation, Transferase

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
TGF-beta receptor type-1Imported
Gene namesi
Name:Tgfbr1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 4

Organism-specific databases

MGIiMGI:98728. Tgfbr1.

Subcellular locationi

GO - Cellular componenti

  1. caveola Source: MGI
  2. integral component of membrane Source: UniProtKB-KW
  3. membrane raft Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

BgeeiE9Q418.
ExpressionAtlasiE9Q418. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliE9Q418.
SMRiE9Q418. Positions 1-45, 106-431.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the protein kinase superfamily.UniRule annotation
Contains protein kinase domain.SAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00760000118876.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
IPR003605. TGF_beta_rcpt_GS.
IPR000333. TGFB_receptor.
[Graphical view]
PANTHERiPTHR23255. PTHR23255. 1 hit.
PfamiPF00069. Pkinase. 1 hit.
PF08515. TGF_beta_GS. 1 hit.
[Graphical view]
SMARTiSM00467. GS. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS51256. GS. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E9Q418-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MCIAEIDLIP RDRPFVCAPS SKTGAVTTTY CCNQDHCNKI ELPTTEKQSA
60 70 80 90 100
GLGPVELAAV IAGPVCFVCI ALMLMVYICH NRTVIHHRVP NEEDPSLDRP
110 120 130 140 150
FISEGTTLKD LIYDMTTSGS GSGLPLLVQR TIARTIVLQE SIGKGRFGEV
160 170 180 190 200
WRGKWRGEEV AVKIFSSREE RSWFREAEIY QTVMLRHENI LGFIAADNKD
210 220 230 240 250
NGTWTQLWLV SDYHEHGSLF DYLNRYTVTV EGMIKLALST ASGLAHLHME
260 270 280 290 300
IVGTQGKPAI AHRDLKSKNI LVKKNGTCCI ADLGLAVRHD SATDTIDIAP
310 320 330 340 350
NHRVGTKRYM APEVLDDSIN MKHFESFKRA DIYAMGLVFW EIARRCSIGG
360 370 380 390 400
IHEDYQLPYY DLVPSDPSVE EMRKVVCEQK LRPNIPNRWQ SCEALRVMAK
410 420 430
IMRECWYANG AARLTALRIK KTLSQLSQQE GIKM
Length:434
Mass (Da):48,888
Last modified:April 5, 2011 - v1
Checksum:iF1A7A89CEC725196
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL772150 Genomic DNA. No translation available.
AL772232 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSMUST00000126171; ENSMUSP00000123761; ENSMUSG00000007613.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL772150 Genomic DNA. No translation available.
AL772232 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortali E9Q418.
SMRi E9Q418. Positions 1-45, 106-431.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000126171 ; ENSMUSP00000123761 ; ENSMUSG00000007613 .

Organism-specific databases

MGIi MGI:98728. Tgfbr1.

Phylogenomic databases

GeneTreei ENSGT00760000118876.

Miscellaneous databases

ChiTaRSi Tgfbr1. mouse.
NextBioi 35555060.
SOURCEi Search...

Gene expression databases

Bgeei E9Q418.
ExpressionAtlasi E9Q418. baseline and differential.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
IPR003605. TGF_beta_rcpt_GS.
IPR000333. TGFB_receptor.
[Graphical view ]
PANTHERi PTHR23255. PTHR23255. 1 hit.
Pfami PF00069. Pkinase. 1 hit.
PF08515. TGF_beta_GS. 1 hit.
[Graphical view ]
SMARTi SM00467. GS. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS51256. GS. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  2. Ensembl
    Submitted (MAY-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiE9Q418_MOUSE
AccessioniPrimary (citable) accession number: E9Q418
Entry historyi
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: November 26, 2014
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3