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E9Q414 (APOB_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 31. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Apolipoprotein B-100

Short name=Apo B-100

Cleaved into the following chain:

  1. Apolipoprotein B-48
    Short name=Apo B-48
Gene names
Name:Apob
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length4505 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Apolipoprotein B is a major protein constituent of chylomicrons (apo B-48), LDL (apo B-100) and VLDL (apo B-100). Apo B-100 functions as a recognition signal for the cellular binding and internalization of LDL particles by the apoB/E receptor.

Subunit structure

Interacts with PCSK9 By similarity.

Subcellular location

Cytoplasm By similarity. Secreted By similarity.

Post-translational modification

Palmitoylated; structural requirement for proper assembly of the hydrophobic core of the lipoprotein particle By similarity.

Sequence similarities

Contains 1 vitellogenin domain.

RNA editing

Edited at position 2179.
The stop codon (UAA) at position 2179 is created by RNA editing. Apo B-48, derived from the fully edited RNA, is produced only in the intestine and is found in chylomicrons. Apo B-48 is a shortened form of apo B-100 which lacks the LDL-receptor region. The unedited version (apo B-100) is produced by the liver and is found in the VLDL and LDL By similarity.

Sequence caution

The sequence AAI41358.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

The sequence AAI41361.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

The sequence BAE27983.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
   Biological processCholesterol metabolism
Lipid metabolism
Lipid transport
Steroid metabolism
Sterol metabolism
Transport
   Cellular componentChylomicron
Cytoplasm
LDL
Secreted
VLDL
   Coding sequence diversityRNA editing
   DomainCoiled coil
Repeat
Signal
   LigandHeparin-binding
   PTMAcetylation
Disulfide bond
Glycoprotein
Lipoprotein
Palmitate
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processartery morphogenesis

Inferred from genetic interaction PubMed 16230502. Source: MGI

cellular response to prostaglandin stimulus

Inferred from electronic annotation. Source: Ensembl

cellular response to tumor necrosis factor

Inferred from electronic annotation. Source: Ensembl

cholesterol efflux

Inferred from genetic interaction PubMed 22363685. Source: MGI

cholesterol homeostasis

Inferred from mutant phenotype PubMed 7878058PubMed 8921909PubMed 9202070PubMed 9502790PubMed 9852051. Source: MGI

cholesterol metabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

cholesterol transport

Inferred from mutant phenotype PubMed 7593600. Source: MGI

fertilization

Inferred from mutant phenotype PubMed 8855280. Source: MGI

in utero embryonic development

Inferred from mutant phenotype PubMed 7878058PubMed 9502790. Source: MGI

lipid catabolic process

Inferred from mutant phenotype PubMed 16455790. Source: MGI

lipid metabolic process

Inferred from direct assay PubMed 12072432. Source: MGI

lipoprotein biosynthetic process

Inferred from genetic interaction PubMed 13130124. Source: MGI

lipoprotein catabolic process

Inferred from genetic interaction PubMed 15863839. Source: MGI

lipoprotein metabolic process

Inferred from mutant phenotype PubMed 10705993PubMed 10713055PubMed 7878058PubMed 9852051. Source: MGI

lipoprotein transport

Inferred from mutant phenotype PubMed 13130124. Source: MGI

low-density lipoprotein particle clearance

Inferred from electronic annotation. Source: Ensembl

low-density lipoprotein particle remodeling

Inferred from electronic annotation. Source: Ensembl

nervous system development

Inferred from mutant phenotype PubMed 7878058PubMed 8921909PubMed 9502790. Source: MGI

