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E9Q418

- E9Q418_MOUSE

UniProt

E9Q418 - E9Q418_MOUSE

Protein
Submitted name:

TGF-beta receptor type-1

Gene

Tgfbr1

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5- Protein inferred from homologyi
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    • History
      Entry version 30 (01 Oct 2014)
      Sequence version 1 (05 Apr 2011)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.SAAS annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. protein binding Source: MGI
    3. receptor signaling protein serine/threonine kinase activity Source: InterPro
    4. transforming growth factor beta-activated receptor activity Source: MGI
    5. transforming growth factor beta binding Source: MGI

    GO - Biological processi

    1. angiogenesis Source: MGI
    2. anterior/posterior pattern specification Source: MGI
    3. artery morphogenesis Source: MGI
    4. blastocyst development Source: MGI
    5. collagen fibril organization Source: MGI
    6. embryonic cranial skeleton morphogenesis Source: MGI
    7. endothelial cell migration Source: MGI
    8. germ cell migration Source: MGI
    9. heart development Source: MGI
    10. in utero embryonic development Source: MGI
    11. kidney development Source: MGI
    12. lens development in camera-type eye Source: MGI
    13. negative regulation of apoptotic process Source: MGI
    14. negative regulation of endothelial cell proliferation Source: MGI
    15. neuron fate commitment Source: MGI
    16. palate development Source: MGI
    17. parathyroid gland development Source: MGI
    18. pharyngeal system development Source: MGI
    19. positive regulation of filopodium assembly Source: MGI
    20. post-embryonic development Source: MGI
    21. regulation of gene expression Source: MGI
    22. regulation of protein binding Source: MGI
    23. skeletal system development Source: MGI
    24. skeletal system morphogenesis Source: MGI
    25. thymus development Source: MGI
    26. transforming growth factor beta receptor signaling pathway Source: MGI

    Keywords - Molecular functioni

    Kinase, ReceptorSAAS annotation, Serine/threonine-protein kinaseUniRule annotationSAAS annotation, Transferase

    Keywords - Ligandi

    ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    TGF-beta receptor type-1Imported
    Gene namesi
    Name:Tgfbr1Imported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 4

    Organism-specific databases

    MGIiMGI:98728. Tgfbr1.

    Subcellular locationi

    GO - Cellular componenti

    1. caveola Source: MGI
    2. integral component of membrane Source: UniProtKB-KW
    3. membrane raft Source: MGI

    Keywords - Cellular componenti

    Membrane

    Expressioni

    Gene expression databases

    ArrayExpressiE9Q418.
    BgeeiE9Q418.

    Structurei

    3D structure databases

    ProteinModelPortaliE9Q418.
    SMRiE9Q418. Positions 1-45, 106-431.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the protein kinase superfamily.UniRule annotation
    Contains protein kinase domain.SAAS annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helixSAAS annotation

    Phylogenomic databases

    GeneTreeiENSGT00730000110337.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR008271. Ser/Thr_kinase_AS.
    IPR003605. TGF_beta_rcpt_GS.
    IPR000333. TGFB_receptor.
    [Graphical view]
    PANTHERiPTHR23255. PTHR23255. 1 hit.
    PfamiPF00069. Pkinase. 1 hit.
    PF08515. TGF_beta_GS. 1 hit.
    [Graphical view]
    SMARTiSM00467. GS. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS51256. GS. 1 hit.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    E9Q418-1 [UniParc]FASTAAdd to Basket

    « Hide

    MCIAEIDLIP RDRPFVCAPS SKTGAVTTTY CCNQDHCNKI ELPTTEKQSA    50
    GLGPVELAAV IAGPVCFVCI ALMLMVYICH NRTVIHHRVP NEEDPSLDRP 100
    FISEGTTLKD LIYDMTTSGS GSGLPLLVQR TIARTIVLQE SIGKGRFGEV 150
    WRGKWRGEEV AVKIFSSREE RSWFREAEIY QTVMLRHENI LGFIAADNKD 200
    NGTWTQLWLV SDYHEHGSLF DYLNRYTVTV EGMIKLALST ASGLAHLHME 250
    IVGTQGKPAI AHRDLKSKNI LVKKNGTCCI ADLGLAVRHD SATDTIDIAP 300
    NHRVGTKRYM APEVLDDSIN MKHFESFKRA DIYAMGLVFW EIARRCSIGG 350
    IHEDYQLPYY DLVPSDPSVE EMRKVVCEQK LRPNIPNRWQ SCEALRVMAK 400
    IMRECWYANG AARLTALRIK KTLSQLSQQE GIKM 434
    Length:434
    Mass (Da):48,888
    Last modified:April 5, 2011 - v1
    Checksum:iF1A7A89CEC725196
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL772150 Genomic DNA. No translation available.
    AL772232 Genomic DNA. No translation available.

    Genome annotation databases

    EnsembliENSMUST00000126171; ENSMUSP00000123761; ENSMUSG00000007613.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL772150 Genomic DNA. No translation available.
    AL772232 Genomic DNA. No translation available.

    3D structure databases

    ProteinModelPortali E9Q418.
    SMRi E9Q418. Positions 1-45, 106-431.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000126171 ; ENSMUSP00000123761 ; ENSMUSG00000007613 .

    Organism-specific databases

    MGIi MGI:98728. Tgfbr1.

    Phylogenomic databases

    GeneTreei ENSGT00730000110337.

    Miscellaneous databases

    ChiTaRSi TGFBR1. mouse.
    NextBioi 35555060.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi E9Q418.
    Bgeei E9Q418.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR008271. Ser/Thr_kinase_AS.
    IPR003605. TGF_beta_rcpt_GS.
    IPR000333. TGFB_receptor.
    [Graphical view ]
    PANTHERi PTHR23255. PTHR23255. 1 hit.
    Pfami PF00069. Pkinase. 1 hit.
    PF08515. TGF_beta_GS. 1 hit.
    [Graphical view ]
    SMARTi SM00467. GS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS51256. GS. 1 hit.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6JImported.
    2. Ensembl
      Submitted (MAY-2011) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: C57BL/6JImported.

    Entry informationi

    Entry nameiE9Q418_MOUSE
    AccessioniPrimary (citable) accession number: E9Q418
    Entry historyi
    Integrated into UniProtKB/TrEMBL: April 5, 2011
    Last sequence update: April 5, 2011
    Last modified: October 1, 2014
    This is version 30 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Caution

    The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3