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E9Q414

- APOB_MOUSE

UniProt

E9Q414 - APOB_MOUSE

Protein

Apolipoprotein B-100

Gene

Apob

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 35 (01 Oct 2014)
      Sequence version 1 (05 Apr 2011)
      Previous versions | rss
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    Functioni

    Apolipoprotein B is a major protein constituent of chylomicrons (apo B-48), LDL (apo B-100) and VLDL (apo B-100). Apo B-100 functions as a recognition signal for the cellular binding and internalization of LDL particles by the apoB/E receptor.

    GO - Molecular functioni

    1. cholesterol transporter activity Source: Ensembl
    2. heparin binding Source: UniProtKB-KW
    3. phospholipid binding Source: Ensembl

    GO - Biological processi

    1. artery morphogenesis Source: MGI
    2. cellular response to prostaglandin stimulus Source: Ensembl
    3. cellular response to tumor necrosis factor Source: Ensembl
    4. cholesterol efflux Source: MGI
    5. cholesterol homeostasis Source: MGI
    6. cholesterol metabolic process Source: UniProtKB-KW
    7. cholesterol transport Source: MGI
    8. fertilization Source: MGI
    9. in utero embryonic development Source: MGI
    10. lipid catabolic process Source: MGI
    11. lipid metabolic process Source: MGI
    12. lipoprotein biosynthetic process Source: MGI
    13. lipoprotein catabolic process Source: MGI
    14. lipoprotein metabolic process Source: MGI
    15. lipoprotein transport Source: MGI
    16. low-density lipoprotein particle clearance Source: Ensembl
    17. low-density lipoprotein particle remodeling Source: Ensembl
    18. nervous system development Source: MGI
    19. positive regulation of cholesterol storage Source: Ensembl
    20. positive regulation of macrophage derived foam cell differentiation Source: Ensembl
    21. post-embryonic development Source: MGI
    22. regulation of cholesterol biosynthetic process Source: MGI
    23. response to carbohydrate Source: Ensembl
    24. response to lipopolysaccharide Source: Ensembl
    25. response to selenium ion Source: Ensembl
    26. response to virus Source: Ensembl
    27. spermatogenesis Source: MGI
    28. sperm motility Source: MGI
    29. triglyceride catabolic process Source: MGI
    30. triglyceride mobilization Source: MGI

    Keywords - Biological processi

    Cholesterol metabolism, Lipid metabolism, Lipid transport, Steroid metabolism, Sterol metabolism, Transport

    Keywords - Ligandi

    Heparin-binding

    Enzyme and pathway databases

    ReactomeiREACT_196581. Scavenging by Class A Receptors.
    REACT_196592. Scavenging by Class B Receptors.
    REACT_196594. Scavenging by Class H Receptors.
    REACT_196603. Scavenging by Class F Receptors.
    REACT_198569. Retinoid metabolism and transport.
    REACT_216017. Chylomicron-mediated lipid transport.
    REACT_222614. LDL-mediated lipid transport.
    REACT_225233. Cell surface interactions at the vascular wall.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Apolipoprotein B-100
    Short name:
    Apo B-100
    Cleaved into the following chain:
    Apolipoprotein B-48
    Short name:
    Apo B-48
    Gene namesi
    Name:Apob
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 12

    Organism-specific databases

    MGIiMGI:88052. Apob.

    Subcellular locationi

    Cytoplasm By similarity. Secreted By similarity

    GO - Cellular componenti

    1. endoplasmic reticulum Source: MGI
    2. extracellular region Source: Reactome
    3. intermediate-density lipoprotein particle Source: Ensembl
    4. low-density lipoprotein particle Source: UniProtKB-KW
    5. mature chylomicron Source: Ensembl
    6. very-low-density lipoprotein particle Source: UniProtKB-KW
    7. vesicle lumen Source: Ensembl
    8. vesicle membrane Source: Ensembl