positive regulation of cholesterol storage

Inferred from electronic annotation. Source: Ensembl

positive regulation of macrophage derived foam cell differentiation

Inferred from electronic annotation. Source: Ensembl

post-embryonic development

Inferred from mutant phenotype PubMed 9852051. Source: MGI

regulation of cholesterol biosynthetic process

Inferred from mutant phenotype PubMed 16455790. Source: MGI

response to carbohydrate

Inferred from electronic annotation. Source: Ensembl

response to lipopolysaccharide

Inferred from electronic annotation. Source: Ensembl

response to selenium ion

Inferred from electronic annotation. Source: Ensembl

response to virus

Inferred from electronic annotation. Source: Ensembl

sperm motility

Inferred from mutant phenotype PubMed 8855280. Source: MGI

spermatogenesis

Inferred from mutant phenotype PubMed 8855280. Source: MGI

triglyceride catabolic process

Inferred from mutant phenotype PubMed 16455790. Source: MGI

triglyceride mobilization

Inferred from mutant phenotype PubMed 10893242. Source: MGI

   Cellular_componentendoplasmic reticulum

Inferred from direct assay PubMed 12072432. Source: MGI

extracellular region

Traceable author statement. Source: Reactome

intermediate-density lipoprotein particle

Inferred from electronic annotation. Source: Ensembl

low-density lipoprotein particle

Inferred from electronic annotation. Source: UniProtKB-KW

mature chylomicron

Inferred from electronic annotation. Source: Ensembl

very-low-density lipoprotein particle

Inferred from electronic annotation. Source: UniProtKB-KW

vesicle lumen

Inferred from electronic annotation. Source: Ensembl

vesicle membrane

Inferred from electronic annotation. Source: Ensembl

   Molecular_functioncholesterol transporter activity

Inferred from electronic annotation. Source: Ensembl

heparin binding

Inferred from electronic annotation. Source: UniProtKB-KW

phospholipid binding

Inferred from electronic annotation. Source: Ensembl

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2727 Potential
Chain28 – 45054478Apolipoprotein B-100
PRO_0000420969
Chain28 – 21782151Apolipoprotein B-48
PRO_0000420970

Regions

Domain46 – 672627Vitellogenin
Region32 – 12695Heparin-binding By similarity
Region232 – 30675Heparin-binding By similarity
Region902 – 95958Heparin-binding By similarity
Region2042 – 2177136Heparin-binding By similarity
Region3155 – 323076Heparin-binding By similarity
Region3168 – 317811Basic (possible receptor binding region) By similarity
Region3368 – 338821LDL receptor binding By similarity
Region3378 – 3511134Heparin-binding By similarity
Region3381 – 33899Basic (possible receptor binding region) By similarity

Amino acid modifications

Modified residue20051N6-acetyllysine By similarity
Glycosylation341N-linked (GlcNAc...) Potential
Glycosylation1851N-linked (GlcNAc...) Potential
Glycosylation9831N-linked (GlcNAc...) Potential
Glycosylation13681N-linked (GlcNAc...) Potential
Glycosylation13771N-linked (GlcNAc...) Potential
Glycosylation15231N-linked (GlcNAc...) Potential
Glycosylation25541N-linked (GlcNAc...) Potential
Glycosylation27731N-linked (GlcNAc...) Ref.5
Glycosylation29761N-linked (GlcNAc...) Ref.5
Glycosylation30951N-linked (GlcNAc...) Potential
Glycosylation33311N-linked (GlcNAc...) Potential
Glycosylation33531N-linked (GlcNAc...) Potential
Glycosylation34601N-linked (GlcNAc...) Potential
Glycosylation38601N-linked (GlcNAc...) Potential
Disulfide bond39 ↔ 88 By similarity
Disulfide bond78 ↔ 97 By similarity
Disulfide bond186 ↔ 212 By similarity
Disulfide bond245 ↔ 261 By similarity
Disulfide bond385 ↔ 390 By similarity
Disulfide bond478 ↔ 513 By similarity
Disulfide bond966 ↔ 976 By similarity

Experimental info

Sequence conflict41 – 422KD → N in AAI00608. Ref.2
Sequence conflict331 – 3322EL → KK in AAI00608. Ref.2
Sequence conflict3351L → K in AAI00608. Ref.2
Sequence conflict14771Q → K in AAH38263. Ref.2
Sequence conflict32651S → R in AAA37246. Ref.3

Sequences

Sequence LengthMass (Da)Tools
E9Q414 [UniParc].

Last modified April 5, 2011. Version 1.
Checksum: 09EADB2D499E7A82

FASTA4,505509,432
        10         20         30         40         50         60 
MGPRKPALRT PLLLLFLLLF LDTSVWAQDE VLENLSFSCP KDATRFKHLR KYVYNYEAES 

        70         80         90        100        110        120 
SSGVQGTADS RSATKINCKV ELEVPQICGF IMRTNQCTLK EVYGFNPEGK ALMKKTKNSE 

       130        140        150        160        170        180 
EFAAAMSRYE LKLAIPEGKQ IVLYPDKDEP KYILNIKRGI ISALLVPPET EEDQQELFLD 

       190        200        210        220        230        240 
TVYGNCSTQV TVNSRKGTVP TEMSTERNLQ QCDGFQPIST SVSPLALIKG LVHPLSTLIS 

