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E9Q414

- APOB_MOUSE

UniProt

E9Q414 - APOB_MOUSE

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Protein

Apolipoprotein B-100

Gene

Apob

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Apolipoprotein B is a major protein constituent of chylomicrons (apo B-48), LDL (apo B-100) and VLDL (apo B-100). Apo B-100 functions as a recognition signal for the cellular binding and internalization of LDL particles by the apoB/E receptor.

GO - Molecular functioni

  1. cholesterol transporter activity Source: Ensembl
  2. heparin binding Source: UniProtKB-KW
  3. phospholipid binding Source: Ensembl

GO - Biological processi

  1. artery morphogenesis Source: MGI
  2. cellular response to prostaglandin stimulus Source: Ensembl
  3. cellular response to tumor necrosis factor Source: Ensembl
  4. cholesterol efflux Source: MGI
  5. cholesterol homeostasis Source: MGI
  6. cholesterol metabolic process Source: UniProtKB-KW
  7. cholesterol transport Source: MGI
  8. fertilization Source: MGI
  9. in utero embryonic development Source: MGI
  10. lipid catabolic process Source: MGI
  11. lipid metabolic process Source: MGI
  12. lipoprotein biosynthetic process Source: MGI
  13. lipoprotein catabolic process Source: MGI
  14. lipoprotein metabolic process Source: MGI
  15. lipoprotein transport Source: MGI
  16. low-density lipoprotein particle clearance Source: Ensembl
  17. low-density lipoprotein particle remodeling Source: Ensembl
  18. nervous system development Source: MGI
  19. positive regulation of cholesterol storage Source: Ensembl
  20. positive regulation of macrophage derived foam cell differentiation Source: Ensembl
  21. post-embryonic development Source: MGI
  22. regulation of cholesterol biosynthetic process Source: MGI
  23. response to carbohydrate Source: Ensembl
  24. response to lipopolysaccharide Source: Ensembl
  25. response to selenium ion Source: Ensembl
  26. response to virus Source: Ensembl
  27. spermatogenesis Source: MGI
  28. sperm motility Source: MGI
  29. triglyceride catabolic process Source: MGI
  30. triglyceride mobilization Source: MGI
Complete GO annotation...

Keywords - Biological processi

Cholesterol metabolism, Lipid metabolism, Lipid transport, Steroid metabolism, Sterol metabolism, Transport

Keywords - Ligandi

Heparin-binding

Enzyme and pathway databases

ReactomeiREACT_196581. Scavenging by Class A Receptors.
REACT_196592. Scavenging by Class B Receptors.
REACT_196594. Scavenging by Class H Receptors.
REACT_196603. Scavenging by Class F Receptors.
REACT_198569. Retinoid metabolism and transport.
REACT_216017. Chylomicron-mediated lipid transport.
REACT_222614. LDL-mediated lipid transport.
REACT_225233. Cell surface interactions at the vascular wall.
REACT_250548. Platelet sensitization by LDL.

Names & Taxonomyi

Protein namesi
Recommended name:
Apolipoprotein B-100
Short name:
Apo B-100
Cleaved into the following chain:
Apolipoprotein B-48
Short name:
Apo B-48
Gene namesi
Name:Apob
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 12

Organism-specific databases

MGIiMGI:88052. Apob.

Subcellular locationi

Cytoplasm By similarity. Secreted By similarity

GO - Cellular componenti

  1. actin cytoskeleton Source: Ensembl
  2. endoplasmic reticulum Source: MGI
  3. extracellular region Source: Reactome
  4. Golgi apparatus Source: Ensembl
  5. intermediate-density lipoprotein particle Source: Ensembl
  6. low-density lipoprotein particle Source: UniProtKB-KW
  7. mature chylomicron Source: Ensembl
  8. plasma membrane Source: Ensembl
  9. very-low-density lipoprotein particle Source: UniProtKB-KW
  10. vesicle lumen Source: Ensembl
  11. vesicle membrane Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Chylomicron, Cytoplasm, LDL, Secreted, VLDL

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2727Sequence AnalysisAdd
BLAST
Chaini28 – 45054478Apolipoprotein B-100PRO_0000420969Add
BLAST
Chaini28 – 21782151Apolipoprotein B-48PRO_0000420970Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi34 – 341N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi39 ↔ 88PROSITE-ProRule annotation
Disulfide bondi78 ↔ 97PROSITE-ProRule annotation
Glycosylationi185 – 1851N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi186 ↔ 212PROSITE-ProRule annotation
Disulfide bondi245 ↔ 261PROSITE-ProRule annotation
Disulfide bondi385 ↔ 390PROSITE-ProRule annotation
Disulfide bondi478 ↔ 513PROSITE-ProRule annotation
Disulfide bondi966 ↔ 976PROSITE-ProRule annotation
Glycosylationi983 – 9831N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1368 – 13681N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1377 – 13771N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1523 – 15231N-linked (GlcNAc...)Sequence Analysis
Modified residuei2005 – 20051N6-acetyllysineBy similarity
Glycosylationi2554 – 25541N-linked (GlcNAc...)Sequence Analysis
Glycosylationi2773 – 27731N-linked (GlcNAc...)1 Publication
Glycosylationi2976 – 29761N-linked (GlcNAc...)1 Publication
Glycosylationi3095 – 30951N-linked (GlcNAc...)Sequence Analysis
Glycosylationi3331 – 33311N-linked (GlcNAc...)Sequence Analysis
Glycosylationi3353 – 33531N-linked (GlcNAc...)Sequence Analysis
Glycosylationi3460 – 34601N-linked (GlcNAc...)Sequence Analysis
Glycosylationi3860 – 38601N-linked (GlcNAc...)Sequence Analysis

Post-translational modificationi

Palmitoylated; structural requirement for proper assembly of the hydrophobic core of the lipoprotein particle.By similarity

Keywords - PTMi

Acetylation, Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

MaxQBiE9Q414.
PRIDEiE9Q414.

Expressioni

Gene expression databases

BgeeiE9Q414.
ExpressionAtlasiE9Q414. baseline and differential.

Interactioni

Subunit structurei

Interacts with PCSK9.By similarity

Protein-protein interaction databases

IntActiE9Q414. 3 interactions.
MINTiMINT-1846293.
STRINGi10090.ENSMUSP00000035761.

Structurei

3D structure databases

ProteinModelPortaliE9Q414.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini46 – 672627VitellogeninPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni32 – 12695Heparin-bindingBy similarityAdd
BLAST
Regioni232 – 30675Heparin-bindingBy similarityAdd
BLAST
Regioni902 – 95958Heparin-bindingBy similarityAdd
BLAST
Regioni2042 – 2177136Heparin-bindingBy similarityAdd
BLAST
Regioni3155 – 323076Heparin-bindingBy similarityAdd
BLAST
Regioni3168 – 317811Basic (possible receptor binding region)By similarityAdd
BLAST
Regioni3368 – 338821LDL receptor bindingBy similarityAdd
BLAST
Regioni3378 – 3511134Heparin-bindingBy similarityAdd
BLAST
Regioni3381 – 33899Basic (possible receptor binding region)By similarity

Sequence similaritiesi

Contains 1 vitellogenin domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Repeat, Signal

Phylogenomic databases

GeneTreeiENSGT00590000083139.
InParanoidiE9Q414.
KOiK14462.
OMAiHIPEFQL.
OrthoDBiEOG7VB2DG.
TreeFamiTF331316.

Family and domain databases

Gene3Di1.25.10.20. 1 hit.
2.20.50.20. 2 hits.
2.20.80.10. 1 hit.
2.30.230.10. 1 hit.
InterProiIPR022176. ApoB100_C.
IPR015819. Lipid_transp_b-sht_shell.
IPR001747. Lipid_transpt_N.
IPR009454. Lipid_transpt_open_b-sht.
IPR015816. Vitellinogen_b-sht_N.
IPR015255. Vitellinogen_open_b-sht.
IPR015817. Vitellinogen_open_b-sht_sub1.
IPR015818. Vitellinogen_open_b-sht_sub2.
IPR011030. Vitellinogen_superhlx.
[Graphical view]
PfamiPF12491. ApoB100_C. 1 hit.
PF06448. DUF1081. 1 hit.
PF09172. DUF1943. 1 hit.
PF01347. Vitellogenin_N. 1 hit.
[Graphical view]
SMARTiSM00638. LPD_N. 1 hit.
[Graphical view]
SUPFAMiSSF48431. SSF48431. 1 hit.
SSF56968. SSF56968. 2 hits.
PROSITEiPS51211. VITELLOGENIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

E9Q414-1 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MGPRKPALRT PLLLLFLLLF LDTSVWAQDE VLENLSFSCP KDATRFKHLR
60 70 80 90 100
KYVYNYEAES SSGVQGTADS RSATKINCKV ELEVPQICGF IMRTNQCTLK
110 120 130 140 150
EVYGFNPEGK ALMKKTKNSE EFAAAMSRYE LKLAIPEGKQ IVLYPDKDEP
160 170 180 190 200
KYILNIKRGI ISALLVPPET EEDQQELFLD TVYGNCSTQV TVNSRKGTVP
210 220 230 240 250
TEMSTERNLQ QCDGFQPIST SVSPLALIKG LVHPLSTLIS SSQTCQYTLD
260 270 280 290 300
PKRKHVSEAV CDEQHLFLPF SYKNKYGIMT RVTQKLSLED TPKINSRFFS
310 320 330 340 350
EGTNRMGLAF ESTKSTSSPK QADAVLKTLQ ELKKLSISEQ NAQRANLFNK
360 370 380 390 400
LVTELRGLTG EAITSLLPQL IEVSSPITLQ ALVQCGQPQC YTHILQWLKT
410 420 430 440 450
EKAHPLLVDI VTYLMALIPN PSTQRLQEIF NTAKEQQSRA TLYALSHAVN
460 470 480 490 500
SYFDVDHSRS PVLQDIAGYL LKQIDNECTG NEDHTFLILR VIGNMGRTME
510 520 530 540 550
QVMPALKSSV LSCVRSTKPS LLIQKAALQA LRKMELEDEV RTILFDTFVN
560 570 580 590 600
GVAPVEKRLA AYLLLMKNPS SSDINKIAQL LQWEQSEQVK NFVASHIANI
610 620 630 640 650
LNSEELYVQD LKVLIKNALE NSQFPTIMDF RKFSRNYQIS KSASLPMFDP
660 670 680 690 700
VSVKIEGNLI FDPSSYLPRE SLLKTTLTVF GLASLDLFEI GLEGKGFEPT
710 720 730 740 750
LEALFGKQGF FPDSVNKALY WVNGRVPDGV SKVLVDHFGY TTDGKHEQDM
760 770 780 790 800
VNGIMPIVDK LIKDLKSKEI PEARAYLRIL GKELSFVRLQ DLQVLGKLLL
810 820 830 840 850
SGAQTLQGIP QMVVQAIREG SKNDLFLHYI FMDNAFELPT GAGLQLQVSS
860 870 880 890 900
SGVFTPGIKA GVRLELANIQ AELVAKPSVS LEFVTNMGII IPDFAKSSVQ
910 920 930 940 950
MNTNFFHESG LEARVALKAG QLKVIIPSPK RPVKLFSGSN TLHLVSTTKT
960 970 980 990 1000
EVIPPLVENR QSWSTCKPLF TGMNYCTTGA YSNASSTESA SYYPLTGDTR
1010 1020 1030 1040 1050
YELELRPTGE VEQYSATATY ELLKEDKSLV DTLKFLVQAE GVQQSEATVL
1060 1070 1080 1090 1100
FKYNRRSRTL SSEVLIPGFD VNFGTILRVN DESAKDKNTY KLILDIQNKK
1110 1120 1130 1140 1150
ITEVSLVGHL SYDKKGDGKI KGVVSIPRLQ AEARSEVHTH WSSTKLLFQM
1160 1170 1180 1190 1200
DSSATAYGST ISKRVTWRYD NEIIEFDWNT GTNVDTKKVA SNFPVDLSHY
1210 1220 1230 1240 1250
PRMLHEYANG LLDHRVPQTD VTFRDMGSKL IVATNTWLQM ATRGLPYPQT
1260 1270 1280 1290 1300
LQDHLNSLSE LNLLKMGLSD FHIPDNLFLK TDGRVKYTMN RNKINIDIPL
1310 1320 1330 1340 1350
PLGGKSSKDL KMPESVRTPA LNFKSVGFHL PSREVQVPTF TIPKTHQLQV
1360 1370 1380 1390 1400
PLLGVLDLST NVYSNLYNWS ASYTGGNTSR DHFSLQAQYR MKTDSVVDLF
1410 1420 1430 1440 1450
SYSVQGSGET TYDSKNTFTL SCDGSLHHKF LDSKFKVSHV EKFGNSPVSK
1460 1470 1480 1490 1500
GLLTFETSSA LGPQMSATVH LDSKKKQHLY VKDIKVDGQF RASSFYAQGK
1510 1520 1530 1540 1550
YGLSCERDVT TGQLSGESNM RFNSTYFQGT NQIVGMYQDG ALSITSTSDL
1560 1570 1580 1590 1600
QDGIFKNTAS LKYENYELTL KSDSSGQYEN FAASNKLDVT FSTQSALLRS
1610 1620 1630 1640 1650
EHQANYKSLR LVTLLSGSLT SQGVELNADI LGTDKINTGA HKATLKIARD
1660 1670 1680 1690 1700
GLSTSATTNL KYSPLLLENE LNAELGLSGA SMKLSTNGRF KEHHAKFSLD
1710 1720 1730 1740 1750
GRAALTEVSL GSIYQAMILG ADSKNIFNFK LSREGLRLSN DLMGSYAEMK
1760 1770 1780 1790 1800
LDHTHSLNIA GLSLDFFSKM DNIYSGDKFY KQNFNLQLQP YSFITTLSND
1810 1820 1830 1840 1850
LRYGALDLTN NGRFRLEPLK LNVGGNFKGT YQNNELKHIY TISYTDLVVA
1860 1870 1880 1890 1900
SYRADTVAKV QGVEFSHRLN ADIEGLTSSV DVTTSYNSDP LHFNNVFHFS
1910 1920 1930 1940 1950
LAPFTLGIDT HTSGDGKLSF WGEHTGQLYS KFLLKAEPLA LIVSHDYKGS
1960 1970 1980 1990 2000
TSHSLPYESS ISTALEHTVS ALLTPAEQTS TWKFKTKLND KVYSQDFEAY
2010 2020 2030 2040 2050
NTKDKIGVEL SGRADLSGLY SPIKLPFFYS EPVNVLNGLE VNDAVDKPQE
2060 2070 2080 2090 2100
FTIIAVVKYD KNQDVHTINL PFFKSLPDYL ERNRRGMISL LEAMRGELQR
2110 2120 2130 2140 2150
LSVDQFVRKY RAALSRLPQQ IHHYLNASDW ERQVAGAKEK ITSFMENYRI
2160 2170 2180 2190 2200
TDNDVLIAID SAKINFNEKL SQLETYAIQF DQYIKDNYDP HDLKRTIAEI
2210 2220 2230 2240 2250
IDRIIEKLKI LDEQYHIRVN LAKSIHNLYL FVENVDLNQV SSSNTSWIQN
2260 2270 2280 2290 2300
VDSNYQVRIQ IQEKLQQLRT QIQNIDIQQL AAEVKRQMDA IDVTMHLDQL
2310 2320 2330 2340 2350
RTAILFQRIS DIIDRVKYFV MNLIEDFKVT EKINTFRVIV RELIEKYEVD
2360 2370 2380 2390 2400
QHIQVLMDKS VELAHRYSLS EPLQKLSNVL QRIEIKDYYE KLVGFIDDTV
2410 2420 2430 2440 2450
EWLKALSFKN TIEELNRLTD MLVKKLKAFD YHQFVDKTNS KIREMTQRIN
2460 2470 2480 2490 2500
AEIQALKLPQ KMEALKLLVE DFKTTVSNSL ERLKDTKVTV VIDWLQDILT
2510 2520 2530 2540 2550
QMKDHFQDTL EDVRDRIYQM DIQRELEHFL SLVNQVYSTL VTYMSDWWTL
2560 2570 2580 2590 2600
TAKNITDFAE QYSIQNWAES IKVLVEQGFI VPEMQTFLWT MPAFEVSLRA
2610 2620 2630 2640 2650
LQEGNFQTPV FIVPLTDLRI PSIRINFKML KNIKIPLRFS TPEFTLLNTF
2660 2670 2680 2690 2700
HVHSFTIDLL EIKAKIIRTI DQILSSELQW PLPEMYLRDL DVVNIPLARL
2710 2720 2730 2740 2750
TLPDFHVPEI TIPEFTIPNV NLKDLHVPDL HIPEFQLPHL SHTIEIPAFG
2760 2770 2780 2790 2800
KLHSILKIQS PLFILDANAN IQNVTTSGNK AEIVASVTAK GESQFEALNF
2810 2820 2830 2840 2850
DFQAQAQFLE LNPHPPVLKE SMNFSSKHVR MEHEGEIVFD GKAIEGKSDT
2860 2870 2880 2890 2900
VASLHTEKNE VEFNNGMTVK VNNQLTLDSH TKYFHKLSVP RLDFSSKASL
2910 2920 2930 2940 2950
NNEIKTLLEA GHVALTSSGT GSWNWACPNF SDEGIHSSQI SFTVDGPIAF
2960 2970 2980 2990 3000
VGLSNNINGK HLRVIQKLTY ESGFLNYSKF EVESKVESQH VGSSILTANG
3010 3020 3030 3040 3050
RALLKDAKAE MTGEHNANLN GKVIGTLKNS LFFSAQPFEI TASTNNEGNL
3060 3070 3080 3090 3100
KVGFPLKLTG KIDFLNNYAL FLSPRAQQAS WQASTRFNQY KYNQNFSAIN
3110 3120 3130 3140 3150
NEHNIEASIG MNGDANLDFL NIPLTIPEIN LPYTEFKTPL LKDFSIWEET
3160 3170 3180 3190 3200
GLKEFLKTTK QSFDLSVKAQ YKKNSDKHSI VVPLGMFYEF ILNNVNSWDR
3210 3220 3230 3240 3250
KFEKVRNNAL HFLTTSYNEA KIKVDKYKTE NSLNQPSGTF QNHGYTIPVV
3260 3270 3280 3290 3300
NIEVSPFAVE TLASSHVIPT AISTPSVTIP GPNIMVPSYK LVLPPLELPV
3310 3320 3330 3340 3350
FHGPGNLFKF FLPDFKGFNT IDNIYIPAMG NFTYDFSFKS SVITLNTNAG
3360 3370 3380 3390 3400
LYNQSDIVAH FLSSSSFVTD ALQYKLEGTS RLMRKRGLKL ATAVSLTNKF
3410 3420 3430 3440 3450
VKGSHDSTIS LTKKNMEASV RTTANLHAPI FSMNFKQELN GNTKSKPTVS
3460 3470 3480 3490 3500
SSIELNYDFN SSKLHSTATG GIDHKFSLES LTSYFSIESF TKGNIKSSFL
3510 3520 3530 3540 3550
SQEYSGSVAN EANVYLNSKG TRSSVRLQGA SKVDGIWNVE VGENFAGEAT
3560 3570 3580 3590 3600
LQRIYTTWEH NMKNHLQVYS YFFTKGKQTC RATLELSPWT MSTLLQVHVS
3610 3620 3630 3640 3650
QLSSLLDLHH FDQEVILKAN TKNQKISWKG GVQVESRVLQ HNAQFSNDQE
3660 3670 3680 3690 3700
EIRLDLAGSL DGQLWDLEAI FLPVYGKSLQ ELLQMDGKRQ YLQASTSLLY
3710 3720 3730 3740 3750
TKNPNGYLLS LPVQELADRF IIPGIKLNDF SGVKIYKKLS TSPFALNLTM
3760 3770 3780 3790 3800
LPKVKFPGID LLTQYSTPEG SSVPIFEATI PEIHLTVSQF TLPKSLPVGN
3810 3820 3830 3840 3850
TVFDLNKLAN MIADVDLPSV TLPEQTIVIP PLEFSVPAGI FIPFFGELTA
3860 3870 3880 3890 3900
RAGMASPLYN VTWSAGWKTK ADHVETFLDS MCTSTLQFLE YALKVVETHK
3910 3920 3930 3940 3950
IEEDLLTYNI KGTLQHCDFN VEYNEDGLFK GLWDWQGEAH LDITSPALTD
3960 3970 3980 3990 4000
FHLYYKEDKT SLSASAASST IGTVGLDSST DDQSVELNVY FHPQSPPEKK
4010 4020 4030 4040 4050
LSIFKTEWRY KESDGERYIK INWEEEAASR LLGSLKSNVP KASKAIYDYA
4060 4070 4080 4090 4100
NKYHLEYVSS ELRKSLQVNA EHARRMVDEM NMSFQRVARD TYQNLYEEML
4110 4120 4130 4140 4150
AQKSLSIPEN LKKRVLDSIV HVTQKYHMAV MWLMDSFIHF LKFNRVQFPG
4160 4170 4180 4190 4200
YAGTYTVDEL YTIVMKETKK SLSQLFNGLG NLLSYVQNQV EKSRLINDIT
4210 4220 4230 4240 4250
FKCPFFSKPC KLKDLILIFR EELNILSNIG QQDIKFTTIL SSLQGFLERV
4260 4270 4280 4290 4300
LDIIEEQIKC LKDNESTCVA DHINMVFKIQ VPYAFKSLRE DIYFVLGEFN
4310 4320 4330 4340 4350
DFLQSILQEG SYKLQQVHQY MKALREEYFD PSMVGWTVKY YEIEENMVEL
4360 4370 4380 4390 4400
IKTLLVSFRD VYSEYSVTAA DFASKMSTQV EQFVSRDIRE YLSMLTDING
4410 4420 4430 4440 4450
KWMEKIAELS IVAKETMKSW VTAVAKIMSD YPQQFHSNLQ DFSDQLSSYY
4460 4470 4480 4490 4500
EKFVGESTRL IDLSIQNYHV FLRYITELLR KLQVATANNV SPYIKLAQGE

LMITF
Length:4,505
Mass (Da):509,432
Last modified:April 5, 2011 - v1
Checksum:i09EADB2D499E7A82
GO

Sequence cautioni

The sequence AAI41358.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAI41361.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAE27983.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti41 – 422KD → N in AAI00608. (PubMed:15489334)Curated
Sequence conflicti331 – 3322EL → KK in AAI00608. (PubMed:15489334)Curated
Sequence conflicti335 – 3351L → K in AAI00608. (PubMed:15489334)Curated
Sequence conflicti1477 – 14771Q → K in AAH38263. (PubMed:15489334)Curated
Sequence conflicti3265 – 32651S → R in AAA37246. (PubMed:2332175)Curated

RNA editingi

The stop codon (UAA) at position 2179 is created by RNA editing. Apo B-48, derived from the fully edited RNA, is produced only in the intestine and is found in chylomicrons. Apo B-48 is a shortened form of apo B-100 which lacks the LDL-receptor region. The unedited version (apo B-100) is produced by the liver and is found in the VLDL and LDL (By similarity).By similarity

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC163900 Genomic DNA. No translation available.
BC038263 mRNA. Translation: AAH38263.1.
BC100607 mRNA. Translation: AAI00608.1.
BC141357 mRNA. Translation: AAI41358.1. Different initiation.
BC141360 mRNA. Translation: AAI41361.1. Different initiation.
M35186 Genomic DNA. Translation: AAA37246.1.
X15191 Genomic DNA. Translation: CAA33265.1.
AK147540 mRNA. Translation: BAE27983.1. Different initiation.
CCDSiCCDS49022.1.
RefSeqiNP_033823.2. NM_009693.2.
UniGeneiMm.221239.

Genome annotation databases

EnsembliENSMUST00000037811; ENSMUSP00000036044; ENSMUSG00000020609.
GeneIDi238055.
KEGGimmu:238055.
UCSCiuc007mzf.2. mouse.