    Keywords - Cellular componenti

    Chylomicron, Cytoplasm, LDL, Secreted, VLDL

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2727Sequence AnalysisAdd
    BLAST
    Chaini28 – 45054478Apolipoprotein B-100PRO_0000420969Add
    BLAST
    Chaini28 – 21782151Apolipoprotein B-48PRO_0000420970Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi34 – 341N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi39 ↔ 88PROSITE-ProRule annotation
    Disulfide bondi78 ↔ 97PROSITE-ProRule annotation
    Glycosylationi185 – 1851N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi186 ↔ 212PROSITE-ProRule annotation
    Disulfide bondi245 ↔ 261PROSITE-ProRule annotation
    Disulfide bondi385 ↔ 390PROSITE-ProRule annotation
    Disulfide bondi478 ↔ 513PROSITE-ProRule annotation
    Disulfide bondi966 ↔ 976PROSITE-ProRule annotation
    Glycosylationi983 – 9831N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1368 – 13681N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1377 – 13771N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1523 – 15231N-linked (GlcNAc...)Sequence Analysis
    Modified residuei2005 – 20051N6-acetyllysineBy similarity
    Glycosylationi2554 – 25541N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi2773 – 27731N-linked (GlcNAc...)1 Publication
    Glycosylationi2976 – 29761N-linked (GlcNAc...)1 Publication
    Glycosylationi3095 – 30951N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi3331 – 33311N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi3353 – 33531N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi3460 – 34601N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi3860 – 38601N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    Palmitoylated; structural requirement for proper assembly of the hydrophobic core of the lipoprotein particle.By similarity

    Keywords - PTMi

    Acetylation, Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

    Proteomic databases

    MaxQBiE9Q414.
    PRIDEiE9Q414.

    Expressioni

    Gene expression databases

    BgeeiE9Q414.

    Interactioni

    Subunit structurei

    Interacts with PCSK9.By similarity

    Protein-protein interaction databases

    IntActiE9Q414. 3 interactions.
    MINTiMINT-1846293.
    STRINGi10090.ENSMUSP00000035761.

    Structurei

    3D structure databases

    ProteinModelPortaliE9Q414.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini46 – 672627VitellogeninPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni32 – 12695Heparin-bindingBy similarityAdd
    BLAST
    Regioni232 – 30675Heparin-bindingBy similarityAdd
    BLAST
    Regioni902 – 95958Heparin-bindingBy similarityAdd
    BLAST
    Regioni2042 – 2177136Heparin-bindingBy similarityAdd
    BLAST
    Regioni3155 – 323076Heparin-bindingBy similarityAdd
    BLAST
    Regioni3168 – 317811Basic (possible receptor binding region)By similarityAdd
    BLAST
    Regioni3368 – 338821LDL receptor bindingBy similarityAdd
    BLAST
    Regioni3378 – 3511134Heparin-bindingBy similarityAdd
    BLAST
    Regioni3381 – 33899Basic (possible receptor binding region)By similarity

    Sequence similaritiesi

    Contains 1 vitellogenin domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil, Repeat, Signal

    Phylogenomic databases

    GeneTreeiENSGT00590000083139.
    KOiK14462.
    OMAiHIPEFQL.
    OrthoDBiEOG7VB2DG.
    TreeFamiTF331316.

    Family and domain databases

    Gene3Di1.25.10.20. 1 hit.
    2.20.50.20. 2 hits.
    2.20.80.10. 1 hit.
    2.30.230.10. 1 hit.
    InterProiIPR022176. ApoB100_C.
    IPR015819. Lipid_transp_b-sht_shell.
    IPR001747. Lipid_transpt_N.
    IPR009454. Lipid_transpt_open_b-sht.
    IPR015816. Vitellinogen_b-sht_N.
    IPR015255. Vitellinogen_open_b-sht.
    IPR015817. Vitellinogen_open_b-sht_sub1.
    IPR015818. Vitellinogen_open_b-sht_sub2.
    IPR011030. Vitellinogen_superhlx.
    [Graphical view]
    PfamiPF12491. ApoB100_C. 1 hit.
    PF06448. DUF1081. 1 hit.
    PF09172. DUF1943. 1 hit.
    PF01347. Vitellogenin_N. 1 hit.
    [Graphical view]
    SMARTiSM00638. LPD_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF48431. SSF48431. 1 hit.
    SSF56968. SSF56968. 2 hits.
    PROSITEiPS51211. VITELLOGENIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    E9Q414-1 [UniParc]FASTAAdd to Basket