       250        260        270        280        290        300 
SSQTCQYTLD PKRKHVSEAV CDEQHLFLPF SYKNKYGIMT RVTQKLSLED TPKINSRFFS 

       310        320        330        340        350        360 
EGTNRMGLAF ESTKSTSSPK QADAVLKTLQ ELKKLSISEQ NAQRANLFNK LVTELRGLTG 

       370        380        390        400        410        420 
EAITSLLPQL IEVSSPITLQ ALVQCGQPQC YTHILQWLKT EKAHPLLVDI VTYLMALIPN 

       430        440        450        460        470        480 
PSTQRLQEIF NTAKEQQSRA TLYALSHAVN SYFDVDHSRS PVLQDIAGYL LKQIDNECTG 

       490        500        510        520        530        540 
NEDHTFLILR VIGNMGRTME QVMPALKSSV LSCVRSTKPS LLIQKAALQA LRKMELEDEV 

       550        560        570        580        590        600 
RTILFDTFVN GVAPVEKRLA AYLLLMKNPS SSDINKIAQL LQWEQSEQVK NFVASHIANI 

       610        620        630        640        650        660 
LNSEELYVQD LKVLIKNALE NSQFPTIMDF RKFSRNYQIS KSASLPMFDP VSVKIEGNLI 

       670        680        690        700        710        720 
FDPSSYLPRE SLLKTTLTVF GLASLDLFEI GLEGKGFEPT LEALFGKQGF FPDSVNKALY 

       730        740        750        760        770        780 
WVNGRVPDGV SKVLVDHFGY TTDGKHEQDM VNGIMPIVDK LIKDLKSKEI PEARAYLRIL 

       790        800        810        820        830        840 
GKELSFVRLQ DLQVLGKLLL SGAQTLQGIP QMVVQAIREG SKNDLFLHYI FMDNAFELPT 

       850        860        870        880        890        900 
GAGLQLQVSS SGVFTPGIKA GVRLELANIQ AELVAKPSVS LEFVTNMGII IPDFAKSSVQ 

       910        920        930        940        950        960 
MNTNFFHESG LEARVALKAG QLKVIIPSPK RPVKLFSGSN TLHLVSTTKT EVIPPLVENR 

       970        980        990       1000       1010       1020 
QSWSTCKPLF TGMNYCTTGA YSNASSTESA SYYPLTGDTR YELELRPTGE VEQYSATATY 

      1030       1040       1050       1060       1070       1080 
ELLKEDKSLV DTLKFLVQAE GVQQSEATVL FKYNRRSRTL SSEVLIPGFD VNFGTILRVN 

      1090       1100       1110       1120       1130       1140 
DESAKDKNTY KLILDIQNKK ITEVSLVGHL SYDKKGDGKI KGVVSIPRLQ AEARSEVHTH 

      1150       1160       1170       1180       1190       1200 
WSSTKLLFQM DSSATAYGST ISKRVTWRYD NEIIEFDWNT GTNVDTKKVA SNFPVDLSHY 

      1210       1220       1230       1240       1250       1260 
PRMLHEYANG LLDHRVPQTD VTFRDMGSKL IVATNTWLQM ATRGLPYPQT LQDHLNSLSE 

      1270       1280       1290       1300       1310       1320 
LNLLKMGLSD FHIPDNLFLK TDGRVKYTMN RNKINIDIPL PLGGKSSKDL KMPESVRTPA 

      1330       1340       1350       1360       1370       1380 
LNFKSVGFHL PSREVQVPTF TIPKTHQLQV PLLGVLDLST NVYSNLYNWS ASYTGGNTSR 

      1390       1400       1410       1420       1430       1440 
DHFSLQAQYR MKTDSVVDLF SYSVQGSGET TYDSKNTFTL SCDGSLHHKF LDSKFKVSHV 

      1450       1460       1470       1480       1490       1500 
EKFGNSPVSK GLLTFETSSA LGPQMSATVH LDSKKKQHLY VKDIKVDGQF RASSFYAQGK 

      1510       1520       1530       1540       1550       1560 
YGLSCERDVT TGQLSGESNM RFNSTYFQGT NQIVGMYQDG ALSITSTSDL QDGIFKNTAS 

      1570       1580       1590       1600       1610       1620 
LKYENYELTL KSDSSGQYEN FAASNKLDVT FSTQSALLRS EHQANYKSLR LVTLLSGSLT 

