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Protein

Receptor protein serine/threonine kinase

Gene

Tgfbr1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.SAAS annotation

GO - Molecular functioni

GO - Biological processi

  • activation of MAPKK activity Source: MGI
  • activin receptor signaling pathway Source: AgBase
  • angiogenesis Source: MGI
  • anterior/posterior pattern specification Source: MGI
  • artery morphogenesis Source: MGI
  • blastocyst development Source: MGI
  • cardiac epithelial to mesenchymal transition Source: AgBase
  • cell motility Source: MGI
  • cellular response to transforming growth factor beta stimulus Source: MGI
  • collagen fibril organization Source: MGI
  • embryonic cranial skeleton morphogenesis Source: MGI
  • endothelial cell activation Source: AgBase
  • endothelial cell migration Source: MGI
  • epithelial to mesenchymal transition Source: MGI
  • germ cell migration Source: MGI
  • heart development Source: AgBase
  • intracellular signal transduction Source: AgBase
  • in utero embryonic development Source: MGI
  • kidney development Source: MGI
  • lens development in camera-type eye Source: MGI
  • male gonad development Source: MGI
  • mesenchymal cell differentiation Source: AgBase
  • negative regulation of apoptotic process Source: MGI
  • negative regulation of endothelial cell proliferation Source: MGI
  • negative regulation of extrinsic apoptotic signaling pathway Source: MGI
  • neuron fate commitment Source: MGI
  • palate development Source: MGI
  • parathyroid gland development Source: MGI
  • pathway-restricted SMAD protein phosphorylation Source: MGI
  • peptidyl-serine phosphorylation Source: MGI
  • peptidyl-threonine phosphorylation Source: MGI
  • pharyngeal system development Source: MGI
  • positive regulation of apoptotic signaling pathway Source: MGI
  • positive regulation of cell growth Source: MGI
  • positive regulation of cell proliferation Source: MGI
  • positive regulation of cellular component movement Source: MGI
  • positive regulation of endothelial cell proliferation Source: AgBase
  • positive regulation of filopodium assembly Source: MGI
  • positive regulation of gene expression Source: AgBase
  • positive regulation of pathway-restricted SMAD protein phosphorylation Source: MGI
  • positive regulation of protein kinase B signaling Source: MGI
  • positive regulation of SMAD protein import into nucleus Source: MGI
  • positive regulation of transcription, DNA-templated Source: AgBase
  • post-embryonic development Source: MGI
  • protein phosphorylation Source: MGI
  • regulation of epithelial to mesenchymal transition Source: AgBase
  • regulation of gene expression Source: AgBase
  • regulation of protein binding Source: MGI
  • regulation of protein ubiquitination Source: MGI
  • regulation of transcription, DNA-templated Source: MGI
  • response to cholesterol Source: MGI
  • signal transduction Source: MGI
  • skeletal system development Source: MGI
  • skeletal system morphogenesis Source: MGI
  • thymus development Source: MGI
  • transforming growth factor beta receptor signaling pathway Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Kinase, ReceptorSAAS annotation, Serine/threonine-protein kinaseUniRule annotationSAAS annotation, Transferase

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Receptor protein serine/threonine kinaseSAAS annotation (EC:2.7.11.30SAAS annotation)
Gene namesi
Name:Tgfbr1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:98728. Tgfbr1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

BgeeiE9Q418.
ExpressionAtlasiE9Q418. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000007757.

Structurei

3D structure databases

ProteinModelPortaliE9Q418.
SMRiE9Q418. Positions 1-45, 106-431.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the protein kinase superfamily.UniRule annotation
Contains protein kinase domain.SAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00760000118876.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
IPR003605. TGF_beta_rcpt_GS.
IPR000333. TGFB_receptor.
[Graphical view]
PANTHERiPTHR23255. PTHR23255. 1 hit.
PfamiPF00069. Pkinase. 1 hit.
PF08515. TGF_beta_GS. 1 hit.
[Graphical view]
SMARTiSM00467. GS. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS51256. GS. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E9Q418-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCIAEIDLIP RDRPFVCAPS SKTGAVTTTY CCNQDHCNKI ELPTTEKQSA
60 70 80 90 100
GLGPVELAAV IAGPVCFVCI ALMLMVYICH NRTVIHHRVP NEEDPSLDRP
110 120 130 140 150
FISEGTTLKD LIYDMTTSGS GSGLPLLVQR TIARTIVLQE SIGKGRFGEV
160 170 180 190 200
WRGKWRGEEV AVKIFSSREE RSWFREAEIY QTVMLRHENI LGFIAADNKD
210 220 230 240 250
NGTWTQLWLV SDYHEHGSLF DYLNRYTVTV EGMIKLALST ASGLAHLHME
260 270 280 290 300
IVGTQGKPAI AHRDLKSKNI LVKKNGTCCI ADLGLAVRHD SATDTIDIAP
310 320 330 340 350
NHRVGTKRYM APEVLDDSIN MKHFESFKRA DIYAMGLVFW EIARRCSIGG
360 370 380 390 400
IHEDYQLPYY DLVPSDPSVE EMRKVVCEQK LRPNIPNRWQ SCEALRVMAK
410 420 430
IMRECWYANG AARLTALRIK KTLSQLSQQE GIKM
Length:434
Mass (Da):48,888
Last modified:April 5, 2011 - v1
Checksum:iF1A7A89CEC725196
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL772150 Genomic DNA. No translation available.
AL772232 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSMUST00000126171; ENSMUSP00000123761; ENSMUSG00000007613.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL772150 Genomic DNA. No translation available.
AL772232 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortaliE9Q418.
SMRiE9Q418. Positions 1-45, 106-431.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000007757.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000126171; ENSMUSP00000123761; ENSMUSG00000007613.

Organism-specific databases

MGIiMGI:98728. Tgfbr1.

Phylogenomic databases

GeneTreeiENSGT00760000118876.

Miscellaneous databases

ChiTaRSiTgfbr1. mouse.
NextBioi35555060.
SOURCEiSearch...

Gene expression databases

BgeeiE9Q418.
ExpressionAtlasiE9Q418. baseline and differential.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
IPR003605. TGF_beta_rcpt_GS.
IPR000333. TGFB_receptor.
[Graphical view]
PANTHERiPTHR23255. PTHR23255. 1 hit.
PfamiPF00069. Pkinase. 1 hit.
PF08515. TGF_beta_GS. 1 hit.
[Graphical view]
SMARTiSM00467. GS. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS51256. GS. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  2. Ensembl
    Submitted (MAY-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiE9Q418_MOUSE
AccessioniPrimary (citable) accession number: E9Q418
Entry historyi
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: June 24, 2015
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.