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    MGPRKPALRT PLLLLFLLLF LDTSVWAQDE VLENLSFSCP KDATRFKHLR     50
    KYVYNYEAES SSGVQGTADS RSATKINCKV ELEVPQICGF IMRTNQCTLK 100
    EVYGFNPEGK ALMKKTKNSE EFAAAMSRYE LKLAIPEGKQ IVLYPDKDEP 150
    KYILNIKRGI ISALLVPPET EEDQQELFLD TVYGNCSTQV TVNSRKGTVP 200
    TEMSTERNLQ QCDGFQPIST SVSPLALIKG LVHPLSTLIS SSQTCQYTLD 250
    PKRKHVSEAV CDEQHLFLPF SYKNKYGIMT RVTQKLSLED TPKINSRFFS 300
    EGTNRMGLAF ESTKSTSSPK QADAVLKTLQ ELKKLSISEQ NAQRANLFNK 350
    LVTELRGLTG EAITSLLPQL IEVSSPITLQ ALVQCGQPQC YTHILQWLKT 400
    EKAHPLLVDI VTYLMALIPN PSTQRLQEIF NTAKEQQSRA TLYALSHAVN 450
    SYFDVDHSRS PVLQDIAGYL LKQIDNECTG NEDHTFLILR VIGNMGRTME 500
    QVMPALKSSV LSCVRSTKPS LLIQKAALQA LRKMELEDEV RTILFDTFVN 550
    GVAPVEKRLA AYLLLMKNPS SSDINKIAQL LQWEQSEQVK NFVASHIANI 600
    LNSEELYVQD LKVLIKNALE NSQFPTIMDF RKFSRNYQIS KSASLPMFDP 650
    VSVKIEGNLI FDPSSYLPRE SLLKTTLTVF GLASLDLFEI GLEGKGFEPT 700
    LEALFGKQGF FPDSVNKALY WVNGRVPDGV SKVLVDHFGY TTDGKHEQDM 750
    VNGIMPIVDK LIKDLKSKEI PEARAYLRIL GKELSFVRLQ DLQVLGKLLL 800
    SGAQTLQGIP QMVVQAIREG SKNDLFLHYI FMDNAFELPT GAGLQLQVSS 850
    SGVFTPGIKA GVRLELANIQ AELVAKPSVS LEFVTNMGII IPDFAKSSVQ 900
    MNTNFFHESG LEARVALKAG QLKVIIPSPK RPVKLFSGSN TLHLVSTTKT 950
    EVIPPLVENR QSWSTCKPLF TGMNYCTTGA YSNASSTESA SYYPLTGDTR 1000
    YELELRPTGE VEQYSATATY ELLKEDKSLV DTLKFLVQAE GVQQSEATVL 1050
    FKYNRRSRTL SSEVLIPGFD VNFGTILRVN DESAKDKNTY KLILDIQNKK 1100
    ITEVSLVGHL SYDKKGDGKI KGVVSIPRLQ AEARSEVHTH WSSTKLLFQM 1150
    DSSATAYGST ISKRVTWRYD NEIIEFDWNT GTNVDTKKVA SNFPVDLSHY 1200
    PRMLHEYANG LLDHRVPQTD VTFRDMGSKL IVATNTWLQM ATRGLPYPQT 1250
    LQDHLNSLSE LNLLKMGLSD FHIPDNLFLK TDGRVKYTMN RNKINIDIPL 1300
    PLGGKSSKDL KMPESVRTPA LNFKSVGFHL PSREVQVPTF TIPKTHQLQV 1350
    PLLGVLDLST NVYSNLYNWS ASYTGGNTSR DHFSLQAQYR MKTDSVVDLF 1400
    SYSVQGSGET TYDSKNTFTL SCDGSLHHKF LDSKFKVSHV EKFGNSPVSK 1450
    GLLTFETSSA LGPQMSATVH LDSKKKQHLY VKDIKVDGQF RASSFYAQGK 1500
    YGLSCERDVT TGQLSGESNM RFNSTYFQGT NQIVGMYQDG ALSITSTSDL 1550
    QDGIFKNTAS LKYENYELTL KSDSSGQYEN FAASNKLDVT FSTQSALLRS 1600
    EHQANYKSLR LVTLLSGSLT SQGVELNADI LGTDKINTGA HKATLKIARD 1650
    GLSTSATTNL KYSPLLLENE LNAELGLSGA SMKLSTNGRF KEHHAKFSLD 1700
    GRAALTEVSL GSIYQAMILG ADSKNIFNFK LSREGLRLSN DLMGSYAEMK 1750
    LDHTHSLNIA GLSLDFFSKM DNIYSGDKFY KQNFNLQLQP YSFITTLSND 1800
    LRYGALDLTN NGRFRLEPLK LNVGGNFKGT YQNNELKHIY TISYTDLVVA 1850
    SYRADTVAKV QGVEFSHRLN ADIEGLTSSV DVTTSYNSDP LHFNNVFHFS 1900
    LAPFTLGIDT HTSGDGKLSF WGEHTGQLYS KFLLKAEPLA LIVSHDYKGS 1950
    TSHSLPYESS ISTALEHTVS ALLTPAEQTS TWKFKTKLND KVYSQDFEAY 2000
    NTKDKIGVEL SGRADLSGLY SPIKLPFFYS EPVNVLNGLE VNDAVDKPQE 2050
    FTIIAVVKYD KNQDVHTINL PFFKSLPDYL ERNRRGMISL LEAMRGELQR 2100
    LSVDQFVRKY RAALSRLPQQ IHHYLNASDW ERQVAGAKEK ITSFMENYRI 2150
    TDNDVLIAID SAKINFNEKL SQLETYAIQF DQYIKDNYDP HDLKRTIAEI 2200
    IDRIIEKLKI LDEQYHIRVN LAKSIHNLYL FVENVDLNQV SSSNTSWIQN 2250
    VDSNYQVRIQ IQEKLQQLRT QIQNIDIQQL AAEVKRQMDA IDVTMHLDQL 2300
