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Protein

Mitogen-activated protein kinase kinase kinase 19

Gene

Map3k19

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei1072 – 10721ATPPROSITE-ProRule annotation
Active sitei1169 – 11691Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi1050 – 10589ATPPROSITE-ProRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Mitogen-activated protein kinase kinase kinase 19 (EC:2.7.11.1)
Alternative name(s):
SPS1/STE20-related protein kinase YSK4
Gene namesi
Name:Map3k19
Synonyms:Ysk4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1203481. Map3k19.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13111311Mitogen-activated protein kinase kinase kinase 19PRO_0000421022Add
BLAST

Proteomic databases

MaxQBiE9Q3S4.
PaxDbiE9Q3S4.

PTM databases

iPTMnetiE9Q3S4.

Expressioni

Gene expression databases

BgeeiE9Q3S4.
ExpressionAtlasiE9Q3S4. baseline and differential.

Interactioni

Protein-protein interaction databases

IntActiE9Q3S4. 1 interaction.
STRINGi10090.ENSMUSP00000056254.

Structurei

3D structure databases

ProteinModelPortaliE9Q3S4.
SMRiE9Q3S4. Positions 1019-1308.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1044 – 1307264Protein kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0198. Eukaryota.
ENOG410XQGS. LUCA.
GeneTreeiENSGT00800000124036.
InParanoidiE9Q3S4.
KOiK17533.
OMAiVTKNQNI.
OrthoDBiEOG7ZD1V1.
PhylomeDBiE9Q3S4.
TreeFamiTF332735.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E9Q3S4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSMPRPERH AESLLDICHE AGSTPMEMTV SQTENLTLQS ISSSEDFDLE
60 70 80 90 100
DDFSPFILAR EGAAPRGENW PRRTEGVEII VTFPPDPLQE ASQEDLKESN
110 120 130 140 150
QVTSEHQERE QVHPVSPPDD AEMVGLTGRM LTTQPSLLKT DGSSEELCGV
160 170 180 190 200
DVALSPPRPC LDSSLAASAA GEVAPCVLKE QQRQSDEFPT SDISYSSRRT
210 220 230 240 250
GLPLPPLSCL PMRSCIFNME KSPKSPRHRE RKVPSLSLSV PKLLEPLSRP
260 270 280 290 300
LSQSAEFSSS KNHQEVTQEG PVEHTLRGSN CTLWSRNMCS FRKSGKQGVA
310 320 330 340 350
ESWPSQEMEG WDKTKTSGFK EGPSLFSCES VKEDTTPTER ERDSGYHVSE
360 370 380 390 400
MQRGGEDSQY LSSRKKESWT ARVVERDSGV EHPILCKLLE VSNSEMTPAE
410 420 430 440 450
EKEIGNENVP DAKSNSVHKS GAMEPHAASE EVSVPKNGPS VNSDGPAEEL
460 470 480 490 500
EGHRDIEQNR KIPMEEETNP EMNGVVPLTH IAFPGEGTSK GPARAEPHLQ
510 520 530 540 550
RRKRPAQNSN SFNLLAHREH DKLQTNTHRT KLDSRTKARN RAPPNLMVSI
560 570 580 590 600
QASIKPNMHK NSIKTQVFPA LELIDHRPHP SSKFQRRAPL TEKKSTHQTQ
610 620 630 640 650
KPKKQAFPRI GKHAGIKKPG IPLSAETTDP RLHFLDLKYS DMFKEINSAS
660 670 680 690 700
NGPGIYEMFG TPVYCHIREA ERHDHRCYRE IRTAPSGRCV VNKCQSSESD
710 720 730 740 750
RCSNSRARLL QKRQHIKPPK PLHGLRQKHR GFISKDKGCK DMGGHTEDSV
760 770 780 790 800
SEPDGQMKSP GNDFLSSKDD AQLMHLIPIP ELSPEQKAPA PVSDLSIVEE
810 820 830 840 850
IFTEECADEE GILNDDSLTQ SLGDLKEPEG LHPQAPLVPS ENSWAVLSEK
860 870 880 890 900
RSGKRVSPEK HNVEPLDKIN AEQMFPGYLE FDSLSEKSKT LVSFSSCSFQ
910 920 930 940 950
ENLERAPSPT EQHWARSLEQ DSLENNSTTY QTFGKISQEI LDPGKNEELT
960 970 980 990 1000
DELLGCLVEE LLALDEKDNN SCQIMTNEAD AKNLNLVFSR RGNTIEELGR
1010 1020 1030 1040 1050
ETTDVKLQRC INGFRIYDEE NFLTSNEKKT LSDKSLNHEE AIFWTKGEIL
1060 1070 1080 1090 1100
GRGAYGTVYC GLTSLGQLIA VKQVALDTSD KLATEKEYRK LQEEVDLLKA
1110 1120 1130 1140 1150
LKHVNIVAYL GTCLEENTLS IFMEFVPGGS ISSIINRFGP LPEMVFCKYT
1160 1170 1180 1190 1200
RQILQGVAYL HDNCVVHRDI KGNNVMLMPT GIIKLIDFGC AKRLAWAGLN
1210 1220 1230 1240 1250
GTHSDMLKSM RGTPYWMAPE VINESGYGRK SDIWSIGCTV FEMATGKPPL
1260 1270 1280 1290 1300
ASMDRMAAMF YIGAHRGLMP PLPARFSEPA ADFVRLCLTR DQHERPSALQ
1310
LLKHSFLKRS Q
Length:1,311
Mass (Da):146,412
Last modified:April 5, 2011 - v1
Checksum:iC69E361F52305D44
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC121883 Genomic DNA. No translation available.
AC163690 Genomic DNA. No translation available.
CCDSiCCDS48347.1.
RefSeqiNP_035867.1. NM_011737.1.
UniGeneiMm.246566.

Genome annotation databases

EnsembliENSMUST00000061512; ENSMUSP00000056254; ENSMUSG00000051590.
GeneIDi22625.
KEGGimmu:22625.
UCSCiuc011wra.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC121883 Genomic DNA. No translation available.
AC163690 Genomic DNA. No translation available.
CCDSiCCDS48347.1.
RefSeqiNP_035867.1. NM_011737.1.
UniGeneiMm.246566.

3D structure databases

ProteinModelPortaliE9Q3S4.
SMRiE9Q3S4. Positions 1019-1308.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiE9Q3S4. 1 interaction.
STRINGi10090.ENSMUSP00000056254.

PTM databases

iPTMnetiE9Q3S4.

Proteomic databases

MaxQBiE9Q3S4.
PaxDbiE9Q3S4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000061512; ENSMUSP00000056254; ENSMUSG00000051590.
GeneIDi22625.
KEGGimmu:22625.
UCSCiuc011wra.1. mouse.

Organism-specific databases

CTDi80122.
MGIiMGI:1203481. Map3k19.

Phylogenomic databases

eggNOGiKOG0198. Eukaryota.
ENOG410XQGS. LUCA.
GeneTreeiENSGT00800000124036.
InParanoidiE9Q3S4.
KOiK17533.
OMAiVTKNQNI.
OrthoDBiEOG7ZD1V1.
PhylomeDBiE9Q3S4.
TreeFamiTF332735.

Miscellaneous databases

PROiE9Q3S4.
SOURCEiSearch...

Gene expression databases

BgeeiE9Q3S4.
ExpressionAtlasiE9Q3S4. baseline and differential.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.

Entry informationi

Entry nameiM3K19_MOUSE
AccessioniPrimary (citable) accession number: E9Q3S4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 6, 2013
Last sequence update: April 5, 2011
Last modified: June 8, 2016
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.