TGF-beta receptor type-1 - Mus musculus (Mouse)

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E9Q418 (E9Q418_MOUSE) Unreviewed, UniProtKB/TrEMBL

Last modified May 29, 2013. Version 18. History...

Clusters with 100%, 90%, 50% identity |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry info Customize order

Names and origin

Protein names

Submitted name:
TGF-beta receptor type-1 Ensembl ENSMUSP00000123761

Gene names

Name:

Tgfbr1 Ensembl ENSMUSP00000123761 MGI 98728

Organism

Mus musculus (Mouse) [Reference proteome] Ensembl ENSMUSP00000123761

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	434 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities	Belongs to the protein kinase superfamily. RuleBase RU000305
Caution	The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data. Ensembl ENSMUSP00000123761

Ontologies

Keywords
Ligand	ATP-binding RuleBase RU000304 Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase RuleBase RU000305 Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	angiogenesis Inferred from mutant phenotype PubMed 11285230. Source: MGI anterior/posterior pattern specification Inferred from genetic interaction PubMed 16845371. Source: MGI artery morphogenesis Inferred from mutant phenotype PubMed 17078885. Source: MGI blastocyst development Inferred from direct assay PubMed 9921650. Source: MGI collagen fibril organization Inferred from mutant phenotype PubMed 15993878. Source: MGI embryonic cranial skeleton morphogenesis Inferred from mutant phenotype PubMed 16806156. Source: MGI endothelial cell migration Inferred from mutant phenotype PubMed 11285230. Source: MGI germ cell migration Inferred from mutant phenotype PubMed 15993878. Source: MGI heart development Inferred from mutant phenotype PubMed 17078885. Source: MGI induction of apoptosis Inferred from mutant phenotype PubMed 16806156. Source: MGI kidney development Inferred from genetic interaction PubMed 16845371. Source: MGI lens development in camera-type eye Inferred from mutant phenotype PubMed 11641223. Source: MGI negative regulation of apoptotic process Inferred from mutant phenotype PubMed 17078885. Source: MGI negative regulation of endothelial cell proliferation Inferred from genetic interaction PubMed 21832243. Source: MGI neuron fate commitment Inferred from mutant phenotype PubMed 15744664. Source: MGI palate development Inferred from mutant phenotype PubMed 16806156. Source: MGI parathyroid gland development Inferred from mutant phenotype PubMed 17078885. Source: MGI pharyngeal system development Inferred from mutant phenotype PubMed 17078885. Source: MGI positive regulation of filopodium assembly Inferred from mutant phenotype PubMed 16806156. Source: MGI post-embryonic development Inferred from mutant phenotype PubMed 16806156. Source: MGI regulation of gene expression Inferred from mutant phenotype PubMed 16806156. Source: MGI regulation of protein binding Inferred from mutant phenotype PubMed 16601693. Source: MGI thymus development Inferred from mutant phenotype PubMed 17078885. Source: MGI transforming growth factor beta receptor signaling pathway Inferred from direct assay PubMed 14580334 PubMed 15820682. Source: MGI
Cellular_component	caveola Inferred from sequence orthology PubMed 17878231. Source: MGI
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW transforming growth factor beta-activated receptor activity Inferred from direct assay PubMed 15820682. Source: MGI
Complete GO annotation...

Sequences

Sequence

Length

Mass (Da)

Tools

E9Q418 [UniParc].

Last modified April 5, 2011. Version 1.
Checksum: F1A7A89CEC725196
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FASTA

434

48,888

        10         20         30         40         50         60 
MCIAEIDLIP RDRPFVCAPS SKTGAVTTTY CCNQDHCNKI ELPTTEKQSA GLGPVELAAV 

        70         80         90        100        110        120 
IAGPVCFVCI ALMLMVYICH NRTVIHHRVP NEEDPSLDRP FISEGTTLKD LIYDMTTSGS 

       130        140        150        160        170        180 
GSGLPLLVQR TIARTIVLQE SIGKGRFGEV WRGKWRGEEV AVKIFSSREE RSWFREAEIY 

       190        200        210        220        230        240 
QTVMLRHENI LGFIAADNKD NGTWTQLWLV SDYHEHGSLF DYLNRYTVTV EGMIKLALST 

       250        260        270        280        290        300 
ASGLAHLHME IVGTQGKPAI AHRDLKSKNI LVKKNGTCCI ADLGLAVRHD SATDTIDIAP 

       310        320        330        340        350        360 
NHRVGTKRYM APEVLDDSIN MKHFESFKRA DIYAMGLVFW EIARRCSIGG IHEDYQLPYY 

       370        380        390        400        410        420 
DLVPSDPSVE EMRKVVCEQK LRPNIPNRWQ SCEALRVMAK IMRECWYANG AARLTALRIK 

       430 
KTLSQLSQQE GIKM

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J Ensembl ENSMUSP00000123761.
[2]	Ensembl Submitted (MAY-2011) to UniProtKB Cited for: IDENTIFICATION. Strain: C57BL/6J Ensembl ENSMUSP00000123761.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL772150 Genomic DNA. No translation available. AL772232 Genomic DNA. No translation available.
IPI	IPI01016088.
3D structure databases
ProteinModelPortal	E9Q418.
SMR	E9Q418. Positions 1-45, 106-431.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000126171; ENSMUSP00000123761; ENSMUSG00000007613.
Organism-specific databases
MGI	MGI:98728. Tgfbr1.
Phylogenomic databases
GeneTree	ENSGT00560000076615.
Gene expression databases
ArrayExpress	E9Q418.
Bgee	E9Q418.
Family and domain databases
InterPro	IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR008271. Ser/Thr_kinase_AS. IPR003605. TGF_beta_rcpt_GS. [Graphical view]
Pfam	PF00069. Pkinase. 1 hit. PF08515. TGF_beta_GS. 1 hit. [Graphical view]
SMART	SM00467. GS. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
PROSITE	PS51256. GS. 1 hit. PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	TGFBR1. mouse.
NextBio	35555060.
SOURCE	Search...

Entry information

Entry name

E9Q418_MOUSE

Accession

Primary (citable) accession number: E9Q418

Entry history

Integrated into UniProtKB/TrEMBL:	April 5, 2011
Last sequence update:	April 5, 2011
Last modified:	May 29, 2013
This is version 18 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Names·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry info

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information