    RTAILFQRIS DIIDRVKYFV MNLIEDFKVT EKINTFRVIV RELIEKYEVD 2350
    QHIQVLMDKS VELAHRYSLS EPLQKLSNVL QRIEIKDYYE KLVGFIDDTV 2400
    EWLKALSFKN TIEELNRLTD MLVKKLKAFD YHQFVDKTNS KIREMTQRIN 2450
    AEIQALKLPQ KMEALKLLVE DFKTTVSNSL ERLKDTKVTV VIDWLQDILT 2500
    QMKDHFQDTL EDVRDRIYQM DIQRELEHFL SLVNQVYSTL VTYMSDWWTL 2550
    TAKNITDFAE QYSIQNWAES IKVLVEQGFI VPEMQTFLWT MPAFEVSLRA 2600
    LQEGNFQTPV FIVPLTDLRI PSIRINFKML KNIKIPLRFS TPEFTLLNTF 2650
    HVHSFTIDLL EIKAKIIRTI DQILSSELQW PLPEMYLRDL DVVNIPLARL 2700
    TLPDFHVPEI TIPEFTIPNV NLKDLHVPDL HIPEFQLPHL SHTIEIPAFG 2750
    KLHSILKIQS PLFILDANAN IQNVTTSGNK AEIVASVTAK GESQFEALNF 2800
    DFQAQAQFLE LNPHPPVLKE SMNFSSKHVR MEHEGEIVFD GKAIEGKSDT 2850
    VASLHTEKNE VEFNNGMTVK VNNQLTLDSH TKYFHKLSVP RLDFSSKASL 2900
    NNEIKTLLEA GHVALTSSGT GSWNWACPNF SDEGIHSSQI SFTVDGPIAF 2950
    VGLSNNINGK HLRVIQKLTY ESGFLNYSKF EVESKVESQH VGSSILTANG 3000
    RALLKDAKAE MTGEHNANLN GKVIGTLKNS LFFSAQPFEI TASTNNEGNL 3050
    KVGFPLKLTG KIDFLNNYAL FLSPRAQQAS WQASTRFNQY KYNQNFSAIN 3100
    NEHNIEASIG MNGDANLDFL NIPLTIPEIN LPYTEFKTPL LKDFSIWEET 3150
    GLKEFLKTTK QSFDLSVKAQ YKKNSDKHSI VVPLGMFYEF ILNNVNSWDR 3200
    KFEKVRNNAL HFLTTSYNEA KIKVDKYKTE NSLNQPSGTF QNHGYTIPVV 3250
    NIEVSPFAVE TLASSHVIPT AISTPSVTIP GPNIMVPSYK LVLPPLELPV 3300
    FHGPGNLFKF FLPDFKGFNT IDNIYIPAMG NFTYDFSFKS SVITLNTNAG 3350
    LYNQSDIVAH FLSSSSFVTD ALQYKLEGTS RLMRKRGLKL ATAVSLTNKF 3400
    VKGSHDSTIS LTKKNMEASV RTTANLHAPI FSMNFKQELN GNTKSKPTVS 3450
    SSIELNYDFN SSKLHSTATG GIDHKFSLES LTSYFSIESF TKGNIKSSFL 3500
    SQEYSGSVAN EANVYLNSKG TRSSVRLQGA SKVDGIWNVE VGENFAGEAT 3550
    LQRIYTTWEH NMKNHLQVYS YFFTKGKQTC RATLELSPWT MSTLLQVHVS 3600
    QLSSLLDLHH FDQEVILKAN TKNQKISWKG GVQVESRVLQ HNAQFSNDQE 3650
    EIRLDLAGSL DGQLWDLEAI FLPVYGKSLQ ELLQMDGKRQ YLQASTSLLY 3700
    TKNPNGYLLS LPVQELADRF IIPGIKLNDF SGVKIYKKLS TSPFALNLTM 3750
    LPKVKFPGID LLTQYSTPEG SSVPIFEATI PEIHLTVSQF TLPKSLPVGN 3800
    TVFDLNKLAN MIADVDLPSV TLPEQTIVIP PLEFSVPAGI FIPFFGELTA 3850
    RAGMASPLYN VTWSAGWKTK ADHVETFLDS MCTSTLQFLE YALKVVETHK 3900
    IEEDLLTYNI KGTLQHCDFN VEYNEDGLFK GLWDWQGEAH LDITSPALTD 3950
    FHLYYKEDKT SLSASAASST IGTVGLDSST DDQSVELNVY FHPQSPPEKK 4000
    LSIFKTEWRY KESDGERYIK INWEEEAASR LLGSLKSNVP KASKAIYDYA 4050
    NKYHLEYVSS ELRKSLQVNA EHARRMVDEM NMSFQRVARD TYQNLYEEML 4100
    AQKSLSIPEN LKKRVLDSIV HVTQKYHMAV MWLMDSFIHF LKFNRVQFPG 4150
    YAGTYTVDEL YTIVMKETKK SLSQLFNGLG NLLSYVQNQV EKSRLINDIT 4200
    FKCPFFSKPC KLKDLILIFR EELNILSNIG QQDIKFTTIL SSLQGFLERV 4250
    LDIIEEQIKC LKDNESTCVA DHINMVFKIQ VPYAFKSLRE DIYFVLGEFN 4300
    DFLQSILQEG SYKLQQVHQY MKALREEYFD PSMVGWTVKY YEIEENMVEL 4350
    IKTLLVSFRD VYSEYSVTAA DFASKMSTQV EQFVSRDIRE YLSMLTDING 4400
    KWMEKIAELS IVAKETMKSW VTAVAKIMSD YPQQFHSNLQ DFSDQLSSYY 4450
    EKFVGESTRL IDLSIQNYHV FLRYITELLR KLQVATANNV SPYIKLAQGE 4500
    LMITF 4505
    Length:4,505
    Mass (Da):509,432
    Last modified:April 5, 2011 - v1
    Checksum:i09EADB2D499E7A82
    GO