      1630       1640       1650       1660       1670       1680 
SQGVELNADI LGTDKINTGA HKATLKIARD GLSTSATTNL KYSPLLLENE LNAELGLSGA 

      1690       1700       1710       1720       1730       1740 
SMKLSTNGRF KEHHAKFSLD GRAALTEVSL GSIYQAMILG ADSKNIFNFK LSREGLRLSN 

      1750       1760       1770       1780       1790       1800 
DLMGSYAEMK LDHTHSLNIA GLSLDFFSKM DNIYSGDKFY KQNFNLQLQP YSFITTLSND 

      1810       1820       1830       1840       1850       1860 
LRYGALDLTN NGRFRLEPLK LNVGGNFKGT YQNNELKHIY TISYTDLVVA SYRADTVAKV 

      1870       1880       1890       1900       1910       1920 
QGVEFSHRLN ADIEGLTSSV DVTTSYNSDP LHFNNVFHFS LAPFTLGIDT HTSGDGKLSF 

      1930       1940       1950       1960       1970       1980 
WGEHTGQLYS KFLLKAEPLA LIVSHDYKGS TSHSLPYESS ISTALEHTVS ALLTPAEQTS 

      1990       2000       2010       2020       2030       2040 
TWKFKTKLND KVYSQDFEAY NTKDKIGVEL SGRADLSGLY SPIKLPFFYS EPVNVLNGLE 

      2050       2060       2070       2080       2090       2100 
VNDAVDKPQE FTIIAVVKYD KNQDVHTINL PFFKSLPDYL ERNRRGMISL LEAMRGELQR 

      2110       2120       2130       2140       2150       2160 
LSVDQFVRKY RAALSRLPQQ IHHYLNASDW ERQVAGAKEK ITSFMENYRI TDNDVLIAID 

      2170       2180       2190       2200       2210       2220 
SAKINFNEKL SQLETYAIQF DQYIKDNYDP HDLKRTIAEI IDRIIEKLKI LDEQYHIRVN 

      2230       2240       2250       2260       2270       2280 
LAKSIHNLYL FVENVDLNQV SSSNTSWIQN VDSNYQVRIQ IQEKLQQLRT QIQNIDIQQL 

      2290       2300       2310       2320       2330       2340 
AAEVKRQMDA IDVTMHLDQL RTAILFQRIS DIIDRVKYFV MNLIEDFKVT EKINTFRVIV 

      2350       2360       2370       2380       2390       2400 
RELIEKYEVD QHIQVLMDKS VELAHRYSLS EPLQKLSNVL QRIEIKDYYE KLVGFIDDTV 

      2410       2420       2430       2440       2450       2460 
EWLKALSFKN TIEELNRLTD MLVKKLKAFD YHQFVDKTNS KIREMTQRIN AEIQALKLPQ 

      2470       2480       2490       2500       2510       2520 
KMEALKLLVE DFKTTVSNSL ERLKDTKVTV VIDWLQDILT QMKDHFQDTL EDVRDRIYQM 

      2530       2540       2550       2560       2570       2580 
DIQRELEHFL SLVNQVYSTL VTYMSDWWTL TAKNITDFAE QYSIQNWAES IKVLVEQGFI 

      2590       2600       2610       2620       2630       2640 
VPEMQTFLWT MPAFEVSLRA LQEGNFQTPV FIVPLTDLRI PSIRINFKML KNIKIPLRFS 

      2650       2660       2670       2680       2690       2700 
TPEFTLLNTF HVHSFTIDLL EIKAKIIRTI DQILSSELQW PLPEMYLRDL DVVNIPLARL 

      2710       2720       2730       2740       2750       2760 
TLPDFHVPEI TIPEFTIPNV NLKDLHVPDL HIPEFQLPHL SHTIEIPAFG KLHSILKIQS 

      2770       2780       2790       2800       2810       2820 
PLFILDANAN IQNVTTSGNK AEIVASVTAK GESQFEALNF DFQAQAQFLE LNPHPPVLKE 

      2830       2840       2850       2860       2870       2880 
SMNFSSKHVR MEHEGEIVFD GKAIEGKSDT VASLHTEKNE VEFNNGMTVK VNNQLTLDSH 

      2890       2900       2910       2920       2930       2940 
TKYFHKLSVP RLDFSSKASL NNEIKTLLEA GHVALTSSGT GSWNWACPNF SDEGIHSSQI 

      2950       2960       2970       2980       2990       3000 
SFTVDGPIAF VGLSNNINGK HLRVIQKLTY ESGFLNYSKF EVESKVESQH VGSSILTANG 

