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Protein
Submitted name:

EGF-containing fibulin-like extracellular matrix protein 2

Gene

Efemp2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. transmembrane signaling receptor activity Source: InterPro

GO - Biological processi

  1. blood coagulation Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
EGF-containing fibulin-like extracellular matrix protein 2Imported
Gene namesi
Name:Efemp2Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 19

Organism-specific databases

MGIiMGI:1891209. Efemp2.

Subcellular locationi

GO - Cellular componenti

  1. extracellular vesicular exosome Source: MGI
  2. plasma membrane Source: InterPro
  3. proteinaceous extracellular matrix Source: MGI
  4. vesicle Source: MGI
Complete GO annotation...

PTM / Processingi

Keywords - PTMi

Disulfide bondSAAS annotation

Expressioni

Gene expression databases

BgeeiE9Q3F3.
ExpressionAtlasiE9Q3F3. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliE9Q3F3.
SMRiE9Q3F3. Positions 32-218.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

EGF-like domainUniRule annotationSAAS annotation, RepeatSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00760000118806.

Family and domain databases

InterProiIPR026823. cEGF.
IPR026824. Efemp2.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR009030. Growth_fac_rcpt_N_dom.
IPR001491. Thrombomodulin.
[Graphical view]
PANTHERiPTHR24048:SF2. PTHR24048:SF2. 1 hit.
PfamiPF12662. cEGF. 2 hits.
PF07645. EGF_CA. 1 hit.
[Graphical view]
PRINTSiPR00907. THRMBOMODULN.
SMARTiSM00181. EGF. 1 hit.
SM00179. EGF_CA. 3 hits.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 1 hit.
PROSITEiPS00010. ASX_HYDROXYL. 3 hits.
PS01186. EGF_2. 3 hits.
PS50026. EGF_3. 3 hits.
PS01187. EGF_CA. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

E9Q3F3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLPFASCLPG SLLLWAFLLL LLGAASPQDP EEPDSYTECT DGYEWDADSQ
60 70 80 90 100
HCRDIDECRY RYCQHRCVNL PGSFRCQCEP GFQLGPNNRS CVDVNECDMG
110 120 130 140 150
APCEQRCFNS YGTFLCRCNQ GYELHRDGFS CSDIDECGYS SYLCQYRCVN
160 170 180 190 200
EPGRFSCHCP QGYQLLATRL CQDIDECETG AHQCSEAQTC VNFHGGYRCV
210 220 230 240 250
DTNRCVEPYV QVSDNRCLCP ASNPLCREQP SSIVHRYMSI TSERSVPADV
260 270 280
FQIQATSVYP GAYNAFQIRS GNTQGDFYIR
Length:280
Mass (Da):31,621
Last modified:April 5, 2011 - v1
Checksum:iF2A55877C8097121
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei280 – 2801Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC126029 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSMUST00000166253; ENSMUSP00000127312; ENSMUSG00000024909.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC126029 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortaliE9Q3F3.
SMRiE9Q3F3. Positions 32-218.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000166253; ENSMUSP00000127312; ENSMUSG00000024909.

Organism-specific databases

MGIiMGI:1891209. Efemp2.

Phylogenomic databases

GeneTreeiENSGT00760000118806.

Miscellaneous databases

ChiTaRSiEfemp2. mouse.
NextBioi35554985.
SOURCEiSearch...

Gene expression databases

BgeeiE9Q3F3.
ExpressionAtlasiE9Q3F3. baseline and differential.

Family and domain databases

InterProiIPR026823. cEGF.
IPR026824. Efemp2.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR009030. Growth_fac_rcpt_N_dom.
IPR001491. Thrombomodulin.
[Graphical view]
PANTHERiPTHR24048:SF2. PTHR24048:SF2. 1 hit.
PfamiPF12662. cEGF. 2 hits.
PF07645. EGF_CA. 1 hit.
[Graphical view]
PRINTSiPR00907. THRMBOMODULN.
SMARTiSM00181. EGF. 1 hit.
SM00179. EGF_CA. 3 hits.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 1 hit.
PROSITEiPS00010. ASX_HYDROXYL. 3 hits.
PS01186. EGF_2. 3 hits.
PS50026. EGF_3. 3 hits.
PS01187. EGF_CA. 4 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  2. Ensembl
    Submitted (MAY-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiE9Q3F3_MOUSE
AccessioniPrimary (citable) accession number: E9Q3F3
Entry historyi
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: March 4, 2015
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.