    Sequence cautioni

    The sequence AAI41358.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence AAI41361.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence BAE27983.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti41 – 422KD → N in AAI00608. (PubMed:15489334)Curated
    Sequence conflicti331 – 3322EL → KK in AAI00608. (PubMed:15489334)Curated
    Sequence conflicti335 – 3351L → K in AAI00608. (PubMed:15489334)Curated
    Sequence conflicti1477 – 14771Q → K in AAH38263. (PubMed:15489334)Curated
    Sequence conflicti3265 – 32651S → R in AAA37246. (PubMed:2332175)Curated

    RNA editingi

    The stop codon (UAA) at position 2179 is created by RNA editing. Apo B-48, derived from the fully edited RNA, is produced only in the intestine and is found in chylomicrons. Apo B-48 is a shortened form of apo B-100 which lacks the LDL-receptor region. The unedited version (apo B-100) is produced by the liver and is found in the VLDL and LDL By similarity.By similarity

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC163900 Genomic DNA. No translation available.
    BC038263 mRNA. Translation: AAH38263.1.
    BC100607 mRNA. Translation: AAI00608.1.
    BC141357 mRNA. Translation: AAI41358.1. Different initiation.
    BC141360 mRNA. Translation: AAI41361.1. Different initiation.
    M35186 Genomic DNA. Translation: AAA37246.1.
    X15191 Genomic DNA. Translation: CAA33265.1.
    AK147540 mRNA. Translation: BAE27983.1. Different initiation.
    CCDSiCCDS49022.1.
    RefSeqiNP_033823.2. NM_009693.2.
    UniGeneiMm.221239.

    Genome annotation databases

    EnsembliENSMUST00000037811; ENSMUSP00000036044; ENSMUSG00000020609.
    GeneIDi238055.
    KEGGimmu:238055.
    UCSCiuc007mzf.2. mouse.