      3010       3020       3030       3040       3050       3060 
RALLKDAKAE MTGEHNANLN GKVIGTLKNS LFFSAQPFEI TASTNNEGNL KVGFPLKLTG 

      3070       3080       3090       3100       3110       3120 
KIDFLNNYAL FLSPRAQQAS WQASTRFNQY KYNQNFSAIN NEHNIEASIG MNGDANLDFL 

      3130       3140       3150       3160       3170       3180 
NIPLTIPEIN LPYTEFKTPL LKDFSIWEET GLKEFLKTTK QSFDLSVKAQ YKKNSDKHSI 

      3190       3200       3210       3220       3230       3240 
VVPLGMFYEF ILNNVNSWDR KFEKVRNNAL HFLTTSYNEA KIKVDKYKTE NSLNQPSGTF 

      3250       3260       3270       3280       3290       3300 
QNHGYTIPVV NIEVSPFAVE TLASSHVIPT AISTPSVTIP GPNIMVPSYK LVLPPLELPV 

      3310       3320       3330       3340       3350       3360 
FHGPGNLFKF FLPDFKGFNT IDNIYIPAMG NFTYDFSFKS SVITLNTNAG LYNQSDIVAH 

      3370       3380       3390       3400       3410       3420 
FLSSSSFVTD ALQYKLEGTS RLMRKRGLKL ATAVSLTNKF VKGSHDSTIS LTKKNMEASV 

      3430       3440       3450       3460       3470       3480 
RTTANLHAPI FSMNFKQELN GNTKSKPTVS SSIELNYDFN SSKLHSTATG GIDHKFSLES 

      3490       3500       3510       3520       3530       3540 
LTSYFSIESF TKGNIKSSFL SQEYSGSVAN EANVYLNSKG TRSSVRLQGA SKVDGIWNVE 

      3550       3560       3570       3580       3590       3600 
VGENFAGEAT LQRIYTTWEH NMKNHLQVYS YFFTKGKQTC RATLELSPWT MSTLLQVHVS 

      3610       3620       3630       3640       3650       3660 
QLSSLLDLHH FDQEVILKAN TKNQKISWKG GVQVESRVLQ HNAQFSNDQE EIRLDLAGSL 

      3670       3680       3690       3700       3710       3720 
DGQLWDLEAI FLPVYGKSLQ ELLQMDGKRQ YLQASTSLLY TKNPNGYLLS LPVQELADRF 

      3730       3740       3750       3760       3770       3780 
IIPGIKLNDF SGVKIYKKLS TSPFALNLTM LPKVKFPGID LLTQYSTPEG SSVPIFEATI 

      3790       3800       3810       3820       3830       3840 
PEIHLTVSQF TLPKSLPVGN TVFDLNKLAN MIADVDLPSV TLPEQTIVIP PLEFSVPAGI 

      3850       3860       3870       3880       3890       3900 
FIPFFGELTA RAGMASPLYN VTWSAGWKTK ADHVETFLDS MCTSTLQFLE YALKVVETHK 

      3910       3920       3930       3940       3950       3960 
IEEDLLTYNI KGTLQHCDFN VEYNEDGLFK GLWDWQGEAH LDITSPALTD FHLYYKEDKT 

      3970       3980       3990       4000       4010       4020 
SLSASAASST IGTVGLDSST DDQSVELNVY FHPQSPPEKK LSIFKTEWRY KESDGERYIK 

      4030       4040       4050       4060       4070       4080 
INWEEEAASR LLGSLKSNVP KASKAIYDYA NKYHLEYVSS ELRKSLQVNA EHARRMVDEM 

      4090       4100       4110       4120       4130       4140 
NMSFQRVARD TYQNLYEEML AQKSLSIPEN LKKRVLDSIV HVTQKYHMAV MWLMDSFIHF 

      4150       4160       4170       4180       4190       4200 
LKFNRVQFPG YAGTYTVDEL YTIVMKETKK SLSQLFNGLG NLLSYVQNQV EKSRLINDIT 

      4210       4220       4230       4240       4250       4260 
FKCPFFSKPC KLKDLILIFR EELNILSNIG QQDIKFTTIL SSLQGFLERV LDIIEEQIKC 

      4270       4280       4290       4300       4310       4320 
LKDNESTCVA DHINMVFKIQ VPYAFKSLRE DIYFVLGEFN DFLQSILQEG SYKLQQVHQY 

