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E9Q3Z4

- E9Q3Z4_MOUSE

UniProt

E9Q3Z4 - E9Q3Z4_MOUSE

Protein
Submitted name:

Hexokinase-3

Gene

Hk3

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 27 (01 Oct 2014)
      Sequence version 1 (05 Apr 2011)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. fructokinase activity Source: RefGenome
    3. glucokinase activity Source: RefGenome
    4. hormone binding Source: Ensembl
    5. mannokinase activity Source: RefGenome

    GO - Biological processi

    1. carbohydrate phosphorylation Source: GOC
    2. cellular glucose homeostasis Source: RefGenome
    3. glucose 6-phosphate metabolic process Source: GOC
    4. glycolytic process Source: RefGenome

    Keywords - Molecular functioni

    KinaseUniRule annotationSAAS annotation, Transferase

    Keywords - Biological processi

    GlycolysisUniRule annotationSAAS annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Hexokinase-3Imported
    Gene namesi
    Name:Hk3Imported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 13

    Organism-specific databases

    MGIiMGI:2670962. Hk3.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: RefGenome
    2. mitochondrion Source: MGI
    3. protein complex Source: Ensembl

    Expressioni

    Gene expression databases

    ArrayExpressiE9Q3Z4.
    BgeeiE9Q3Z4.

    Structurei

    3D structure databases

    ProteinModelPortaliE9Q3Z4.
    SMRiE9Q3Z4. Positions 1-863.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the hexokinase family.UniRule annotation

    Phylogenomic databases

    GeneTreeiENSGT00390000017159.
    KOiK00844.

    Family and domain databases

    InterProiIPR001312. Hexokinase.
    IPR022673. Hexokinase_C.
    IPR019807. Hexokinase_CS.
    IPR022672. Hexokinase_N.
    [Graphical view]
    PANTHERiPTHR19443. PTHR19443. 1 hit.
    PfamiPF00349. Hexokinase_1. 2 hits.
    PF03727. Hexokinase_2. 2 hits.
    [Graphical view]
    PRINTSiPR00475. HEXOKINASE.
    PROSITEiPS00378. HEXOKINASES. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    E9Q3Z4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEQALKGQDS PAPSVRMLPT YVRSTPHGTE QGDFLVLELG ATGASLRVLW    50
    VTLTGTKECR VEPRSREFVI PQEVILGAGQ QLFDFAARCL SEFLDAYPVE 100
    NQGLKLGFNF SFPCHQTGLD RSTLISWTKG FRCSGVEGQD VVQLLRDAIQ 150
    RQGTYRIDVV AMVNDTVGTM MGCELGTRPC EVGLIVDTGT NACYMEEARH 200
    VAALDEDRGR TCVSIEWGSF YDEDALGPVL TTFDSALDRE SLTPGAQRFE 250
    KMIGGLYLGE LVRLVLVHLT QHGVLFDGCA SPALLSQGCI LLDHVAEMED 300
    TATGTARVHT ILQDLGLSPR ASDAELVQYV CVAVCTRAAQ LCAAALAAVL 350
    SRLQHSREQQ TLQVAVATGG RVFERHPRFL RILKETVTLL APNCDVSFIP 400
    SVDGGGRGVA MVTAVAARLA AHRRILEETL APFQLTLEQM TVVQAQMREA 450
    MIRGLQGEAS SLRMLPTYVR ATPDGSERGD FLALDLGGTN FRVLLVRVAE 500
    GSVQIINQVY SIPECRAQGS GQKLFDHIVD CIVDFQKRQG LSGQSLPLGF 550
    TFSFPCKQLG LDQGILLNWT KGFNASGCEG QDVVYLLREA IRRRQAVELN 600
    VVAIVNDTVG TMMSCGYDDP RCEMGLIVGT GTNACYMEEL RNVASVPGDS 650
    GLMCINMEWG AFGDDGSLGT LSTRFDTSVD QASINPGKQR FEKMISGMYL 700
    GEIVRHILLH LTNLGVLFRG QKTQCLQARD IFKTKFLSEI ESDSLALRQV 750
    RAILEDLGLT LTSDDALMVL EVCQAVSRRA AQLCGAGVAA VVEKIRENRG 800
    LQELTVSVGV DGTLYKLHPH FSKLVSATVR KLAPQCTVTF LQSEDGSGKG 850
    AALVTAVACR LTQMAHV 867
    Length:867
    Mass (Da):94,231
    Last modified:April 5, 2011 - v1
    Checksum:i00043A686D3E52DE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC154610 Genomic DNA. No translation available.
    RefSeqiNP_001193321.1. NM_001206392.1.
    UniGeneiMm.267479.

    Genome annotation databases

    EnsembliENSMUST00000153665; ENSMUSP00000115227; ENSMUSG00000025877.
    GeneIDi212032.
    KEGGimmu:212032.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC154610 Genomic DNA. No translation available.
    RefSeqi NP_001193321.1. NM_001206392.1.
    UniGenei Mm.267479.

    3D structure databases

    ProteinModelPortali E9Q3Z4.
    SMRi E9Q3Z4. Positions 1-863.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000153665 ; ENSMUSP00000115227 ; ENSMUSG00000025877 .
    GeneIDi 212032.
    KEGGi mmu:212032.

    Organism-specific databases

    CTDi 3101.
    MGIi MGI:2670962. Hk3.

    Phylogenomic databases

    GeneTreei ENSGT00390000017159.
    KOi K00844.

    Miscellaneous databases

    NextBioi 373427.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi E9Q3Z4.
    Bgeei E9Q3Z4.

    Family and domain databases

    InterProi IPR001312. Hexokinase.
    IPR022673. Hexokinase_C.
    IPR019807. Hexokinase_CS.
    IPR022672. Hexokinase_N.
    [Graphical view ]
    PANTHERi PTHR19443. PTHR19443. 1 hit.
    Pfami PF00349. Hexokinase_1. 2 hits.
    PF03727. Hexokinase_2. 2 hits.
    [Graphical view ]
    PRINTSi PR00475. HEXOKINASE.
    PROSITEi PS00378. HEXOKINASES. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6JImported.
    2. Ensembl
      Submitted (MAY-2011) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: C57BL/6JImported.

    Entry informationi

    Entry nameiE9Q3Z4_MOUSE
    AccessioniPrimary (citable) accession number: E9Q3Z4
    Entry historyi
    Integrated into UniProtKB/TrEMBL: April 5, 2011
    Last sequence update: April 5, 2011
    Last modified: October 1, 2014
    This is version 27 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Caution

    The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3