    Keywords - Coding sequence diversityi

    RNA editing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC163900 Genomic DNA. No translation available.
    BC038263 mRNA. Translation: AAH38263.1 .
    BC100607 mRNA. Translation: AAI00608.1 .
    BC141357 mRNA. Translation: AAI41358.1 . Different initiation.
    BC141360 mRNA. Translation: AAI41361.1 . Different initiation.
    M35186 Genomic DNA. Translation: AAA37246.1 .
    X15191 Genomic DNA. Translation: CAA33265.1 .
    AK147540 mRNA. Translation: BAE27983.1 . Different initiation.
    CCDSi CCDS49022.1.
    RefSeqi NP_033823.2. NM_009693.2.
    UniGenei Mm.221239.

    3D structure databases

    ProteinModelPortali E9Q414.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi E9Q414. 3 interactions.
    MINTi MINT-1846293.
    STRINGi 10090.ENSMUSP00000035761.

    Proteomic databases

    MaxQBi E9Q414.
    PRIDEi E9Q414.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000037811 ; ENSMUSP00000036044 ; ENSMUSG00000020609 .
    GeneIDi 238055.
    KEGGi mmu:238055.
    UCSCi uc007mzf.2. mouse.

    Organism-specific databases

    CTDi 338.
    MGIi MGI:88052. Apob.

    Phylogenomic databases

    GeneTreei ENSGT00590000083139.
    KOi K14462.
    OMAi HIPEFQL.
    OrthoDBi EOG7VB2DG.
    TreeFami TF331316.

    Enzyme and pathway databases

    Reactomei REACT_196581. Scavenging by Class A Receptors.
    REACT_196592. Scavenging by Class B Receptors.
    REACT_196594. Scavenging by Class H Receptors.
    REACT_196603. Scavenging by Class F Receptors.
    REACT_198569. Retinoid metabolism and transport.
    REACT_216017. Chylomicron-mediated lipid transport.
    REACT_222614. LDL-mediated lipid transport.
    REACT_225233. Cell surface interactions at the vascular wall.

    Miscellaneous databases

    ChiTaRSi APOB. mouse.
    NextBioi 383653.
    PROi E9Q414.
    SOURCEi Search...

    Gene expression databases

    Bgeei E9Q414.

    Family and domain databases

    Gene3Di 1.25.10.20. 1 hit.
    2.20.50.20. 2 hits.
    2.20.80.10. 1 hit.
    2.30.230.10. 1 hit.
    InterProi IPR022176. ApoB100_C.
    IPR015819. Lipid_transp_b-sht_shell.
    IPR001747. Lipid_transpt_N.
    IPR009454. Lipid_transpt_open_b-sht.
    IPR015816. Vitellinogen_b-sht_N.
    IPR015255. Vitellinogen_open_b-sht.
    IPR015817. Vitellinogen_open_b-sht_sub1.
    IPR015818. Vitellinogen_open_b-sht_sub2.
    IPR011030. Vitellinogen_superhlx.
    [Graphical view ]
    Pfami PF12491. ApoB100_C. 1 hit.
    PF06448. DUF1081. 1 hit.
    PF09172. DUF1943. 1 hit.
    PF01347. Vitellogenin_N. 1 hit.
    [Graphical view ]
    SMARTi SM00638. LPD_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48431. SSF48431. 1 hit.
    SSF56968. SSF56968. 2 hits.
    PROSITEi PS51211. VITELLOGENIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-1477 AND 3004-4505.
      Strain: FVB/N.
      Tissue: Liver.
    3. "Sequence of the putative low-density lipoprotein receptor-binding regions of apolipoprotein B in mouse and hamster."
      Smith T.J., Hautamaa D., Maeda N.
      Gene 87:309-310(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 2734-3518.
    4. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2962-4505.
      Strain: C57BL/6J.
      Tissue: Placenta.
    5. "Proteome-wide characterization of N-glycosylation events by diagonal chromatography."
      Ghesquiere B., Van Damme J., Martens L., Vandekerckhove J., Gevaert K.
      J. Proteome Res. 5:2438-2447(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-2773 AND ASN-2976.
      Strain: C57BL/6.
      Tissue: Plasma.

    Entry informationi

    Entry nameiAPOB_MOUSE
    AccessioniPrimary (citable) accession number: E9Q414
    Secondary accession number(s): Q3UH74
    , Q497D8, Q61314, Q61318, Q8CGG8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 6, 2013
    Last sequence update: April 5, 2011
    Last modified: October 1, 2014
    This is version 35 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3