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E9Q418 (E9Q418_MOUSE) Unreviewed, UniProtKB/TrEMBL

Last modified July 9, 2014. Version 28. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein attributes

Sequence length434 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + [receptor-protein] = ADP + [receptor-protein] phosphate. SAAS SAAS000333

Sequence similarities

Belongs to the protein kinase superfamily. RuleBase RU000305

Contains protein kinase domain. SAAS SAAS000333

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data. Ensembl ENSMUSP00000123761

Ontologies

Keywords
   Cellular componentMembrane
   DomainTransmembrane
Transmembrane helix SAAS SAAS000333
   LigandATP-binding RuleBase RU000304 SAAS SAAS000333
Nucleotide-binding
   Molecular functionKinase
Receptor SAAS SAAS000333
Serine/threonine-protein kinase RuleBase RU000305 SAAS SAAS000333
Transferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processangiogenesis

Inferred from mutant phenotype PubMed 11285230. Source: MGI

anterior/posterior pattern specification

Inferred from genetic interaction PubMed 16845371. Source: MGI

artery morphogenesis

Inferred from mutant phenotype PubMed 17078885. Source: MGI

blastocyst development

Inferred from direct assay PubMed 9921650. Source: MGI

collagen fibril organization

Inferred from mutant phenotype PubMed 15993878. Source: MGI

embryonic cranial skeleton morphogenesis

Inferred from mutant phenotype PubMed 16806156. Source: MGI

endothelial cell migration

Inferred from mutant phenotype PubMed 11285230. Source: MGI

germ cell migration

Inferred from mutant phenotype PubMed 15993878. Source: MGI

heart development

Inferred from mutant phenotype PubMed 17078885. Source: MGI

in utero embryonic development

Inferred from mutant phenotype PubMed 11285230PubMed 14729481PubMed 17078885. Source: MGI

kidney development

Inferred from genetic interaction PubMed 16845371. Source: MGI

lens development in camera-type eye

Inferred from mutant phenotype PubMed 11641223. Source: MGI

negative regulation of apoptotic process

Inferred from mutant phenotype PubMed 16806156PubMed 17078885. Source: MGI

negative regulation of endothelial cell proliferation

Inferred from genetic interaction PubMed 21832243. Source: MGI

neuron fate commitment

Inferred from mutant phenotype PubMed 15744664. Source: MGI

palate development

Inferred from mutant phenotype PubMed 16806156. Source: MGI

parathyroid gland development

Inferred from mutant phenotype PubMed 17078885. Source: MGI

pharyngeal system development

Inferred from mutant phenotype PubMed 17078885. Source: MGI

positive regulation of filopodium assembly

Inferred from mutant phenotype PubMed 16806156. Source: MGI

post-embryonic development

Inferred from mutant phenotype PubMed 16806156. Source: MGI

regulation of gene expression

Inferred from mutant phenotype PubMed 16806156. Source: MGI

regulation of protein binding

Inferred from mutant phenotype PubMed 16601693. Source: MGI

skeletal system development

Inferred from genetic interaction PubMed 16845371. Source: MGI

skeletal system morphogenesis

Inferred from genetic interaction PubMed 16845371. Source: MGI

thymus development

Inferred from mutant phenotype PubMed 17078885. Source: MGI

transforming growth factor beta receptor signaling pathway

Inferred from direct assay PubMed 14580334PubMed 15820682. Source: MGI

   Cellular_componentcaveola

Inferred from sequence orthology PubMed 17878231. Source: MGI

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

membrane raft

Inferred from sequence orthology PubMed 17878231. Source: MGI

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

protein binding

Inferred from physical interaction PubMed 14580334PubMed 23868260. Source: MGI

transforming growth factor beta binding

Inferred from physical interaction PubMed 17878231. Source: MGI

transforming growth factor beta-activated receptor activity

Inferred from direct assay PubMed 15820682. Source: MGI

Complete GO annotation...

Sequences

Sequence LengthMass (Da)Tools
E9Q418 [UniParc].

Last modified April 5, 2011. Version 1.
Checksum: F1A7A89CEC725196

FASTA43448,888
        10         20         30         40         50         60 
MCIAEIDLIP RDRPFVCAPS SKTGAVTTTY CCNQDHCNKI ELPTTEKQSA GLGPVELAAV 

        70         80         90        100        110        120 
IAGPVCFVCI ALMLMVYICH NRTVIHHRVP NEEDPSLDRP FISEGTTLKD LIYDMTTSGS 

       130        140        150        160        170        180 
GSGLPLLVQR TIARTIVLQE SIGKGRFGEV WRGKWRGEEV AVKIFSSREE RSWFREAEIY 

       190        200        210        220        230        240 
QTVMLRHENI LGFIAADNKD NGTWTQLWLV SDYHEHGSLF DYLNRYTVTV EGMIKLALST 

       250        260        270        280        290        300 
ASGLAHLHME IVGTQGKPAI AHRDLKSKNI LVKKNGTCCI ADLGLAVRHD SATDTIDIAP 

       310        320        330        340        350        360 
NHRVGTKRYM APEVLDDSIN MKHFESFKRA DIYAMGLVFW EIARRCSIGG IHEDYQLPYY 

       370        380        390        400        410        420 
DLVPSDPSVE EMRKVVCEQK LRPNIPNRWQ SCEALRVMAK IMRECWYANG AARLTALRIK 

       430 
KTLSQLSQQE GIKM 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL772150 Genomic DNA. No translation available.
AL772232 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortalE9Q418.
SMRE9Q418. Positions 1-45, 106-431.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000126171; ENSMUSP00000123761; ENSMUSG00000007613.

Organism-specific databases

MGIMGI:98728. Tgfbr1.

Phylogenomic databases

GeneTreeENSGT00730000110337.

Gene expression databases

ArrayExpressE9Q418.
BgeeE9Q418.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
IPR003605. TGF_beta_rcpt_GS.
IPR000333. TGFB_receptor.
[Graphical view]
PANTHERPTHR23255. PTHR23255. 1 hit.
PfamPF00069. Pkinase. 1 hit.
PF08515. TGF_beta_GS. 1 hit.
[Graphical view]
SMARTSM00467. GS. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS51256. GS. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSTGFBR1. mouse.
NextBio35555060.
SOURCESearch...

Entry information

Entry nameE9Q418_MOUSE
AccessionPrimary (citable) accession number: E9Q418
Entry history
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: July 9, 2014
This is version 28 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)