      4330       4340       4350       4360       4370       4380 
MKALREEYFD PSMVGWTVKY YEIEENMVEL IKTLLVSFRD VYSEYSVTAA DFASKMSTQV 

      4390       4400       4410       4420       4430       4440 
EQFVSRDIRE YLSMLTDING KWMEKIAELS IVAKETMKSW VTAVAKIMSD YPQQFHSNLQ 

      4450       4460       4470       4480       4490       4500 
DFSDQLSSYY EKFVGESTRL IDLSIQNYHV FLRYITELLR KLQVATANNV SPYIKLAQGE 


LMITF 

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References

« Hide 'large scale' references
[1]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-1477 AND 3004-4505.
Strain: FVB/N.
Tissue: Liver.
[3]"Sequence of the putative low-density lipoprotein receptor-binding regions of apolipoprotein B in mouse and hamster."
Smith T.J., Hautamaa D., Maeda N.
Gene 87:309-310(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 2734-3518.
[4]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2962-4505.
Strain: C57BL/6J.
Tissue: Placenta.
[5]"Proteome-wide characterization of N-glycosylation events by diagonal chromatography."
Ghesquiere B., Van Damme J., Martens L., Vandekerckhove J., Gevaert K.
J. Proteome Res. 5:2438-2447(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-2773 AND ASN-2976.
Strain: C57BL/6.
Tissue: Plasma.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC163900 Genomic DNA. No translation available.
BC038263 mRNA. Translation: AAH38263.1.
BC100607 mRNA. Translation: AAI00608.1.
BC141357 mRNA. Translation: AAI41358.1. Different initiation.
BC141360 mRNA. Translation: AAI41361.1. Different initiation.
M35186 Genomic DNA. Translation: AAA37246.1.
X15191 Genomic DNA. Translation: CAA33265.1.
AK147540 mRNA. Translation: BAE27983.1. Different initiation.
RefSeqNP_033823.2. NM_009693.2.
UniGeneMm.221239.

3D structure databases

ProteinModelPortalE9Q414.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActE9Q414. 3 interactions.
MINTMINT-1846293.
STRING10090.ENSMUSP00000035761.

Proteomic databases

PRIDEE9Q414.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000037811; ENSMUSP00000036044; ENSMUSG00000020609.
GeneID238055.
KEGGmmu:238055.
UCSCuc007mzf.2. mouse.

Organism-specific databases

CTD338.
MGIMGI:88052. Apob.

Phylogenomic databases

GeneTreeENSGT00590000083139.
KOK14462.
OMAHIPEFQL.
OrthoDBEOG7VB2DG.
TreeFamTF331316.

Enzyme and pathway databases

ReactomeREACT_196573. Binding and Uptake of Ligands by Scavenger Receptors.

Gene expression databases

BgeeE9Q414.

Family and domain databases

Gene3D1.25.10.20. 1 hit.
2.20.50.20. 2 hits.
2.20.80.10. 1 hit.
2.30.230.10. 1 hit.
InterProIPR022176. ApoB100_C.
IPR015819. Lipid_transp_b-sht_shell.
IPR001747. Lipid_transpt_N.
IPR009454. Lipid_transpt_open_b-sht.
IPR015816. Vitellinogen_b-sht_N.
IPR015255. Vitellinogen_open_b-sht.
IPR015817. Vitellinogen_open_b-sht_sub1.
IPR015818. Vitellinogen_open_b-sht_sub2.
IPR011030. Vitellinogen_superhlx.
[Graphical view]
PfamPF12491. ApoB100_C. 1 hit.
PF06448. DUF1081. 1 hit.
PF09172. DUF1943. 1 hit.
PF01347. Vitellogenin_N. 1 hit.
[Graphical view]
SMARTSM00638. LPD_N. 1 hit.
[Graphical view]
SUPFAMSSF48431. SSF48431. 1 hit.
SSF56968. SSF56968. 2 hits.
PROSITEPS51211. VITELLOGENIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSAPOB. mouse.
NextBio383653.
PROE9Q414.
SOURCESearch...

Entry information

Entry nameAPOB_MOUSE
AccessionPrimary (citable) accession number: E9Q414
Secondary accession number(s): Q3UH74 expand/collapse secondary AC list , Q497D8, Q61314, Q61318, Q8CGG8
Entry history
Integrated into UniProtKB/Swiss-Prot: February 6, 2013
Last sequence update: April 5, 2011
Last modified: April 16, 2014
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot