ID   E9Q3Z8_MOUSE            Unreviewed;       238 AA.
AC   E9Q3Z8;
DT   05-APR-2011, integrated into UniProtKB/TrEMBL.
DT   10-OCT-2018, sequence version 2.
DT   27-MAR-2024, entry version 80.
DE   SubName: Full=Discs large MAGUK scaffold protein 4 {ECO:0000313|Ensembl:ENSMUSP00000115206.4};
DE   Flags: Fragment;
GN   Name=Dlg4 {ECO:0000313|Ensembl:ENSMUSP00000115206.4,
GN   ECO:0000313|MGI:MGI:1277959};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000115206.4, ECO:0000313|Proteomes:UP000000589};
RN   [1] {ECO:0007829|PubMed:16452087}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=16452087; DOI=10.1074/mcp.T500041-MCP200;
RA   Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L.;
RT   "Comprehensive identification of phosphorylation sites in postsynaptic
RT   density preparations.";
RL   Mol. Cell. Proteomics 5:914-922(2006).
RN   [2] {ECO:0000313|Ensembl:ENSMUSP00000115206.4, ECO:0000313|Proteomes:UP000000589}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000115206.4,
RC   ECO:0000313|Proteomes:UP000000589};
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [3] {ECO:0007829|PubMed:21183079}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
RN   [4] {ECO:0000313|Ensembl:ENSMUSP00000115206.4}
RP   IDENTIFICATION.
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000115206.4};
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   AlphaFoldDB; E9Q3Z8; -.
DR   SMR; E9Q3Z8; -.
DR   SwissPalm; E9Q3Z8; -.
DR   jPOST; E9Q3Z8; -.
DR   PeptideAtlas; E9Q3Z8; -.
DR   ProteomicsDB; 308249; -.
DR   Antibodypedia; 1930; 1049 antibodies from 50 providers.
DR   Ensembl; ENSMUST00000134376.10; ENSMUSP00000115206.4; ENSMUSG00000020886.18.
DR   AGR; MGI:1277959; -.
DR   MGI; MGI:1277959; Dlg4.
DR   VEuPathDB; HostDB:ENSMUSG00000020886; -.
DR   GeneTree; ENSGT00940000157956; -.
DR   HOGENOM; CLU_103583_0_0_1; -.
DR   ChiTaRS; Dlg4; mouse.
DR   Proteomes; UP000000589; Chromosome 11.
DR   Bgee; ENSMUSG00000020886; Expressed in retinal neural layer and 176 other cell types or tissues.
DR   ExpressionAtlas; E9Q3Z8; baseline and differential.
DR   CDD; cd00992; PDZ_signaling; 2.
DR   Gene3D; 2.30.42.10; -; 2.
DR   InterPro; IPR019590; DLG1_PEST_dom.
DR   InterPro; IPR001478; PDZ.
DR   InterPro; IPR036034; PDZ_sf.
DR   PANTHER; PTHR23119; DISCS LARGE; 1.
DR   PANTHER; PTHR23119:SF33; DISKS LARGE HOMOLOG 4; 1.
DR   Pfam; PF10608; MAGUK_N_PEST; 1.
DR   Pfam; PF00595; PDZ; 2.
DR   SMART; SM01277; MAGUK_N_PEST; 1.
DR   SMART; SM00228; PDZ; 1.
DR   SUPFAM; SSF50156; PDZ domain-like; 2.
DR   PROSITE; PS50106; PDZ; 2.
PE   1: Evidence at protein level;
KW   Proteomics identification {ECO:0007829|MaxQB:E9Q3Z8,
KW   ECO:0007829|PeptideAtlas:E9Q3Z8};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000589}.
FT   DOMAIN          95..182
FT                   /note="PDZ"
FT                   /evidence="ECO:0000259|PROSITE:PS50106"
FT   DOMAIN          190..238
FT                   /note="PDZ"
FT                   /evidence="ECO:0000259|PROSITE:PS50106"
FT   NON_TER         238
FT                   /evidence="ECO:0000313|Ensembl:ENSMUSP00000115206.4"
SQ   SEQUENCE   238 AA;  25512 MW;  CA0F80BD73C52AA7 CRC64;
     MDCLCIVTTK KYRYQDEDTP PLEHSPAHLP NQVNAPELVH VAERNLSHLE AVHGVVGHAH
     LSSLKANSPP VIVNTDTLEA PGYVNGTEGE MEYEEITLER GNSGLGFSIA GGTDNPHIGD
     DPSIFITKII PGGAAAQDGR LRVNDSILFV NEVDVREVTH SAAVEALKEA GSIVRLYVMR
     RKPPAEKIIE IKLIKGPKGL GFSIAGGVGN QHIPGDNSIY VTKIIEGGAA HKDGRLQI
//