ID   E9Q3N9_MOUSE            Unreviewed;       402 AA.
AC   E9Q3N9;
DT   05-APR-2011, integrated into UniProtKB/TrEMBL.
DT   05-APR-2011, sequence version 1.
DT   27-MAR-2024, entry version 91.
DE   SubName: Full=Epidermal growth factor-containing fibulin-like extracellular matrix protein 2 {ECO:0000313|Ensembl:ENSMUSP00000129746.2};
GN   Name=Efemp2 {ECO:0000313|Ensembl:ENSMUSP00000129746.2,
GN   ECO:0000313|MGI:MGI:1891209};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000129746.2, ECO:0000313|Proteomes:UP000000589};
RN   [1] {ECO:0000313|Ensembl:ENSMUSP00000129746.2, ECO:0000313|Proteomes:UP000000589}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000129746.2,
RC   ECO:0000313|Proteomes:UP000000589};
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [2] {ECO:0000313|Ensembl:ENSMUSP00000129746.2}
RP   IDENTIFICATION.
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000129746.2};
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC       matrix {ECO:0000256|ARBA:ARBA00004498}.
CC   -!- SIMILARITY: Belongs to the fibulin family.
CC       {ECO:0000256|ARBA:ARBA00006127}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR   AlphaFoldDB; E9Q3N9; -.
DR   MaxQB; E9Q3N9; -.
DR   PeptideAtlas; E9Q3N9; -.
DR   ProteomicsDB; 316358; -.
DR   Antibodypedia; 16033; 415 antibodies from 33 providers.
DR   Ensembl; ENSMUST00000167371.8; ENSMUSP00000129746.2; ENSMUSG00000024909.16.
DR   AGR; MGI:1891209; -.
DR   MGI; MGI:1891209; Efemp2.
DR   VEuPathDB; HostDB:ENSMUSG00000024909; -.
DR   GeneTree; ENSGT00940000159437; -.
DR   ChiTaRS; Efemp2; mouse.
DR   Proteomes; UP000000589; Chromosome 19.
DR   Bgee; ENSMUSG00000024909; Expressed in humerus cartilage element and 211 other cell types or tissues.
DR   ExpressionAtlas; E9Q3N9; baseline and differential.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   CDD; cd00054; EGF_CA; 2.
DR   Gene3D; 2.10.25.10; Laminin; 5.
DR   InterPro; IPR026823; cEGF.
DR   InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR   InterPro; IPR000742; EGF-like_dom.
DR   InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR   InterPro; IPR018097; EGF_Ca-bd_CS.
DR   InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR   PANTHER; PTHR24034:SF96; EGF-CONTAINING FIBULIN-LIKE EXTRACELLULAR MATRIX PROTEIN 2; 1.
DR   PANTHER; PTHR24034; EGF-LIKE DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF12662; cEGF; 2.
DR   Pfam; PF07645; EGF_CA; 2.
DR   PRINTS; PR00907; THRMBOMODULN.
DR   SMART; SM00181; EGF; 4.
DR   SMART; SM00179; EGF_CA; 5.
DR   SUPFAM; SSF57184; Growth factor receptor domain; 2.
DR   PROSITE; PS00010; ASX_HYDROXYL; 3.
DR   PROSITE; PS01186; EGF_2; 2.
DR   PROSITE; PS50026; EGF_3; 2.
DR   PROSITE; PS01187; EGF_CA; 2.
PE   1: Evidence at protein level;
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW   ProRule:PRU00076}; Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW   Proteomics identification {ECO:0007829|MaxQB:E9Q3N9,
KW   ECO:0007829|PeptideAtlas:E9Q3N9};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Secreted {ECO:0000256|ARBA:ARBA00022530};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..27
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           28..402
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5003244402"
FT   DOMAIN          123..161
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          202..241
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   REGION          91..114
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   402 AA;  44888 MW;  6BB44040C8F7E2A5 CRC64;
     MLPFASCLPG SLLLWAFLLL LLGAASPQDP EEPDSYTECT DGYEWDADSQ HCRDVNECLT
     IPEACKGEMK CINHYGGYLC LPRSAAVISD LHGEGPPPPA AHAQQPNPCP QGYEPDEQES
     CVDIDECRYR YCQHRCVNLP GSFRCQCEPG FQLGPNNRSC VDVNECDMGA PCEQRCFNSY
     GTFLCRCNQG YELHRDGFSC SDIDECGYSS YLCQYRCVNE PGRFSCHCPQ GYQLLATRLC
     QDIDECETGA HQCSEAQTCV NFHGGYRCVD TNRCVEPYVQ VSDNRCLCPA SNPLCREQPS
     SIVHRYMSIT SERSVPADVF QIQATSVYPG AYNAFQIRSG NTQGDFYIRQ INNVSAMLVL
     ARPVTGPREY VLDLEMVTMN SLMSYRASSV LRLTVFVGAY TF
//