Keywords - Coding sequence diversityi

RNA editing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC163900 Genomic DNA. No translation available.
BC038263 mRNA. Translation: AAH38263.1 .
BC100607 mRNA. Translation: AAI00608.1 .
BC141357 mRNA. Translation: AAI41358.1 . Different initiation.
BC141360 mRNA. Translation: AAI41361.1 . Different initiation.
M35186 Genomic DNA. Translation: AAA37246.1 .
X15191 Genomic DNA. Translation: CAA33265.1 .
AK147540 mRNA. Translation: BAE27983.1 . Different initiation.
CCDSi CCDS49022.1.
RefSeqi NP_033823.2. NM_009693.2.
UniGenei Mm.221239.

3D structure databases

ProteinModelPortali E9Q414.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi E9Q414. 3 interactions.
MINTi MINT-1846293.
STRINGi 10090.ENSMUSP00000035761.

Proteomic databases

MaxQBi E9Q414.
PRIDEi E9Q414.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000037811 ; ENSMUSP00000036044 ; ENSMUSG00000020609 .
GeneIDi 238055.
KEGGi mmu:238055.
UCSCi uc007mzf.2. mouse.

Organism-specific databases

CTDi 338.
MGIi MGI:88052. Apob.

Phylogenomic databases

GeneTreei ENSGT00590000083139.
InParanoidi E9Q414.
KOi K14462.
OMAi HIPEFQL.
OrthoDBi EOG7VB2DG.
TreeFami TF331316.

Enzyme and pathway databases

Reactomei REACT_196581. Scavenging by Class A Receptors.
REACT_196592. Scavenging by Class B Receptors.
REACT_196594. Scavenging by Class H Receptors.
REACT_196603. Scavenging by Class F Receptors.
REACT_198569. Retinoid metabolism and transport.
REACT_216017. Chylomicron-mediated lipid transport.
REACT_222614. LDL-mediated lipid transport.
REACT_225233. Cell surface interactions at the vascular wall.
REACT_250548. Platelet sensitization by LDL.

Miscellaneous databases

ChiTaRSi Apob. mouse.
NextBioi 383653.
PROi E9Q414.
SOURCEi Search...

Gene expression databases

Bgeei E9Q414.
ExpressionAtlasi E9Q414. baseline and differential.

Family and domain databases

Gene3Di 1.25.10.20. 1 hit.
2.20.50.20. 2 hits.
2.20.80.10. 1 hit.
2.30.230.10. 1 hit.
InterProi IPR022176. ApoB100_C.
IPR015819. Lipid_transp_b-sht_shell.
IPR001747. Lipid_transpt_N.
IPR009454. Lipid_transpt_open_b-sht.
IPR015816. Vitellinogen_b-sht_N.
IPR015255. Vitellinogen_open_b-sht.
IPR015817. Vitellinogen_open_b-sht_sub1.
IPR015818. Vitellinogen_open_b-sht_sub2.
IPR011030. Vitellinogen_superhlx.
[Graphical view ]
Pfami PF12491. ApoB100_C. 1 hit.
PF06448. DUF1081. 1 hit.
PF09172. DUF1943. 1 hit.
PF01347. Vitellogenin_N. 1 hit.
[Graphical view ]
SMARTi SM00638. LPD_N. 1 hit.
[Graphical view ]
SUPFAMi SSF48431. SSF48431. 1 hit.
SSF56968. SSF56968. 2 hits.
PROSITEi PS51211. VITELLOGENIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-1477 AND 3004-4505.
    Strain: FVB/N.
    Tissue: Liver.
  3. "Sequence of the putative low-density lipoprotein receptor-binding regions of apolipoprotein B in mouse and hamster."
    Smith T.J., Hautamaa D., Maeda N.
    Gene 87:309-310(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 2734-3518.
  4. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2962-4505.
    Strain: C57BL/6J.
    Tissue: Placenta.
  5. "Proteome-wide characterization of N-glycosylation events by diagonal chromatography."
    Ghesquiere B., Van Damme J., Martens L., Vandekerckhove J., Gevaert K.
    J. Proteome Res. 5:2438-2447(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-2773 AND ASN-2976.
    Strain: C57BL/6.
    Tissue: Plasma.

Entry informationi

Entry nameiAPOB_MOUSE
AccessioniPrimary (citable) accession number: E9Q414
Secondary accession number(s): Q3UH74
, Q497D8, Q61314, Q61318, Q8CGG8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 6, 2013
Last sequence update: April 5, 2011
Last modified: November 26, 2014
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3